荜茇酰胺 Piperlongumine

Des cription

Piperlo ngumine is isolated from several species of the Piper plant and displays many beneficial characteristics, including antithrombotic, anti-inflammatory, anti-atherosclerotic, and chemotherapeutic activities. Piperlo ngumine directly inhibits thromboxane A2 (TxA2) receptors, inhibiting platelet aggregation in vivo. Piperlo ngumine also decreases NF-κB activation and inhibits PDGFR signaling in vivo, inhibiting cell migration and decreasing atherosclerotic plaque formation. In a cellular model of prostate cancer, piperlo ngumine inhibits NF-κB activity and decreases ex pression of IL-6, IL-8, MMP9, and ICAM-1, decreasing cell invasion and growth; in a separate study using a similar model, this compound prevented trans cription of androgen receptors, decreasing androgen receptor protein levels. In several other cellular models of cancer (including glioblastoma multiforme and co lon cancer), piperlo ngumine inhibits the ubiquitin-proteasome system, likely at a pre-proteasomal stage, increasing reactive oxygen species (ROS) and stimulating activation of p38, resulting in autophagy and cell death.