銆€銆€鎹簡瑙o紝杩欑椋熷搧閰舵槸鐢遍潪杞熀鍥燭alaromyces cellulolyticus鑿屾牚NITE BP-03478鐢熶骇鐨勶紝鏃ㄥ湪鐢ㄤ簬鍏椋熷搧鍒堕€犺繃绋嬶細鐑樼剻杩囩▼銆侀吙閫犺繃绋嬨€佹灉姹佺敓浜т腑鐨勬按鏋滃拰钄彍鍔犲伐銆佽憽钀勯厭鍜岃憽钀勯厭閱嬬敓浜с€佹灉姹佷互澶栦骇鍝佺殑姘存灉鍜岃敩鑿滃姞宸ャ€佺簿鍒舵﹦姒勬补鐢熶骇鐨勬按鏋滃拰钄彍鍔犲伐銆佸挅鍟¤眴鑴辫泲鐧藉拰娣€绮夌敓浜т腑鐨勮胺鐗╁鐞嗐€�
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銆€銆€The food enzyme containing endo-polygalacturonase ((1–4)-α-d-galacturonan glycanohydrolase; EC 3.2.1.15) and cellulase (4-(1,3;1,4)-β-d-glucan 4-glucanohydrolase; EC 3.2.1.4) activities is produced with the non-genetically modified Talaromyces cellulolyticus strain NITE BP-03478 by Meiji Seika Pharma Co., Ltd. It is intended to be used in eight food manufacturing processes: baking processes, brewing processes, fruit and vegetable processing for juice production, wine and wine vinegar production, fruit and vegetable processing for products other than juices, fruit and vegetable processing for refined olive oil production, coffee bean demucilation and grain treatment for starch production. Since residual amounts of total organic solids (TOS) are removed during three food processes (refined olive oil production, coffee bean demucilation and grain treatment for starch production), dietary exposure was not calculated for these food processes. For the remaining five food processes, dietary exposure was estimated to be up to 3.193 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 806 mg TOS/kg bw per day, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 252. A search for the similarity of the amino acid sequences of the food enzyme to known allergens was made and six matches with pollen allergens were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, especially in individuals sensitised to pollen. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
銆€銆€鏈枃鐢遍鍝佷紮浼寸綉椋熷搧璧勮涓績缂栬緫锛屾湁浠讳綍鐤戦棶锛岃鑱旂郴news@www.sqrdapp.com銆�