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Des
cription
Leptomycin is a polyketide antibiotic produced by Streptomyces. Leptomycin exhibits anticancer and antifungal activity. Leptomycin inhibits CRM1, preventing nuclear export of proteins. In lung cancer cells, leptomycin induces G1 phase cell cycle arrest; in cervical carcinoma cells, leptomycin increases activation of p53, inducing apoptosis.
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| Specifications |
| Cas No. |
87081-35-4 |
| Product ID |
L1761 |
| Product Name |
Leptomycin B 来普霉素 分析标准品 |
| Chemical Name |
19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- 2,10,12,16,18-Nonadecapentaenoic acid |
| Synonym |
LMB; Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720. |
| Formula |
C33H48O6 分子式 |
| Formula Wt. |
540.74 分子量 |
| Melting Point |
41oC-44oC |
| Purity |
≥98% 纯度 |
| Solubility |
Soluble in ethanol or methanol. |
| Stability |
WARNING: Small quantities of LepB are reported to be unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of LepB, because rapid decomposition may result. |
| Store Temp |
-20oC |
| References |
Sun Q, Carrasco YP, Hu Y, et al. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1303-8. PMID: 23297231.
Abkallo HM, Kawano H, Watanabe K, et al. A new cell-based reporter system for sensitive screening of nuclear export inhibitors. Drug Discov Ther. 2011 Dec;5(6):286-92. PMID: 22466439.
Lu C, Shao C, Cobos E, et al. Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. PLoS One. 2012;7(3):e32895. PMID: 22412944.
Hamamoto T, Gunji S, Tsuji H, et al. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. J Antibiot (Tokyo). 1983 Jun;36(6):639-45. PMID: 6874585. |
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