10(E),12(Z) 十八碳二烯酸甲酯21870-97-3

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10(E),12(Z)-十八碳二烯酸 10(E),12(Z)-Octadecadienoic acid 25mg

10(E),12(Z) - 十八碳二烯酸甲酯 Methyl 10(E), 12(Z)-octadecadienoate 25mg

9(Z),11(E)-十八碳二烯酸 9(Z),11(E)-Octadecadienoic acid 25mg

9(Z),11(E) - 十八碳二烯酸甲酯 Methyl 9(Z), 11(E)-octadecadienoate 25mg

Application Notes:

This product is a methyl ester and is ideal as a gas chromatography standard. 10(E),12(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals, including dairy products. It has several biological properties including anti-carcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Animals fed a diet containing high levels of CLA have been observed to have improved feed efficiency (lean body mass increased while body fat decreased) and this seems to be due, mainly or exclusively, to the 10(E),12(Z)- Octadecadienoic acid.2 However, this isomer appears to increase oxidative stress and inflammatory biomarkers in obese men, which can lead to insulin resistance.3,4 10(E),12(Z)-Octadecadienoic acid increases LDL:HDL cholesterol and total:HDL cholesterol in humans.

References:
1. Helen B. MacDonald, Journal of the American College of Nutrition, Vol. 19, No. 90002, 111S-118S, 2000
2. Yanwen Wang and Peter JH Jones, The American Journal of Clinical Nutrition, June, Vol. 79, No. 6, 1153S-1158S, 2004
3. Ulf Risérus, MMed; Samar Basu, PhD; Stefan Jovinge, MD, PhD; Gunilla Nordin Fredrikson, PhD; Johan ?rnl?v, MD; Bengt Vessby, MD, PhD,Circulation 106:1925, 2002
4. Soonkyu Chung, J. Mark Brown, J. Nathan Provo, Robin Hopkins and Michael K. McIntosh, The Journal of Biological Chemistry, September, Vol. 280: 38445, 2005