南湖新闻网讯（通讯 宗茂）近日，华中农业大植物科学技术学陡a href='//www.sqrdapp.com/news/tag_2869.html' class='zdbq' title='农药相关食品资讯' target='_blank'>农药
毒理?/a>叉a href='//www.sqrdapp.com/news/tag_4424.html' class='zdbq' title='有害生物相关食品资讯' target='_blank'>有害生物抗药性团队研究成果以Redox and Near-Infrared Light-Respo
nsive Nanoplatform for Enhanced Pesticide Delivery and Pest Co
ntrol in Rice: Construction, Efficacy, and Potential Mechanisms为题在ACS Applied Materials & Interfaces上发表。研究采用了一种创新的纳米平台，成功实现了寸a href='//www.sqrdapp.com/news/tag_1739.html' class='zdbq' title='水稻相关食品资讯' target='_blank'>水稻重要害虫褐飞虱防控药剂的高效智能递送，进一步阐明了其增效机制、/div>
褐飞虱（Nilaparvata lugens）是我国水稻生产上的重要害虫，对水稻产量和品质造成严重危害。基于此，研究团队开发了一种镶嵌硫化铜的有机二氧化硅纳米复合载体，将其应用于新烟碱类杀虫剂烯啶虫胺的控制释放。硫化铜纳米颗粒可将近红外光能转化为热量，从而实现农药的快速释放和协同增效效应。同时，有机二氧化硅纳米颗粒具有丰富的孔隙结构和较大的比表面积，可高效负载农药分子，并对害虫体内谷胱甘肽作出响应。硫化铜可实现快速光热转化，纳米平台具有较高的光热转化率，在近红外光的激发下，与烯啶虫胺原药相比，纳米平台对褐飞虱田间种群和抗药性种群的毒力均显著提升。进一步发现纳米平台可显著抑制褐飞虱抗药性种群中P450基因（NlCYP6ER1，NlCYP6AY1，NlCYP4C76）的表达，进而提高其对杀虫剂的敏感性，研究结果为害虫抗药性的治理提供了新思路。该纳米平台在有害生物绿色高效防控方面具有巨大应用潜力、/div>
植物科学技术学院硕士研究生宗茂为论文第一作者，何顺副教授为论文通讯作者，李建洪教授、万虎教授和马康生副教授参与了项目的指导。该研究得到湖北省重点研发计划和国家自然科学基金等项目资助、/div>
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审核人：李建?/div>
【英文摘要【/div>
The brown planthopper （BPH）， Nilaparvata lugens （St?l）， is a major rice pest in various Asian countries, causing significant negative impacts on rice yield and quality. In this study, we developed a novel nanoplatform （NIT@MON@CuS for pesticide delivery that respo
nds to redox and near-infrared light stimuli. The nanoplatform co
nsisted of CuS nanoparticles with mesoporous organic silica （MON）， loaded with nitenpyram （NIT） With an average size of 190 nm and a loading efficiency of 22%, the NIT@MON@CuS exhibited remarkable thermal respo
nse in the near-infrared region, demo
nstrating excellent photothermal co
nversion ability and stability. In vitro release kinetics demo
nstrated that rapid released nitenpyram under near-infrared light and glutathione conditions, facilitating a satisfactory temperature increase and accelerated drug release. The NIT@MON@CuS treated group exhibited a higher mortality of N. lugens, increasing from 62% to 88% compared to the group treated with nitenpyram technical after 96 hours. Bioassay revealed that NIT@MON@CuS significantly enhanced nitenpyram toxicity by more than 1.4-fold against both laboratory insecticide-resistant and field strains of N. lugens. Furthermore, RT-qPCR results demo
nstrated that MON@CuS had the capability to reduce P450 gene ex
pression thereby improving the sensitivity of N. lugens to insecticides. These findings suggest that MON@CuS hold great potential as an intelligent pest co
ntrol platform, offering a sustainable and efficient approach to protect crops against pests.
论文链接：https://pubs.acs.org/doi/abs/10.1021/acsami.3c08413
日期９a href="//www.sqrdapp.com/news/2023-10-04.html">2023-10-04
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