鎵弿浜岀淮鐮 鍒嗕韩濂藉弸鍜屾湅鍙嬪湀
鐩镐俊鍦ㄤ负瀹濆疂绮炬寫缁嗛€夊ザ绮夋椂锛屼笉灏戜汉瀵?ldquo;HMO”閮戒笉闄岀敓锛屽緢澶氬浗澶栧搧鐗岀殑HMO濠撮厤涔崇矇宸茬粡閫氳繃璺ㄥ鐢靛晢娓犻亾杩涘叆鍥藉唴甯傚満锛屾瘮濡傞泤鍩广€佽揪鑳姐€侀泙宸㈢瓑浼佷笟閮芥湁鐩稿叧浜у搧甯冨眬銆?023骞碒MO鍦ㄥ浗鍐呮寮忓厑璁稿湪濠村辜鍎块厤鏂归鍝佷腑浣跨敤鍚庯紝璇稿濠撮厤浼佷笟绾风悍寮€濮嬩簡HMO鏂伴厤鏂圭殑鐮斿彂銆佸簲鐢ㄤ互鍙婃敞鍐岀敵鎶ュ伐浣溿€侶MO鍘熸枡鍦ㄥ浗鍐呭┐閰嶉鍝佷腑鎵瑰噯浣跨敤涔嬫墍浠ヨ兘寮曞彂琛屼笟鐨勯厤鏂瑰彉鏇存疆锛屾槸鍥犱负鍦ㄦ秷璐硅€呰鐭ヤ腑锛屾坊鍔燞MO鐨勫┐閰嶄钩绮夊線寰€鎰忓懗鐫€钀ュ吇鏇村叏闈紝鍗充究浠锋牸绋嶉珮涔熼兘瑙夊緱鐗╂湁鎵€鍊笺€備笉杩囷紝杩橦MO鍒板簳鏄綍鏂圭鍦ｏ紵鑺辨洿澶氱殑閽辫喘涔板惈鏈塇MO鐨勫ザ绮夛紝鐪熺殑鑳芥敹鑾蜂笌涔嬪尮閰嶇殑浠峰€煎悧锛熶粖澶╋紝椋熷搧浼欎即缃戜笌澶у涓€鍚屾繁鍏ユ帰绌跺┐骞煎効閰嶆柟涔崇矇 閿 “鏂板疇”鎴愬垎HMO銆侟/p>
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Human Milk Oligosaccharides锛岀畝绉癏MO锛屼腑鏂囧悕涓烘瘝涔充綆鑱氱硸锛屾槸姣嶄钩涓粎娆′簬涔崇硸鍜岃剛鑲殑绗笁澶у浐浣撴垚鍒嗭紝鏄汉浣撲腑鐙壒鐨勭⒊姘村寲鍚堢墿锛屽湪鍏朵粬鍝轰钩鍔ㄧ墿涓湭鍙戠幇鐩稿悓鐨勭绫诲拰缁勬垚[1]銆侶MO鍚噺鍦ㄥ垵涔充腑鏈€楂橈紝绾︿负20~25g/L锛屾垚鐔熶钩涓惈閲忕害涓?~20g/L[2]銆傛牴鎹粨鏋勭被鍨嬩笉鍚岋紝HMO涓昏鍒嗕负浠ヤ笅鍑犵[3]锛欬/p>
琛 1 HMO涓昏绉嶇被
| 绉嶇被 | 涓句緥 |
| 涓€у博钘荤硸鍩哄寲HMO | 宀╄椈绯栧熀涔崇硸锛?'-fucosyllactose锛?'-FL锛堻/td> |
| 3-宀╄椈绯栧熀涔崇硸锛?-fucosyllactose锛?-FL锛堻/td> | |
| 涓€ч潪宀╄椈绯栧熀鍖朒MO | 涔崇硸-N-鍥涚硸锛坙acto-N-tetraose锛孡NT锛堻/td> |
| 涔崇硸-N-鏂板洓绯栵紙lacto-N-neotetraose锛孡NnT锛堻/td> | |
| 閰告€у斁娑查吀鍖朒MO | 3’-鍞炬恫閰镐钩绯栵紙3'-sialyllactose锛?'-SL锛堻/td> |
| 6’-鍞炬恫閰镐钩绯栵紙6'-sialyllactose锛?'-SL锛堻/td> |
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鍙傝€冩枃鐚?/p>
[1] YANG L H, ZHU Y Y, ZHANG W L, et al. Recent progress in health effects and biosynthesis of lactoN-tetraose, the most dominant core structure of human milk oligosaccharide[J]. Critical Reviews in Food Scienceand Nutrition, 2023: 1-10.
[2] HILL D R, CHOW J M, BUCK R H. Multifunctional benefits of prevalent HMO: Implications for infant health[J]. Nutrients, 2021, 13(10): 3364.
[3] 涓浗椋熷搧绉戝鎶€鏈浼?姣嶄钩浣庤仛绯栵紙HMO锛夌殑绉戝鍏辫瘑[J].涓浗椋熷搧瀛︽姤,2023,23(06):452-457.DOI:10.16429/j.1009-7848.2023.06.044.
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[5] EL-HAWIET A, KITOVA E N, KLASSEN J S. Recognition of human milk oligosaccharides by bacterial exotoxins[J]. Glycobiology, 2015, 25(8): 845-854.
[6] LAUCIRICA D R, TRIANTIS V, SCHOEMAKER R, et al. Milk oligosaccharides inhibit human rotavirus infectivity in MA104 cells[J]. The Journal of Nutrition, 2017, 147(9): 1709-1714.
[7] JANTSCHER-KRENN E, LAUWAET T, BLISS L A, et al. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro[J]. The British Journal of Nutrition, 2012, 108(10): 1839-1846.
[8] WARD R E, NI onUEVO M, MILLS D A, et al. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri[J]. Applied and Environmental Microbiology, 2006, 72(6):4497-4499.
[9] THOMSON P, MEDINA D A, GARRIDO D. Human milk oligosaccharides and infant gut bifidobacteria:Molecular strategies for their utilization[J]. Food Microbiology, 2018, 75: 37-46.
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[11] ZHANG D, JIAN Y P, ZHANG Y N, et al. Short-chain fatty acids in diseases[J]. Cell Communication and Signaling, 2023, 21(1): 212.
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