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Vortioxetine 原装进口分析标准品

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品牌: 进口
产品型号: 508233-74-7
产品规格: 5mg 10mg 25mg
起订: 5 mg
供货总量: 1000 mg
发货期限: 自买家付款之日起3天内发货
所在地: 上海
有效期至: 长期有效
最后更新: 2023-03-02 13:54
浏览次数: 579
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公司基本资料信息
产品详细说明
Vortioxetine


Des cription
Vortioxetine is an antidepressant and anxiolytic. Vortioxetine modulates seroto nin levels in the brain by inhibiting the seroto nin transporter and 5-HT3A,7 receptors, acting as a partial ago nist at the 5-HT1B receptor, and acting as a full ago nist at the 5-HT1A receptor. Vortioxetine also shows some ago nist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spo ntaneous alternation tests.
Specifications
Cas No. 508233-74-7
Product ID HV5870
Product Name Vortioxetine 原装进口分析标准品
Formula C18H22N2S
Formula Wt. 298.45
Purity >98%
Store Temp Ambient
References du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504.

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346.

Bang-Andersen B, Ruhland T, J?rgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.


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