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榛戞洸闇堻/a>鑿屾牚NPH鐢熶骇鐨勶紝鏃ㄥ湪鐢ㄤ簬涓夌椋熷搧鐢熶骇杩囩▼锛氱儤鐒欎骇鍝併€佽捀棣忛厭绮句互鍙婂姞宸ユ鐗╁拰鐪熻弻琛嶇敓浜у搧浠ョ敓浜ф鐗╁熀鐗涘ザ鍜屽ザ鍒跺搧绫讳技鐗┿€侟/div>
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銆€銆€The food enzyme 3-phytase (myo-inositol-hexakisphosphate 3-phosphohydrolase EC 3.1.3.8) is produced with the genetically modified Aspergillus niger strain NPH by DSM Food Specialties. The genetic modifications do not give rise to safety concerns. The food enzyme was co
nsidered free from viable cells of the production organism and its DNA. It is intended to be used in three food manufacturing processes: processing of cereals and other grains for the production of (1) baked products and (2) distilled alcohol, and the processing of plant- and fungal-derived products for the production of (3) plant-ba
sed analogues of milk and milk products. Since no residual amounts of total organic solids (TOS) are carried over into distilled alcohol, dietary exposure was calculated o
nly for the remaining two food manufacturing processes. It was estimated to be up to 0.553 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 833 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 1506. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel co
nsidered that the risk of allergic reactions by dietary exposure cannot be excluded (except for distilled alcohol production), but the likelihood is low. ba
sed on the data provided, the Panel co
ncluded that this food enzyme does not give rise to safety concerns, under the intended co
nditions of use.
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鏈枃鐢遍鍝佷紮浼寸綉椋熷搧璧勮涓績缂栬緫锛屼緵缃戝弸鍙傝€冿紝鏈変换浣曠枒闂紝璇疯仈绯籲ews@www.sqrdapp.com銆侟/span>
