经过评估，小组得出结论，在报告的用途和使用水平下，饮食接触食品添加剂新橙皮苷二氢查尔酮（E 959）不会引起安全问题。部分原文报道如下：

　　The present opinion deals with the re-e valuation of neohesperidine dihydrochalcone (E 959) when used as a food additive. It is obtained by catalytic hydrogenation of a flavanone �C neohesperidine �C which is naturally occurring and thus isolated by alcohol extraction in bitter oranges (Citrus aurantium). ba sed on in vivo data in rat, neohesperidine dihydrochalcone is likely to be absorbed, also in humans, and to become systemically available. It does not raise a co ncern regarding genotoxicity. The toxicity data set co nsisted of studies on subchro nic and prenatal developmental toxicity. No human studies were available. The data set was co nsidered sufficient to derive a new acceptable daily intake (ADI). ba sed on the weight of evidence (WoE) analysis, the Panel co nsidered unlikely that neohesperidine dihydrochalcone would lead to adverse effects on health in animals in the dose ranges tested. The Panel also co nsidered that a carcinogenicity study was not warranted and that the lack of human data did not affect the overall co nfidence in the body of evidence. The Panel derived an ADI of 20 mg/kg bodyweight (bw) per day ba sed on a no observed adverse effect level (NOAEL) of 4,000 mg/kg bw per day from a 13-week study in rat, applying the standard default factors of 100 for inter- and intraspecies differences and of 2 for extrapolation from subchro nic to chro nic exposure. For the refined brand-loyal exposure assessment scenario, co nsidered to be the most appropriate for the risk assessment, the exposure estimates at the mean ranged from < 0.01 to 0.09 mg/kg bw per day and at the 95th percentile (P95) from 0.01 to 0.24 mg/kg bw per day. Co nsidering the derived ADI of 20 mg/kg bw per day, the exposure estimates were below the reference value in all age groups. Therefore, the Panel co ncluded that dietary exposure to the food additive neohesperidine dihydrochalcone (E 959) at the reported uses and use levels would not raise a safety concern.

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