Des
cription
Vortioxetine is an antidepressant and anxiolytic. Vortioxetine modulates seroto
nin levels in the brain by inhibiting the seroto
nin transporter and 5-HT3A,7 receptors, acting as a partial ago
nist at the 5-HT1B receptor, and acting as a full ago
nist at the 5-HT1A receptor. Vortioxetine also shows some ago
nist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spo
ntaneous alternation tests.
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