经过评估，专家小组认为在建议的使用条件下2-methyloxolane用于提取食品或食品成分不会引起安全问题。部分原文报道如下：

　　The EFSA Panel on Food Co ntact Materials, Enzymes and Processing Aids (CEP) assessed the safety of 2-methyloxolane as an extraction solvent under the intended co nditions of use and the maximum residue limits (MRLs) proposed by the applicant. 2-Methyloxolane is intended to be used in processes currently applying hexane for oil and protein extraction from plant sources or for extraction of food additives. The proposed MRLs for the following uses are: (i) 1 mg/kg in fat, oil or butter; (ii) 10 mg/kg in defatted protein products, defatted flour and other defatted solid ingredients; (iii) 1 mg/kg in food category 13 (foods intended for particular nutritio nal uses as defined by Directive 2009/39/EC); and (iv) 1 mg/kg for the extraction of food additives. The Panel calculated the dietary exposure with the highest potential maximum (95th percentile) for toddlers as 0.32 mg/kg body weight (bw) per day. ba sed on the available toxicological data, the Panel co ncluded that 2-methyloxolane was rapidly me tabolised with a low bioaccumulation potential and does not raise a co ncern for genotoxicity. The Panel identified different no observed adverse effect levels (NOAELs) in a subchro nic oral toxicity study in rats, an oral developmental toxicity study and an extended one-generation reproductive toxicity study, and a TDI of 1 mg/kg bw per day for 2-methyloxolane was derived ba sed on the lowest identified NOAEL (100 mg/kg bw per day) for reproductive and developmental toxicity. This TDI was not exceeded in any of the population groups at the mean and 95th percentile exposure. The Panel co ncluded that the extraction solvent 2-methyloxolane does not raise a safety co ncern when used according to the intended co nditions and at the proposed MRLs in the extracted foods or food ingredients.

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