人参皂苷Rb2 | CAS:11021-13-9

IC50 Value & Target:

In Vitro: Treatment of 0.1 to 10μM Rb2 promoted the proliferation of MC3T3-E1 cells, improved alkaline phosphatase (ALP) ex pression, elevated calcium mineralization and mRNA ex pressions of Alp, Col1a1, osteocalcin (Ocn) and osteopo ntin (Opn) against oxidative damage induced by H2O2. im portantly, Rb2 reduced the ex pression levels of receptor activator of nuclear factor kappa-B ligand (RANKL) and IL-6 and inhibited the H2O2-induced production of ROS [1]. Ginsenoside-Rb2 showed the highest protective activity, although other dammarane-type and oleanolic acid-type ginsenosides also induced a significant protection against HVJ [2]. Rb2 (3~30 μM), perfused into an adrenal vein for 90 min, inhibited ACh (5.32 mM)-evoked CA secretory respo nse in a dose- and time-dependent fashion. Rb2 (10 μM) also time-dependently inhibited the CA secretion evoked by DMPP (100 μM, a selective neuro nal nicotinic receptor agonist) and high K(+) (56 mM, a direct membrane depolarizer) [3].

In Vivo: Multiple administrations of ginsenoside-Rb2 after the intravenous inoculation of B16-BL6 melanoma cells resulted in a significant inhibition of lung me tastasis as compared with the untreated co ntrol [1].