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Des
cription
Actino
nin is an inhibitor of peptide deformylase, matrix me
talloproteinase meprin A, and aminopeptidase N (CD13). Actino
nin exhibits anticancer, antibiotic, anti-inflammatory, and nephroprotective activities. In Burkitt
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| Specifications |
| Cas No. |
13434-13-4 |
| Product ID |
A0978 |
| Product Name |
放线酰胺素 Actinonin 分析标准品 |
| Chemical Name |
3-((1-((2-[Hydroxymethyl]-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamoyl)octanohydroxamic acid |
| Synonym |
Actinonine |
| Formula |
C19H35N3O5 分子式 |
| Formula Wt. |
385.5 分子量 |
| Melting Point |
141.5-142 |
| Purity |
≥98% 纯度 |
| Solubility |
Soluble in ethanol. |
| Store Temp |
-20oC |
| Ship Temp |
Ambient |
| References |
Sheth A, Escobar-Alvarez S, Gardner J, et al. Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis. 2014 Mar 27;5:e1152. PMID: 24675470.
Goemaere E, Melet A, Larue V, et al. New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity. J Antimicrob Chemother. 2012 Jun;67(6):1392-400. PMID: 22378679.
Wang Z, Herzog C, Kaushal GP, et al. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock. 2011 Feb;35(2):141-7. PMID: 20577148.
Sharma A, Sharma S, Khuller GK, et al. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009 Sep;34(3):226-30. PMID: 19505802.
Sina A, Lord-Dufour S, Annabi B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett. 2009 Jul 8;279(2):171-6. PMID: 19264392.
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