欧盟评估转基因黑曲霉菌株NPH生产?-植酸酶的安全?/h1>
放大字体缩小字体时间?024-01-16 11:01 来源:食品伙伴网 作者: 泽夕
核心提示?024??2日,欧盟食品安全局就一种食品酶3-植酸酶(3-phytase)的安全性评价发布意见、/div>
   食品伙伴网讯2024??2日, 欧盟食品安全局就一种食品酶3- 植酸酵/a>?-phytase)的安全性评价发布意见
  据了解,这种食品酶是田a href='//www.sqrdapp.com/news/tag_2434.html' class='zdbq' title='转基因相关食品资? target='_blank'>转基囟/a> 黑曲霈/a>菌株NPH生产的,旨在用于三种食品生产过程:烘焙产品、蒸馏酒精以及加工植物和真菌衍生产品以生产植物基牛奶和奶制品类似物、/div>
  经过评估,专家小组认为,在预期的使用条件下,不能排除通过饮食接触引起过敏反应的风险(蒸馏酒精生产除外),但这种情况发生的可能性很低。根据所提供的数据,小组得出结论,该食品酶在预期的使用条件下不会引起安全问题。部分原文报道如下:
  The food enzyme 3-phytase (myo-inositol-hexakisphosphate 3-phosphohydrolase EC 3.1.3.8) is produced with the genetically modified Aspergillus niger strain NPH by DSM Food Specialties. The genetic modifications do not give rise to safety concerns. The food enzyme was co nsidered free from viable cells of the production organism and its DNA. It is intended to be used in three food manufacturing processes: processing of cereals and other grains for the production of (1) baked products and (2) distilled alcohol, and the processing of plant- and fungal-derived products for the production of (3) plant-ba sed analogues of milk and milk products. Since no residual amounts of total organic solids (TOS) are carried over into distilled alcohol, dietary exposure was calculated o nly for the remaining two food manufacturing processes. It was estimated to be up to 0.553 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 833 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 1506. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel co nsidered that the risk of allergic reactions by dietary exposure cannot be excluded (except for distilled alcohol production), but the likelihood is low. ba sed on the data provided, the Panel co ncluded that this food enzyme does not give rise to safety concerns, under the intended co nditions of use.
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日期9a href="//www.sqrdapp.com/news/2024-01-16.html">2024-01-16
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