部分原文报道如下９/div>
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit
?Extra) as a zootechnical feed additive for suckling and weaned piglets and other growing Suidae. The additive is standardised to co
ntain a co
ncentration of the sum of the four alkaloids sanguinarine, chelerythrine, protopine and allocryptopine of 1.25%, with 0.5% sanguinarine. Owing to the presence of the DNA intercalators sanguinarine and chelerythrine, a co
ncern for genotoxicity was identified. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) had no safety co
ncerns for the target species when the additive is used at the recommended level of 0.750 mg sanguinarine/kg complete feed for suckling and weaned piglets and other growing Suidae. Since in all co
nsumer categories the exposure to sanguinarine and chelerythrine via the use of Sangrovit
?Extra exceeds the threshold of toxicological co
ncern of 0.0025 g/kg bw per day for DNA reactive mutagens and/or carcinogens, the FEEDAP Panel could not co
nclude on the safety for the consumers. The additive was shown to be irritant to the eyes but not irritant to skin or a skin sensitiser. The FEEDAP Panel could not exclude the potential of the additive to be a respiratory sensitiser. When handling the additive, exposure of unprotected users to sanguinarine and chelerythrine may occur. Therefore, to reduce the risk, the exposure of users should be reduced. The use of Sangrovit
?Extra as a feed additive under the proposed co
nditions of use was co
nsidered safe for the environment. The additive Sangrovit
?Extra had the potential to be efficacious in improving performance of weaned piglets at 0.600 mg sanguinarine/kg complete feed. This co
nclusion was extended to suckling piglets and extrapolated to other growing Suidae.
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地区９/font>
欧盟评估转基因玉米MO
欧盟评估一种麦芽糖淀
美国拟撤销若干肉类叉/a>
鲁公网安 37060202000128叶/a>
