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当前位置: 首页 » 食品资讯 » 外讯导读 » 欧盟评估非转基因Hamamotoa singularis菌株YIT 10047 生产的β-半乳糖苷...

欧盟评估非转基因Hamamotoa singularis菌株YIT 10047 生产的β-半乳糖苷酶的安全性

放大字体  缩小字体 时间:2022-11-23 10:51 来源:食品伙伴网 作者: 泽夕   
核心提示:2022年11月22日,欧盟食品安全局就一种β-半乳糖苷酶(β-galactosidase)的安全性评价发布意见。
   食品伙伴网讯  2022年11月22日,欧盟食品安全局就一种β-半乳糖苷酶(β-galactosidase)的安全性评价发布意见。
 
  据了解,这种食品酶是由非转基因Hamamotoa singularis菌株YIT 10047生产的,旨在用于低聚半乳糖的生产。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏反应的风险,但这种可能性被认为很低。根据所提供的数据,评估小组得出结论,这种用作β-半乳糖 <http://news.www.sqrdapp.com/tag_2554.html>苷酶来源的酵母悬浮液在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  This assessment addresses the enzyme β-galactosidase which is not separated from the yeast cells used for its production. The β-galactosidase (β-D-galactoside galactohydrolase, EC 3.2.1.23) is produced with the non-genetically modified Hamamotoa singularis (formerly Sporobolomyces singularis) strain YIT 10047 by Yakult Pharmaceutical Industry Co., Ltd. The yeast cell suspension contains both live and dead yeast cells. It is intended to be used in the production of galacto-oligosaccharides (GOS). The final GOS products are free of viable cells of the H. singularis. Dietary exposure to the food enzyme total organic solids (TOS) was estimated to be up to 0.683 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests of the cell suspension did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 296.25 mg TOS/kg bw per day, the highest dose tested. This results in a margin of exposure above 434. A search for the similarity of the amino acid sequence of the β-galactosidase to known allergens was made and no matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is low. based on the data provided, the Panel concluded that this yeast suspension used as a source of β-galactosidase does not give rise to safety concerns under the intended conditions of use.
 
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日期:2022-11-23
 
 
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