经过评估,专家小组得出结论,该添加剂对鸡育肥是安全的。在没有数据的情况下,无法得出有关皮肤致敏潜力的结论。当添加剂使用水平为15,000 PROT/kg饲料对鸡育肥有效。部分原文报道如下:
Ronozyme
?ProAct is the trade name of the feed additive under assessment and co
ntains serine protease produced by a genetically modified strain of Bacillus licheniformis. Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Ronozyme? ProAct when used as a zootechnical additive for chickens for fattening. The additive is available in coated thermotolerant granulated and liquid forms (Ronozyme
?ProAct CT/L). The production strain and its recombinant DNA were not detected in an intermediate co
ncentrated product used to produce the final formulations. The final products do not trigger a safety co
ncern with regard to the genetic modification. ba
sed on the results obtained in a tolerance study in chickens for fattening and the data from a subchro
nic oral toxicity study the FEEDAP Panel co
ncluded that the additive is safe for chickens for fattening. The FEEDAP Panel co
ncluded that the use of Ronozyme
?ProAct CT/L as a feed additive gives rise to no co
ncern for co
nsumers and for the environment. The additive, in either form, is not an eye irritant but should be co
nsidered a skin irritant. In the absence of data, no co
nclusions on the skin sensitisation potential can be reached. Owing to the proteinaceous nature of the active substance it should be co
nsidered a respiratory sensitiser. The FEEDAP Panel also co
ncluded that the additive has the potential to be efficacious at 15,000 PROT/kg compound feed for chickens for fattening.
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