涓囧缓姘戦櫌澹洟闃熸壘鍒拌皟鎺ф按绋绘爱绱犻珮鏁堝埄鐢ㄢ€滈椄闂ㄢ€�

銆€銆€涓婁笘绾�60骞翠唬浠ユ潵锛屾爱鑲ョ殑澶у箙鎶曞叆淇冭繘浜嗙伯椋熷崟浜х殑鎻愬崌銆備絾绉戝瀹朵滑鍙戠幇锛岃繃閲忔柦鐢ㄦ爱鑲ュ鑷存棤鏁堝垎铇栬繃閲忕敓闀匡紝鎶戝埗姘寸ɑ鏈夋晥鍒嗚槚鐨勫舰鎴愶紝鍙嶈€屼細闄嶄綆姘寸ɑ浜ч噺鍜屾爱绱犲埄鐢ㄦ晥鐜囥€�6鏈�13鏃ワ紝鍗椾含鍐滀笟澶у涓囧缓姘戦櫌澹洟闃熼娆″湪鍒嗗瓙閬椾紶瀛﹀眰闈㈤槓鏄庝簡杩囬噺姘偉瀵艰嚧姘寸ɑ鏃犳晥鍒嗚槚褰㈡垚鐨勬満鐞嗭紝浠庢按绋昏嚜鐒剁兢浣撲腑鍙戞帢浜嗘爱楂樻晥浼樺紓鍗曞€嶅瀷杞綍鍥犲瓙OsGATA8-H锛屽悓鏃剁粨鍚�鍩哄洜缂栬緫鍜屽洖浜よ偛绉嶆妧鏈垱鍒朵簡浼樺紓姘珮鏁堣偛绉嶆潗鏂欙紝鐩稿叧鎴愭灉鍙戣〃浜庨仐浼犲鏉冨▉鏈熷垔銆婅嚜鐒堕仐浼犲銆婲ature Genetics涓娿€�

 

銆€銆€鍗曚綅闈㈢Н鏈夋晥鍒嗚槚鏁版槸鍐冲畾姘寸ɑ鍗曚骇鐨勫叧閿洜绱犱箣涓€銆傝繃閲忔柦鐢ㄦ爱鑲ュ鑷存棤鏁堝垎铇栬繃閲忕敓闀匡紝鎶戝埗姘寸ɑ鏈夋晥鍒嗚槚鐨勫舰鎴愶紝浠庤€岄檷浣庢按绋讳骇閲忓拰姘礌鍒╃敤鏁堢巼銆�

 

銆€銆€鐮旂┒鍥寸粫浠sGATA8-H涓烘牳蹇冪殑鍒嗗瓙璋冩帶妯″潡锛岄槓鏄庝簡姘皟鎺ф湁鏁堝垎铇栧舰鎴愮殑閲嶈绉戝闂銆�“姝ゆ鍙戠幇鐨勮浆褰曞洜瀛怬sGATA8-H绫讳技璋冩帶閾电瀛愯浆杩愮殑涓€閬�‘闂搁棬’”锛屾嵁鎴愭灉鍏卞悓閫氳浣滆€呫€佸洟闃熺帇鏄ユ槑鏁欐巿浠嬬粛锛屽洟闃熷彂鐜帮紝杩欓亾“闂搁棬”鍙互“鍙屽悜璋冩帶”姘礌鍒╃敤鏁堢巼锛屽湪浣庢爱鏉′欢涓嬶紝“闂搁棬”閫氳繃澧炲姞OsAMT3.2琛ㄨ揪锛屼績杩涙按绋婚摰鍚告敹锛涘湪楂樻爱鏉′欢涓嬶紝杩欓亾“闂搁棬”鍙堣兘閫傚綋鎻愰珮OsTCP19鐨勮〃杈撅紝淇冭繘鏇村鍒嗚槚鍙戣偛鎴愭湁鏁堝垎铇栵紝鍑忓皯鏃犳晥鍒嗚槚鐨勫舰鎴愩€�

 

銆€銆€鍦ㄦ鍩虹涓婏紝鍥㈤槦鍙堥€氳繃鍩哄洜缁勭紪杈戝拰鍩哄洜鑱氬悎鎶€鏈紝灏嗕紭寮傚崟鍊嶅瀷鍩哄洜OsGATA8-H瀵煎叆鐜颁唬鏍藉煿鍝佺涓紝涓烘按绋绘爱楂樻晥鑲茬銆佸噺灏戝寲鑲ヤ娇鐢紝鎺ㄨ繘缁胯壊鍐滀笟鐨勫彲鎸佺画鍙戝睍鎻愪緵浜嗘柟鍚戙€�

 

銆€銆€杩欎竴鎴愭灉鍓嶅悗鍘嗙粡浜嗗崄浣欏勾鏃堕棿銆傛嵁浜嗚В锛屽洟闃熻嚜2013骞磋捣锛屼粠1涓囦唤鑲茬鏉愭枡涓簿蹇冪瓫閫夛紝鎸戦€夊嚭浜�1000浠芥€х姸浼樺紓鐨勪翰鏈€傚湪杩欏熀纭€涓婏紝杩涗竴姝ョ瓫閫夊嚭175浠芥潗鏂欒繘琛屽叏鍩哄洜缁勬祴搴忓垎鏋愶紙WGS锛夈€傚湪鍒濆畾浣嶃€佺簿缁嗗畾浣嶅拰鍩哄洜鍏嬮殕鐨勫熀纭€涓婏紝鏈€缁堟壘鍒颁簡OsGATA8-H杩欓亾鍏抽敭鐨�“闂搁棬”锛屽苟杩炵画3骞寸敯闂村疄楠岋紝閫氳繃鍩哄洜鏁查櫎鍜岃繃琛ㄨ揪瀹屾垚浜嗕粠鍩哄洜鍒拌〃鍨嬬殑鍙屽悜楠岃瘉銆�

 

銆€銆€寰峰浗鑾卞竷灏艰尐妞嶇墿閬椾紶鍜屼綔鐗╃爺绌舵墍鎵€闀縉icolaus von Wiren鍗氬＋璇勪环锛�“鐮旂┒浜哄憳閴村畾浜嗘爱楂樻晥鍏抽敭杞綍鍥犲瓙GATA8骞舵帰绱簡绛変綅鍩哄洜澶氭牱鎬э紝鏄竴椤圭郴缁熸繁鍏ョ殑鍘熷垱鎬ф垚鏋溿€傚湪鐜颁唬姘寸ɑ鍝佺涓彂鐜颁簡浼樺紓鍗曞€嶅瀷GATA8-H锛屽皢瀵规按绋绘爱楂樻晥閬椾紶鑲茬鐮旂┒浜х敓娣辫繙鐨勫奖鍝嶃€�”

 

銆€銆€鍗椾含鍐滀笟澶у涓囧缓姘戦櫌澹拰鐜嬫槬鏄庢暀鎺堜负鍏卞悓閫氳浣滆€咃紝鍗氬＋鐢熷帆濞佸拰钁ｅ皬楦ユ暀鎺堜负鍏卞悓绗竴浣滆€呫€傛垚鏋滆幏寰楀浗瀹堕噸鐐圭爺鍙戦」鐩€佸浗瀹惰嚜鐒剁瀛﹀熀閲戦」鐩拰姹熻嫃鐪佺敓鐗╄偛绉嶉挓灞卞疄楠屽绛夎祫鍔┿€�

 

銆€銆€鍘熸枃閾炬帴锛歨ttps://www.nature.com/articles/s41588-024-01795-7