部分原文报道如下9/div>
The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS provides a scientific opinion re-e
valuating the safety of agar (E 406 as a food additive. In the European unio (EU), agar (E 406 has been e
valuated by the Scientific Committee for Food (SCF in 1989, who allocated to agar a not specified acceptable daily intake (ADI), and by the Joint FAO/WHO Expert Committee on Food Additives (JECFA in 1974, who co
nsidered very few data to co
nclude to a not limited ADI. According to the co
nceptual f
ramework for the risk assessment of certain food additives re-e
valuated under Commission Regulation (EU No 257/2010, the Panel co
nsidered that the safety assessment is limited to the use and use levels received from industry in 7 food categories for which data were co
nsidered in this opinion out of the 70 food categories in which agar (E 406 is authorised; an indicative high refined exposure assessment up to 26 mg/kg body weight (bw per day has been calculated in toddlers at the 95th percentile (non-brand-loyal scenario); agar is unlikely to be absorbed unchanged and slightly fermented by intestinal microbiota; sufficient toxicity data were available; there was no co
ncern with respect to the genotoxicity of agar; no carcinogenic effects were reported in carcinogenicity studies in mice and rats at the doses of 4,500 mg/kg bw per day and 2,500 mg/kg bw per day, respectively, the highest doses tested; oral intake of agar ?,500 mg/person correspo
nding to 64 mg/kg bw per day was tolerated in humans for 12 weeks without noticeable side effects. Therefore, the Panel co
ncluded that there is no need for a numerical ADI for agar and that there is no safety co
ncern for the general population at the refined exposure assessment for the reported uses of agar as a food additive.
原文链接:http://www.efsa.europa.eu/en/efsajournal/pub/4645