据了解，这种食品酶是由Collariella gracilis 菌株ATCC?6153生产的，旨在用于糖的生产和加工中、/div>
经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏和诱发反应的风险，但这种情况发生的可能性很低。根据提供的数据，小组得出结论，该食品酶在预期的使用条件下不会引起安全隐患。部分原文报道如下：
The food enzyme dextranase (6?alpha;‐d‐glucan 6‐glucanohydrolase, EC 3.2.1.11) is produced with the non‐genetically modified Collariella gracilis strain ATCC?6153 by Mitsubishi‐Kagaku Foods Corporation. The food enzyme is free from viable cells of the production organism. The food enzyme is intended to be used in sugar production and processing. As residual amounts of total organic solids (TOS) are removed during the production of refined sugars, dietary exposure was calculated o
nly for unrefined sugar products. ba
sed on the maximum use levels, dietary exposure to the food enzyme TOS was estimated to be up to 15 g TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) of 110 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, results in a sufficiently high margin of exposure (MoE) of at least 7,300. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and no match was found. The Panel co
nsidered that, under the intended co
nditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is co
nsidered to be low. ba
sed on the data provided, the Panel co
ncluded that this food enzyme does not give rise to safety co
ncerns under the intended co
nditions of use.
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地区９/font>
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