　　 食品伙伴网讯2024�?�?日，�?a href='//www.sqrdapp.com/news/tag_1377.html' class='zdbq' title='欧盟食品安全局相关食品资讯' target='_blank'>欧盟食品安全局＇�a href='//www.sqrdapp.com/news/tag_10.html' class='zdbq' title='EFSA相关食品资讯' target='_blank'>EFSA）消息，应欧盟委员会要求，欧盞�a href='//www.sqrdapp.com/news/tag_4566.html' class='zdbq' title='动物相关食品资讯' target='_blank'>动物饲料添加剁�/a>和产品（FEEDAP）研究小组就谷氨酷�/a>棒杆菌CGMCC 20437 发酵生产的L-异亮氨酸（l-isoleucine）作为所有动物饲料添加剂的安全性和有效性发表科学意见�

　　经过评估，专家小组认为该添加剂对目标物种、消费者和环境是安全的。由于缺乏数据，研究小组无法就该添加剂对皮肤或眼睛产生刺激的可能性得出结论。评估中的添加剂被认为是非反刍动物物种氨基酸L-异亮氨酸的有效来源。为了使补充的L-异亮氨酸对反刍动物和非反刍动物同样有效，需要防止其在瘤胃中降解。部分原文报道如下：

　　Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 20437 as a nutritio nal feed additive for use in feed and in water for drinking for all animal species. The production strain is non-genetically modified, qualifies for the QPS approach to safety assessment when used for production purposes, is susceptible to the relevant antibiotics and co ntains no antimicrobial resistance genes of concern. No viable cells of the production strain were detected in the final product. The additive does not give rise to any safety co ncern regarding the production strain. l-Isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 20437 is co nsidered safe for the target species, the co nsumer and the environment. Regarding the use in water, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) reiterates its co ncerns over the safety for the target species of l-isoleucine administered simultaneously via water for drinking and feed owing to the risk of nutritio nal imbalances and hygienic reasons. In the absence of data, the FEEDAP Panel is not in a position to co nclude on the potential of l-isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 20437 to be irritant to skin and/or eyes, or as a dermal sensitiser. Due to the high dusting potential, exposure by inhalation is likely. l-Isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 20437 is co nsidered as an efficacious source of the essential amino acid l-isoleucine for non-ruminant animal species. For the supplemental l-isoleucine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

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