人参皂苷Rc | CAS:11021-14-0

IC50 Value & Target:

In vitro: Rc reduced the proliferation and viability of 3T3-L1 preadipocytes in a dose-dependent manner. Treatment with Rc decreased the number of adipocytes and reduced lipid accumulation in maturing 3T3-L1 preadipocytes, demo nstrating an inhibitory effect on lipogenesis. Rc directly induced lipolysis in adipocytes and down-regulated the ex pression of major trans cription factors of the adipogenesis pathway, such as PPARγ and C/EBPα [1]. Overex pression of catalase induced by Rc resulted in suppression of RS production in kidney human embryo kidney 293T cells (HEK293T) cells, and that oxidative stress induced activation of PI3K/Akt and inhibition of the AMPK pathway and FoxO1 phosphorylation, leading to down-regulation of catalase, a FoxO1-targeting gene. In addition, treatment of HEK293T cells with Rc resulted in cAMP-respo nse element-binding protein (CREB)-binding protein (CBP) regulated FoxO1 acetylation [2].

In Vivo: Have no relevant experimental datas.