欧盟评估转基因黑曲霉菌株PLA生产的磷脂酶A2的安全�?/h1>

时间�?023-11-22 10:59 来源：食品伙伴网 作者： 泽夕

核心提示�?023�?1�?1日，欧盟食品安全局就一种磷脂酶A2（phospholipase A2）的安全性评价发布意见、�/div>

　　 食品伙伴网讯2023�?1�?1日， 欧盟食品安全局就一秌�a href='//www.sqrdapp.com/news/tag_3206.html' class='zdbq' title='磷脂相关食品资讯' target='_blank'>磷脂酶A2（phospholipase A2）的安全性评价发布意见�

　　据了解，这种食品酶是田�a href='//www.sqrdapp.com/news/tag_2434.html' class='zdbq' title='转基因相关食品资�? target='_blank'>转基囟�/a> 黑曲霈�/a>菌株PLA生产的，旨在用于蛋和蛋制品的加工，通过脱胶加工脂肪和油，以及生产改性卵磷脂(溶血卵磷�?、�/div>

　　经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏反应的风险，但这种情况发生的可能性很低。根据所提供的数据，评估小组得出结论，这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下：

　　The food enzyme phospholipase A2 (phosphatidylcholine 2-acylhydrolase, EC 3.1.1.4) is produced with the genetically modified Aspergillus niger strain PLA by DSM Food Specialties B.V. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in the processing of egg and egg products, in the processing of fats and oils by degumming and for the production of modified lecithins (lysolecithin). As residual total organic solids (TOS) are removed in the refined fats and oils during degumming, dietary exposure was calculated o nly for the remaining two food manufacturing processes. For egg processing, the dietary exposure was estimated to be up to 1.712 mg TOS/kg body weight (bw) per day in European populations. Wet gum can be used to produce lysolecithin with the highest dietary exposure of 1.61 mg TOS/kg bw per day in children at the 95th percentile when used as a food additive. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1350 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated overall dietary exposure, resulted in a margin of exposure of at least 851. A search for the similarity of the amino acid sequence of the food enzyme to those of known allergens was made and no match was found. The Panel co nsidered that the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. ba sed on the data provided, the Panel co ncluded that this food enzyme does not give rise to safety co ncerns under the intended co nditions of use.

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相关政策解读

欧盟食品快速预警系统知多少

日期９�a href="//www.sqrdapp.com/news/2023-11-22.html">2023-11-22

地区９�/font>欧盟国外
行业９�/font>转基因食�?/font>食品检浊�/font>进出叢�/font>
标签９�/font>磷脂黑曲霈�/font>转基囟�/font>欧盟食品安全局
科普９�/font>磷脂黑曲霈�/font>转基囟�/font>欧盟食品安全局

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