华中农业大学精准营养与代谢团队揭示黑米饮食对结直肠癌发展的健康效用及潜在机制

　　The co nsumption of dietary fiber and anthocyanin has been associated with a reduced risk of colorectal cancer （CRC）� This study scrutinizes the potential antitumorigenic attributes of a black rice diet, abundantly rich in dietary fiber and anthocyanin. Our results demo nstrate notable antitumorigenic effects in mice on the black rice diet, indicated by a reduction in both the size and number of intestinal tumors and a co nsequent extension in life span, compared to co ntrol diet-fed counterparts. Furthermore, fecal transplants from black rice diet-fed mice to germ-free mice led to a decrease in colo nic cell proliferation, coupled with maintained integrity of the intestinal barrier. The black rice diet was associated with significant shifts in gut microbiota composition, specifically an augmentation in probiotic strains Bacteroides uniformis and Lactobacillus. Noteworthy changes in gut me tabolites were also docu mented, including the upregulation of Indole-3-lactic acid and Indole. These me tabolites have been identified to stimulate the intestinal aryl hydrocarbon receptor （AHR� pathway, inhibiting CRC cell proliferation and colorectal tumorigenesis. In summary, these findings propose that a black rice diet may modulate the progression of intestinal tumors by fostering protective gut microbiota and me tabolite profiles. The study accentuates the potential health advantages of whole-grain foods, emphasizing the potential utility of black rice in promoting health.

　　原文链接：https://onlinelibrary.wiley.com/doi/10.1002/imt2.165