　　 食品伙伴网讯2021�?�?日，欧盟食品安全局就一种内�?beta;-1�?�?（�a href='//www.sqrdapp.com/news/tag_1412.html' class='zdbq' title='葡聚糖相关食品资�? target='_blank'>葡聚糕�/a>酶（ endo�?,3(4)�?beta;‐glucanase）的安全性评价发布意见�

　　据了解，这种食品酶是由转基因枯草芽孢杆菌菌株DP‐Ezm28生产的，旨在用于蒸馏酒精的生产和酿造过程中、�/div>

　　经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏和诱发反应的风险，但这种情况发生的可能性很低。根据提供的数据，小组得出结论，该食品酶在预期的使用条件下不会引起安全隐患。部分原文报道如下：

　　The food enzyme endo�?,3(4)�?beta;‐glucanase (3(or 4)�?beta;‐d‐glucan 3(4)‐glucanohydrolase; EC 3.2.1.6) is produced with a genetically modified Bacillus subtilis strain DP‐Ezm28 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The production strain of the food enzyme co ntains multiple copies of a known antimicrobial resistance gene. However, ba sed on the absence of viable cells and DNA from the production organism in the food enzyme, this is not co nsidered to be a risk. The food enzyme is intended to be used in distilled alcohol production and brewing processes. Since residual amounts of total organic solids (TOS) are removed by distillation, dietary exposure was o nly calculated for brewing processes. ba sed on the maximum use levels recommended for brewing processes and individual data from the EFSA Comprehensive European Food Databa se, dietary exposure to the food enzyme�Ctotal organic solids was estimated to be up to 0.183 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 5464. Similarity of the amino acid sequence to those of known allergens was searched and two matches were found. The Panel co nsidered that, under the intended co nditions of use, the risk of allergic sensitisation and elicitation reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood is co nsidered low. ba sed on the data provided, the Panel co ncluded that this food enzyme does not give rise to safety co ncerns under the intended co nditions of use.