ࡱ> )+ !"#$%&'([ RLbjbjSS^ 11փ6$$+++++$",",",Pr,3", 98E6F"GGGt #i4k4k4k4k4k4k4$B<>P45+k_rtkk4++GG]+8KKKk^+RG+Gi4Kki4KKr!T+" "Gr/[/!U480 9!D?]D? "D?+ "HkkKkkkkk44Kkkk 9kkkkD?kkkkkkkkk$, P*: lQJTDN1 0AQOePߘTXyvOePRvU_ ^%{Q }eEQBR 2020t^Hr _Bla?z 0 ^SOePRYl1 gRNX:_MQuRRcP'`ċNelDT2 gRNb'lSR3R9eU_R4ƉɉuRR5nTmUR6 gRN9eUaw wR7SORuRR8:'lR9 gRNSOQR10 gRN9eU[^R119eU:'`+@R12 gRN9eUuuR13 gRN9eUĞeR14 gRN9eUv4lNrQR 15 gRNS̃RcP'`ċNelDT16 gRNmSR17 gRNmOR18RObÀ|R19 gRN~c@eP^4ls^ƀV/ul No R20 gRN~c@|eP^4ls^R21 gRN~c@SeP^4ls^R22[Sf['`_c$O gRObR23[5uy\qS[ gRObR24 gRNcŔR 0OePߘTRċNel2020t^Hr _Bla?z 0 v U_ ,{NR0OePߘTċNՋyv0ՋSRS~g$R[& & & & & & & & & & & & & & 1 N0 gRNX:_MQuRR& & & & & & & & & & & & & & & & & & & & & & & & & & & 1 N0 gRNb'lSR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & 1 N0R9eU_R& & & & & & & & & & & & & & & & & & & & & & & & & & & & & 2 V0ƉɉuRR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & 3 N0nTmUR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & 3 mQ0 gRN9eUaw wR& & & & & & & & & & & & & & & & & & & & & & & & & & & & 4 N0SORuRR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & 4 kQ0:'lR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & 5 ]N0 gRNSOQR& & & & & & & & & & & & & & & & & & & & & & & & & & 5 AS0 gRN9eU[^R& & & & & & & & & & & & & & & & & & & & & & & & & & & 6 ASN09eU:'`+@R& & & & & & & & & & & & & & & & & & & & & & & & & & & 7 ASN0 gRN9eUuuR& & & & & & & & & & & & & & & & & & & & & & & & & & & 7 AS N0 gRN9eUĞeR& & & & & & & & & & & & & & & & & & & & & & & & & & 8 ASV0 gRN9eUv4lNrQR& & & & & & & & & & & & & & & & & & & & & & & 8 ASN0 gRNS̃R& & & & & & & & & & & & & & & & & & & & & & & & & 8 ASmQ0 gRNmSR& & & & & & & & & & & & & & & & & & & & & & & & & & & & & 9 ASN0 gRNmOR& & & & & & & & & & & & & & & & & & & & & & & & & & & 10 ASkQ0RObÀ|R& & & & & & & & & & & & & & & & & & & & & & & & & & & 11 AS]N0 gRN~c@eP^4ls^ƀV/ul No R& & & & & & & & & & & & & ...11 NAS0 gRN~c@|eP^4ls^R& & & & & & & & & & & & & & & & & & & & & & & 13 NASN0 gRN~c@SeP^4ls^R& & & & & & & & & & & & & & & & & & & & & & 14 NASN0[Sf['`_c$O gRObR& & & & & & & & & & & & & & & & & & & & & 14 NAS N0[5uy\qS[ gRObR& & & & & & & & & & & & & & & & & & & & & 15 NASV0 gRNcŔR& & & & & & & & & & & & & & & & & & & & & & & & & & & & 16 ,{NR Rf[hel& & & & & & & & & & & & & & & & & & & & & & & & & & & ..17 N0 gRNX:_MQuRRhel& & & & & & & & & & & & & & & & & & & & & & & 17 N0 gRNb'lSRhel& & & & & & & & & & & & & & & & & & & & & & & & & 30 N0R9eU_Rhel& & & & & & & & & & & & & & & & & & & & & & & & & 51 V0ƉɉuRRhel& & & & & & & & & & & & & & & & & & & & & & & & & 62 N0nTmURhel& & & & & & & & & & & & & & & & & & & & & & & & & & & 65 mQ0 gRN9eUaw wRhel& & & & & & & & & & & & & & & & & & & & & & & & 71 N0SORuRRhel& & & & & & & & & & & & & & & & & & & & & & & & & 74 kQ0:'lRhel& & & & & & & & & & & & & & & & & & & & & & & & & & & & 80 ]N0 gRNSOQRhel& & & & & & & & & & & & & & & & & & & & & & 82 AS0 gRN9eU[^Rhel& & & & & & & & & & & & & & & & & & & & & & & 86 ASN09eU:'`+@Rhel& & & & & & & & & & & & & & & & & & & & & & & 93 ASN0 gRN9eUuuRhel& & & & & & & & & & & & & & & & & & & & & & & 104 AS N0 gRN9eUĞeRhel& & & & & & & & & & & & & & & & & & & & & & 106 ASV0 gRN9eUv4lNrQRhel& & & & & & & & & & & & & & & & & & & 108 ASN0 gRNS̃Rhel& & & & & & & & & & & & & & & & & & & & & 110 ASmQ0 gRNmSRhel& & & & & & & & & & & & & & & & & & & & & & & & & 115 ASN0 gRNmORhel& & & & & & & & & & & & & & & & & & & & & & & 120 ASkQ0RObÀ|Rhel& & & & & & & & & & & & & & & & & & & & & & & 124 AS]N0 gRN~c@eP^4ls^ƀV/ul No Rhel& & & & & & & & & ...128 NAS0 gRN~c@|eP^4ls^Rhel& & & & & & & & & & & & & & & & & & & 134 NASN0 gRN~c@SeP^4ls^Rhel& & & & & & & & & & & & & & & & & & 144 NASN0[Sf['`_c$O gRObRhel& & & & & & & & & & & & & & & & & 147 NAS N0[5uy\qS[ gRObRhel& & & & & & & & & & & & & & & & & 154 NASV0 gRNcŔRhel& & & & & & & & & & & & & & & & & & & & & & & & 162 ,{NR0OePߘTċNՋyv0ՋSRS~g$R[ 1 gRNX:_MQuRR 1.1 Ջyv 1.1.1 SO͑ 1.1.2 hV/SO͑k/SO͑k

m]~ހlS[ ߏSWS`S^[ 1.1.4 SOmMQuRKm[bSOub~ހhKm @nn@ }Km[ 1.1.5 US8h ]lV~ހRKm[\ x^n[ \ yT]lV~ހTlV!~~ހ[ 1.1.6 NK~ހ;m'`Km[ 1.2 ՋSR 1.2.1 @bRchGW:N_ZPyv0 1.2.2 Ǒ(uck8^bMQuRNO Nv!jWRirۏL[0 1.3 ~g$R[ gRNX:_MQuRR$R[(W~ހMQuR0SOmMQuR0US8h ]lV~ހR0NK~ހ;m'`V*NebN$N*Neb~g3'` S$R[SՋ7hTwQ g gRNX:_MQuRR\O(u0 vQ-N~ހMQuRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[~ހMQuRKm[~g3'`0SOmMQuRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[SOmMQuRKm[~g3'`0US8h ]lV~ހRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[US8h ]lV~ހR~g3'`0NK~ހ;m'`Km[[vN*NN NBRϑ~~g3'` S$R[NK~ހ;m'`~g3'`0 2 gRNb'lSR 2.1 Ջyv 2.1.1 Rir[ 2.1.1.1 SO͑ 2.1.1.2 ('lSNirNNb@n8-h"l'l_MRRz }8-Isoprostane 2.1.1.3 ˆ}v('lSNirˆ}v(W 2.1.1.4 b'lSv'lSirgkSvb7uǏ'lSirv 2.1.1.5 b'lSir(؏SW7u 2.1.2 NSOՋߘՋ 2.1.2.1 ('lSNirNNb@n8-h"l'l_MRRz }8-Isoprostane 2.1.2.2 'lSirgkSv 2.1.2.3 7uǏ'lSirv 2.2 ՋSR 2.2.1 Rir[TNSOՋߘՋ@bRvchGW:N_Kmyv0 2.2.2 ('lSNirch-NNNT@n8-h"l'l_MRRz }N vQNۏLchKm[ Rir[b'lSvch-N'lSirgkSvT7uǏ'lSirvN vQNۏLchKm[0 2.2.3 'lS_c$O!jWRirTRirN vQNۏLuSchKm[0 2.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 2.3 ~g$R[ 2.3.1 Rir[('lSNir0ˆ}v('lSNir0b'lSv0b'lSir(Vych-N Ny3'` S$R[SՋ7hT gRNb'lSRRir[~g3'`0 2.3.2 NSOՋߘՋ('lSNir0'lSirgkSv07uǏ'lSirv Nych-NNy3'` N[:gSOeP^eq_T S$R[SՋ7hTwQ g gRNb'lSRv\O(u0 3 R9eU_R 3.1 Ջyv 3.1.1 Rir[ 3.1.1.1 SO͑ 3.1.1.2 S[ 3.1.1.3 f[ 3.1.1.4 zh{[ 3.1.1.5 4l[[ 3.1.2 NSOՋߘՋ 3.1.2.1 cT_ 3.1.2.2 T`f[`N 3.1.2.3 Va1uV_ 3.1.2.4 eaINVb_Q 3.1.2.5 NPyrpT|V_ 3.1.2.6 _FU 3.2 ՋSR 3.2.1 Rir[TNSOՋߘՋ:N_ZPyv0 3.2.2 S[0f[0zh{[04l[[VyRir[-N\^ Ny NO[~gvS`'`0 3.2.3 ck8^RirN_x!jWRirN vQN0 3.2.4 Rir[^͑ YN!k͑er{QRir ͑ Y@bZP[ 0 3.2.5 NSOՋߘՋ~NO(u4N^_ϑh0 3.2.6 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 3.3 ~g$R[ 3.3.1 Rir[S[0f[0zh{[04l[[Vy[-NNNy[~g3'`0N͑ Y[~gN@b͑ Yv TNy[$N!k~gGW:N3'` SN$R[SՋ7hTR9eU_RRir[~g3'`0 3.3.2 NSOՋߘՋ_FU~g3'` S$R[SՋ7hTwQ gR9eU_Rv\O(u0 4 ƉɉuRR 4.1 NSOՋߘՋyv 4.1.1 R+RNՋߘMRTۏLfW'`P<0.05 0 4.3.2 Ջ~ꁫkbՋ~N[gq~~k fƉcEN^]_ g>fW'`P<0.05 Ns^GWfƉcEN^cؚ'YNI{N10%0 wQY4.3.1S4.3.2S$R[SՋirwQ gƉɉuRR0 5 nTmUR 5.1 Ջyv 5.1.1 Rir[ 5.1.1.1 SO͑ 5.1.1.2 'Y ht ieQ[ 5.1.1.3 'Y [ 5.1.1.4 \ 3[ 5.1.2 NSOՋߘՋTur0SO_ 5.2 ՋSR 5.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 5.2.2 ^[4N^ur0SO_ۏL‰[0 5.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 5.3 ~g$R[ 5.3.1 Rir['Y ht ieQ[~g3'` Te'Y [b\ 3[~gNaNy3'` S$R[SՋ7hTnTRRir[~g:N3'`0 5.3.2 NSOՋߘՋՋߘ~ꁫkSՋߘ~N[gq~~k TurSSO_ gf>f9eU urSSO_v9eUsf>fXR S$R[SՋ7hTwQ gnTmUR0 6 gRN9eUaw wR 6.1 Ջyv 6.1.1 SO͑ 6.1.2 ^ b]kYaw we[ 6.1.3 b]kYb]kY  NBRϑP w[ 6.1.4 ]kYaw w\oOg[ 6.2 ՋSR 6.2.1 @bRchGW:N_ZPyv0 6.2.2 ‰[SՋ7hT[Rirvcaw wv\O(u0 6.3 ~g$R[ ^ b]kYaw we[0 b]kYb]kY  NBRϑP w[0]kYaw w\oOg[ Ny[-NNNy3'` Nef>fvcaw w\O(u S$R[SՋ7hTwQ g gRN9eUaw wRv\O(u0 7 SORuRR 7.1 [yv 7.1.1 RirSO͑ 7.1.2 ͑8nl[ 7.1.3 @sNx 7.1.4 @n?\ } 7.1.5 |Sb|S 7.2 ՋSR 7.2.1 Rir[@bRchGW:N_ZPyv0 7.2.2 [MR_{[ TybSՋ7hTۏLݏyoirvhKm0 7.2.3 ЏR[NuSchhKmv~T0 7.3 ~g$R[ ͑8nl[~g3'` @sNx0@n?\ }0|CQ/|CQ NyuSch-NNNych3'` S$R[SՋ7hTwQ gSORuRRv\O(u0 8 :'lR 8.1 Ջyv 8.1.1 SO͑ 8.1.2 8^S:'l[ 8.1.3 N]xx-NkX[;m[ 8.1.4 %`'`:@'`:'l[ 8.2 ՋSR @bRchGW:N_ZPyv0 8.3 ~g$R[ 8^S:'l[0N]xx-NkX[;m[0%`'`:@'`:'l[ Ny[-NNNy[~g3'` S$R[SՋ7hTwQ g:'lRv\O(u0 9 gRNSOQR 9.1 Ջyv 9.1.1 Rir[ 9.1.1.1 SO͑0SO͑X͑ 9.1.1.2 Ddߘϑ0DdeQ;`pϑ 9.1.1.3 SOQ͑ϑ~w8NShTVW 9.1.1.4 /SOk 9.1.2 NSOՋߘՋ 9.1.2.1 SO͑ 9.1.2.2 pV0V 9.1.2.3 SOQ+Tϑ 9.2 ՋSR 9.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 9.2.2 Rir[-N'Y ր!jWlT2'Y ր!jWlN vQN0 9.2.3 Q\SOQYYO NUS~NQ{SO͑:Nvh0 9.2.4 _wylbb6Rߘ2kvSՋ7hT N\O:N gRNSOQRߘT0 9.2.5 ke%{Q }DdeQϑ^W,gO:gSOck8^u}T;mRv0 9.2.6 [:gSOeP^ef>f_c[0 9.2.7 [MR^[ TybSՋ7hTۏLݏyoirvhKm0 9.2.8 NTy%{Q }:N;NbRfN;Nߘv gRNSOQRߘTSN NۏLRir[ NۏLNSOՋߘՋ0 9.2.9 NfN;Nߘv gRNSOQRՋ ^[ՋߘMRTvSՋߘTЏRrQۏL‰[0 9.2.10 fN;Nߘv gRNSOQRՋ d_U\ NfN;NߘvchY ؏^zSO;mR0`~0]\ORI{KmϑhfW'` Ddߘϑ N>fWNON!jW[gq~ S$R[SՋ7hTRir gRNSOQR[~g3'`0 9.3.2 NSOՋߘՋ NfN;Nߘv gRNSOQRSՋ7hTՋߘ~ꁫkSՋߘ~N[gq~~k SOQ͑ϑQ\ v NV*Np-NN$N*NpQ\ pVNVKNNQ\ N]_ g>fW'` ЏRR N NM [:gSOeP^ef>f_c[ v^cdߘSЏR[ gRNSOQR\O(uvq_T S$R[SՋ7hTwQ g gRNSOQRv\O(u0 fN;Nߘv gRNSOQRSՋ7hTՋߘ~ՋMRTꁫk vQSOQ+TϑQ\ v NV*Np-N\ g$N*NpQ\ pVNVKNNQ\ N]_ g>fW'`P<0.05 _ϑCQ }0~u }%{Qf[ċNe_8^ ЏRR N NM `~0]\OR NSq_T v^cdЏR[ gRNSOQR\O(uvq_T S$R[SՋ7hTwQ g gRNSOQRv\O(u0 10 gRN9eU[^R 10.1 Ջyv Rir[R:NeHhNe:N;NvSՋir TeHhN N+Tb NNe:N;NvSՋir $Ny0 10.1.1 SO͑ 10.1.2 +Tϑ 10.1.3 [^ 10.2 ՋSR 10.2.1 9hncSՋ7hT\O(uStv N T eHhNTeHhNN vQNۏLRir[0 10.2.2 @bRchGW:N_ZPyv0 10.2.3 O(u*gybQ(uNߘTvvSTir d_ZPyvY ؏_{ۏL8T6esvKm[O(u^\%{Q:_SBRVQvnSegnfߘTvnYSߘRirv0vYI{ SN NۏLv8T6es[0 10.3 ~g$R[ eHhN +Tϑb[^>fWؚNNO[gq~N NNONv^BRϑvxx[gq~ v8T6es NNONxx[gq~ S$R[SՋ7hTwQ g gRN9eU[^Rv\O(u0 eHhN N+TvNT +Tϑb[^!jW[gq~f>fXR N]_ g>fW'` S$R[SՋ7hTwQ g gRN9eU[^Rv\O(u0 NNe:N;NS\ϑ+T vNT +Tϑb[^!jW[gq~f>fXR ]_ g>fW'` N NNONv^BRϑvxx[gq~ v8T6es NNONxx[gq~ S$R[SՋ7hTwQ g gRN9eU[^Rv\O(u0 11 9eU:'`+@R 11.1 Ջyv 11.1.1 Rir[ 11.1.1.1 SO͑ 11.1.1.2 @~ˆ}v 11.1.1.3 ~~ހSy/~~ހ8nyS_SIU 11.1.2 NSOՋߘՋ 11.1.2.1 @~ˆ}v 11.1.2.2 @nˆ}v 11.1.2.3 ~~ހQ8nyS_SIU/@nЏˆ}vqT^ 11.2 ՋSR 11.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 11.2.2 [?QzvNSOՋߘՋ SKm@~ˆ}vT~~ހQ8nyS_SIU0 11.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 11.3 ~g$R[ 11.3.1 Rir[@~ˆ}vch3'` ~~ހQ8nyS_SIU/~~ހSyNychNych3'` S$R[SՋ7hT9eU:'`+@RRir[~g:N3'`0 11.3.2 NSOՋߘՋ 11.3.2.1 [9eU?Qz:'`+@Rv @~ˆ}vT~~ހQ8nyS_SIUNych3'` S$R[SՋ7hTwQ g9eU:'`+@R\O(u0 11.3.2.2 [9eUbN:'`+@Rv @~ˆ}vch3'` @nˆ}v0~~ހQ8nyS_SIU/@nЏˆ}vqT^NychNych3'` S$R[SՋ7hTwQ g9eU:'`+@R\O(u0 12 gRN9eUuuR 12.1 NSOՋߘՋyv 12.1.1 uupeϑ 12.1.2 v_crQ 12.1.3 vlN 12.2 ՋSR 12.2.1 @bRvchGW:N_ZPyv0 12.2.2 ՋMRT^[V[vVQvuupeϑSv_crQۏLRg0 12.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 12.3 ~g$R[ Ջߘ~uupeϑf>fQ\N'YNI{N20 v_c z^yRf>fQ\ ]_GW g>fW'` vlN N>fWXR S$R[SՋ7hTwQ g gRN9eUuuRv\O(u0 13 gRN9eUĞeR 13.1 NSOՋߘՋyv 13.1.1 Ğeby 13.1.2 Ğer 13.2 ՋSR 13.2.1 @bRvchGW:N_ZPyv0 13.2.2 ՋMRT^[V[vVQvĞebySrۏLRg0 13.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 13.3 ~g$R[ Ջߘ~Ğebyf>fQ\N'YNI{N10% ryRf>f NM ]_GW g>fW'` N NNuevĞe S$R[SՋ7hTwQ g gRN9eUĞeRv\O(u0 14 gRN9eUv4lNrQR 14.1 NSOՋߘՋyvv4lN 14.2 ՋSR 14.2.1 v4lNf9eU ]_ g>fW'` S$R[SՋ7hTwQ g gRN9eUv4lRrQRv\O(u0 15 gRNS̃R 15.1 Ջyv 15.1.1 Rir[ 15.1.1.1 SO͑ 15.1.1.2 SgkFg̃ 15.1.1.3 sNFg̃ 15.1.1.4 t̃ 15.1.1.5 Fg̃ 15.1.1.6 NlZh̃ 15.1.2 NSOՋߘՋ 15.1.2.1 SgkFg̃ 15.1.2.2 sNFg̃ 15.1.2.3 t̃ 15.1.2.4 Fg̃ 15.1.2.5 bFg̃ 15.1.2.6 NlZh̃ 15.2 ՋSR 15.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 15.2.2 ck8^RirbS̃ }qN!jWRirN vQN0 15.2.3 SՋ7hT-N+TSgkFg̃0sNFg̃NYvvQ[vũe ^(WRirTNSOՋ-NRKmvũ0 15.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 15.3 ~g$R[ 15.3.1 Rir[&{TN NNNy S$R[SՋ7hT gRNS̃RRir[~g3'`0 15.3.1.1 SgkFg̃T/bsNFg̃bvQ[vũ f>fXR h̃Q\bef>fSS t̃0Fg̃ef>fSS0 15.3.1.2 SgkFg̃T/bsNFg̃bvQ[vũ f>fXR h̃Q\bef>fSS t̃T/bFg̃f>fXR FOXRvE^^NONSgkFg̃0sNFg̃bvQ[vũ XRvE^^0 15.3.2 NSOՋߘՋ&{TN NNNy S$R[SՋ7hTwQ g gRNS̃Rv\O(u0 15.3.2.1 SgkFg̃T/bsNFg̃bvQ[vũ f>fXR h̃Q\bef>fSS t̃0Fg̃0bFg̃ef>fSS0 15.3.2.2 SgkFg̃T/bsNFg̃bvQ[vũ f>fXR h̃Q\bef>fSS t̃T/bFg̃0bFg̃f>fXR FOXRvE^^NONSgkFg̃0sNFg̃bvQ[vũ XRvE^^0 16 gRNmSR 16.1 Ջyv 16.1.1 Rir[ 16.1.1.1 SO͑0SO͑X͑0DdߘϑTߘir)R(us 16.1.1.2 \ЏR[ 16.1.1.3 mSvKm[ 16.1.2 NSOՋߘՋ 16.1.2.1 ?QzeHh 16.1.2.1.1 ߘ2k 16.1.2.1.2 ߘϑ 16.1.2.1.3 OPߘrQ 16.1.2.1.4 SO͑ 16.1.2.1.5 @~ˆ}v+Tϑ 16.1.2.2 bNeHh 16.1.2.2.1 4N^ur‰[ 16.1.2.2.2 À/ЏR[ 16.2 ՋSR 16.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 16.2.2 9hncSՋ7hTv(uNyrp(WNSOՋߘՋeHh-NN vQN0 16.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 16.3 ~g$R[ 16.3.1 Rir[RirSO͑0SO͑X͑0Ddߘϑ0ߘir)R(us \ЏR[TmSvKm[ Neb-NNNeb[~g3'` S$R[SՋ7hT gRNmSRRir[~g3'`0 16.3.2 NSOՋߘՋ 16.3.2.1 [9eU?QzmSRv ߘ2k0ۏߘϑ0OPߘ9eU~g3'` SO͑T@~ˆ}vNych-NNNych~g3'` S$R[SՋ7hTwQ g gRNmSRv\O(u0 16.3.2.2 [9eUbNmSRv 4N^urf>f9eU À/ЏR[~g3'` S$R[SՋ7hTwQ g gRNmSRv\O(u0 17 gRNmOR 17.1 Ջyv 17.1.1 Rir[ 17.1.1.1 SO͑ 17.1.1.2 \ЏR[ 17.1.1.3 cOe 17.1.1.4 |O͑ϑ 17.1.1.5 |O|pe 17.1.1.6 |O'`r 17.1.2 NSOՋߘՋ 17.1.2.1 urSO_ 17.1.2.2 |O'`r 17.1.2.3 cO!kpe 17.1.2.4 cOrQ 17.2 ՋSR 17.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 17.2.2 d[Oy!jWRirTy_KmchۏL‰[Y ؏^[ck8^RirۏL‰[ N__wRirf>fyl0 17.2.3 cO!kpev‰[eՋMRT^OcN0 17.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 17.3 ~g$R[ 17.3.1 Rir[c|O͑ϑT|O|peNy~g3'` Te\ЏR[TcOeNy~g3'` S$R[SՋ7hT gRNORRir[~g3'`0 17.3.2 NSOՋߘՋcO!kpef>fXR Te|O'`rTcOrQNy~gf>f9eU S$R[SՋ7hTwQ g gRNmORv\O(u0 18 RObÀ|R 18.1 Ջyv 18.1.1 Rir[ 18.1.1.1 SO͑ 18.1.1.2 À|_c$O'YSO‰[ 18.1.1.3 À|~~utf[hg 18.1.2 NSOՋߘՋ 18.1.2.1 4N^ur 18.1.2.2 SO_ 18.1.2.3 À\‰[ 18.2 ՋSR 18.2.1 Rir[vSO͑TÀ|_c$O'YSO‰[:N_ZPyv À|~~utf[hg:N ZPyvNSOՋߘՋ@bRchGW:N_ZPyv0 18.2.2 e4lYN0mpu%`'`À|_c$O!jWbQxba'`Ànu!jWN vQNۏLRir[0 18.2.3 (WۏLNSOՋߘՋe ^[SՋ7hTv[hQ'`\OۏNekv‰[0 18.3 ~g$R[ 18.3.1 Rir[[~N!jW[gq~k À|_c$Of>f9eU S$R[SՋ7hTRir[~g:N3'`0 18.3.2 NSOՋߘՋՋߘ~N[gq~k 4N^ur0SO_yRf>fQ\ À\ Yg~g g9eUb NR͑ S$R[SՋ7hTwQ gRObÀ|Rv\O(u0 19 gRN~c@eP^4ls^ƀV/ul No R 9hnc@_8^v{|W gRN~c@eP^4ls^ƀV/ul No R cgq N Tv@_8^RWzR{|vRir[TNSOՋߘՋ0 19.1 Ջyv 19.1.1 9hncSՋ7hTv\O(u:g6R Rb Ny`Q 19.1.1.1 gRN~c@eP^4ls^R Te~c@;`ƀVT@ul NoeP^4ls^ 19.1.1.2 gRN~c@ƀVeP^4ls^RUS~~c@ƀVeP^4ls^ 19.1.1.3 gRN~c@ul NoeP^4ls^RUS~~c@ul NoeP^4ls^ 19.1.2 ‰[ch 19.1.2.1 SO͑ 19.1.2.2 @n;`ƀV 19.1.2.3 @nul No 19.1.2.4 @nؚ[^ˆ}vƀV 19.1.2.5 @nNO[^ˆ}vƀV 19.1.3 NSOՋߘՋ 19.1.3.1 @n;`ƀV 19.1.3.2 @nul No 19.1.3.3 @nؚ[^ˆ}vƀV 19.1.3.4 @nNO[^ˆ}vƀV 19.2 ՋSR 19.2.1 Rir[TNSOՋߘՋ@bRchGW:N_Kmyv0 19.2.2 9hncSՋ7hTv\O(u:g6R S(WRir[v$N*NRir!jW-NN Ny0 19.2.3 9hncSՋ7hTv\O(u:g6R S(WNSOՋߘՋv N*NeHh-NN Ny0 19.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 19.3 ~g$R[ 19.3.1 Rir[ 19.3.1.1 mTWؚ@uRir!jW gRN~c@eP^4ls^ƀV/ul No R~g$R[!jW[gq~Tzz}v[gq~k @nul NoGSؚ @n;`ƀVbNO[^ˆ}vƀVGSؚ ]_GW g>fW'` $R[!jWbz01 TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO NNNBRϑ~@nul NoMNO ]_GW g>fW'` TeTBRϑ~@nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@eP^4ls^Rir[~g3'`02 TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO ]_GW g>fW'` TeTBRϑ~@nul No N>fWؚN!jW[gq~ TBRϑ~@nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RRir[~g3'`03 TBRϑ~N!jW[gq~k NNBRϑ~@nul NoMNO ]_GW g>fW'` TeTBRϑ~@n;`ƀVSNO[^ˆ}vƀV N>fWؚN!jW[gq~ @nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@ul NoeP^4ls^RRir[~g3'`0 19.3.1.2 ؚƀV@uRir!jW !jW[gq~Tzz}v[gq~k @n;`ƀVTC bNO[^ˆ}vƀVLDL-C GSؚ ]_ g>fW'` @nul NoTG ]_e>fW'` $R[!jWbz0TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO ]_ g>fW'` v^NTBRϑ~@nؚ[^ˆ}vƀVHDL-C N>fWNON!jW[gq~ @nul No N>fWؚN!jW[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RRir[~g3'`0 19.3.2 NSOՋߘՋ ch$R[hQ gHeTC MNO>10%bMck8^TG MNO>15%bMck8^HDL-C NGS>0.104mmol/L0 eHe*g0R gHehQ0 19.3.2.1 gRN~c@eP^4ls^ƀV/ul No R~g$R[ Ջߘ~ꁫkSՋߘ~N[gq~~k SՋ@n;`ƀV0ul No0NO[^ˆ}vƀVMNO ]_GW g>fW'` Te@nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~;` gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@eP^4ls^ƀV/ul No NSOՋߘՋ~g3'`0 19.3.2.2 gRN~c@ƀVeP^4ls^R~g$R[ Ջߘ~ꁫkSՋߘ~N[gq~~k SՋ@n;`ƀV0NO[^ˆ}vƀVMNO ]_ g>fW'` Te@nul No N>fWؚN[gq~ @nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~@n;`ƀV gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RNSOՋߘՋ~g3'`0 19.3.2.3 gRN~c@ul NoeP^4ls^R~g$R[ Ջߘ~ꁫkSՋߘ~N[gq~~k SՋ@nul NoMNO ]_ g>fW'` Te@n;`ƀVTNO[^ˆ}vƀV N>fWؚN[gq~ @nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~@nul No gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@ul NoeP^4ls^RNSOՋߘՋ~g3'`0 20 gRN~c@|eP^4ls^R 20.1 Ջyv 20.1.1 Rir[ R:NeHhN\_c$Oؚ@|!jW TeHhN\ }bb|/N" }qN!jW $Ny 20.1.1.1 eHhN\_c$Oؚ@|!jW 20.1.1.1.1 SO͑ 20.1.1.1.2 zzy@| 20.1.1.1.3 |ϑ 20.1.1.2 eHhN\ }bb|/N" }qN!jW 20.1.1.2.1 SO͑ 20.1.1.2.2 zzy@| 20.1.1.2.3 |ϑ 20.1.1.2.4 \ } 20.1.1.2.5 ;`ƀV 20.1.1.2.6 ul No 20.1.2 NSOՋߘՋ 20.1.2.1 zzy@| 20.1.2.2 T2\e@| 20.1.2.3 |S@~ˆ}vHbA1c b|S@nˆ}v 20.1.2.4 ;`ƀV 20.1.2.5 ul No 20.2 ՋSR 20.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 20.2.2 9hncSՋ7hT\O(uSt N T eHhNTeHhNRir!jWN vQNۏLRir[0 20.2.3 d[ؚ@|!jWRirۏL@bRchvhKmY ^ۏLSՋ7hT[ck8^Rirzzy@|q_Tv‰[0 20.2.4 NSOՋߘՋS(W4N^luvW@x NۏL0 20.2.5 ^[4N^urTSO_ۏL‰[0 20.2.6 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 20.3 ~g$R[ 20.3.1 Rir[ eHhNzzy@|T|ϑNych-NNych3'` N[ck8^Rirzzy@|eq_T sSS$R[SՋ7hT gRN~c@|eP^4ls^Rir[~g3'`0 eHhNzzy@|T|ϑNych-NNych3'` @;`ƀV0ul No ef>fGSؚ N[ck8^Rirzzy@|eq_T sSS$R[SՋ7hT gRN~c@|eP^4ls^RRir[~g3'`0 20.3.2 NSOՋߘՋzzy@|0T2\e@|0|S@~ˆ}vb|S@nˆ}v 0@VychGWe>fWGSؚ Nzzy@|0T2\e@|$Nych-NNych3'` [:gSOeP^e N)Rq_T S$R[SՋ7hTwQ g gRN~c@|eP^4ls^Rv\O(u0 21 gRN~c@SeP^4ls^R 21.1 Ջyv 21.1.1 Rir[ 21.1.1.1 SO͑ 21.1.1.2 @S 21.1.1.3 _s 21.1.2 NSOՋߘՋ 21.1.2.1 4N^urNSO_ 21.1.2.2 @S 21.1.2.3 _s 21.2 ՋSR 21.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 21.2.2 Rir[^ bؚ@S!jWRirTck8^RirۏL@bRchv‰[0 21.2.3 NSOՋߘՋS(W4N^luvW@x NۏL0 21.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 21.3 ~g$R[ 21.3.1 Rir[[~Rir@Sf>fNON[gq~ N[[~Rir_sTck8^Rir@SS_seq_T S$R[SՋ7hT gRN~c@SeP^4ls^RRir[~g3'`0 21.3.2 NSOՋߘՋ _Sb6e)SNych-NNNch~g3'` S$R[SՋ7hTwQ g gRN~c@SeP^4ls^Rv\O(u0 22 [Sf['`_c$O gRObR 22.1 Ջyv Rir[R:NeHhNV/lSx_c$O!jW TeHhNR|_c$O!jW $Ny0 22.1.1 eHhNV/lSx_c$O!jW 22.1.1.1 SO͑ 22.1.1.2 7Nl(lvALT 22.1.1.3 7Il(lvAST 22.1.1.4 ~~utf[hg 22.1.2eHhNR|_c$O!jW 22.1.2.1 SO͑ 22.1.2.2 NNMDA 22.1.2.3 ؏SW7uGSH 22.1.2.4 ul NoTG 22.1.2.5 ~~utf[hg 22.2 ՋSR 22.2.1 @bRchGW:N_ZPyv0 22.2.2 9hncSՋ7hT\O(uStv N T eHhNTeHhNN vQNۏLRir[0 22.3 ~g$R[ eHhNV/lSx_c$O!jW ut~g3'` 7Nl(lvT7Il(lvNch-NNNych3'` S$R[SՋ7hTwQ g[Sf['`_c$O gRObR\O(u0 eHhNR|_c$O!jW `$MDA0GSH0TG Nych~g3'` S$R[SՋ7hT[YN_wv_c$O gRObR a$MDA0GSH0TG Nch-NNNych3'` Nut~g3'` S$R[SՋ7hTwQ g[YN_wv_c$O gRObR\O(u0 23[5uy\qS[ gRObR 23.1 [yv 23.1.1 SO͑ 23.1.2 YhT@}v~ހpe 23.1.3 Ӛ~ހDNA+TϑbӚ g8h~ހpe 23.1.4 \ Ӛ~ހ_8h[ 23.1.5 @~~-N'lSirgkSv;m'`[ 23.1.6 @nn@ }+Tϑ[ 23.2 [SR YhT@}v~ހpe0Ӛ~ހDNA+TϑbӚ g8h~ހpe0\ Ӛ~ހ_8h[0@~~-N'lSirgkSv;m'`[0@nn@ }+Tϑ[-NN b NyۏL[0 23.3 ~g$R[ (WYhT@}v~ހpe0Ӛ~ހDNA+TϑbӚ g8h~ހpe0\ Ӛ~ހ_8h0@~~-N'lSirgkSv;m'`0@nn@ }+TϑNy[-NNUONy[~g3'` S$R[SՋ7hTwQ g[5uy\qS[ gRObRv\O(u0 24 gRNcŔR 24.1 Ջyv 24.1.1 Rir[ 24.1.1.1 SO͑ 24.1.1.2 @Ŕ 24.1.1.3 Ŕ 24.1.1.4 ~~Ŕ 24.1.2 NSOՋߘՋ 24.1.2.1 @Ŕ 24.1.2.2 ?\Ŕ 24.1.2.3 ?\ 24.1.2.4 ?\ 24.2 ՋSR 24.2.1 Rir[TNSOՋߘՋ@bRchGW:N_ZPyv0 24.2.2 ^[4N^ur0SO_ۏL‰[0 24.2.3 [?\ŔۏLY!kKm[ NNSOQŔvcQ`Q0 24.2.4 (WۏLNSOՋߘՋe ^[SՋ7hTvߘ(u[hQ'`\OۏNekv‰[0 24.3 ~g$R[ 24.3.1 Rir[[~N!jW[gq~k Ŕ+Tϑ>fWMNO Te@ŔbŔ+Tϑ>fWMNO S$R[SՋ7hTRir[~g:N3'`0 24.3.2 NSOՋߘՋՋߘ~N[gq~~k \$N*N‰[ep?\ŔcQϑXRN>fWؚNՋMR b;`?\ŔcQϑf>fXR0 Te [;`?\0;`?\ vcQef>fq_T b;`?\0;`?\ cQXRvE^^\N;`?\ŔcQXRvE^^ S$R[SՋ7hTwQ g gRNcŔRv\O(u0 ,{NR Rf[hel N0 gRNX:_MQuRRhel 1. [Rir cP(uяN|\ 18 22g USN'`+R k~10 15S0 2. BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0 SՋ7hT~Ne30)Y _eS^45)Y0MQu!jWRir[eSS_^0 3. [el 3.1 ConA [v\ >m]~ހlS[ SN NRelKNN 3.1.1 MTTl 3.1.1.1 St S_Tm]~ހSConA:RoTSuk~ހSuXkS^ ;m~ހyr+R/fXk~ހ-Nv~|SO4lvS\MTTNymĞrvU.lv R:NpQ+}r~vf vQIQ[^~ހ`m6RY ẽS> nNv gϑẽHank'sms^v-N (uJP[{{\>xx 6RbUS*N~ހ`m0~200v[{QǏn b(u4B\~^\>xx (uHank'smm2!k k!ky_10min1000r/min 06qT\~ހ`nmN1mLv[hQW{Qm-N (uSZpQgrpe;m~ހpe^(W95%N N te~ހSm^:N3106*N/mL0 3.1.1.3.3 m]~ހXkS^ \kNN>~ހ`mR$NT[ReQ24T[W{Qg-N kT[1mL NT[R75L ConA mvS_N7.5g/mL SNT[\O:N[gq n5%CO2 37!CO2u[{-NW{Q72h0W{Q~_gMR4h kT[{{8TS Nnm0.7mL ReQ0.7mL N+T\[r@nvRPMI1640W{Qm TeReQMTT5mg/mL 50L /T[ ~~W{Q4h0W{Q~_gT kT[ReQ1mLx'`_N 9TSbmS O+}r~vf[hQn06qTRň0R96T[W{Qg-N k*NT[\O3*Ns^LT[ (uvhN N570nmlKm[IQ[^fW'`FfWؚN[gq~vIQ[^]

fXR Y(WW{Qm-NReQ3H z'VvU8h3H-TdR RSlS-Nv~ހDdeQ0Km[hm]~ހv>e\:_^SS fm]~ހXkv z^0 3.1.2.2 NhVTPge RPMI-1640 ~ހW{Qm0\[r@n02-]WYN2-ME 0R }0 }0RFˆ}vAConA 0Hank'sm0PBSQmpH7.2-7.4 03H-TdR0pm[2,5-NWv`UPPO 0.5g01,4-S-5-Wv`UW -POPOP 0.25g0N2u500mLmS] 200v[{Q 96T[W{Qgs^^ Kb/ghVh0N'lSxW{Q{0Q]\OS0mSOpN0Y4Y~ހSƖhV049Wst~~n~0 3.1.2.3 [ek 3.1.2.3.1 >~ހ`m6RY ẽS> nNv gϑẽHank'smv\s^v-N (uJP[{{\>dx 6RbUS~ހ`m0~200v[{QǏn (uHank'smm3!k k!ky_10min1000r/min 06qT\~ހ`nmN2mLv[hQW{Qm-N (uSZpQgrpe;m~ހpe^(W95%N N gT(uRPMI1640[hQW{Qm\~ހpeb5106*N/mL0 3.1.2.3.2 m]~ހXkS^ \>~ހ`mReQ0R96T[W{Qg-N 200L/T[ kNN>~ހ`mRň6*NT[ 3T[RConA5g/mL S3*NT[ NRConA\O:N[gq0n5% CO2 37!W{Q72h W{Q~_gMR6h kT[ReQ3H-TdR 20L OvQ~Sm^:N3.7-18.5 104Bq/mL0(uY4Y~ހ6eƖhV\~ހSƖNst~~n~ N0n~GrEQRr^qTnKmϑt-N ReQ7mLpm (umNKm[kR Qpecpm 0 3.1.2.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWؚN[gq~vSI

fW'`FfWؚNN[gq~v͑ϑ]

fW'`FfWؚN[gq~v]

~ހ`mNN[ϑvSRBCmT (WeSOSN N ORlbSOv>~ހhTVvSRBCn b_beeQ gstsvmp̃%b_t-N gN*NeTGdR N1~~ >eeQ4!Q{OX[Y(u SOX[2hT0 3.3.3.2 6RYeSO ǑƖZ @ RyQ@n\5SZ vmT@n \1mLSySRBCReQ0R5mLZ @n-N 4!Q{>en30min ~8^/ca y_S Nn Rň 70!OX[0(ueNSAQm c18 15zʑ0 3.3.3.3 sGrm (WnmsGr N7R NNB\~ހ`m6RY \SRBCMQu4^5)YTv\ i1Y{k SQ> >e(Wv gHank'smv\s^vQ {{xx> 6Rb~ހ`m ~200v[{QǏn b(u4B\~^\>xx y_1000r/min 10min (uHank'smm2M gT\~ހ`nm(W5mL RPMI1640W{Qm-N pe~ހ v^\~ހSm^te:N5x106*N/mL0_NS\~ހ`nm(W8mL Hank'sm0 3.3.3.6 zzevKm[ \hB\W{QW1ge45^50!4ltmO)n NI{ϑpH7.2^7.402 PSm^vHank'smmT Rň\Ջ{ k{0.5mL QT{QR50L 10% SRBCv/v (uSAQmM6R 20L>~ހ`m5106*N/mL b25L>~ހ`m ŏmS >PPN]7Re(WGrg N >eeQN'lSxW{Q{-Nu[1^1.5h 6qT(uSAQmzʑveSO18 ReQ0RsGrgQiQ ~~)n1^1.5hT pen@zzepe0 3.3.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`F~ހbzzepe/hQ>~ހegh:y SՋ7hT~vzzepe>fWؚN[gq~vzzepe S$R[y[~g3'`0 3.4 @nn@ }vKm[ SN NRelKNN0 3.4.1 @Ql 3.4.1.1 St (uSRBCMQuRirT NubSRBCbSOn@ } )R(uvQQƖSRBCv z^eghKmn@ }v4ls^0 3.4.1.2 NhVTPge SRBC0utv4l0_ϑ@Q[g0y_:g 3.4.1.3 [ek 3.4.1.3.1 SRBC ~Y S@ \@>eeQ gstsvmp̃%b_t-N gN*NeTGdR N1~~ >eeQ4!Q{OX[Y(u SOX[2hT0 3.4.1.3.2 MQuRirS@nRy S@ (uutv4lmm3!k k!ky_2000r/min 10min0\SySRBC(uutv4lMb2%v/v v~ހ`m kS yTl\0.2mLۏLMQu04^5)YT Xdden~1h \QV@N{XeRy O@nEQRgQ 2000r/miny_10min 6eƖ@n0 3.4.1.3.3 QƖS^ (uutv4l\@n Pkzʑ \ N Tzʑ^v@nR+RnN_ϑ@Q[gQ kT[100L QReQ100L 0.5%v/v vSRBC`m mS ňeQnmvs^vQRv N37!)n{u[3h ‰[@tQƖ z^0 3.4.1.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWؚN[gq~vbSO4ls^ S$R[y[~g3'`0 bSO4ls^S1+2S2+3S3& & nSn _-N10203& & nNh[ Pzʑvcpe SNhQƖ z^v~+R bSOype'Y h:y@nbSOؚ0 0~ ~~ހhQ Nl Ɩ-N(WT[^b_b[vWpr VhTmSOnpf0 I~ ~~ހ'YRlƖ(WT[^bVpr VhT g\ϑQƖv~~ހ0 II~ QƖv~~ހ(WT[^b_bB\ -N_SNf>f0RN*Nu~gv~p0 III~ QƖv~~ހGWS0Wce(WT[^bNB\ -N_~SN*N\~p0 IV~ QƖv~~ހGWS0Wce(WT[^bNB\ QWW gebwSbr0 3.4.1.5 laNy @nzʑeEQRmS0gTN*Nzʑ^^ NQsQƖsa0 3.4.2 JSpen@e@~ˆ}v ǏKm[@~ˆ}v+TϑS fRir@n-Nn@ }v+Tϑ0 3.4.2.2 NhVTPge 721RIQIQ^0y_:g0R`)n4ltm0SRBC0eSOZ @n 0SAQm0lՋBRxx"l1.0g0ؚ0lS0.2g00lS0.05g R4l1000mL 3.4.2.3 [ek 3.4.2.3.1 SRBC ~Y S@ \@>eeQ gstsvmp̃%b_t-NgN*NeTGdR N1~~ >eeQ4!Q{OX[Y(u SOX[2hT0 3.4.2.3.2 6RYeSO ǑƖZ @ RyQ@n\5SZ vmT@n \1mLSySRBCReQ0R5mLZ @n-N >e4!Q{30min ~8^/ca y_S Nn Rň 70!OX[0(ueNSAm c18zʑ0 3.4.2.3.3 MQuRirS@nRy S@ (uutv4lmm3!k k!ky_2000r/min 10min0\SySRBC(uutv4lMb2v/v v~ހ`m kS yTl\0.2mLۏLMQu04^5)YT Xdden~1h O@nEQRgQ 2000r/miny_10min b6000r/min 4min 6eƖ@n0 3.4.2.3.4 n@S^ 3.4.2.3.4.1 RIQIQ^l S@n(uSAQmzʑN,:N200^500 P 0\zʑTv@n1mLnՋ{Q O!kReQ10%v/v SRBC 0.5mL eSO1mL(uSAm c1:8zʑ 0S NR@nv[gq{NSAQmNf 0n37!R`)n4ltm-NO)n15^30minT Qtm~bkS^02000r/miny_10min0S Nnm1mL RlՋBR3mL TeS10%v/v SRBC 0.25mLRlՋBR4mL EQRmS >en10minT N540nmYN[gq{\Ozz}v R+RKm[T{IQ[^en10minT N540nmY(uhQꁨRvhNKm[TT[IQ[^fW'`FfWؚN[gq~vHC50 S$R[y[~g3'`0 HC50 3.5 \ x^n[ 3.5.1 St (WN[VQ SOQx|ndsN@xSm^HTcQpesQ|0 N@xSm^[pe͑ϑq_TTlVs N,N!hckTlVcpeah:y0 3.5.2 NhVTՋBR 721RIQIQ^0ehV0@r }8T{0pS^XAl0Na2CO3 3.5.3 [ek 3.5.3.1 nmM6R l\(uXAl \pS^XAlSm(uutv4lzʑ3^4 P0 Na2CO3nm S0.1gNa2CO3 R4l100mL0 3.5.3.2 l\XAl cSO͑N\ >\Y leQzʑvpS^XAl10ml/kg _XAlleQ zsSe0 3.5.3.3 Km[ leQXAlT2010min R+RNQ&wY NS@20L v^zsS\vQR0R 2mL 0.1%Na2CO3nm-N0(u721RIQIQ^(W600nmlYKmIQ[^ (un~8Tr^hVhb@al R+Ry͑0 NTlVcpeh:y\ x^nvR0 c N_{TlVcpea0SՋ7hT~vTlVcpe>fWؚN[gq~vTlVcpe S$R[y[~g3'`0 lgOD1 lgOD2 K%%%%%%% t2 t1 TlVcpea 3.5.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Fen-N x|SlNt^ 4N(uMR^GdS0 O(uevXAle ^(W[MRxd"}N*NgXAlleQϑ sSck8^\ (W20minQ Nf^n0 3.6 \ yT]lV~ހTlV!~~ހ[ SN NRelKNN0 3.6.1 \ yT]lV~ހTlV!~~ހ[nGrl 3.6.1.1 St )R(u]lV~ހ[IQnhbYsthbwQ g|Dvyr'` \+T g]lV~ހvyTmnN}sGr N ReQ!~~ހ u[N[eT Qmc*g|Dv~ހ V[gr (W>f_\ NpeTlV!~~ހv]lV~ހvTlVsTTlVcpe ncdk$R[]lV~ހvTlVR0 3.6.1.2 NhVTPge >f_\037!u[{0pehV0Kb/ghVhNWY0l\hV0n{04Y8T{08T3t0}sGr0gri0Ջ{ 3.6.1.2.1 sGrYt ͑ YO(uv}sGr~mmxml0mQ~fr^T ~R|xmlǏY0(uMRN~^br^b~fr^ &TROq_T]lV~ހ|DT\h0(WsGr NhS (u3%en55^60!4ltm{Q2\e NeGdS QReQ2uGdS OX[Y(u0 b.zʑYY(lgrmO(ue (upH6.8vQm8N RYY(lgrmSm1N sSb^(um0 3.6.1.2.3.5 Giemsagm1rmM6Rel2u20mL 4l80mL0mTTR2N HCl2nsSb0 3.6.1.3[ek \ ]lV~ހvo;m:[MR4)Y~kS\ yTl\2%Sy@~~ހ0.2mL0(ui1lY{k\ yTl\R\[r@nvHank'sm4mL/S {{ ccy20!k NEQRmQyT]lV~ހ 6qT\yXjR_N*N\S (u4Y8T{8TSyTmm2mLNՋ{Qb(ul\hV 0(u1mLR7hhV8TSyTmm0.5mLReQv g0.5mL 1%!@~~ހ`mvՋ{Q mS0(ul\hVň'Y4Y 8TS0.5mLmTm ReQsGrvenu[{Q37!u[15 20R0u[~_gTŏ(uutv4l\*g4X~ހQc N2um-NV[1R Giemsamgr15R0(u4lQmr^Q ~fr^ (u40>f_\peTlVsTTlVcpe0TlVs:Nk100*N]lV~ހ-N TlV!~~ހv]lV~ހ@b`Sv~vRsTlVcpe:Ns^GWk*N]lV~ހTlV!~~ހv*Npe0 3.6.1.4 pencYtS~g$R[ 3.6.2.4. 3.6.1.5laNy i1Y{k\ R(uRǏ'Y 2bkyTQ@{TQ4xˆQ@q_T[~g0 >enGrv*dtvQ^OcN[vn^ N2mSOr^q0 u[Tvh,gQm!kpev]+R N[*Y'Y f NvcQ(W g~ހvR0 [d\OǏ z-N^%Nf_\0!~~ހ0Nn02u0utv4l0Giemsagm0 3.6.2.3 [ek 3.6.2.3.1 !~~ހ`m6RY S!@nN gstsv%b_t-N gN*NeTEQRGdR N1~~0(uutv4lmm2^3!k y_2000r/min 10min S Nn (uutv4lMb20%v/v v!~~ހ`m0 3.6.2.3.2 TlVRKm[ k yTl\20% !~~ހ`m1mL030min-1.5h i1Y{kRir \vQNMOV[N g N ck-NjR_yXv ~yTleQutv4l2mL lR g1min06qT8TQyTmm1mL s^GWRnN2Gr}sGr N >eeQW gnl^v*dtvQ yn37!u[{)n30min0u[k Nutv4l-Nom NdS*g4Gr~ހ0~fr^ N1:1Nn2unmV[ 4%v/v Giemsa- xxQmgr3min Q(u4lom~fr^0 l\ Npe]lV~ހ k _Grpe100*N c N_{TlV~vRsTTlVcpe0 TlV~vRs% =  TlVcpe= (Wpee ^ Te‰[!~~ހmSv z^0PN$R[]lV~ހTlVNmSR 8^R:N4~ I~*gmS0TlVv!~~ހ[te ހ(Em~bEmĞ&^~r ހ8hEm+}r0 II~{^mS0ހ(EmĞ~r0ހ8hV)HT+}݄r0 III~͑^mS0ހ(mg ހ8hmEmppr0 IV~[hQmS0]lV~ހQNb_`{|fW'`FfW'` eS$R[y[~g3'`0 3.7 NK~ހ;m'`Km[ SN NRelKNN 3.7.1 sNx1"lvLDH Km[l 3.7.1.1 St ck8^`Q N ;m~ހހFmQv+T gLDH NǏ~ހ S_~ހS0RNK~ހv@g$OT LDHʑ>e0R~ހY0LDHSOsNx1"l ۏ ONAD؏SbNADH TQ~"lSO)TUN2uokxxvPMS ؏Sx]xW/lSV.lU݄INT INT cSH ؏Sb+}~r2u܁{|STir0(WvhN N(u490nmkrKm[0 3.7.1.2 NhVTPge vhN0YAC-1~ހ0Hank'smpH7.2^7.4 0RPMI1640[hQW{Qm0sNxbsNx0x]xW/lSV.lU݄INT 0)TUN2uokxxvPMS 0NAD00.2mol/LvTris-HClQmpH8.2 01%NP40b2.5%Triton 3.7.1.3 [ek 3.7.1.3.1 LDHW(mvM6R sNx 510-2mol/L x]xW/lSV.lU݄INT 6.610-4mol/L )TUN2uokxxvPMS 2.810-4mol/L 'lSWv`!NAD 1.310-3mol/L \ NՋBRnN0.2mol/LvTris-HClQm-NpH8.2 3.7.1.3.2 v~ހv ONYAC-1~ހ [MR24h\v~ހۏL ONW{Q0(uMRNHank'smm3!k (uRPMI1640[hQW{Qmte~ހSm^:N4105*N/mL0 3.7.1.3.3 >~ހ`mv6RYHe^~ހ ẽS> nNv gϑẽHank'smv\s^v-N (uJP[{{\>xx 6RbUS~ހ`m0~200v[{QǏn b(u4B\~^\>xx b(uHank'smm2!k k!ky_10min1000r/min 0_ Nn\~ހFm9_w ReQ0.5mLmp̃4l20y ˆ㉢~~ހTQReQ0.5mL2 PHank smS8mLHank sm 1000r/min 10miny_bǑ(uNH4Cl-Tris~~ހˆ㉲mˆ㉢~~ހ y_10min1000r/min _~r Nn0(u1mL+T10%\[r@nvRPMI1640[hQW{Qm͑` (u1%QxzʑTpe;m~ހpe^(W95%N N (uSZpQgrpe;m~ހpe^(W95%N N gT(uRPMI1640[hQW{Qmte~ހSm^:N2107*N/mL0 3.7.1.3.4 NK~ހ;m'`hKm Sv~ހTHe^~ހT100LHevk50:1 ReQUW96T[W{Qg-Nv~ހ6qʑ>eT[Rv~ހTW{QmT100L v~ހg'Yʑ>eT[Rv~ހT1%NP40b2.5%TritonT100L NTyGW N*Ns^LT[ N37!05%CO2W{Q{-NW{Q4h 6qT\96T[W{QgN1500r/miny_5min kT[8TS Nn100Lns^^96T[W{Qg-N TeReQLDHW(m100L 9hnc[)n N TS^3~10min kT[ReQ1mol/LvHCl 30L (WvhN490nmYKm[IQ[^fWؚN[gq~vNK~ހ;m'` sSS$R[y[~g3'`0 NK~ހ;m'`(%) 3.7.1.4 pencYtS~g$R[ NK~ހ;m'`ۏLpenclbc XSin-1 _-NP:NNK~ހ;m'` (u\peh:y 6qTQۏLe]Rg ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWؚN[gq~vNK~ހ;m'` S$R[y[~g3'`0 3.7.1.5 laNy v~ހTHe^~ހ_{e ~ހX[;ms^'YN95%0 S^esX)n^^OcR`[0 LDHW(m^4N(uMRM6R0 (WN[VQ NK~ހ;m'`NHevkeQeg vQʑ>evϑNNK~ހ;m'`bckk0ǏKm[v~ހ3H-TdRvʑ>essSSS^NK~ހv;m'`0 3.7.2.2 NhVTPge mSOpN0Y4Y~ހSƖhV0N'lSxW{Q{03H-TdR0RPMI1640 [hQW{Qm0Hank'smpH7.2^7.4 0YAC-1~ހ0Triton X-100 3.7.2.3. [ek 3.7.2.3.1 v~ހvh S ONT24huo}YvYAC-1~ހX[;ms>95% c1106/mL YAC-1~ހ`mR3H-TdR 10uCiۏLh N37!05%CO2W{Q{-NW{Q2h k30min/ca1!k0hTv~ހ(uW{Qmmm3!k ͑`NW{Qm-N O~ހSm^:N1105*N/mL0 3.7.2.3.2 >~ހ`mv6RYHe^~ހ ẽS> nNv gϑẽHank'smv\s^v-N (uJP[{{\>dx 6RbUS~ހ`m0~200v[{QǏn (uHank'smm3!k k!ky_10min1000r/min 06qT\~ހ`nmN2mLv[hQW{Qm-N (uSZpQgrpe;m~ހpe^(W95%N N gT(uRPMI1640[hQW{Qmte~ހSm^:N1107*N/mL0 3.7.2.3.3 NK~ހ;m'`Km[ (W96T[W{Qg-NkT[R100Lhvv~ހ [T[R100LHe^~ހ zz}v[gqT[R100LW{Qm g'Yʑ>eT[R100L 2.5% Triton X-1000k*N7hT3*N YT[ n5%CO2037!W{Q{Q)n4h (uY4Y~ހ6eƖhV\~ހ6eƖ(Wst~~n~ N (umSOpNۏLKmϑ0 c N_{NK~ހ;m'` [T[cpm NK~ހ;m'`(%)=1 %%%%%%%%%%%%%%%%%% 100% zz}v[gqT[cpm g'Yʑ>eT[cpm 3.7.2.4 pencYtS~g$R[ NK~ހ;m'`ۏLpenclbc XSin-1 _-NP:NNK~ހ;m'` (u\peh:y0(WۏLe]Rge ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWؚN[gq~vNK~ހ;m'` S$R[y[~g3'`0 4. gRNX:_MQuRR~g$R[ gRNX:_MQuRR$R[(W~ހMQuR0SOmMQuR0US8h ]lV~ހR0NK~ހ;m'`V*NebN$N*Neb~g3'` S$R[SՋ7hTwQ g gRNX:_MQuRR\O(u0 vQ-N~ހMQuRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[~ހMQuRKm[~g3'`0SOmMQuRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[SOmMQuRKm[~g3'`0US8h ]lV~ހRKm[yv-Nv$N*N[~gGW:N3'` bNN*N[v$N*NBRϑ~~g3'` S$R[US8h ]lV~ހR~g3'`0NK~ހ;m'`Km[[vN*NN NBRϑ~~g3'` S$R[NK~ހ;m'`~g3'`0 N0 gRNb'lSRhel 1 Rir[ 1.1 [Rir (u10gN N'Y b8gN N\ _NS(u'lS_c$O!jW 0USN'`+R \ k~10 15S 'Y 8 12S0 1.2 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*NnBR[gq~ NNSOcPϑv10 P\ b5 P'Y :NvQ-NvN*NBRϑ~ S$N*NBRϑ~ ؚBRϑN, NǏ30 P _e3'`[gq~0zz}v[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 1.3 [el 1.3.1 Rir (u10gN N'Y b8gN N\ c@-NMDA4ls^R~ :gR:N1*NnBR[gq~T3*NSՋ7hTBRϑ~03*NBRϑ~~N N TSm^SՋ7hT [gq~~N TSOynBR [~_geY{kRirKm('lSNir+Tϑ0ˆ}v(W+Tϑ0؏SW7u+Tϑ0b'lSv;mR0 1.3.2 D JSsN|'lS_c$O!jW 1.3.2.1St D-JSsN|O~Ǐϑ 8^Nu;m'`'l Sb4xNScNW O!j_v;m'`'lNuNmdvs^ar` _wǏ'lSHe^0 1.3.2.2 !jel 25-30geP^bt^\ dzz}v[gq~Y vQYORir(uD-JSsN|40mg 1.2g/kg BẀ萮v Nl\byTl\ !j l\ϑ:N0.1mL/10g ke1!k ޏ~ !j6hT S@KmMDA cMDA4ls^R~0:gR:N1*N!jW[gq~T3*NSՋ7hTBRϑ~ 3*NBRϑ~~S~N N TSm^SՋ7hT !jW[gq~~N TSOynBR (W~SՋ7hTv Te !jW[gq~TTBRϑ~~~~Nv TBRϑD-JSsN|̀萮v NbyTl\ [~_gY{kRirKm('lSNir+Tϑ0ˆ}v(W+Tϑ0؏SW7u+Tϑ0b'lSv;mR0 1.3.3 YN'lS_c$O!jW 1.3.3.1 St YN'YϑDdeQ o;m'lRP[Nu1uW [~~~ހǏ'lSHe^SSOQ؏SW7uvz0 1.3.3.2 !jel 25 30geP^bt^\ 180 220g'Y :gR:N4*N~ 1*N!jW[gq~T3*NSՋ7hTBRϑ~ _eSX1*Nzz}v[gq~03*NBRϑ~~N N TSm^SՋ7hT !jW[gq~~N TSOynBR ޏ~LpÀ30)Y +g!kLpÀT !jW~[gq~T3*NBRϑ~yߘ16\eǏY 6qT1!k'`LpÀ~N50%YN12mL/kg BW 6\eTSPgzz}v[gq~ N\OYt NyߘSPg Km@nb~~('lSNir+Tϑ0ˆ}v(W+Tϑ0؏SW7u+Tϑ0b'lSv;mR0 1.3.4('lSNirKm[ 1.3.4.1 @-NǏ'lS(M㉧NirNNMDA +TϑKm[ @-NǏ'lS(M㉧NirNNMDA +TϑSǑ(ugIQlTkrlKm[ elN vQN0 1.3.4.1.1 gIQl 1.3.4.1.1.1 gIQlSt MDAmalondiadehycle /f~ހ(Ǐ'lSv~NirKNN KmvQ+TϑSc0O(Ǐ'lSv z^01*NNNMDA RP[N2*NkxN]kYxTBA RP[(Wx'`agN NqQp b_b|~r YTir0Nl536nm:NoSIQ (W550nm gg:_gIQ:_^0S(ugIQlۏL_ϑKm[0 1.3.4.1.1.2 NhVNՋBR NhVgIQRIQIQ^0_ϑR7hhV0R`)n4ltm0nfy_:g0mehV0wQ^Xy_{ ՋBR 10mmol/LVYN'lWNp.Ym hrt4!OX[12*Ng 4N(uMR(u~4lzʑb1nmol/mL 29mmol/LkxN]kYx]\Om kxN]kYx 0.209g EDTA(2H2O 25mg 7u؏SW 1mg (u0.02mol/L NaOH 50 mL n_)nRn hrt4!OX[2hT x4l㉲m 0.1mol/L H2SO4 125mL 0.1mol/L Na2SO4 125mL R4l150mL(u H2SO4 pH 1.5 R4lzʑ500mL ckN N N@b(usthVvGW~50%]xxxml24hT Q~4l0S4lmmr^q ՋBR AR~ g}Y(uS4lM6R0 1.3.4.1.1.3 [ek 1.3.4.1.1.3.1 7hT6RY hQ@ NnmS@50LReQ0.5mLutv4l 2000r/miny_10min S Nnm_Km0 @n7hTS@0.5mL[)nYn10min 2000r/miny_10min S Nnm_Km0 1.3.4.1.1.3.2 hQf~6R\O \10nmol/mLVYN'lWNp (uS4lzʑb0.000.2500.501.001.5020305010nmol/mLR+RS0.1mLReQx4l㉲m2mL0TBA]\Om0.5mL!mS IQ0l4ltm60min!Am4lQtS[)n!3mLckN/cabc1min!3000r/miny_5min!S NnmckNB\ KmgIQ:_^eQ\r1.5nm Q\r5nm oSl536nm S\l550nm NVYN'lWNpSm^:N*jPWh gIQ:_^:N~PWh\OV0 1.3.4.1.1.3.37hTKm[ ՋBRzz}v{7h,g{hQ{10mLwQ^Xy_{0.1mL4l0.1mL@n*0.1mLhQx4l㉲m2mL2mL2mLTBA]\Om0.5mL0.5mL0.5mLmS IQl4ltm60min Am4lQtSckN3mL3mL3mL/cabc1min 3000r/min y_5min*hQ@ Nnm 0.5mLzz}v{R4l0.5mL hQ{RhQ0.1mL04l0.4mL 1nmol/mLVYN'lWNphQ @n0.1mLbhQ@ Nnm0.5mL !ReQx4l㉲m 2mL0TBA]\Om0.5mL!mS IQ0l4ltm60min!Am4lQtS[)n!3mLckN/cabc1min!3000r/miny_5min!S NnmckNB\ KmgIQ:_^eQ\r1.5nm Q\r5nm oSl536nm S\l550nm 1.3.4.1.1.3.4 {lQ_ B-A B-A Ǐ'lS(+Tϑnmol/mL@n    CK =     11 F-A F-A B-A B-A 1 Ǐ'lS(+Tϑnmol/mL@m    CK =    1    F-A F-A 0.05 Azz}v{gIQ^ B7hTgIQ^ FVYN'lWNpgIQ^ CVYN'lWNpSm^1nmol/mL Kzʑ Ppe 1.3.4.1.2krl 1.3.4.1.2.1krlSt MDAmalondiadehycle /f~ހ(Ǐ'lSv~NirKNN KmvQ+TϑSc0O(Ǐ'lSv z^01*NNNMDA RP[N2*NkxN]kYxTBA RP[(Wx'`agN NqQp b_b|~r YTir0ir((Wl532nm gg'Y8T6e\0S(uRIQIQlۏLKm[0 1.3.4.1.2.2 NhVNՋBR NhVSIQRIQIQ^0vhN0_ϑR7hhV0R`)n4ltm0nfy_:g0mehV0wQ^Xy_{0 ՋBR0.2MYNxvQm pH3.5 0.2MYNxnm 185mL 0.2MYNxnm 15mL 1mmol/LVYN'lWNp.Ym 4!OX[3*Ng 4N(uMR(u4lzʑb40nmol/mL 8.1%ASNpWkxxSDS 0.8%kxN]kYxTBA 0.2MxxvQm pH7.4 0.2Mxx"lN 1920mL 0.2M xxN"l 480mL 1.3.4.1.2.3 [ek 1.3.4.1.2.3.1 7hT6RY n@m7hTS@20LReQ0.98mL4l6Rb2%n@m0 1.3.4.1.2.3.2 7hTKm[ ՋBRzz}v{7hT{hQ{2%n@m*0.2mL40nmol/mLVYN'lWNp0.2mL8.1%SDS0.2mL0.2mL0.2mL0.2MYNxvQm 1.5mL1.5mL1.5mL0.8%TBA1.5mL1.5mL1.5mLH2O0.8mL0.6mL0.6mLmS IQl4ltm60min Am4lQtS N532nmkrlY(uՋBRv S cՋBRvvd\OBlۏL0 *(u@n 7hT{0.15mL hQ{0.15mL0 1.3.4.1.2.3.3 { B  A B  A Ǐ'lS(+Tϑnmol/mL2%n@m     CK =      401 F  A F  A B  A B  A Ǐ'lS(+Tϑnmol/mL@n     CK =      401 F  A F  A A: zz}v{8TIQ^ B7hT8TIQ^ FVYN'lWNp8TIQ^ CVYN'lWNpSm^40nmol/mL Kzʑ Ppe 1.3.4.2 ~~-NǏ'lS(M㉧NirNNMDA +TϑKm[ 1.3.4.2.1 St 1.3.4.1.2.1 1.3.4.2.2 NhVNՋBR NhVSIQRIQIQ^0vhN0_ϑR7hhV0R`)n4ltm0nfy_:g0mehV0wQ^Xy_{0~~SFmhV ՋBR1.3.4.1.2.2 1.3.4.2.3 [ek 1.3.4.2.3.1 7hT6RY ~~SFm7hTSN[ϑv@bhV utv4lQm0br^0y͑0jRx nSFmhV-N ReQ0.2MxxvQm N20000r/minSFm10s Gk30s S YۏL3!k 6Rb10%~~SFmW/V 3000r/miny_5 10min S Nnm_Km0 1.3.4.2.3.2 7hTKm[ ՋBRzz}v{7hT{hQ{10%~~SFm0.2mL40nmol/mLVYN'lWNp0.2mL8.1%SDS0.2mL0.2mL0.2mL0.2MYNxvQm 1.5mL1.5mL1.5mL0.8%TBA1.5mL1.5mL1.5mLH2O0.8mL0.7mL0.7mLmS IQl4ltm60min Am4lQtS N532nmkrlY(uՋBRv S cՋBRvvd\OBlۏL 1.3.4.2.3.3 { B - A B- A 1 Ǐ'lS(+Tϑ      CK =    40         nmol/mg~~ F - A F - A 0.210%1000 Azz}v{8TIQ^ B7hT{8TIQ^ FVYN'lWNp8TIQ^ CVYN'lWNpSm^40nmol/mL Kzʑ Ppe 1.3.4.3 @n-N8-h"l'l-_MRRz }8-Isoprostane Km[ 1.3.4.3.1 St 8-h"l'l-_MRRz }8-Isoprostane /fSOQ('lS^oS^3z[ wQ gyr_'`vh_ir vQ+TϑcS^V:gSOQ1uWvNu [~~~ހv(Ǐ'lS z^0 1.3.4.3.2NhVNՋBR NhVvhN0uSW{Q{0_ϑ/cahV0_ϑR7hhV0mg:g ՋBR8-Isoprostane KIA Kit (vTMQuՋBRv) 8-Isoprostane EIA bSO@n08-Isoprostane AChE:y*ir08-Isoprostane EIAhQT0EIAQm0mmQm0T)n200 b-TQIgGbSO0EIA:y*grBR0EIAbSO@ngrBR0Ellman sՋBR 1.3.4.3.3[ek 1.3.4.3.3.17hT6RY \ en10 minT N11000r/minvl y_10 min S Nnm_Km0 1.3.5.2.3.2d\Oek ՋBRKm[{[gq{~~SFm Nnm0.1mL0.1mL10 mmol/L 2 4-N]xW0.4mL2 mol/L HCL0.4mLmemS1R 37!QnxIQS^30R200 g/L N/lYNx0.5mL0.5mLmemS1R N4! N N12000r/miny_10min _ Nn Yulme4lYNYNxYNomT^(um1.0mL1.0mLmemS1R N4! N N12000r/miny_10min _ Nn Yulme4lYNYNxYNomT^(um1.0mL1.0mLmemS1R N4! N N12000r/miny_10min _ Nn Yulme4lYNYNxYNomT^(um1.0mL1.0mLmemS1R N4! N N12000r/miny_10min _ Nn Yulme4lYNYNxYNomT^(um1.0mL1.0mLmemS1R N4! N N12000r/miny_10min _ Nn Yulm6 mol/L vx̀1.25mL1.25mLmST 37!Qnx4ltm15RmemS \hQ萉lmn N12000r/miny_15min S Nnm(W370nmYkr 6 mol/L vx̀ՋBR Km[ODfvXSS v;m'`Nuirt^vXbSk0md1uWvRNv;m'`bckk0 1.3.6.1 @b~~-N'lSirgkSvSOD ;mRKm[ 1.3.6.1.1 St O2'lSvg~Nir:NN]xxv T(W[(lWxxS2u\O(u NHTs+}~r (Wl530nmY gg'Y8T6e\ S(uRIQIQ^lۏLKm[ S_SODmdO2Tb_bvN]xxvQ\0 1.3.6.1.2NhVNՋBR NhV SIQRIQIQ^0vhN0y_:g0R`)n4ltm0SFmhV ՋBR 65mMxxvQmPBS pH7.8 10mmol/Lvx vx6.95mg RPBS10mL 7.5mmol/LĞ VdT Ğ VdT11.41mg R0.1M NaOH 2.5mLn RPBS10mL 0.2g/LĞ VdT'lSv S10g/LĞ VdT'lSv0.2mLRQQPBS 9.8mL10mL 0.1%2u S0.2g -2unN40mLl4l Q[)nR50mLQx QR110mLQ4l200mL 0.33%[(lWxx S0.66g[(lWxxnN150mL)n4l R50mLQx200mL SODhQT N/l2up 95%YNv/v 0.9%utv4l 1.3.6.1.3 [ek ~~ހbcm6RY10LhQ@QeQ0.5mLutv4l 2000r/miny_3min _ Nn RQQvS4l0.2mLmS ReQ95%YN0.1mL /ca30s ReQ N/l2up0.1mL n_mThVbc1min 4000r/miny_3min RB\ NB\:NSODbcm -NB\:N@~ˆ}vlmir NB\:N N/l2up U_ NnmSOy_Km0 ~~SFmv6RYjRSN[ϑv@bhV utv4lQm0br^0y͑0jRx stSFmhV-NReQQutv4l20000r/minSFm10s Gk30s S YۏL N!k 6Rb1%~~SFm g}Y(uXlSuhVYt30s O~|SO/c4x N-N'`~ yl~Bgrf~|SO]/cx0N4000r/miny_5min S Nnm20L_Km0 SODhQb6Rf~ \SODhQT(uxxvQmM6Rb750U/mLvnm Qzʑ0R50 P sSSODϑ:N15U/mL1.5g/mL (u,glKm[ N TϑvSODhQmv~vRb6Rs N~vRb6Rs:N~PWh NSOD;mRUSMOU/mL:N*jPWh~6RhQf~0 [gq{OD Km[{OD SOD~vRb6Rs%%%%%%%%%%%%%%%%%100% [gq{OD {kmLS^m-NSODb6Rs50%e@b[^vSODϑ:NN*NUSMO0 [gq{OD-Km[{OD 100% [gq{OD S^m;`ϑ6mL SOD;mRU/mL %%%%%%%%%%%%%%%%%% %%%%%%%%%%%%7hTzʑ Ppe 50% Smϑ _NS(uvk;mlsSNk{7hTv~vRb6RsNSODhQf~gQv^vSOD U/mL XNNzʑ Ppe1mL/S7hϑ 0 7hT:N~~SFmm 9hncSFmSm^b~~ˆ}v(+Tϑ \USMObc{:NU/g~~bU/mgˆ}v07hT:N~~ހbcm 9hnc@~ˆ}v+Tϑ Sbc{:NU/g Hb0 7hTKm[ek ՋBRKm[{[gq{1/15mol/LxxvQm pH7.8mL 1.01.07hTA*10mmol/LvxmL 0.10.17.5mmol/LĞ VdTmL 0.20.20.2mg/mLĞ VdT'lSvmL 0.20.2S4lmL 0.490.49mS 37!R`)n4ltm30min 0.33%[(lWxxmL 2.02.00.1%2umL 2.02.0mS15minT PeQ1cmIQ_krog N4l 530nmYkrKm[ODfrm DTNB40mggjx N1.0gR4l100mL 4!IQOX[1*Ng0 0.2MxxQmpH7.4 0.9%utv4l 1.3.6.2.3 [ek 1.3.6.2.3.1 7hT6RY n@mS @10LReQ0R1mLS4l-N EQR/cGd OKNhQ萶n@1:100_Km 4hQKm[v;mR0S_)Yeg NSKm[ \ }bQhQ@n-20!QX[ 3dQKm[ 4!X[>e 28hQ_{Km[0KmMRSQ7hT[)n6q㉻Q0 ~~ NnmRiryߘǏY Y{kT zsSSQ@bhV >eeQQutv4l-NmSnm@ TRdS~~~ n~8Tr^T (WQtm NjRbxWW ySϑ~~ RQ0.2MxxQm N20000r/minSFm10s Gk30s S Y3!k6Rb5%~~SFm d\O(WQtm-NۏL SFmN12500gy_10minNO)nؚy_:g Nlm:N4xxv~ހ0~ހxGr08hS~|SO Nnm(uNKmހm-Nvv;mR g}YS_)YKm &TRR20%v/v ulRňNQXe{ >en-20 -80! SOX[pehT v;mR NQ0 1.3.6.2.3.2 GSHhQf~v6R\O S1.0mmol/LGSHnm000.200.400.600.801.0mL R+RnN10mL\[hVt-N TReQOPxxlmBR8mL (uS4lzʑ10mL;R^ sS_0RSm^:N00200400600800100mol/Lv GSHhQm0 S N N TSm^hQmT2mL >eeQՋ{-N ReQ0.32mol/L Na2HPO4 2.5mL krMRReQDTNB>frm0.5mL(uIQ_1cmog 5minQ(WSIQ423nmlKmOD

frm0.50.50.5>frS^1minTN423nml1cmIQ_ OD

fr NNNte*NS^SO|-N"lyP[Sm^ gsQ ؏SS^eP6R0ReQ>frBRT S^SO|pH:N6.5e 11min_Y>fr dkekr5minQpeQnx0 1.3.7b'lSir(؏SW7uGSH Km[ 7u/fNyNORP[ndBR [SndO2-0H2O20LOOH07u/f7(lx0u(lxTJS(lx~bvNy N /f~~-N;Nv^ˆ}v(v]WSTir /fGSH-PxTGST$Nyv{|v^ir :Nُ$NyvR"lǏ'lSir@b_ [3z[+T]Wvv T2bk@~ˆ}vSvQ[RVP[S'lS_c$O :ONbzGSHOOOYSf[ir(bsXV }Nu-Nk\O(u GSHϑvY\/faϑ:gSOb'lSR'Y\v͑V }0 1.3.7.1@b~~-N؏SW7uGSH Km[el 1.3.7.1.1St GSH-T5,5'-Nkx[]xW2uxDTNB S^(WGSH-PxPS NSubĞrv5-kxN2-]xW2ux4yP[ N420nml gg8T6e\ Km[勻yP[Sm^ sSS{GSHv+Tϑ0 1.3.7.1.2NhVTՋBR NhVSIQRIQIQ^0vhN0NO)nؚy_:g0SFmhV0R`)n4ltm0_ϑR7hhV ՋBR0.9%utv4l 4%xW4lhgxnm 0.1mol/L PBSnmpH=8.0  ySNa2HPO4 13.452g KH2PO4 0.722g R4l1000mL0 0.004%DTNBnm ySDTNB 40mgnN1000mLv0.1mol/L PBSnmpH=8.0 -N0 S.l~Qm NaN316.25 mgEDTA-Na2  7.44 mgNa2HPO4 1.732 gNaH2PO4  1.076 g R4l1000mL (u\ϑHCl0NaOHpH7.0 4!OX[0 hQnmyS؏SWGSH 15.4mg RS.l~Qm50mL ~Sm^:N 1mmol/L 4N(uMRM6R0 1.3.7.1.3 [ek 1.3.7.1.3.1 7hT6RY n@m NnmS0.1mLbQhQ@RS4l0.9mL19n@m EQRmS vN:Nbk0Sn@m0.5mLR4%xW4lhgx0.5mLmS [)n N3500rpmy_10R S NnmY(u0 @n NnmS0.1mL@nR4%xW4lhgx0.1mLmS [)n N3500rpmy_10R S NnmY(u0 ~~ NnmS~~0.5gRutv4l4.5mLEQRxxb~Fm10%SFm mSTSFmm0.5mLR4%xW4lhgx0.5mLmS [)n N3500rpmy_10R S NnmY(u0 1.3.7.1.3.2 7hTKm[ n@mb~~7hTKm[ Km[{zz}v{ Nnm0.5mL 4%xW4lhgx 0.5mLDTNB4.5mL4.5mLmS [)n>en10 RT 420nmYKm[8TIQ^0 @n7hTKm[ Km[{zz}v{ Nnm0.1mL 4%xW4lhgx 0.1mLDTNB0.9mL0.9mLmS [)n>en10 RT 420nmYKm[8TIQ^0 lchhKm e7hTSPgTS_)Y[b0(uS)2lKm[@nbn@m 0~~SFmˆ}v(+Tϑ0Y(uՋBRv S cՋBRvvd\OBlۏL0 1.3.7.1.3.3 hQf~ S1mmol/L GSHhQnm0010020050010001500200L R+RReQutv4l0.5mL sS_0R00200400100020003000400mol/LvGSHhQm|R T{ReQDTNB4.5mL mS [)n>en10RT zz}v{ 420nmYKm[8TIQ^0NSm^:N*jPWh 8TIQ^:N~PWh ZPhQf~0 12345671mmol/L GSHmL 00.010.020.050.100.150.20utv4lmL 0.500.490.480.450.400.350.30DTNBmL 4.504.504.504.504.504.504.50GSHϑ(mol/L 020401002003004001.3.7.1.3.4 { 7hTGSH+Tϑ = [^f~Sm^fW'`Ff0_0000@mu` eg goS _?aSՋOMTvN0 2.2 cdSՋhQ 2.2.1Y ZbTsNgYsY [OePߘTǏOe0 2.2.2Tv^ g_00T @|~I{%N͑uu`0 2.2.3wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.2.4 N&{T~eQhQ *g cĉ[ߘ(uSՋ7hT el$R[RHebDe NhQq_TRHeb[hQ'`$Re0 2.3 SՋR~ [SՋ cMDA0SOD0GSH-Px4ls^:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^0'`+R0u;mnߘ`N`I{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.4 Ջel Ǒ(uꁫT~$Ny[gq0Ջ~ ccP g(uel0 g(uϑke g(uSՋNT [gq~S g(u[paBRbǑ(u4'`[gq0SՋ7hT~Ne3*Ng _eS^6*Ng0Ջg[gq~TՋߘ~Su;m0nߘ NS0 2.5 ‰[ch Tych(WՋ_YS~_geThKm1!k0 2.5.1 [hQ'`ch 2.5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{ 2.5.1.2 @0?\0O8^ĉhg 2.5.1.3 0Rhg 2.5.1.4 Gr0_5uV0yBhg 2.5.2RHech 2.5.2.1 Ǐ'lS(+Tϑ ‰[ՋMRTMDAvSSSMDA NM~vRs0Km[el1.3.4.1 ՋMRMDA  ՋTMDA MDA NM~vRs= (100% ՋMRMDA ‰[ՋMRT8-IsoprostanevSSS8-Isoprostane NM~vRs0Km[el2.8 ՋMR8-Isoprostane  ՋT8-Isoprostane 8-Isoprostane NM~vRs= (100% ՋMR8-Isoprostane 2.5.2.2 'lSirgkSv ‰[ՋMRTSODvSSSSODGSؚ~vRs0Km[el1.3.6.1 ՋTSOD  ՋMRSOD SODGSؚ~vRs= (100% ՋMRSOD 2.5.2.3 7uǏ'lSirv ‰[ՋMRTGSH-PxvSSSGSH-PxGSؚ~vRs0Km[el2.7 ՋTGSH-Px  ՋMRGSH-Px GSH-PxGSؚ~vRs= 100% ՋMRGSH-Px 2.6pencYtT~g$R[ Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0(WՋMR~k]_e>fW'`vMRc N SۏLՋT~k0 TRHe‰[chՋMRTꁫkTՋߘT~kGW g~f[aIN eS$R[ch3'`0 Ǐ'lS(+Tϑ0'lSirgkSv07uǏ'lSirv Ny[-NNNy[~g3'` S$R[SՋ7hTwQ g gRNb'lSR\O(u 2.7 @-N7uǏ'lSirvGSH-Px ;mRKm[ 2.7.1 St 7uǏ'lSirvGSH-Px /fSOQX[(WvNy+TRxnd1uWTb6R1uWS^v|~0[2bkSOQ1uW_w(Ǐ'lSyr+R͑ vQ;mRNPSGSH'lSvS^^ SUSMOeQGSHQ\vϑegh:y GSHT5 5 -Nkx[]xW2uxDTNB S^(WGSH-PxPS NSubĞrv5-kxN2-]xW2ux4yP[ N423nml gg'Y8T6e\ Km[勻yP[Sm^ sSS{QGSHQ\vϑ 1uNGSHۏL^vS^'lS @bNgT{v;mRe _{cbd^vS^@b_wvGSHQ\0 2.7.2 ՋBRTNhV NhVSIQRIQIQ^0vhN0R`)n4ltm0_ϑR7hhV0y_:g ՋBRS.lxxQm pH7.0 NaN316.25mg~Sm^2.5mmol/LEDTA-Na27.44mg~Sm^0.2mmol/LNa2HPO41.732g~Sm^0.2mol/LNaH2PO41.076g~Sm^0.2mol/LR4l100mL (u\ϑHCL0NaOHpH7.0 4!OX[0 1mmol/L7u؏SWGSH nm GSH 30.7mgRS.lxxQm100mL 4N(uMRM6R QQOX[1 2e0 1.25 1.5mmol/L H2O2nm S30%H2O2 0.15 0.17mL (uS4lzʑ100mL \O:N.Ym 4!IQOX[ 4N(uMR\.Ym(uS4lzʑ10 PsSS0 OPxxlmm HPO316.7gHQ(u4ln EDTA0.5gNaCl280gR4l1000mL (unfn~Ǐn [)nOX[0 0.32mol/L Na2HPO4nm: Na2HPO4 22.7gR4l500mL [)nOX[0 DTNB>frm DTNB40mggjx N1.0gR4l100mL 4!IQOX[1*Ng0 2.7.3 [ek 2.7.3.1 7hT6RY n@mS@20LReQ0R1mL S4l-N EQR/cGd OKNhQ萶n@1:100_Km 4\eQKm[v;mR0S_)Yeg NSKm[ \ }bQhQ@n-20!QX[ 3)YQKm[ 4!X[>e 28\eQ_{Km[0KmMRSQ7hT[)n6q㉻Q0 2.7.3.2 GSHhQf~v6R\O S1.0mmol/L GSHnm000.200.400.600.801.0mL R+RnN10mL\[hVt-N TReQOPxxlmBR8mL (uS4lzʑ10mL;R^ sS_0RSm^:N00200400600800100mol/Lv GSHhQm0 S N N TSm^hQmT2mL >eeQՋ{-N ReQ0.32mol/L Na2HPO4 2.5mL krMRReQDTNB>frm0.5mL(uIQ_1cmog 5minQ(WSIQ423nmlKmOD

frm0.50.5>frS^1minTN423nml1cmIQ_ OD

fr NNNte*NS^SO|-N"lyP[Sm^ gsQ ؏SS^eP6R0ReQ>frBRT S^SO|pH:N6.5e 11min_Y>fr dkekr5minQpeQnx0 2.8 @n-N8-h"l'l-_MRRz }8-Isoprostane Km[ 2.8.1St 8-h"l'l-_MRRz }8-Isoprostane /fSOQ('lS^oS^3z[ wQ gyr_'`vh_ir vQ+TϑcS^V:gSOQ1uWvNu [~~~ހv(Ǐ'lS z^0 2.8.2NhVNՋBR NhVvhN0uSW{Q{0_ϑ/cahV0_ϑR7hhV0mg:g ՋBR8-Isoprostane KIA Kit (vTMQuՋBRv) 8-Isoprostane EIA bSO@n08-Isoprostane AChE:y*ir08-Isoprostane EIAhQT0EIAQm0mmQm0T)n200 b-TQIgGbSO0EIA:y*grBR0EIAbSO@ngrBR0Ellman sՋBR 2.8.3[ek 2.8.3.17hT6RY Y S@ 3000r/miny_10min0S Nnm (uEIA Qmzʑ15 PY(u0 2.8.3.27hTKm[ cՋBRvfd\O0 8-h"l'l_MRRz }hQT[Sm^R+R:N500 pg/mL0200 pg/mL080 pg/mL032 pg/mL012.8 pg/mL05.1 pg/mL02.0 pg/mL00.8pg/mL ekՋBRzz}vTANSBB0hQ/7hT1.RՋBREIA Qm--100L50L-hQ/7hT----50LAChE:y*ir--50L50L50LbSO@n---50L50L2.W{Q(u\gv}Yvhg v^(W4!IQagN NW{Q18\e3.nmnm@b gS^T[N!k4.RՋBRAChE:y*ir-5L---Ellman s200L200L200L200L200L5.W{Q(u\gv}Yvhg v^(W8^)nIQagN NW{Q45 90R6.pe(Wl412nmYKmϑTT[8TIQ^B0(W 0.3 1.0 A.UV  hQb7hTT[8TIQ^  NSBT[8TIQ^ %B/B0=                   100 B0T[8TIQ^  NSBT[8TIQ^ NhQirvSm^v[pelog :N*jPWh %B/B0:N~PWh~6RhQf~ NS\penclbcblogit(B/B0)bln[B/B0/(1 B/B0)]ZP:N~PWh~6RhQf~ {VR_e z0\7hTv%B/B0

eeQS^{QS N0S N ^sX3min 6qT\Rir>enS^{Qvܔh N zsSN36v vNAm5u0RirS0R5uQ vQck8^S^/fVs^S~SO N$O['`:Ro0YpeRirSQ!kbY!kܔh N S0R5uQSŏVs^S N0~N!kT \Rir>e(WS^{Qvs^S N U_5min QT Ns^Sv!kpeT,{N!k Ns^Sv\oOg Ndk\O:Nf[`Nb~024b48h TۏL͑Km \\ >e(Ws^S N U_T ,{N!k Ns^Sv\oOg0T 3min Q5uQ!kpeTS5uQvRirpe;`pe Te{QsS^vRirv~vRsS5uQvRirpe`S~Rir;`pev~vRs 0\Pbk~5)YTSb,{5)Y SN(W N TveۏLN!kbY!k_m[el T͑Km 0 1.1.3.3.2 SՋ7hT[_x!jW\ vq_T 1.1.3.3.2.1 !j __x!jW6R ~MR10min yTl\jgxbNꃱx5mg/kg BW _]Vx!jW6R ~MR10min yTl\s]pN120mg/kg BW _Qsx!jW6R ͑KmMR30min LpÀ30%vYN10mL/kg BW0 1.1.3.3.2.2 _KmՋvd\Oel T1.1.3.3.10 1.1.4 pencYtS~g$R[ \oOg~g:NϑDe S(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Ff^ !kpeb Ns^SvRirpef>f\N[gq~ ]_ g>fW'` N N Nych-N NNych3'` GWS$R[y[3'`0 1.1.5 laNy 1.1.5.1 Rir(W24h Q gvQ;mRhTg N TevYN N Tvɉ4ls^ Eek!k[^ b TNev NHS8 12pb NHS1 4p 0 1.1.5.2 [^(W IQ:_^T)n0n^[NOcNvL:N[[ۏL0 1.1.5.3 cPO(u~|Rir [MRpe)Y\Riry[[N^hTVsX0 1.1.5.4 [_{k)YNRirc YU4l0UߘTbxdRir0 1.1.5.5 Q\^yr_'`r^pb Y`~0la0R:g0ɉ0ЏR;mR4ls^0^oTQRlI{V }0 1.1.5.6 QRiry^\]_0 1.2 fl 1.2.1 St )R(u\ Ufv`N'`N*Nňn NJS/ff[ NJS/ff[ -N gN\mvޏ0f[^ g5uvܔh v^NNehVvޏ ehVSꁨRU_\oOgve0\ ۏeQf[sSS0R5uQ eꁨR\Pbk0 1.2.2 NhVTՋBR fNňnRff$N[0f['Y\:N12cm4.5cm vQ Ne~20cm Y`N40w opN0f['Y 'Y\:N17cm4.5cm $N[KN gNv_~3cm vWm0$N[^GWNܔh0f[^-NMOnvܔhSN5u 5uQ:_^S(WNe NNa b0N,Ǒ(u40v 5uS0f[NNehVvޏ ehVSꁨRU_\oOgve0 ՋBRjgx0Nꃱx0s]pN0YN0 1.2.3 [el 1.2.3.1 [Rir T1.1.3.1 1.2.3.2 BRϑTR~ T1.1.3.2 1.2.3.3 [elSek 1.2.3.3.1 SՋ7hT[ck8^\ _vq_T +g!k~7hT!kebN!k~7hT1h _Y~0[e\\ b̀TmS>eeQf[ Te/TRehV0RirzǏmSۏeQf[S0R5uQ ehVꁨR\Pbk SQ\ U_k N>eeQf[ۏeQf[m5uQ@bve dksS\oOg ~5min v^U_5minQ5uQ!kpe024hb48hT͑\OKm U_kSRirۏeQf[v\oOgT5min Qv5uQ!kpe v^{5min QۏeQf[S^ vRir~vRs0\Pbk~5)YTSN(W N TveۏLN!kbY!k_m[0 1.2.3.3.2 SՋ7hT[_x!jW\ vq_T: 1.2.3.3.2.1 !jW6R el T1.1.3.3.2.1 1.2.3.3.2.2 d\Oel T1.2.3.3.1 1.2.4 pencYtS~g$R[ \oOge:NϑDe S(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfN[gq~ 5minQۏeQf[v!kpeb5min QۏeQf[vRirpe\N[gq~ N]_ g>fW'` N N Nych-NNNych3'` GWS$R[y[3'`0 1.2.5 laNy T1.1.5 1.3 zh{[STV[ 1.3.1 StagNS\ 1.3.2 NhVNՋBR NhV'Y zh{0ňn1u[{TꁨRU_SbpSňn~b0[{'Y\:N50cm16cm18cm0{^eeQ{QNUONO 20s T_YHTsopIQb# c~20s T10s Q Te~N5u:Ro100V 0.2mA 50Hz AC 0'Y (Wm5uQTsS _{э0R[Ovz !cOOIQ5u{TMbS-Ne5uQ dk:NRVS^ (Wk!k5uQMR~NagN:Ro S Y:_ST 'Y (WcSagN:RoTsST[Ov^!cOOIQ5u{ 5uQ dk:N;NRVS^ k)Y~NV kV50!k ޏ~~4 5VT Rirv;NRVS^sS80 90%N N09hncSbpS~gRgY NchRirS^!kpe Rir;NRVe RirRVe Rir;NRVs0\Pbk~5 50)YQ R2 3!kKm[vQ_m`Q0 1.3.3.3.2 SՋ7hT[_x!jW'Y agNS\^zvq_T 1.3.3.3.2.1 !jW6R  T1.1.3.3.2.1 1.3.3.3.2.2 d\Oel T1.3.3.3.10 1.3.4 pencYtS~g$R[ Rir;NRVeTRVe:NϑDe S(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfwN[gq~ ]_ g>fW'` S$R[:Nch3'`0 1.3.5 laNy T1.1.50 1.4 4l[[ 1.4.1 St Rir gNy c"} T ff >PT S_y_N*Ne ;`/fэT EN *gэǏv e 0\ N?a(W4l-N V [~b,rQ4lbv6h ~T \ OO~b0R6hv~0 1.4.2 NhVNՋBR 4l[ꁨRU_N0NhV/f1u[8nl{TꁨRU_N$NR~b0[8nl{1uZYNpQXe6Rb 100cm0[100cm0ؚ30cmQ_90cm0[90cm0ؚ30cm lS[12cm lSpTV[0DV0 1.4.3 [el 1.4.3.1 [Rir cPO(uяN|\ esN bbt^ USN'`+R ̖ĖGWS0 1.4.3.2 BRϑn0~7h_TgP GW T1.1.3.20 1.4.3.3 [el 1.4.3.3.1 SՋ7hT[ck8^\ _vq_T  ޏ~~7h30)Y +g!k~7h!ke_Y~0~g~~~7h k)YN!k0[lS4lm9cm 4l)n~20!n"15! 0\\ ~eP[:N2min (W2minQ*g0R~pv\ GW:N2min0 ,{N!k~MR\\ >e(WhP[Dя OvQꁨR,r N3!k0NTk!k~MR\\ >e(WhP[Dя ̀g|ih OvQꁨR,r N1!k0[R6kۏL ƉRirf[`Nb~ekR z0,{N!k~e(uN!cg(WAYch{k NAY_Y~ U_NAp0R~pve0,{N!k~R z NBY_Y dk z~~3!k Rirpe80%N N(W2minQ0R~pTQ^ z R+RU_T k!kNBp0R~p@bveTSuv!kpeۏeQNUON*NvzN!kGW{N!k 0+g!kKmՋNwpۏL \\ >e(Wwp U_Nwp0R~p@bveTSuv!kpe0k!k~e [2minQ*g0R~pv\ ^_[vQ0R~p N~pv|ih Neg 0R~vvv0k!k~bKmeGW\4YgwYp0gT{T~Rir5!k~TKmՋv;`!kpe 0R~pv;`eS2minQ0R~pv;`Rirpe~vRs \Pbk~5)YTS(W N TveNwpۏLm[0 1.4.3.3.2 SՋ7hT[_x!jW\ vq_T 1.4.3.3.2.1 !jW6R el: T1.1.3.3.2.1 1.4.3.3.2.2 d\Oel: T1.4.3.3.10 1.4.4 pencYtS~g$R[ 0R~pve^\ϑDe S(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Ff\N[gq~ b2minQ0R~pvRirpef>fYN[gq~ N~~f[h]_ g>fW'`0vQ-NNNych:N3'` S$R:Ny[3'`0 1.4.5 laNy 1.4.5.1 ~e(Wvh:S~p \PYuve N*Yw &TR1YS:_SHeg0 1.4.5.2 k)Y~~_gT [[{ۏLnm NndRirYu NvlsT0 1.4.5.3 [MRS[RirۏLR[{ ~~T 2minQN N8n~pmpl0 1.4.5.4 vQYO T1.1.50 _KmՋchNȉh Km Ջ y v ċ N c h @b(uNhV R S[ RVe0!kpeTRir SN V QsS^~vRs  f[ T N fN ;N R USTV[ h@bv~!kpe zh{ V  STV[ VeTVs zh{ 4l[[ 0R[hQSveTh [ @bv~!kpe 0RirQ Ջ sS^vRir~vRs 4l[ 1.5 ~g$R[ S[0f[0zh{[04l[[Vy[-NNNy[~g3'`0N͑ Y[~gN@b͑ Yv TNy[$N!k~gGW:N3'` SN$R[SՋ7hTR9eU_RRir[~g3'`0 2 NSOՋߘՋ 2.1 9eU_vOePߘTNSOՋߘՋvN,SR 2.1.1 SՋ^,g@wɉ?avSR0 2.1.2 ^NOSՋveP^:NMRc0 2.1.3;NՋ_{~ǏN蕄vW S_~NfNTeSۏLyՋ0 2.2 bSՋvSR 2.2.1 NkƖ-N0Tebq_TV }'Yv TvSO-Nc SՋ kYf[!h0bvQ[SO0 2.2.2 eS z^W,gN0 2.2.3 ^\ TNt^~ Y N(W TNt^~ R^[ϑhRۏL!hck0 2.2.4 *gcSǏ{|fW'` Vdk NNN g7hMRTꁫkv~g N~ _{ns^L[gq0 2.3.3 Sv[gq~_{ g(u[paBR N+T gHebR FOvQBRW0rl0Y‰0Sa0SňI{GWNSՋ7hTv T Nmd_tf:yvq_T;NՋ(WeKme NwS g7hT  g[paBR Nmd;NՋ;N‰OPTvq_T OKmՋ~g[‰S`0 2.3.4 TNSՋMRT$N!kKmՋ1u TN;NՋۏL0 2.3.5 eKmz^N,/fHQ,TɉKmTƉɉKm0wQSOKmz^/f1 cT_ 2 T`f[`N 3 eaINVb_Q 4 Va1uV_ 5 NPyrpT|V_0 2.3.6 R~el g7hMR[SՋۏL,{N!k_FUKmՋT 6qT c_FU:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }YeS4ls^0t^I{ ۏLGWa'`h NO~Sk'`0k~SՋ N\N50O0 2.3.7 SՋ7hTvBRϑTO(uelՋߘ~ c7hTvcPBRϑTel g(uSՋ7hT [gq~ g(u[paBR0SՋ7hT~Ne30)Y _eS^45)Y0 2.4 ‰[ch 2.4.1 [hQ'`ch 2.4.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0_sI{?QzSBlۏL_,Tʋ0>ʋI{N,SO\]0eY>e k~͋hQ>e[kT BlSՋzsSV_ QBl_vN{|͋ NN[ c>evz^V_ 0;NՋ cSՋV_vz^ \@bQvQ[(WU_~ N cz^(upeW[(Wv^͋ Nbveev͋Q[y:N mR'` RQ(WU_~ N~͋Tbzze,{N~͋ el TMR0(W,{N~͋V_[kT SՋ dNBl`vRirbz4b ُ{|͋NY `؏_+Rv͋T ُ1\/f ^cT_ ~g SU_(WhQmBg͋ Nbve\] ; ;P[ YNWYcT_͋HTsz^:N 1. \S P[ 'Y ܃ Ğt ss| ~gh AbF Qt h ;zP[ i w hgh }v܃ Ch h ܃ ~g ʃ ܃ gh F܃ 2. V] t Yr وP[ KbWY w{P[ gQ w c  jRR 'Yc 5uop P[ kpg ~:g v 7RP[ lk Abb k kb^ I=^ 2.6.2 T`f[`NkWY g12[1u2*N͋~bb[v͋ vQ-N[fvb[T`͋ g;T| NVvb[T`͋e;T| b[͋T6[ [fT`SbSIN͋YV--[f 0 T{|͋Y*Y3--gN TN^\͋YrrS--[rl T$N[VT`SbwQSO--wQSOYt--c g 0ba--wQSOYRbe--5uop Tba--baYIQf-- gN b[͋T$N[0(uNhg[ N Tb[͋v_`Q0Nk[͋3sv^Q $N[͋KN2s 12[͋:gcR (ud>eY>e qQ>e NM sSSՋ g N!kf[`N:gO FOkM͋>evz^ N T0k>eNMT ;NՋ_k[͋vMRbN*N͋sS:Ro͋ BlSՋT{QTbN*N͋egsSS^͋ ;NՋ\~gU_(Wv^eT [[fv͋kT{[N*N0.5R 6[qQ3RVv͋kT{[N*N1R 6[qQ6R 6[[fT6[V͋KNT:N9R NMvnR:N27R0 2.6.3 Va1uV_Sb2~;u girSOvVGrPge k~15 _ @b;uvirSO/fNN8^v0q`vTfNvN Ye(uT0N]wQI{0k _VGrHTs4s0VGr2s VGrz^:gcR015 _VGrHTs[kT BlSՋzsSV_Q@b_vVGrQ[ NN[ c:RoHTsvz^V_ 0;NՋ cSՋV_vz^ \@b_vVGr(WU_~ N cz^(upeW[(Wv^VGr Ty Nve50% vDe^(uyTh0 ~g$R[(WՋMR$N~_FUGWavMRc N ՋߘTՋߘ~v_FUؚN[gq~ N]_ g>fW'` TeՋߘ~ՋTv_FUؚNvQՋMRv_FU N]_ g>fW'` SN$R[SՋ7hTwQ gR9eU_Rv\O(u0 2.8 laNy 2.8.1 _tKm_{1uSǏ~vNXTۏL &TRq_TՋ~g0 2.8.2 KmՋ^S_(WN*N[Yv?bQۏL0dSՋT;NՋY =\ϑMQ gvQ[N(W:W0 2.8.3 ,gϑhQ g NyTƉɉ gsQvRKm [QIQ~_{O w_nZi:RoVGr0=\ϑcdV,TRbƉR NsO q_T_b~0 2.8.4 _{laSՋSKmev|^yr` Km(WSՋ`~ck8^0 NS[cSKmՋ0laRkƖ-Nv`Q NۏL0SՋ/f&Tu&P laR/f&TƖ-N /f&TMT0[KmՋ/f&T'} _ /f&T gO_I{GWU_(WU_~vu N0 2.8.5 TNSՋvKmՋBlN!kZP[0(W(ut^ϑhRkRKmb~e _{la N TRKm/f&T(Wv Tv|^yr` NۏLv0 2.8.6 kXQU__{w W[nZi0kXQelaN NQp 2.8.6.1 u_{ykXQ sSSՋvY T0'`+RTt^ NShgegTe0 2.8.6.2 kXQeS z^TLN\O:NNSՋcSKmv̀ofPge0 2.8.6.3 kXQeP^rQbʋe MRNYaw w`QbS_eu&PN&T0 2.8.6.4 [hfS_e|^yrQvTy YMT z^0laR0'} _r`0O_I{_NkXQnZi0 2.8.6.5 dU_SՋ_VT{vckY ^S_ NVT{vwQSOQ[ NYRgxvz(u0 2.8.6.6 /f&T^(u_elNSO(uNHNel[_xvz/f gvv0(W(udkϑhۏLxvze^S_U_dky0 2.8.6.7 TyRKmb~vSYReQu;`~h-N HQ~ Yg YgeeSkXeQSYRyQ0 V0ƉɉuRRhel 1SՋ~eQhQ 1.1 18\ 65\vbN0 1.2 g(u3!k)Y 6.3 ƉR9eUs :NSch0NՋߘTՋߘMRcؚ$NL:N9eU ~$N~ g(uSՋirTvƉR9eUs\O:NSch0Sch N\O:N[ƉuRR/f&T gHev$R[hQ0 6.4 fƉcEN^ Ջߘ~ꁫkbՋߘ~N[gq~~k fƉcEN^]_ g>fW'`P<0.05 Ns^GWfƉcEN^cؚ'YNI{N10%:N gHe0 7 pencYtT~Rg ϑDeS(uthۏLRg0ꁫ[gqǑ(uM[th $N~GWpekǑ(ub~th0[^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyTh0(WՋߘMR~k]_e>fW'`vMRc N SۏLՋT~k0 peDeS(u(2h0VfW'`P<0.05 0 8.2 Ջߘ~ꁫkbՋߘ~N[gq~~k fƉcEN^]_ g>fW'`P<0.05 Ns^GWfƉcEN^cؚ'YNI{N10%0 wQY8.1S8.2NƉR9eUs Nf>fMNO S$R[SՋirwQ gƉɉuRRv\O(u0 DU_fƉcEN^Km[el fƉcEN^Km[ dkl/f(uNċNƉuRvNyel0S_N'Yv(tQKY'`MNOe ƉɉRgR NM fW'`FfW'` ۏNekO(uY*N[~TN*N[gq~GWpev$N$NkelۏL~Rg0[^ck`R^be] NPvpencۏLS_vSϑlbc _nck`R^be]PvBlT (ulbcTvpencۏL~Rg~SϑlbcN N0Rck`R^be]Pvvv R9e(uyThۏL~Rg0 ~g$R[[~Nzz}v[gq~k Qϑf>f NM ~~Yt]_ g>fW'` S$R[SՋ7hT'Y ht ieQ[~g3'`0 1.1.7 laNy 1.1.7.1 @b(uht͑ϑShby[[~gq_T'Y Ee(W[-N ^=\SO@b(uht͑ϑThbyяfW'`FfW'` ۏNekO(uY*N[~TN*N[gq~GWpev$N$NkelۏL~Rg0[^ck`R^be] NPvpencۏLS_vSϑlbc _nck`R^be]PvBlT (ulbcTvpencۏL~Rg~SϑlbcN N0Rck`R^be]Pvvv R9e(uyThۏL~Rg0 ~g$R[[~Nzz}v[gq~k NNep:RoMRT[ysf>fQ\ ]_ g>fW'` S$R[SՋ7hT'Y [~g3'`0 1.2.7 laNy 1.2.7.1 pBRleQv(ϑ[[~gq_T_'Y leQpBRe ^\RirTbv NSTc_TsQeTv Nl\pBR v^^=\SORir NR0^1uNN#pBRvl\ NO[~gvN'`0 1.2.7.2 Kmϑ[ye %NeeQKmϑR{Q S_4ls^bN NvKmϑh~͑Se R_sQ U_[y (u8T4l~dr^ Nv4lT R+RQۏL,{2!kT,{3!kKm[0:NMQKmϑ] Km[NXT^NHQۏL~ cc\ >eeQKmϑR{QvgsOe_ k*N7hTvKmϑg}Y1uNNۏL0 1.2.7.3 k!kKm[vMOV[0 1.3 \ 3[ 1.3.1 [St N2u:NeronmSO mbN\ 3^T 1uNvQ:Ro\O(u S_w 3@\k~@{EQ@ '`XR [%`'`pu0k[~T[gq~N2u\O(uT3sv]_ Nnx[SՋ7hT/f&TwQ gr^%`'`pu\ 3 v\O(u0 1.3.2 NhVTPge v_9mmSbT[hV0pBRN2u 0_ϑR7hhV0Rg)Ys^ 1.3.3 [Rir cPO(uяN|Ė'`\ SO͑18 22KQ k~10 15S0 1.3.4BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*Nzz}v[gq~ N*NBRϑ~-N^SbN*NNSOcPϑ10 PvBRϑ~ _e3'`[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 1.3.5 [ek rlSN2u20L nR(W\ S3YOb3^v-N.Y vQ1uibce 30RT \\ 1iY{k jR NS3 (u9mmv_SbT[hV(W$N3v TMOSb N3Grv^y͑ N$N3͑ϑKN]:N3^

fW'`FfW'` ۏNekO(uY*N[~TN*N[gq~GWpev$N$NkelۏL~Rg0[^ck`R^be] NPvpencۏLS_vSϑlbc _nck`R^be]PvBlT (ulbcTvpencۏL~Rg~SϑlbcN N0Rck`R^be]Pvvv R9e(uyThۏL~Rg0 ~g$R[[~Nzz}v[gq~k 3^sf>fQ\ ]_ g>fW'` S$R[SՋ7hT\ 3[~g3'`0 1.3.7 laNy 1.3.7.1 N2uwQ g[f9eS 2.6 pencYtT~g$R[ yRSSS(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50 vDe^(uyTh0 9eUs:NpeDe S(u(2h VfMNO Nur0SO_9eUs[gq~ gf>fXR ]_ g>fW'` S$R[SՋ7hTwQ gnTmUR0 2.7 laNy VTurhg&^ g'Yv;N‰'` ^1uNN#@b gSՋՋߘMRTvhg =\SO$RehQvN'`0 mQ0 gRN9eUaw wRhel 1 [Rir cP(ubt^\ USN'`+R 18 22KQ k~10 15S0 2 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 3 [el 3.1 vcaw w[ 3.1.1 d\Oek:‰[SՋ~Rir~N3*NBRϑvSՋ7hT [gq~~N TSOynBRT /f&TQsaw wsa0aw wNckS\m1Y:Nch0S_\ nǸgSMOe zsSckMO0YǏ30-60y Nck sS:NckS\m1Y ۏeQaw w0ckS\b` YsS:NRirɉ ckS\m1Yb` Yُke:NRiraw we U_4'`[gq~NSՋ7hT~eQawRirpeSaw we0 3.1.2 pencYtS~g$R[ aw we:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` R[~g3'`0 3.2 ^ b]kYaw we[ 3.2.1 St (W b]kYP wvW@x N ‰[SՋir/f&T^aw we aw we^ RfSՋirN b]kY gOS T\O(u0 3.2.2 ՋBR b]kY(uMReM6R 3.2.3 d\Oek ZPck_[MRHQۏL[ nx[ORir100%eQaw FOS NOaw weǏv b]kYBRϑ30-60mg/kg BW (udkBRϑck_[0 Rir+g!k~NnBRS N TBRϑSՋ7hTT Qs\\O(uMR10-15R ~T~RiryTl\ b]kY l\ϑ:N0.2mL/20g NckS\m1Y:Nch ‰[SՋ7hT&T^ b]kYaw we0 3.2.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` R[~g3'`0 3.3 b]kYb]kY  NBRϑP w[ 3.3.1 St ‰[SՋirN b]kYb]kY vOS T\O(u01uN b]kYǏvN" [v gb6R\O(uvoir _N^ b]kYaw we @bN:Ncdُyq_T ^ۏL NBRϑ[0 3.3.2 ՋBR b]kYb]kY (uMReM6R0 3.3.3 d\Oek ck_[MRHQۏL[ nx[ b]kYb]kY  NP wBRϑ b]kY16-30mg/kg BWb]kY100-150mg/kg BW sS80-90%\ ckS\ Nm1Yv b]kYg'Y NBRϑ0Rir+g!k~NnBRS N TSm^SՋ7hTT Qs\\O(uMR10-15R T~RiryTl\ b]kYg'Y NP wBRϑ U_30RQeQawRirpeckS\m1YRN N 0[[(W24-25![YsX NۏL0 3.3.4 pencYtT~g$R[ eQawRirpe:NpeDe(u(2h VfW'` R[~g3'`0 3.4 ]kYaw w\oOg[ 3.4.1 St (W]kYP wvW@x N ‰[SՋir/f&T)weQaw\oOg aw w\oOg)w RfSՋirN]kY gOS T\O(u0 3.4.2 ՋBR ]kY(uMReM6R 3.4.3 d\Oek ZPck_[MRHQۏL[ nx[ORir100%eQaw FOS NOaw weǏv]kYvBRϑ200-300mg/kg BW (udkBRϑck_[0 Rir+g!k~NnBRS N TSm^SՋ7hT10-20RT ~T~RiryTl\]kY l\ϑ:N0.2mL/20g NckS\m1Y:Nch ‰[SՋ7hT[]kYaw w\oOgvq_T0 3.4.4 pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` R[~g3'`0 4 ~g$R[ ^ b]kYaw we[0 b]kYb]kY  NBRϑP w[0]kYaw w\oOg[ Ny[-NNy3'` Nef>fvcaw w\O(u S$R[SՋ7hTwQ g gRN9eUaw wR\O(u0 5 laNy 5.1 [[sX_{[Y0R`)n0R`n NnxOagNvR`[0 5.2 1uNRirꁫV gvuirf[yr_T`N'` [SՋ7hTvS^X[(W@wy^\0'`+R0t^I{ebv]_0N,eg {|;mR(WYk}v)Y;mÍ ̖'`kĖ'`ff>f t^'YvRir-Ng^y~S^ NOea0ُ{|[^=\ϑ[c(WY TNeۏL [)n24 25!:N[0 5.3 [e^ORir(WKm[[^peRTQۏLck_KmՋ [~N[gq~NSۏLKmՋ0 N0SORuRRhel Rir[ 1 ͑8nl[ 1.1 hSt ЏRRvcؚ/fbuRRR:_gvcvhs 8nlevwSNS^RirЏRuRv z^0 1.2 NhVNhVPg 8nl{'Y\~50cm50cm40cm 5uP[)Ys^0Ŕv0 1.3 [el 1.3.1 [Rir cPO(u~|\ bt^\ SO͑18 22g0 1.3.2 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 1.3.3 [ek +g!k~NSՋ7hT30minTR{|7hTKmՋS_)YSN NLpÀ \>\9hw5%SO͑Ŕvv\ nN8nl{-N8nl04lm N\N30cm 4l)n25!1.0! U_\ 8nl_Y{kNve sS\ ͑8nle0 1.4 pencYtS~g$R[ 8nle:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfN[gq~ N]_ g>fW'` S$R[勞[~g3'`0 1.5 laNy 1.5.1 kN8nl{N!k>eeQv\ N[*YY &TRNv$c` q_T[~g0 1.5.2 4l)n[\ v8nle gf>fvq_T VdkBlT~4l)nc6RN kNyb\ N4lKNMR^Kmϑ4l)n 4l)nN25!:N[ YgǏNOS_w\ uc q_T[~g Ǐؚ30! R8nle*Y NONd\O0 1.5.3 Ŕv ~~g'}^[0 1.5.4 ‰[^(Wte*N[Ǐ z-NOkS\ VOcЏR0Yg\ onm(W4lbV NR S(u(gh(WvQDяdR0 1.5.5 N Tybv\ Vr{QsX0c[I{SVvSSSO( NOQs]_0VdkSՋ7hT~T[gq~^Ǒ(u TNybRir TeۏL[0 2 @n?\ }Km[ hQꁨRuSNKm[TNYNp lN Ny0 2.1 hQꁨRuSNKm[ c gsQNhVffNTՋBRvd\O0 2.2 NYNp l 2.2.1 St 7hT-N?\ }(W/lSؚ xxnm-NNNYNp Tkx(l2qQnq b_bNy~rvSTirDiazine vQrvmEmN?\ }+Tϑbckk0N T7hYtv?\ }hQ{k SBlQ?\ }v+Tϑ0 2.2.2 NhVTՋBR 2.2.2.1 721RIQIQ^ 10mL &^^XՋ{ 1mLb1.5mL QXey_{ 5up  LpÀ4Y0 2.2.2.2 ?\ }ՋBRvNYNp l NYNp ^(um0/lS xx^(um0?\ }hQm200 mg/L 0 2.2.2.3 eՋBRv SLM6RՋBR0ՋBRM6RelY N 1g/L NYNp nmSNYNp 1.0g (lWkx2thiosemicarbazide 0.2g /lS4.5g nN4lv^R1000mL0 33g/L N/lSnmS N/lS1.0gnNSmxx20mL -N R4l10mL GdS0 xnmS4l800mL babaReQSmkxx50mL RGdQReQ85%xx50mL GdS0ReQ33g/L N/lSnm1.5mL R4l1L0 10 mmol/L ?\ }hQm?\ }28.01mg/dL |nxyS?\ }AR 150.3mg nN16 mmol/L 2uxnmv^R250mL0 16 mmol/L 2uxmS2ux2.0g nN4l1000mL -N RSmkxx0.8mL0 2.2.3 [el 2.2.3.1 [Rir bt^\ b'Y \ SO͑18-22g Wistar bSD'Y SO͑160-200g0cPO(uĖ'`\ 0 2.2.3.2 BRϑTR~ 'Y NNSOcPϑv5 P:NW,gBRϑ0vQYO T1.3.20 2.2.3.3 [ek 2.2.3.3.1 ؚ?\ }!jWv^zSh,g6RY+g!k~SՋ7hT30min T (W)n^:N30!v4l-N N͑8nl90min Oo`60minTǑ@0'Y Ǒ>\@ \ bfW'`FfW'` S$R[勞[~g3'`0 2.4 laNy 2.4.1 :NMQr^ly ^(Wh,gReQT30min QQ8TIQ^eeQ500mgn 10gkx2 S_GdRpogmS0QtSTX[>eNQ{-N SOX[$NhT0 3.3 [el 3.3.1 [Rir T2.2.3.1 3.3.2 BRϑTR~ 'Y BRϑNNSOcPߘ(uϑib'Y5 P\O:NW,gBRϑ vQYO T1.3.20 3.3.3 [ek +g!k~7hT30minY{kRir S~utv4lomT(un~8Tr^ |nxyS100mg ReQ8mL TCA k{SFm1min \SFmmPeQy_{ N3000r/min y_15min \ NnmlySNՋ{Q0 S1mL Nnm>eeQ10mLy_{-Nk7hTSZP$Ns^L{NO_S`~g k{ReQ95%vYN4mL EQRmS$NymSO NYu gLub0(ur^Q^XP[^X N [)n Nzz>enǏY_NS (u\Ջ{>e(W37-40!4ltm3h 0lm[hQT \Ջ{N3000r/min y_15min0\_Pc Nnmv^OՋ{Pz>en10min0 (u2mL4ln|S R4le\{Xv|Sm N0Y{^v|S NzsSn /ca{P[v0R[hQn0 6R\OՋBRzz}vThQ{ ՋBRzz}v8T2mL4l0Rr^Qy_{0 hQ{8T0.5mLa|hQm+T100mg/dLa| T1.5mL4l>eeQ T7hv{P[0 dke\10mLnՋBR(uRReQT{ mAmnՋBR vcۏeQ{P[-N.Y OEQRmT}Y0N{P[-NleQnՋBRew \{P[>e(WQ4l4Y NQQ0(W@b g{P[0RQ4l)n^T \vQxmNl4ltm4ltmm^euؚN{P[mb 15min 6qTy0RQ4ltm0\{QmSOyeQkr{ (W620nml N (uՋBRzz}v{TKm[8TIQ^09hnc@bySv͑ϑbc{b|S+TϑNmg/g h:y v^ۏL~Rg0 3.3.3.3 |S+Tϑ{ DU cSmSOy k100KQ~~-N|SvkKQpe%%%0.5%%%%%%%1000.9 DS ~~KQpe DU7hT{8TIQ^ DShQ{8TIQ^ 0.5:N0.5mLa|hQmm-Nva|+Tϑ0 0.9:N\a|bc{b|Sv|pe0 cSmSOy:N8mL ~~KQpe:N0.1g 3.4 pencYtS~g$R[ |Spenc:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfؚN[gq~ N]_ g>fW'` S$R[勞[~g3'`0 3.5 laNy 3.5.1 Km[v[elGW:N[ϑBl Vdk@b gS7hRՋBRGWQnx0 3.5.2 |SKm[-NQtS0RpeN'lS؏S\O(u gsQ Vdkec6RQnx0 3.5.3 n>frBR N3z[ N4N(ueM6R:N[ laMQǑ(u~^balgv|{|ۏeQnS^0 4 @sNxKm[ 4.1 St 4.1.1MՋBRKm[el (WܔyP[PS N sNxNSmkxx(Wl4l-NS^ sNxlS:NYN YNN[WTS^Nu+}rSTir (Wl560nmY g:_pvIQ8T6e EeSۏL[ϑKm[0 4.1.2sNxvKm[NKm[el: hKmc4Y Nň gNGr NB\v vQ-NB\:NV[vsNxv'lSv0hbvvc4YMONEQnQmv7hT[Q S_7hTleQ7hT[T R^irOnۏ-NS_[Nc0RV[vsNxv'lSv eOŏ'lS NuǏ'lS"l0Ǐ'lS"lH2O2 ~ (W”3g N'lSNu5uP[0S_Ǐ'lS"lubsTy_V[B\vs0R3z[eOS_0RN*NR`s^ar` S(u3z`T^h:y05uP[AmN3z`Ǐ'lS"lSm^b~'`kO VdkNsNxvSm^bckk0 4.2 NhVNՋBR 4.2.1 NhV 4.2.1.1 @sNxKm[ MՋBRKm[el_ϑ8T{ R`)n4ltm 5up4l{ RIQIQ^0 4.2.1.2 sNxNKm[elsNxN0R7hhV0/cahV0 4.2.2ՋBR 4.2.2.1 MՋBRKm[el 4%CuSO40SmkxxAR 01%NaF nm0 ˆ}vlmBR cSOyR+RSNN10%vx NN1/3 mol/L kxx QN28N4lmTsSb0 lmBR NaF mTm cSOyR+RS3NlmBR 1N1%NaFmTsSb0 1.5% [WTnmyS1.5g [WTnN100mL pv0.5% NaOH-NSOX[JSt^ 0 sNxhQPYm1g/L yS106.6mg sNxb171mgsNx N10%v N/lYNx[[100mL[)n NSOX[JSt^ 0 sNxhQ^(um0.01g/L Qnx8TS1.0mL sNxhQPYmzʑ[[100mL dkmBls(usM0 4.2.2.2 sNxNKm[el4xm0xxvQm0/lS0 4.3 [el 4.3.1 [Rir T2.2.3.1 4.3.2 BRϑTR~'Y NNSOkeklQeSO͑cPϑv5 P:NW,gBRϑ vQYO T1.3.2 4.3.3 [ek 4.3.3.1 ؚ@sNx!jWv6R\OS@h,g6RY +g!k~7h30min TǑ@ 6qT N͑(W)n^:N30!v4l-N8nl10minT\Pbk0sNxNKm[el(W8nlMRTǑ@20LReQ40L4xm-N zsSEQR/ca4xx~ހ8nlTzsSǑ@20LReQ40L4xm-N/caOo`20min TQTǑ@20LReQ40L4xm-N/ca (usNxNKm[0MՋBRKm[el T7h(W N N*NepTǑ@20L cN Nekd\O0'Y Ǒ>\@ \ (uk~{NQ&wǑ@0 4.3.3.2 Km[ek 4.3.3.2.1MՋBRKm[N5mLՋ{-NReQ0.48mL 1% NaFnm Qnx8TShQ@20L ReQՋ{^0(uՋ{ Nnmnm_ϑ8T{pe!k QReQ1.5mLˆ}vlmBR /camS N3000r/min y_10min S Nnm c Nhd\O0 zz}v{mL hQ{mL Km[{mL lmBR NaFmTm0.5  sNxhQ^(um 0.5  Nnm  0.54%CuSO40.10.10.1Smkxx333EQRmS nl4ltmRp5min SQT>eeQQ4ltmQtS10min1.5% [WT0.10.10.1 Nek[bT GdS n30!4ltm30mink10min /cGdN!k 0SQT>eeQl4ltm-NRp90s SQQtS[)n (Wl560nmY(u5mmIQ_krvkr zz}v{0 4.3.3.2.2 sNxvKm[NKm[el cNhVd\OffNd\O0 4.3.3.3 @sNx+Tϑ{ AKm[{ 4.3.3.3.1MՋBRKm[el @sNx+Tϑmg/L = %%%% 10010 AhQ{ 4.3.3.3.2 sNxvKm[NKm[elvcNsNxN Npe [EfW'`FfW'` S$R[勞[~g3'`0 @sNxf~ Nby{el @sNxf~ Nby1/28nlMR@sNxeeQv g5gwppv250mLxStQkt1S (uQXg\tS v%N OKN Nol zsSe N|T8T\Pbk:Nch ‰[\ V:'l {kNve0 1.6 ~elS~g$R[ :'le:Nϑpenc Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Fe1S\ N2Nvr^pbq_T:'lRvKm[0 1.7.2 xStN[[\%N N2ol &TROq_T[~g0 1.7.3 xSt_{I{[ϑ](1mL [MRHQ(u4lRN!hck0 1.7.4 kyb[RirvSO͑^=\ϑOcN0 2 N]xx-NkX[;m[ 2.1 St N]xxOck8^NN@~ˆ}vlS:N NN@~ˆ}v 4xOW@~ˆ}v:d'lR b~~:'l{kN0 2.2 Pge N]xx0yh01mLl\hV 2.3 [Rir cP(uяN|bt^\ USN'`+R 18-20g k~10 15S0 2.4 BRϑR~ T1.4 2.5 [ek TBRϑ~~Sޏ~~N N TSm^SՋ7hT [gq~~N TI{[ϑnBR N+g!kLpÀT1\e T~Rir c200 240mg/kg BWBRϑyTl\N]xx l\ϑ:N0.1mL/10g zsSe U_RirX[;me0 2.6 ~elS~g$R[ X[;me:Nϑpenc Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Ff:yQ gĉ_0W _SUl NUle:Nch S‰[SՋ7hT[:@'`:'lvOb\O(u QO'lMNOvSՋ7hT GW^RirUle0 3.2 Pge jRR0yh 3.3 [Rir T1.3 3.4BRϑR~ T1.4 3.5 [ek TBRϑ~~Sޏ~~N N TSm^SՋ7hT [gq~~N TI{[ϑnBR N+g!kLpÀT1\e T~RirꁈSe4Y zsS cyhU_\ e4YT _SUl\Pbke0 3.6 ~elS~g$R[ Ul\Pbke:Nϑpenc Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfsUl;mR0 ]N0 gRNSOQRhel 1 Rir[ 1.1 St ,gel/fNؚpϑߘirSRirր Q~NSՋ7hTր!jW b(W~Nؚpϑߘir Te~NSՋ7hT2ր!jW ‰[RirSO͑0SOQ+TϑvSS0 1.2 NhVSՋBR Rir)Ys^ VRhVhI{ b]kY0 1.3 [el 1.3.1 [Rir (uĖ'`'Y ^g~_ge SO͑20020g k~8-12S0 1.3.2BRϑR~SSՋ7hT~Ne  BJ`bfhlrvz|~ĶĨsfsYMY>sh=CJOJPJQJaJo(h=CJOJQJaJh=CJOJQJaJo(h3MCJOJQJaJo(h=CJOJQJaJh=CJOJQJaJo(h=5CJOJQJaJh=5CJOJQJaJo(h=CJ,OJPJ^JaJ,h=B*CJ,PJaJ,ph*h=B*CJ,OJPJQJ^JaJ,o(ph'h#{h=CJ OJPJQJ^JaJ o(!h=CJ OJPJQJ^JaJ o( 0@bhrx$@&#$/Ifb$$$@&#$/Ifa$b$$da$$a$xz~jVE3$@&#$/1$Ifb$$@&#$/Ifb$$$@&#$/Ifa$b$kd$$IfFY#oV, 6@0    44 lae4ytFhTC1$@&#$/1$Ifb$$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF     $ * , . : > D F H N R X Z \ n r x | ~     " h'CJOJQJaJo(h=h=CJOJQJaJo('h=B*CJKHOJQJ^JaJphh=CJOJQJaJh3MCJOJQJaJo(BhTCC$@&#$/Ifb$$$@&#$/Ifa$b$kdf$$If4FY#oV, 6@0    44 lae4ytFhTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF   & ( hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF( * . @ B hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kdB$$If4FY#oV, 6@0    44 lae4ytFB D H T V hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytFV X \ t v hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytFv x ~ hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kdg$$If4FY#oV, 6@0    44 lae4ytF hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kd$$If4FY#oV, 6@0    44 lae4ytF   hTCC$@&#$/Ifb$$$@&#$/Ifa$b$kdC $$If4FY#oV, 6@0    44 lae4ytF   $ < P hfRAA$1+&#$/Ifb$$$1+&#$/Ifa$b$kd $$If4FY#oV, 6@0    44 lae4ytF" $ 6 : < B J N R V X b f l       $ ( * . L P R V t x z ~ .h#{h=@CJ0OJPJQJ\^JaJ0o(h=5@CJHaJHo(h=hNCJOJQJaJhNCJOJQJaJo(h3MCJOJQJaJo(h'CJOJQJaJo(h'CJOJQJaJ

4*| rhdgd@V2 $da$gd@V2 $dha$gdNjffb ^ZXZ\dgd@V2\^`X\TVXPTVRTX  \`b ^bdfhjnprѹ h=5CJ h=5;CJOJQJ\h=.h[hG @CJ0OJPJQJ\^JaJ0o(h[h[OJQJaJhN.hTaJhN.h[aJ h:LaJo(hN.h:LaJ<dfhjnr(r&8\ddXD2$a$$da$$dpa$$a$gd^q $da$gd@V2dgd@V2r &4p~$&.68DZhHJ2 4 ! !!!0!2!6!:!>!@!F!H!L!P!T!V!!!!!!!!!" h=o(h=h=5\o( h=5\ h=5 h=5o(h=5CJ o(SJ !!2!H!!!"<"V"""" #F##,$x$$%%%Q`$a$d dWD`dXD2"""":"<"T"V"Z"d""""""""""## ###D#F#R#d#####*$,$0$4$6$8$v$x$z$$$$%%%"%%%%%%%%%%%%%%%% &&&& &(&*&,&Ǿ h=5 h=5o(h=5CJOJh=CJOJo( h=aJ h=aJo(h=OJQJaJo( h=5\h=5\o( h=o(h=F%%%%&*&D&`&|&&&&&'*'B'T'''"(b(((()*dXD2dddXD2$a$,&:&B&D&F&T&^&`&b&p&z&|&~&&&&&&&&&&&&&&&&&&'' ''('*',':'@'B'D'J'R'T'V'`''''''''' ("($(.(`(b(d(l((((((((((((((())))****,*.*0*6* h=5o( h=5 h=5\h=5\o( h=o(h=W**.*H***+"+J+n+++8,,,,- -6-R-t---- 8XDdYD2d7$8$9DWD`ddXD2$a$d6*F*H*L*T**********+ +++++"+&+.+@+F+H+J+N+V+l+n+r+z+++++++++&,(,*,2,6,8,<,B,,,,,,,,,,,,,,,,- ----- -$-,-4-6-𿻿h= h=o( h=5 h=5o(h=6]aJo(h=6]aJ h=aJ h=aJo( h=5\h=5\o(J6-:-F-J-R-V-b-r-t-x------------------*.,.0.8.T.V.Z.^.`.b.........F/H/L/T/b////////000000 0"0$0.0H0J0L0V0`0b0l0n0~0000000 h=@ h=@o( h=5o( h=5 h=5\h=5\o(h= h=o(Q--,.V...H////0"0J000001 11112242dVDWD^`dXD2$a$d 8XDdYD20000000000 11111 1F1H1R1T1111111112222222&2224262@2H2J2L2V2^2`2b2l2z2|2~2222222222222222233 3"3(30323`3b33333333h= h=o( h=5 h=5o( h=@ h=@o(h=5\o( h=5\R42J2`2|2222 323333334(4J4\4t4455$565L5l5d`$a$ dWD`dXD2d33333333334444&4(4*444H4J4L4R4Z4\4r4t4v4|444555 5 5"5$5,54565\5j555H6Z6v88888"9R9V9Z9999999999 :轷轷轷豩 h=@h=@aJ h=aJ h=KHh=KHaJh=5OJQJ\h=5OJQJ\o( h=5o( h=5h= h=o(h=5\o( h=5\@l555556*6H6Z6667^7777j8899 :::"<$d7$8$H$WD`a$ $d7$8$H$a$dXD2d : :F:R::; <<<|=~=======>&>0><>D>F>P>X>Z>h>>>>>???????|A~AAAAAAAAAAAAAAAAAAABB6B>BJBLBRB^BfB¹¹h=KHaJh=KHaJo(h=5KHaJh=5KHaJo( h=o( h=5\h=5\o( h=5 h=5o( h=6]h=KHaJh=B"<z=|===>>0>F>Z>>>???:@B@@~AAA d2` d2G$`d2dd`dXD2$a$$da$ dWD`AAAAB0BLBhBBBBCZCCCRDnDDEEEEEF.FBFjFdXD $a$d 8XDdYD2fBhBnBzBBBBBBBBBBBBCCCC`CdCCCCCCCCPDRDXD^DEEEEEEEEEE FF$F,F.F8F@FBFPFhFxFFFGG GG8G>GGGGGGGGGGGG Hȼȼȼ h=o(h=h=5\o( h=5\ h=5o( h=5h=5KHaJh=5KHaJo(h=KHaJo(h=KHaJHjFFGGGGGGGH*HRHHHHIIIII"JpJJJKK.Kd$a$ dXD `dXD  HHH H(H*H8HPHXHZH`HHHHHHHHIIIIIIIIIIIIIIIII J,J.J0JnJpJzJJJJJK KKK$K,K@KDKXK`KtKzKKKKKKKKLLLLLLLLM&MxMMMMMMMMNN`OO:PPP Q$a$dXD2d\NNNNNNNOO^OnOOOOO8PLPVPXPPPPPPPQ QQQQQ"Q,Q4QHQjQ~QQQQQQQQQR,R.R0R8RLRNRPRTRhRjRlRxRRRRRRRRRRRS0S@SxSSSSSSSSTTTT@UTU h=5\h=5\o( h=5 h=5o(h= h=0Jo( h=o(T QQ6QlQQQQQQR:RVRzRRRRR2SzSSSTTBUUUUU V$a$dTUUUUUUUUUUUUVV VVV V"V&V4V@VBVFVTV\V^VbVpVVVVVVVVVVVVVWBWHWPWRWVW`WWWWWWWWX(X*X.X8XvXxX|XXXXXXY Y$Y.YYYYYYYYYYY ZZ$Z0Zh= h=5\h=5\o( h=5o( h=5 h=o(V V"VBV^VzVVVVVW"W>WRWWW*XxXX YYYYYY Z2ZZZ$a$d` pd^p`d0Z2Z8ZJZXZZZ`ZvZ|ZZZZZZZZZZL[Z[`[f[h[z[~[[[[[[[[[\ \\ \\\\\\]]]]] ]"]T]]]]]]]]^*^@^F^N^d^l^^^^^^^^^^h=KHQJaJo(h=KHQJaJh=KHaJh=KHaJo( h=5o( h=5 h=5\h=5\o( h=o(h=HZZvZZZZZZ[[\\\]]T]]]^n^^ _"_:_Z_z__ $d7$8$H$a$dXD2$d7$8$H$WD`a$$a$d^^^^^^___ _4_8_L_X_l_x________``(`<`R`f`|`~```````````aa"a*ahajapaxaaaaaaaaaaaaaabb>bHbRb^bdbpbtbb콵h=QJaJh=QJ\aJ h=5\h=5\o(h=h=KHaJh=KHQJaJo(h=KHQJaJh=KHaJo(G___ `*`T`~```ajaaaabeehggghhdh$ d7$8$H$WD` a$$d7$8$H$WD`a$dXD2d $d7$8$H$a$bbbbdcnccccc*d6d^dhdzdddddd,e8eXebete~eeeeeeeeeeeeeef f"f&f(f6fDfHfffffgg6gTgfghgngvgggggggggggggggghhh=5KHaJh=QJaJh=KHQJaJo(h=KHaJo(h=KHaJh=KHQJaJh=QJ\aJKhh h"h,hZhbhdh,iViliritiiiiiiijjjjjjjjjjjjjkkkklll:lm@mƿƿh= h=o( h=5\h=5\o( h=5 h=5o(h=KHQJaJo(h=KHaJo(h=KHaJh=KHQJaJHdhniijjllsRsjssssss$a$d`dXD2dzq2r:rVrXrrrsssBsHsPsRsVs`shsjsns|sssssssssssssstt"t&t,t4t8tw@wDwRw^wdwfw h=5\h=5\o( h=5 h=5o(h= h=o(Vst"t8tttttBuXuuxvzvvvv(w@whwwwwwxBxfxxxd`$a$dXD2dfwhwlwzwwwwwwwwwwwwwwwwwwwwx xxxxx x"x(x8x>x@xBxFxLxNxTx^xbxdxfxjxpxrxxxxxxxxxxxxxxxxxxxxxxxyyyy(yyyyyyyyyyyh=OJQJh=CJOJh=CJOJo( h=5\h=5\o( h=o(h=Rxxy(yyzzzz{ {R{v{{{{t||X}Z}p}}}}dXD2dd`Udd`dXD2H`y2z4z8z>z@zFzHzLzzzzzzzzzz{ { {*{,{.{R{\{v{{{{{{{{*|r|t|~||||V}X}Z}^}`}n}p}t}z}}}}}}}}}}}}йСܘܘh=CJPJ\ h=@o(h=CJOJh=CJOJo(h=@CJKHOJaJo(h=5\o( h=5\ h=5h=CJPJ\o( h=5o(h=h=OJQJ h=o(<}}}}}}}}}}~~ ~~ ~"~&~4~8~:~>~L~P~R~V~d~h~j~n~|~~~~~~~~~~~~~~~8:>DFH $.(*DFhlrz|h=5CJ o(h=5CJ aJo( h=5 h=aJo( h=5\h=5\o( h=o(h=O}}}~"~:~R~j~~~~~: (DFhjl| dWD`d$dpa$dXD2dXD2d܁ށLN‚ނ "$.6|ʃ܃$@BDL^dfrv|(:BX`bl~ƅ҅ ,8: h=H* h=H*o(h=5\o( h=5\ h=o(h=WށN ̃*Db܆,vʇ&L dWD`dXD2d`d:@BNPXZ^`n~ʆІچ܆(*248:HL^`ftvȇއFL\^p|ƈ"$:JLhl|ΉЉ҉ h=H* h=H* h=o(h=^҉։؉ډމ$*4BRbhjvxDJTZlvz~$&*,468:D$8@ȍʍҍڍ"*N\hz~ŽȎʎЎ h=6] h=o( h=H*h=\ʍPj`|(BfΒ`4@dXD2 ydYD2` dWD`dd`^pz؏ڏ܏(046:FLNVXZ\`bjtx|&8@VdfƑԑ$*X^l|̒Β h=o(h= h=H*_":>@HP\^`fhjntz̓Γғԓޓ,2TZ^pʔ̔ДҔԔ֔ؔ  &*2:<@LPbfȖږh=5\o( h=5\jh=EHU h=6] h=H* h=H*h= h=o(PHNjlnp0BJ`hrvƘ̘$8NRV|ҙޙ*4djx "*,.0: "(x h=H* h=6] h=o(h=]2Lj:zzx xd` dWD`dʜ֜ޜ$*,HJV^̝؝ܝ.26<>@Rlvz|~Ğƞ  "$(*,4@Fv (*,.8 h=H* h=6] h=H*h= h=o(Z *0v "$*,4FP\^jnpܢ,6@tzƣʣڣ^`vx|ΤԤؤ.2@DLNPRTX^px|ޥh=5\o( h=5\h= h=o([,^p 8ܣ~`v0ܬpd` dWD`dXD2d*<>Hjvx|~ئ "LXħƧЧԧ8@BDJ\ptƨ֨ڨ4>Jlpt~0 h=H* h=o(h=`024<DHZ\^`~ <>BDLNPR\.08>@NPƬڬ*2LTnЭحJLbdh~خh=5\o( h=5\ h=H*o( h=H* h=6] h=o(h=TڭjȰ8LԳhƴ0FĶ޶lFhd`h$da$d`d(2468\`ȯЯԯ(0BDNPX|ưȰ$&DFJLTVXZd68LNRTʲ̲βԲֲܲ޲JNPTҳԳ h=H* h=6]h= h=o(\Գڳ޳$(LNfhnrĴδ"&.@DNPXnv"@H\`z¶ԶܶLNdfjƷʷҷط޷"048:<>DZlpĸҸԸظ޸ h=H*h= h=o(_8<N`dnr $*<@B`flptx~ƺʺֺ̺$*268XdjzFJdhFJtxʽν"4FH h=H* h=6]h= h=o(\$H8F^r>V Vd` dWD`dXD2d`d`dľƾʾ̾Ծ־ؾھпԿؿ6<@BDFN\^lpr46<JTd"&(46:<HRTfnrh=5\o( h=5\jh=EHU h=H* h=6] h=o(h=S&<>BDNT`j|FHDFJLNPRZ\z|l|8BNPXxzh=5\o( h=5\ h=6]jh=EHU h=H*h= h=o(RnpPz dWD`dXD2d`d` dWD`d  d`WD` gd'd8` d` zH^fhBV0246:LTZlrtx|@Dnpr|(0<BH h=H* h=o(h=`JhD<nDp h.hd`d dWD`HJVZbltz 0:BD\^n04BLx $.6D|<@hn fh h=H*h= h=o(_,:fx|~ .6L\`(48DLX^dx.2<Fz&P\^`dfltvx|"Pjh=EHUjNh=EHUh= h=o(Yh~8(NPjlz|Rd`dH`d`d`d`d` dWD`dPR~JLNTXZ`b BDP\^fx"8>DLnth=5\o( h=5\ h=H* h=6]jh=EHU h=H*h=KHaJh=KHaJo(jh=UmHnHsHtH h=o(h=DD^z,T|:D dWD`ddXD2d`d` d$pd7$8$9DH$VDWD^`pa$ ".2<>DHX"*FR\bfhlp$&*.BP`br| h=H* h=@o( h=H*o( h=o(h=Z.0268:@BXtv $&8T^dh~<BDJTdvz 0<>R\dltvx| h=H*o( h=H*h= h=o(\Dv>2>b Bdd`dXD2d` dWD`d`d"$&*,8<DHRdhp~(,02<@VZrv nptvxz| h=6]j"h=EHU h=H*j' h=EHU h=H*h= h=o(R 48>F`p *,6bf @BLN`lxz $06<>@DFXbdz h=H* h=o( h=6]h=[ $@Jdp<BP`xz|0^jlv~4:HPRT\^`& h=H*h= h=o( h=H*]BD >$dpa$d` dWD`ed`eXd`Xd&(*046<>@D<>z|&(>Brv>BDH\ľ h=5CJ h=5CJ o( h=CJ h=CJ aJo( h=5\h=5\o( h=H* h=6]j%h=EHU h=H* h=o(h=D^Zlz4<R 8XDdYD2 dWD`d`dXD2d$dpa$\^fXZbjlxxz*24:<@Bjlt|~ 02&(*:<DFLPR h=OJQJo( h=o(h=5\o( h=5\h=X4Pt n bl HdWD`H dWD` dWD` $d9DH$a$ 8XDdYD2d`d HJ24<>HNPXZhrz| BLXb68>B\~  h=H* jh=h=KHaJo(h=KHaJh=5\o( h=5\h= h=o(P<@BRTZ\^bj,0:@hl,.<FNXZlpz    h=H*o( h=H* h=o(h=].H| $d$Ifa$d dWD` HdWD`H 28BNTV\bl &0:DFHz @Fn~ .8@NP`lnrvz h=H*o( h=o(h=_ $d$Ifa$pkd8'$$If\ #! 3[44 a (08 $d$Ifa$pkd'$$If\ #! 3[44 a8:HT`l $d$Ifa$pkd($$If\ #! 3[44 alnJ7kd($$If#!?!44 a $d$Ifa$pkd($$If\ #! 3[44 aNvJ?:?d dWD`7kd)$$If#!?!44 a $d$Ifa$pkdF)$$If\ #! 3[44 a,08blv|4F T X d h |                  ^ ` j p x z           r t z            & B P ` l |           h=KHaJo(h=KHaJ h=o(h=[6l  B D V f ~       t    dWD`d` dWD` $d9DH$a$hd`hdhd`hd  : X t    .n $d$Ifa$ dWD`d dWD` dWD` $,.@DJNRV`blvxFRDHZ\`bnptvz,0<@LPdhzh=KHaJo(h=KHaJ h=5 h=H*h= h=o(V $d$Ifa$pkd*$$If\@ \ K44 a $d$Ifa$pkd|*$$If\@ \ K44 a$0< $d$Ifa$pkd*$$If\@ \ K44 a<>Vbnz $d$Ifa$pkdT+$$If\@ \ K44 az| $d$Ifa$pkd+$$If\@ \ K44 a $d$Ifa$pkd,,$$If\@ \ K44 aF|JEEE@dd7kd-$$If44 a $d$Ifa$pkd,$$If\@ \ K44 ard*>Nf8 dWD`$hd9DH$`ha$hd`hh`hdd  ",68NVfz~ "$*,26DLNjv68br|V,0>BVZl h=H* h=o(h=`$,46FHTVpkdT-$$If\@ \ K44 a $d$Ifa$ VXxz| $d$Ifa$pkd-$$If\@ \ K44 a $d$Ifa$pkd:.$$If\@ \ K44 a $d$Ifa$pkd.$$If\@ \ K44 a&2 $d$Ifa$pkd/$$If\@ \ K44 a24<HT` $d$Ifa$pkd~/$$If\@ \ K44 a`bXJEE@@dd7kdV0$$If44 a $d$Ifa$pkd/$$If\@ \ K44 a.@XX\x0  $$Ifa$ dWD`dhd`hdl2^`prVXRTZ\vx.0  $(24BDFHJjtvxz| h=H*aJh=H*aJo( h=aJ h=aJo(h=QJaJh=QJaJo( h=o(h=O&(!kd0$$IfT֞# 3 @044 laT $$Ifa$(4DHLXbf $$Ifa$fhjv) $$Ifa$kd\1$$IfT4֞# 3 `@044 laTvz~ $$Ifa$) $$Ifa$kd2$$IfT4֞# 3 @044 laT $$Ifa$) $$Ifa$kd2$$IfT4֞# 3 @044 laT :BZdft( 0 V X Z \   !!:!j!l!!!!!!!""\"^"f"z"|"~"""""""""##$$$$@$B$D$H$Z$\$^$ϻϻϻϲh=OJQJo( h=H*h=5\o( h=5\h= h=H*o( h=H*aJh=OJQJ^JaJo( h=aJo( h=o( h=aJF $$Ifa$8) $$Ifa$kd3$$IfT4֞# 3 @044 laT8:DX $$Ifa$ukdT4$$IfT0# 044 laTXZfvz $$Ifa$ukd4$$IfT0# 044 laT) $$Ifa$kdP5$$IfT4֞# 3 `@044 laT $$Ifa$& ) $$Ifa$kd6$$IfT4֞# 3 @044 laT& ( 2 z  $$Ifa$ukd6$$IfT0# 044 laTz | ~   8!:!^"|"#$|||ti_iZd 8XDdYD2 dWD`WD` dWD`ukdJ7$$IfT0# 044 laT $$$%x%%,&Z&&&&P'l'r'z'' $$7$8$H$Ifa$ $7$8$H$YD2a$ $d7$8$H$a$d` dWD`d^$b$n$p$r$v$$$$$ %%%<%B%l%n%v%x%%%%%%%%& &,&2&4&B&h&j&&&&&&' 'P'j'l'''''"(0(4(8(<(T((((((( ))(),)6)F)))))Ϸװװװ h=aJo(h=KHOJQJ^JaJo(h=KHaJo(h=KHaJ h=aJh=OJQJo(h=QJaJh=QJaJo( h=o(h=E'''''zl^^ $$7$8$H$Ifa$ $$7$8$H$Ifa$kd7$$IfF 4    0    44 la'''''zl^^ $$7$8$H$Ifa$ $$7$8$H$Ifa$kdP8$$IfF 4    0    44 la'''( (zl^^ $$7$8$H$Ifa$ $$7$8$H$Ifa$kd8$$IfF 4    0    44 la ((:(zl $$7$8$H$Ifa$kd`9$$IfF 4    0    44 la:(<(V(b(n( $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd9$$If J!044 lan(p((zl $$7$8$H$Ifa$kdT:$$IfF 4    0    44 la((((( $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd:$$If J!044 la((H)zl $$7$8$H$Ifa$kdH;$$IfF 4    0    44 laH)J)f)r)~) $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd;$$If J!044 la~)))zl $$7$8$H$Ifa$kd<<$$IfF 4    0    44 la)))*$*8*<*F*V*********$+.+2+6+++,,,.,6,8,,,,-.-<->-R-T-f-h-l-n-p--------....,.~............ѻh=QJaJh=QJaJo( h=aJo(h=OJQJo(h=KHOJ^JaJo( h=o( h=H*aJh=QJaJo(h=h=KHaJh=QJaJ h=aJ@))))* $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd<$$If J!044 la**X*zl $$7$8$H$Ifa$kd0=$$IfF 4    0    44 laX*Z*v*** $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd=$$If J!044 la***zl $$7$8$H$Ifa$kd$>$$IfF 4    0    44 la***++ $$7$8$H$Ifa$ $$7$8$H$Ifa$^kd>$$If J!044 la++8+zl $$7$8$H$Ifa$kd?$$IfF 4    0    44 la8+:++,,8,,,,-.-T-n--~~~yyyi$d7$8$H$`a$d $d7$8$H$a$ $7$8$H$a$ $7$8$H$XD2a$^kd?$$If J!044 la --...t..(/x// 0L0000@1^1123 $7$8$H$a$ dWD`d$d7$8$H$WD`a$$Ud7$8$H$VD^Ua$d` $d7$8$H$a$..........`/h/j/l/v////00 0400@1\1^1t1v1~111111112 2\2^22r333333333444<4P4T4^4n4444444D5L5`5d5n5~55555 h=o(h=h=QJaJh=QJaJo(h=KHaJo(h=KHOJQJ^JaJo(h=KHaJ h=aJh=QJaJH3 3(30323B3N3Z3l^^^ $$7$8$H$Ifa$kd @$$IfF 4    0    44 la $$7$8$H$Ifa$Z3\3333zlll $$7$8$H$Ifa$kd@$$IfF 4    0    44 la33333zlll $$7$8$H$Ifa$kdA$$IfF 4    0    44 la333zl $$7$8$H$Ifa$kdA$$IfF 4    0    44 la33444 $$7$8$H$Ifa$^kd,B$$If J!044 la4 4p4zl $$7$8$H$Ifa$kdB$$IfF 4    0    44 lap4r4444 $$7$8$H$Ifa$^kd C$$If J!044 la444zl $$7$8$H$Ifa$kdC$$IfF 4    0    44 la445"5.5 $$7$8$H$Ifa$^kdD$$If J!044 la.5055zl $$7$8$H$Ifa$kdD$$IfF 4    0    44 la55555 $$7$8$H$Ifa$^kdE$$If J!044 la556zl $$7$8$H$Ifa$kdtE$$IfF 4    0    44 la556T6\6p6t6~66666666F777777888889 99 :Z:\:::;;T<V<^<`<b<r<t<z<<<<<<<<<<<<<<<====== ="=.=d=ƾƾ櫹洹櫹h=OJQJo( h=H* h=o(h=5\o( h=5\h=KHaJo( h=H*aJh=QJaJo(h=h=KHaJh=QJaJ h=aJC6 6&626>6 $$7$8$H$Ifa$^kdE$$If J!044 la>6@66zl $$7$8$H$Ifa$kdhF$$IfF 4    0    44 la66666 $$7$8$H$Ifa$^kdF$$If J!044 la666zl $$7$8$H$Ifa$kd\G$$IfF 4    0    44 la667772888889:;V<~~~rrrrr $d7$8$H$a$ $d7$8$H$a$ $7$8$H$a$ $7$8$H$XD2a$^kdG$$If J!044 la V<t<===>> ?>?X????@X@h@@@8AFAPAfAxAAd^d`hd`hd dWD` 8XDdYD2d=f=============>>>T>^>>>>>>>>>>>>>>>> ? ???&?2?4?N?V?\?d?p?t?z?|???????????@ @@@@*@4@:@L@N@`@f@h@j@x@@@@@@@@@@@@@AAA$A,A>ADAh=OJQJo( h=H* h=o(h=\DAFANATAZAnAvAAAAAAAAAAAAAAB BBB B*B0B6BDBNB`BhBjB|BBBBBBBBCVCZC`CfClCCCCCCCCCDDDD D(D4D8D:D@DZDhDxD|DDDDDDDDDDDEEEFELEPEXEdEpEEEEEEEEEE h=5\ h=o(h=_AB"D E^EEE"FlFFDGG"HHHHHHH $d$Ifa$d$`*d$WD]*` *d$]*`d`dd` dXD2` dWD`EEEEF FF FFFHFNFTFZF`FbFhFjFlFFFFFFFFFFFFFFFGG4GBGxGzGGGGGGGG HHHH H"H`HfHlHtHHHHHHHHHHHHHI*I.I2I4IJIRIIIIII h=H* h=5\h=CJaJo(h=>*CJaJh=>*CJaJo(h=CJaJh= h=o(NHHI I(I $d$Ifa$ xd$If`x]kdPH$$IfFH!      44 a(I*I0I6I8I $d$Ifa$ d$If`]kdH$$IfFH!      44 a8I:I\IdIlI $d$Ifa$ d$If`]kdI$$IfFH!      44 alInIIII $d$Ifa$ d$If`]kdxI$$IfFH!      44 aIIIII $d$Ifa$ d$If`]kdI$$IfFH!      44 aIIIII $d$Ifa$ d$If`]kd4J$$IfFH!      44 aIIJJ*J6JZJ`J|JJJJJJJJJJJJJJJKKKKK&K2KRfRnRxRzRRRRRRRRRRRRRRSS6SUDUFULUjUtUvUUUUUUUUUUUUUUUUUUUUVV.V6VHVJVLVPVRVVVXV\V^VbVdVvVxV h=o(h=bxVVVVVVVVVVVVVVW WWWW"W,W6WYu hd$If`hpkdR$$If\px` (44 a $d$Ifa$>Y@YNYPYRYZYuuu $d$Ifa$ hd$If`hpkdBS$$If\px` (44 aZY\Y~YYYYuuu $d$Ifa$ hd$If`hpkdS$$If\px` (44 aYYYYYYuuu $d$Ifa$ hd$If`hpkdT$$If\px` (44 aYYZTZ|ZZZZ[[ \\||qhh:d]: dWDl`dd$da$pkdT$$If\px` (44 a ZRZXZ^ZnZpZ|ZZZZZZZZZZ[ [[["[([.[J[Z[d[t[x[z[[[[[[[[[[[[[ \T\b\t\v\\\\\\\\\.]^]]]]]]]]^ ^(^6^H^^^^^^^^^^^^^^^^^^^_ h=H*h= h=o(h=CJaJo( h=CJ h=CJo(V\\`]]J^^___`@`p`r``"aVa~aa d]`dXD2]`d]d$] d$>XD]d]dXD2d:d]: :dXD2]:_l_n_z_____________.`>`R`T`V`Z```f`p`z`|`````````````````aa aaaa a"aTaVaZajala~aaaaaaaaaaaaaaaabb b bbbbbbbbbb h=\o( h=\ h=H* h=CJo( h=CJ h=H* h=o(h=Taabbzddd~eeeffHfff g0g:g d$If dWD-`gd' dWD&`  dWD` d`d dWD` 8XDdYD2dXD2dXD2]`bbbbbbbbbccc"c$c&c(cccxdzddddddddddddddde ee"e&e*elBlFlTlVlllllllllllllmh=KHOJ^JaJo( h=o(h=\kk(k,k8k $d$Ifa$dkdV$$IfT4F X: : 4    44 af4T8k:kDkPk\k $d$Ifa$dkdW$$IfT4F X: : 4    44 af4T\k^kkkkkk $d$Ifa$dd`dkd^W$$IfT4F X: : 4    44 af4Tkkkkk $d$Ifa$dkdW$$IfT4F X: : 4    44 af4Tkkkkk $d$Ifa$dkd.X$$IfT4F X: : 4    44 af4Tkklll $d$Ifa$dkdX$$IfT4F X: : 4    44 af4Tl lVlllJnLnRnVnZn^nbnqeeee $d$Ifa$$9d$If^9a$ dWD`dd`dkdX$$IfT4F X: : 4    44 af4T mmJmNmmmmmmmmmmmmnn nnJnjnlnnnnnnnnnnnno o(oHoPoRoZozooooooooooooooooooooooooooooppJpLptpvpppppq qxqzqqqqq*r,r\r^rrr jmh=h=OJQJo( h=o(h=[bnfnjnnnpnn3kdXY$$If4ִX xH<    44 atf4 $d$Ifa$nnnnnnnn $d$Ifa$nnnnno?3333 $d$Ifa$kdY$$If4ִX xH<    44 atf4o oo o*o,o3kdoHoRo\ofopozoo $d$Ifa$oooooo?3333 $d$Ifa$kdZ$$If4ִX xH<    44 atf4oooooo3kd[$$If4ִX xH<    44 atf4 $d$Ifa$ooHpppp2qNqqqrZrrrrTtjtt$uBuu $d9DH$a$ XD2] 8XDdYD2 d8XDdYD2 dWD`d`drrrrrrr*s,s0s2s4s6s8s@sBs`sbsfshspsrstsvssRtTthtjtxttttt"u$u2u@uBuuuuuurvtvvvvvvwwŻתh=OJQJh=OJQJo(h=KHOJaJh=KHOJaJo(h=KHaJh=QJaJo(h=OJQJaJh=OJQJaJo( h=H*aJ h=aJh=6]aJ h=aJo(h=5\o( h=5\h=4uutvvw(wwwwwLxhxxxypyy>zPz{&{d dXD2] dXD2]d 8XDdYD2 dWD`d]w&w(wRw`wwwwwwwwwwwJxLxTxbxhxrxxxxxyypyxyyyyy4z8zzFzNzPz{{{${&{.{N{P{T{b{l{~{{{{{{{{| ||| |,|4|F|T|X|d|j|||||||||||h= h=5o( h=aJ h=o( h=aJo( h=5\h=5\o(P&{V{n{{{{"|6||||*}j}l}}2~~&(: vfd^v`fw^ dXD2^w`^ wed^w`e v^ d^v`^ dd]|||||} }(}*}h}l}}} ~~0~2~4~~~~~$8FJV\vx.08:x€Ȁʀ̀ڀ܀ &(*,08>@BDFHNPR jh=o(jh=Uh= h=o(h=OJQJo(T:|Frƃ@xbd| dWD`d 8XDdYD2 d2WD` d2`dXD2 wed^w`e vfd^v`f vfd^v`fd] wed^w`e,.HJprăƃ>@FH`fhlvx:@PVXbt|…̅ TZ`blpz|҆$&6<VX^`pv h=H* h=5o(h= h=6] h=o(h=5\o( h=5\T|(6P]kdv[$$IfF  <       44 a d$If (d$If`(d` PRbp-]kd\$$IfF  <       44 a d$If (d$If`(]kd[$$IfF  <       44 a‡̇ևއ&,2H\f|~ˆĈƈЈ҈ވ.2:<HPR^p҉  $.:DJblzh=5\o( h=o( h=H*h=Z‡4<JTrynyny dWD`8d`8(d`(]kdf\$$IfF  <       44 a d$If (d$If`( rt~`Jkd]$$If0(K # C44 aD d$IfJkd\$$If0(K # C44 aDԉ<LV`bNJkd]$$If0(K # C44 aD d$If8d`8(d`(JkdV]$$If0(K # C44 aDbnxz؊$*{ $d$Ifa$ d>XD2YDdXD2d(d`(Jkd]$$If0(K # C44 aD d$IfƊΊ֊؊",24hnvxƋ֋ "$*,24>HPntŒ̌Ό֌ތ.06:DPX^hntx h=H* h=o(h=h=5\o( h=5\Zčʍ֍"$(*0:@zƎȎʎ̎Ҏ؎ (FJXbnt|Џ֏"&.<>FNRT\`ltx~ΐ   h=\ h=\o( h=H* h=o(h=[*:JLhpx hd$If`hdkdF^$$IfTF` |     44 aT $d$Ifa$xz $d$Ifa$ hd$If`hdkd^$$IfTF` |     44 aT $d$Ifa$ hd$If`hdkd_$$IfTF` |     44 aTŽĎ܎SF hd$If`h;kd_$$IfT44 aT $d$Ifa$dkd__$$IfTF` |     44 aT*.2SF hd$If`h;kde`$$IfT44 aT $d$Ifa$dkd `$$IfTF` |     44 aT24VXdhlSF hd$If`h;kd a$$IfT44 aT $d$Ifa$dkd`$$IfTF` |     44 aTlnvxz $d$Ifa$ hd$If`hdkdta$$IfTF` |     44 aTz| $d$Ifa$ hd$If`hdkda$$IfTF` |     44 aTƏ $d$Ifa$ hd$If`hdkd&b$$IfTF` |     44 aTƏȏ؏ $d$Ifa$ hd$If`hdkdb$$IfTF` |     44 aT>T8dʑxoo^dXD2]`d8` d8XD2`ddXD2$da$dkdb$$IfTF` |     44 aT "&*,.028DHNT`b‘Ƒȑԑڑ "*6:<>@BȒFNRTX\dlnprtz $ h=H* h=\ h=\o( h=CJo( h=CJ h=H*h= h=o(S"RVXn2 dWD`d  dWD`  8XDdYD2d` dXD2]d] dXD2]$.@HTV\^Ɣ"$6<Xln02:fzҗ~ĻĻᵻᬥ h=H*aJh=H*aJo( h=aJh=QJaJo(h=QJaJh=KHQJaJo(h=KHQJaJ h=aJo( h=5\h=5\o( h=o(h=A $$Ifa$ dWD`˜Ҙ*!! $$Ifa$kd?c$$IfT֞# 3 @044 laT˜ИҘԘؘ֘ "02468\dfhjlęșЙҙ ,.0pxzRTț24DFLNTVМ h=5 h=H*aJh=H*aJo(h=QJaJo( h=o( h=aJ h=aJo(QҘ֘ژ $$Ifa$) $$Ifa$kdc$$IfT4֞# 3 `@044 laT  $$Ifa$ "2) $$Ifa$kdd$$IfT4֞# 3 @044 laT26:DNX $$Ifa$XZ\f) $$Ifa$kdqe$$IfT4֞# 3 @044 laTfjnr| $$Ifa$ƙ) $$Ifa$kd/f$$IfT4֞# 3 @044 laTƙșҙ $$Ifa$ukdf$$IfT0# 044 laT $$Ifa$ukdkg$$IfT0# 044 laT 2) $$Ifa$kdg$$IfT4֞# 3 `@044 laT2>JVbn $$Ifa$npz) $$Ifa$kdh$$IfT4֞# 3 @044 laT $$Ifa$ukdei$$IfT0# 044 laT  Hƛț|||ttkfd$a$d]WD` dWD`ukdi$$IfT0# 044 laT  (02>BLZ`,46>&,TVnx̟Οܟ (,PTV\ڠܠxʡԡ(0Zbbfhp24@B h=H*h=h=5\o( h=5\ h=o(h=5CJ aJo(U"2DΟܠz̡ؤ.ԥ8V dWD`dXD2d̤ΤҤ֤ؤ*,.JVh~Хҥ$68ƦȦ̦Φ֦ئڦܦħ̧ "&<>TV$nprv~ک( h=H*o( jch=6]o( h=H* h=6]h= h=o(Uܩ*pҪܫ:f|ޭ0(hBWD` dWD`dXD2d(:nЪ"ګ ",6@FNfnpz8:HPdrzȭ̭έ.8TX $068>hr$@P "$&. h=H* h=6]h=5\o( h=5\ h=o(h=W.0NPTV^`bdn@L^fֲز (>Hijгس&(ltv~´ƴ68dft|еҵֵ ,.@Nb̶h=5\o( h=5\ h=H* jch=6]o( h=H* h=6] h=o(h=Pг(f0PƸD~4»Իv`xd`` dWD`dXD2d̶Ҷֶ޶"&(.ĸڸ ,\dfhz|   @BFHPRTV^24BD»λһԻth=5\o( h=5\ h=H* h=6]h=OJQJo( h=o(h=S"*.6>F^`bnv̽޽  (>Z^`bjn¾Ⱦ̾&RTؿڿ"$8:FJRZ086Lljajh=Ujh=UmHnHsHtH h=o(h=Xxν*\^b8n.V02$da$ dWD`WD`d`$a$ddfjlnprz,.Tf .248:>@DF\^bdhjnp0BDFNVj h=H* h=H* h=6] h=o(h=[2Dz~JL^*d$d9DH$`a$dXD2 d&dPd d$dNjn (4DTx~@Vn|~HJLP\f(*2BDP$0jlprt h=5h=KHaJh=KHaJo(h=5\o( h=5\h= h=o(R*D&lb<6V`ddXD2`fhn$&:@BH 4:<FTZ\f^dfp~ h=aJo(h=5\o( h=5\ h=o(h=Y&(,.08:dh(,FJz~"$<>^b &(02:<HJXZjl"$*FJh=5\o( h=5\ h=o(h=\(:T  (2<JZl>d`dd`d`d`dXD2dJVXZ\hj"&>B<F"$(*.046:<@BFHLNRTXZ^`dfjlprvx|~h= h=o(a  $&*,0268<>BDHRl|"$(*.04 h=o(h=bJn0j$z.v Fd dWD`d46:<@BFHLNRTXZ^`dfjlprvx|~68VZpt<@Z^`drt|~&*bf"ntxz~ h=o(h=bvz 8<DH\`pr"NR028:<@.0hj~ h=o(h=b"$&:<fh|~<>Rlprvxz|,.<ft (BN R h=CJ h=CJ h=CJ h=CJ h=o(h=XRT*02<  .0$&*,.@Bxz68fjnFHvx|~"(*0pvx~*02<~ h=6]h=5\o( h=5\ h=o(h=Y4&Bx$r, h, $dp7$8$9Da$ dWD`dXD2dflnx*02< "4:<jlt|~PXZ &NTdhtz$TVd| h=5aJh=5\o( h=QJh=OJQJo( h=5\ h=aJo(h=5CJ aJo( h=o(h=L "4vR d $dp7$8$9Da$ TVd|.Z \ $XD2YD2a$dhd 8XDdYD2d`` dWD`|.8Xdfn~ 4:BFXZ^h \^f   h=CJh=5\o( h=5\h=5aJo( h=5aJ h=aJo( h=o(h=PKkdYs$$Ifr Xt"8 044 lal $$Ifa$Kkds$$Ifr Xt"8 044 lal $$Ifa$"&0:DKkdt$$Ifr Xt"8 044 lal $$Ifa$DFPT^tTKKKKK $$Ifa$kdKu$$Ifr Xt"8 044 lalTKKKKK $$Ifa$kdu$$Ifr Xt"8 044 lalRIIIII $$Ifa$kdv$$Ifr Xt"8 044 lal  RIIIII $$Ifa$kdAw$$Ifr Xt"8 044 lal     , 4 < B J P X \ ` b f h n p x z | ~                     N P X b d           $ & @ B        h=6]h=6]o( h=5aJh=5aJo(h=CJOJQJaJo( h=CJo( h=CJh=CJaJo(h= h=o(G  , 0 > L Z RIIIII $$Ifa$kdw$$Ifr Xt"8 044 lalZ \   P d  RLB7B7 dWD` 8XDdYD2`kdx$$Ifr Xt"8 044 lal             24B\ $idh`ia$$da$d dWD` 8XDdYD2 & ( * , .              : D P R T ^ b h r     :@VX^` \^`ľľh=OJQJo(h=5\aJ h=5\aJ o( h=aJh=6]aJh=OJQJaJo(h=5aJo( h=5aJ h=H* jch=6] h=o(h=@`b024rz~<>RTnN`dfpx|,.24»»»» h=@o( h=5\h=5\o(h=5CJ aJh=5CJ aJo( h=CJo(j?yh=Uo( jh=h= h=o(G\r>TNfd4`vpJbr $dXD2a$d dWD` 8XDdYD24@BHJRTbv4lntvxz|DP`v *p 6>JTV`bprh=5\o( h=H* h=6] h=5\ h=@o(h= h=o(Tr(z.f | D!""""##$.$l$$(%>% $dXD2a$d dWD` 8XDdYD2(68  ,@BFHJNX\`ftv .fhnprtv~ " f n p |        &!(!D!L!N!\!`!d!~! h=H* h=6]h= h=o(h=5\o( h=5\W~!!!!" "^"d"f"n"""""""""""P#^#p#|#~######$$.$J$N$P$T$\$`$b$f$l$$$$$$$% %%"%&%(%>%L%P%%%%%%%%&&*&,&8&<&H&\&&&&&&&&&&&&&&&&& h=H* h=6] h=5\h=5\o( h=o(h=W>%&<&\&(|(((6)H)`))*R*j**+T++,R,n,0-R-*.<.d 8XDdYD2$da$ dWD`&& (((b(d(f(h(z(|((((((()6)`)j)p))) ***$*4*B*R*Z*h*j*****2+4+B+J+x+z+++++++ , , ,N,P,R,l,n,,,,,0-P-R-f-h------(.*.<.l.n........../2/ h=aJo( h=5\h=5\o( h=o(h=W<.T..../2/L/00d0001$1D12333"4$4&4(4*4,4$dpa$ dWD`XD2 8XDdYD2d2/L/d/h/r/~//////////00n0p0~00000000"1$1D1P1R1z1|111 2 2:2>2`2d22223 333333333"4`4d4444 h=@ h=@o(h=5@CJ aJo(h=5CJ aJo(h5CJ aJo(h=5\o( h=H* jch=6] h=6] h=5\h= h=o( h=\<,4.40424446484:4<4>4@4B4D4F4H4J4L4N4P4R4T4V4X4Z4\4^4`444d$dpa$4444445555 7,78*99996:H:d:z:;;;P====WD`WD`d4444444444444455555555556 6`6j6 77*7,777777777777777777788888888899(9*9999999994:B:F:H: h=H* jch=6]o( h=H*h= h=6] h=o( h=@ h=@o(h=5@\o(h=5@\JH:b:p:x:z:::::;;6;@;l;~;;;;;&<(<,<.<0<2<4<<<><\<^<b<d<l<n<p<r<|<N=P===============> >>>>>>>>>>>>> ? ???0?J?T?r?x????"@&@h=5@\o(h=5@\ h=H*h= h=6] h=o( h=@ h=@o(P=>>>>|@@AnAAAB B:BPBBCCElEnE|E0F2F@F|FnGGWD`WD`&@6@8@R@T@^@h@z@@@@@@@@@@@@AAAlAnAvAAAAAA BBB B8BFBNBPBtBzBBBBBC C6CHCCCCCCCCCCCCDD&D(D,D.D6D8D:DF@FBFHFzF|F~FFZG^G`GdGlGnGpGvGGGGGGHHHHHH H*H2H4HHHHHHHHHHHHHHHHHHI I*I.I0I6I8IFI`Iƽѯѯѯh=5\o( h=5\ h=5aJh=5aJo(h=5CJ aJo(h= h=o( h=5 h=@ h=@o(h=5@\h=5@\o(BGGGGGGGGGGGGGGGHHHH"H4HHHHH:IWD`` 4dWD`4$dpa$:IbIJJJJ~LLL,MMNNOOBO|OOOPPhPPJQQ$RRSSTWD``IbIJ JJJ&J0J^J`JJJJJJJJJJJJTKVKZK\K^K`KbKjKlKKKKKKKKKK|L~LLLLLLL*M8MMMMMMNN&NNNOO OOO0O2O@OBOJOzOOOOOOOOOOOOOOPNP\PfP~P h=H* h=6]h=5\o( h=5\ h=o(h=W~PPPPPPPPP4QDQHQZQQQQQQQQQQQQQQQQRR R"R0RHRPRZRdRpRxRRRRRRRRRRRRRRSSSS*S:SNS`SdSfSvSzSSSSSSSSSST T TT"T4TgHgNg\gbgpgxg|gggg h=@ h=@o( h=o(h=\fff&gJg^grggggghiii>jjjjj k(kkkxmmmmWD` WD` ggggggghhhnhphthvhxhzh|hhhhhhhhhhhhiiiiiijpppp(qqqRslsdtfthtxttt$IfWD`nnnnnnnnnoo oo(o*o4o6o8o:ouTu\uruuuuuuuuuuvv.v8vu~ug[ $IfWD`kd\$$If\pxX ` 044 a~uuuuuu$If^kd $$IfX t 044 auu`vvv w*wwwxxg_]]]U]]]WD `WD`kd$$If\pxX ` 044 a ~wwwwwwwx.x0x@xBxDxLxTx\xnxpxvxxxxxxxxxxxxxyy&y(y,y.y6y8y:y{H{J{L{N{\{^{z{|{{{{{{{{\|^|v|x|ľ h=aJh=5CJ aJo( h=5 h=6]h=5\o( h=5\ h=H* h=H*o(h= h=o(KxxxzzzF{{{{8|:|<|>|@|B|D|F|H|J|L|N|P|R|T|V|X|Z|\|v|WD`v|x|z|||}(}l}~}}}~~ pҁZ<`WD`x|z|~|||||}}"}&}(}2}j}l}t}|}~}}}}}}}}}}}}}}~~~~~~~ " ,.24<>@BL npxЁށ 026 h=H* h=6]h= h=o(h=5\o( h=5\ h=5aJR68@Xf.4:<DLN  "$:NRZp  68<>FHJLV(*x| h=H* h=6]h=5\o( h=5\ h=o(h= jh=T<N*z|ȇ҇|l~`WD`Ƈȇʇ҇ڇ.0z| (*.08:<>Hlprt|~ hv΋Ȍ6X»h=KHaJ h=5aJh=5aJo(h=5CJ aJo( h=5 h=H* h=6]h=5\o( h=5\h= h=o(Fj‹ċƋȋʋ̋΋Ȍ jzWD`[ N*NBRϑ~TN*N!jW[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ S$N*NBRϑ~ _e3'`[gq~Tzz}v[gq~0SՋ7hT~Ne\~N6hT NǏ10hT0 1.3.3ؚpϑ!jWre (W~cre-NmR15.0%|015.0%*sl ϑvjˆ}v0xx"l0w|I{0dN|Y !jWrev4lR0|ˆ}v0|0|~~0|ppR00x0xGW0R~crevV[hQ0 1.3.4 [ek 1.3.4.1ր!jWl 1.3.4.1.1^gNO\|~ N'Y Ur~cre‰[5 7)Y0 1.3.4.1.2 !jg ^g~_gT cSO͑:gRb2~ 10S'Y ~N~cre\O:Nzz}v[gq~ 60S'Y ~Nؚpϑ!jWre0khTU_~ߘϑ0dߘϑ0iRߘϑ yϑSO͑1!k0 U{Q2hTT ~Nؚpϑrev60S'Y cSO͑X͑c^ mplSO͑X͑NOv1/3րbb'Y 0\[{ Qv40SրOea'Y Q~Nؚpϑre6hT zz}v[gq~ Te~N~cre0 1.3.4.1.3SՋ7hT~N !jg~_gT 40SրOea'Y cSO͑:gRb4~ R+R:N!jW[gq~T N*NBRϑ~0khTU_~ߘϑ0dߘϑ0iRߘϑ yϑSO͑1!k0!jW[gq~T N*NBRϑ~~Nؚpϑ!jWre zz}v[gq~~N~cre0TBRϑ~LpÀ~N N TBRϑvSՋ7hT !jW[gq~Tzz}v[gq~~NI{ϑvv^nBR SՋ7hT~Ne6hT NǏ10hT0 Ջ~_gT ySO͑ 1% b]kY0.5mL/100g BW VRShTV0~w8NhTV v^y͑ {/SOk0 1.3.4.22ր!jWl 1.3.4.2.1^gNO\|~ N'Y Ur~cre‰[5 7)Y0 1.3.4.2.2 !j[{ g ^g~_gT cSO͑:gRb2~ 10S'Y ~N~cre\O:Nzz}v[gq~ 60S~Nؚpϑre\O:N!jW~0khTU_~ߘϑ0dߘϑ0iRߘϑ yϑSO͑1!k0U{Q2hTT ~Nؚpϑrev'Y cSO͑X͑c^ mplSO͑X͑NOv1/3րbb'Y 0 1.3.4.1.3SՋ7hT~N \[{ Qv40SրOea'Y cSO͑:gRb4~ R+R:N!jW~T N*NBRϑ~0!jW[gq~T N*NBRϑ~~Nؚpϑ!jWre zz}v[gq~~N~cre0TBRϑ~LpÀ~N N TBRϑvSՋ7hT !jW[gq~Tzz}v[gq~~NI{ϑvv^nBR SՋ7hT~Ne6hT NǏ10hT0khTU_~ߘϑ0dߘϑ0iRߘϑ yϑSO͑1!k0 Ջ~_gT ySO͑ 1% b]kY0.5mL/100g BW VRShTV0~w8NhTV v^y͑ {/SOk0 1.3.5.‰[ch SO͑0SO͑X͑0Ddߘϑ0DdeQ;`pϑDdߘϑklQerepϑ 0ߘir)R(us0SOQ+Tϑ~w8NShTVW 0/SO͑0 1.4 pencYtT~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` Ddߘϑ N>fWNON!jW[gq~ S$R[SՋ7hTRir gRNSOQR[~g3'`0 2 NSOՋߘՋ 2.1 St US~'`րSՋߘ(uSՋ7hT ‰[SO͑0SOQ+TϑvSSS[:gSOeP^ ge_c[0 2.2 NhV SObRKm[Y0RsLf0_svKmhV0B0vaS0SO͑0 2.3 Ջel 2.3.1 SՋ~eQhQ SՋ[a:NUS~'`րN bNBMIe"30 b;`~vRs0R7u>25% sY>30%v?aSՋ0 2.3.2 SՋcdhQ 2.3.2.1 Tv^ g_00T @|~I{%N͑uu |^yu`0 2.3.2.2 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.3.2.3*g cĉ[ߘ(uSՋ7hT el$R[RHebDe NhQq_TRHeb[hQ'`$Re0 2.3.3 ՋSR~Bl 2.3.3.1 NfN;Nߘv gRNSOQRՋ Ǒ(uꁫ[gqS~[gqՋ0 cSՋvSO͑0SOQ+Tϑ:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^0'`+R0nߘ0ЏRrQI{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.3.3.2 fN;Nߘv gRNSOQRՋ fN;Nߘv gRNSOQRՋSUSNՋߘ~ gHeOpe N\N50N Ǒ(uꁫ[gq NS[gq~0 2.3.4 SՋ7hTvBRϑTO(uel NfN;Nߘv gRNSOQRSՋ7hTՋߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq0 cvlۏLՋߘՋ0SՋ7hT~Ne\60)Y0 fN;Nߘv gRNSOQRSՋ7hT^SNk)Y1 2;Nߘ v^Om9 TeDdSEQv%{Q } ^RXRg,DdeQϑ0SՋ ccPelTcPBRϑ g(uSՋ7hT SՋ7hT~Ne\35)Y0 2.3.5 ‰[ch 2.3.5.1 [hQ'`ch 2.3.5.1.1 N,rQSb|^y0aw w0nߘ0'Y\O0@SI{ 2.3.5.1.2 @0?\0O8^ĉhg 2.3.5.1.3 0Rhg 2.3.5.1.4 Gr0_5uV0yBhgTychNՋMRhgN!k 2.3.5.1.5 @?\x0?\nSO 2.3.5.1.6 ЏRRKmՋЏRRKmՋel:NRsLfՋ0 ՋߘMRTSՋNv TvЏReHhZPRsLfՋ U__s v^^(uAstrandTRyhmingvR~VlcKm[k*NSՋvg'YDd'lϑL/R 0 2.3.5.1.7 vQ[ NoS^‰[YSߘ0ylI{ 2.3.5.2 ߘV }SЏR`Q‰[ NfN;Nߘv gRNSOQRՋ[SՋՋ_YMR0~_gMRۏL N)Yvlߘg :NcdnߘV }[Ջ~gvq_T Bl=\SNe8^nߘvN0[ՋgSՋvЏRrQۏL‰[ BlNe8^ЏR`QN0 fN;Nߘv gRNSOQRՋ d_U\ NfN;NߘvchY ؏^zSO;mR0`~0]\ORI{Kmϑh50% vDe^(uyTh0 3 ~g$R[ NfN;Nߘv gRNSOQRSՋ7hTՋߘ~ꁫkSՋߘTՋߘ~N[gq~k vQSOQ+TϑQ\ v NV*Np-N\ g$N*NpQ\ pVNVKNNQ\ N]_ g>fW'`P<0.05 ЏRR N NM [:gSOeP^e Noq_T v^cdߘSЏR[ gRNSOQR\O(uvq_T S$R[SՋ7hTwQ g gRNSOQR\O(u0 fN;Nߘv gRNSOQRSՋ7hTՋߘ~ՋMRTꁫk vQSOQ+TϑQ\ v NV*Np-N\ g$N*NpQ\ pVNVKNNQ\ N]_ g>fW'`P<0.05 ϑT%{Qf[ċNe_8^ ЏRR N NM `~0]\OR NSq_T v^cdЏR[ gRNSOQR\O(uvq_T S$R[SՋ7hTwQ g gRNSOQR\O(u0 AS0 gRN9eU[^Rhel gRN9eU[^R\O(uhel9hncSՋ7hT\O(uStv N T R:NeHhNe:N;NvSՋir TeHhN N+Tb NNe:N;NvSՋir $Ny0 1 eHhN 1.1 [St :gSO-Nv~'YRPX[NSYr-N 'Y DdeQϑ NOq_T:gSOTvuS hs:NSO͑   ͑ +TϑS[^NONDdߘϑvck8^'Y 0ug'Y (WDdߘNOrevW@x NR+ReEQxx[gq~ bSՋ+TNT[~ k$N(WOۏ:gSOSvuS XRwir(+TϑTXR[^R Nv\O(u N [SՋ7hT gRN9eU[^vRۏLċN0 1.2 NhVTՋBR 1.2.1 NhVSP[8T6eRIQIQ^0[^NUSIQP[[^NbSX~[^NbvsQNhV 0|[aS:\0RirVRhVh0Rir)Ys^0105!p{0 1.2.2 ]xx O~~ ؚ/lx O~~ 'lSg 2%'lSgnm ySRg~'lSg+Tϑ'YN99.99% 25KQ R75mLO~~vx RSyP[4l1000mL0 hQnm yS1.2486KQRg~xx~^'YN99.99% R50mLSyP[4l RvxOKNn0yeQ1000mL[ϑt-N R2%'lSgnm;R^0dknm1.00mLvS_N500(g0PNZYNpt-N 4!OX[ 4N(uezʑ0 1.3 [el 1.3.1 [Rir Qu4hT]SvesN'Y SO͑~60 75KQ TN'`+R k~8 12S0 1.3.2 W@xre(udkW@xreM6RNO[gq~NSTBRϑ~0 h1 W@xreMeCa2+ teCa2+:N150mg/100gre bR%jˆ}v10.0ĞF|(15.0\b|54.0ss|lbul4.0~~ }2.0mTv(2.6mT~u }(1.0/lSƀx0.2d1 ˆ(lx0.2m|(11.0(ؚSYtT(u (mTvkkgmTv-NT~N+TϑKH2PO4 501.4gNaCl 74.0gMgCO3 50.2gsNxN 5.4gsNx 4.16gMnCO3 3.5gCuSO45H2O 0.605gNa2SeO3 6.6mgKI 7.76mgCr3Cl6H2O 0.292gR|0R1kg0 (mT~u }kkgmT~u }-NT~N+Tϑ~u }A 400,000IU~u }D3 100,000IU~u }E 500IU~u }K 5mg~u }B1 600mg~u }B2 600mg~u }B6 700mg~u }B12 1mg<\KQx 3gSx 200mglx 1.6guir } 20mgR|0R1kg0 (S9hncT~_KmSՋirbxx v(uϑm|(uϑ0 1.3.3BRϑR~SSՋ7hT~Ne [ N*NBRϑ~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ TeN*NNO[gq~150mg/100gre TNv^BRϑSՋir4ls^v Tvxx[gq~YNN*Nxx[gq~ cPzNؚBRϑ4ls^v Tvxx[gq~ 0(uNO[gq~150mg/100gre reM6RSՋ7hTTBRϑ~Txx[gq~0SՋ7hT~Ne3*Ng0 1.3.4 SՋir~N_ ~SLpÀ~NSՋir elLpÀe\SՋirceQre v^U_kSRirvreDdeQϑ0 1.3.5.[ek Qu4hTvesN'Y ~^gNhTT yߘ12\e ySO͑ cSO͑:gR~ R<{r{Q0n(uSyP[4lNMQNn4l-N_0 1.4 ‰[ch 1.4.1 SO͑Km[ yߘ12\eT Km[SO͑0khTN!k0 1.4.2 ͑ϑKm[: RirU{Q3*NgTY{k eRyQSO N105!p{-NpR`͑ yϑr^͑0 1.4.3 [^Km[: (u[^N USIQP[[^NbSX~[^NbvQ[vsQNhV Kmϑ-NpS܏_zv[^0 1.4.3.1 (W܏_zS-Np;uQhNnx[Kmϑp0 -NpKmϑpvnx[KmϑhQ ǏvQ-Np l*j*bbeT;uNv~ dk:N-NpKmϑp*bb 0 ܏_zKmϑpvnx[N܏_zsQQig NYnx[Kmϑp Ǐdkp ;uNN N-NpYhs^Lvv~ dk:N܏_zKmϑp*bb 0 1.4.3.2 KmϑMR(u!jW[NhVۏL!hQ0 1.4.3.3 ~!hQSNO(uT ~~Km[!jWv^NvQhQenNKmϑS NN[^NcKm4YyReTWvyR_Km NvQ_Kmph~NcKm4YyRhNKmϑS NvWvbq_͑T0_YKmϑ kp^͑ YKm[$N!k Y$N!k~g Ns^L]'YN10% ^S_͑eKmϑ0\$N!k~gSs^GW

fW'`FfWؚNNO[gq~N NNONv^BRϑxx[gq~ v8T6es NNONxx[gq~ S$R[SՋirwQ g gRN9eU[^Rv\O(u0 2 eHhN 2.1 [St ̖'`bt^'Y RduS]T N"X:_ v^Su͑8T6e4x \O(u'YNubb \O(uvSS0ُySShs:Nϑ"N1Y ~ǏN[evy/} SN b[^MNO!jW0(W^z!jWv Teb!jW^zKNT~!jW[~'Y eEQSՋ7hT ǏSՋirb6R4xbOۏbI{N"\O(u ‰[vQ(WXR[^RS+TϑvHeg N [SՋ7hT gRN9eU[^vRۏLċN0 2.2 [Rir WistarbSD̖'`'Y 300KQ]S [MR^1hT0 2.3 reMe SgqAIN93reMeM6RJSbTre (uS_vir(fbcre-NegnN'YFvbR NMQ'YF_ĞnI{ iir̖o }[[~gvr^pb0SMe Nh0 h2 SreMe bR+Tϑ% jˆ}v23DL-ˆ(lx0.3ss|m|32|30~~5ss|l5mTwirv13.5mT~u }21NRwxƀx0.21 +T gmg/kgre  MnSO4 110 CuSO4 0.8 FeSO4 1.2 KI 18.0 ZnSO4 2 960 CaHPO4 2 890 MgSO4 1.251040 2 +T g/kgre  VitA 1.4104IU VitD 1 500 IU VitE 120mg VitK 3mg VitB1 12mg VitB2 20mg VitB6 12mg VitB12 0.03mg px 60mg lx 24mg Sx 6mg uir } 0.54mg0 2.4 NhVTՋBR 2.4.1 NhVSP[8T6eRIQIQ^0USIQP[[^NbSX~[^NbvQ[vsQNhV0|[aS:\0RirVRhVh0Rir)Ys^0105!p{0 2.4.2 ՋBR ]xx O~~ ؚ/lx O~~ 'lSg 2%'lSgnm ySRg~'lSg+Tϑ'YN99.99% 25g R75mLO~~vx RSyP[4l1000mL0 hQnm yS1.2486gRg~xx~^'YN99.99% R50mLSyP[4l RvxOKNn0yeQ1000mL[ϑt-N R2'lSgnm;R^0dknm1.00mLvS_N500(g0PNZYNpt-N 4!OX[ 4N(uezʑ0 2.5 [T[BRϑ 2.5.1uS]Rd/gS/gT[{g 'Y ~yTl\30 mg/kg BWv b]kYnm yMOV[TNy-N~ݍ4SS3-4cmYSk R+R(uxRTR|mk _ zr^TR_vTy~2-3cm RSƉΑS}vr b_B\~b0RP[[T {{\NOP[[҉bQ (WvQ+gzSVSvuS]0RyV OS0R|~rbĞ~rvuS] Nbk@9YOOuS] 6qT\uS] NuS{Sb (uN~~Nb jRduS]hg/f&T[hQjRd zR\P[[҉VyT-N. TljRdSOuS]0yTvRB\TT Q!kmk0gT~Tl\2NUR }0_NS~̀萋 ҉RSLuS]Rd/g0:NOKb/gbR 'Y XdduS]T5)Y ۏL4SmGrhg(un{8TS\ϑutv4l {{ceQ4S1-2cm Qmpe!kT8TQ mNsGr N \ N‰[ k)YN!k ޏ~7)Y Nhg'Y uS]/f&T[hQXddYmGrHTR`S^\ N'YϑJSf0Abs^vhv~ހ hfRiruS]Rd N[hQ ^_S N(u0 g~S NۏL/gT[{g0 2.5.2 RirR~ 'Y ~^'`r{QTR~ [Rir cSO͑:gR~:NGPKb/g~0RduS]~ nBR~0RduS] NOBRϑSՋir~0RduS] -NBRϑSՋir~0RduS] ؚBRϑSՋir~0_eRduS] 3'`[gq~wQ̖o };m'`vir( 0k~Rir8 12S0 2.5.3 BRϑR~SSՋ7hT~Ne YgSՋir:N N+TNT [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0YgSՋir/f NNe:N;NS\ϑ+T vNT (W9hncbNklQeNSOcPϑn N*NBRϑSՋir~vW@x N SQNv^SՋir4ls^venNKmϑS NN[^NcKm4YyReTWvyR_Km NvQ_Kmph~NcKm4YyRhNKmϑS NvWvbq_͑T0_YKmϑ kp^͑ YKm[$N!k Y$N!k~g Ns^L]'YN10% ^S_͑eKmϑ0\$N!k~gSs^GW

fW'`FfWNONGPKb/g~ hf b'Y [^NO N!jWuS]Rd+SՋir~v+Tϑb[^uS]Rd+nBR~>fWXR vQ[chSO͑dY N>fWNONuS]Rd+nBR~ S$R[SՋirwQ g gRN9eU[^R\O(u0 NNe:N;NS+T\ϑ vNT uS]Rd+nBR~+Tϑb[^>fWNONGPKb/g~ hf b'Y [^NO N!jWuS]Rd+SՋir~v+Tϑb[^uS]Rd+nBR~>fWXR N NNONv^BRϑvCaCO3[gq~ vQ[chSO͑dY N>fWNONuS]Rd+nBR~ S$R[SՋirwQ g gRN9eU[^R\O(u0 DU_8T6e[ 1 St (W3z[r` NKm['Y DdeQvϑS|O-NcQvϑ $Nv]99.99% 25g R75mLO~~vx RSyP[4l1000mL0 2.7 hQnmyS1.2486gRg~xx~^'YN99.99% R50 mLSyP[4l RvxOKNn0yeQ1000 mL[ϑt-N R2%'lSgnm;R^0dknm1.00mLvS_N500(g0PNZYNpt-N 4!OX[ 4N(uezʑ0 3 [el 3.1 [RirQu4hT]SvesN'Y 3.2 W@xreNOreMeh1 4 RirR~SBRϑn [ N*NBRϑ~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ TeN*NNO[gq~150mg/100gre TNv^BRϑSՋir4ls^v Tvxx[gq~YNN*Nxx[gq~ cPzNؚBRϑ4ls^v Tvxx[gq~ 0(uNO[gq~150mg/100gre reM6RSՋ7hTTBRϑ~Txx[gq~0 4.1 uS QuVhTvesN'Y ~^g1hTT R<{r{Q4hT0k~\ g TN'`+RRir8S0n(uSyP[4lNMQNn4l-N_0khTKmϑ0SO͑N!k0 4.2 N"[ [3hTTۏL3)YN"[0U_3)Yۏߘϑ 6eƖ72\e|O Km[reS|O-N+Tϑ0 4.3 reS|O-NvKm[el(uSP[8T6eRIQIQ^lۏLKm[ 4.3.1 7hTǑƖN6RYre7hT~GWSmTv^Ǐ20v[{ |7hT(W80!p{-Npr^ nr^qhV-NQtSTx~0la2bk(W7hT6RYǏ z-Nvalg0 4.3.2 7hTmS9hnc7hT-Nv+Tϑ |nxySpr^x~vGWS7hT0.30-1.00g nN150mL N҉t-N Nv\oe0ReQmTx]xx:ؚ/lx=4:1 15-20mL (W5upg NRpmSvmSmQ}vpv^fer0xm NYeSNQR\ϑmTx0mSmferTRpekGSSyP[4l nqlNvdiRYOvx ͑ Y$N!k gTmSmvSOy NǏ1mL0mS7hTe^ Te\Ozz}v[ ReQNSՋ7hTmSev TSOyvmTx (Wv TagN NmS0mSmly[ϑtv^(uSyP[4l[[0 4.3.3 Km[ cgqSP[8T6eRIQIQ^NhVffNvekۏL0Km[m0hQnmTzz}vGW(u'lSgnmzʑ0 4.4 { DdeQmg/d =re-N+Tϑmg/g rem9ϑg/d |mg/d =|O-N+Tϑmg/g |OcQϑg/d 4.5 reS |-NvKm[_NS(un[lۏLGB 12398.90 0 5 pencYtS~g$R[ pencǑ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWNONv TDdeQ4ls^v[gq~Rir bSՋ7hT@b+Tv8T6es>fWNONv TDdeQ4ls^xxv8T6esR^$R[:N N\O:NeNT0 SՋ7hTv8T6esYNv TDdeQ4ls^vxxvя e>fW'`]_ SՋ7hTSN\O:NeBR0 SՋ7hTv8T6es(W$NyDdeQ4ls^ NGW>fWؚNv T4ls^xx RSN$R[SՋ7hT:N 8T6esؚ 0 ASN09eU:'`+@Rhel 1 Rir[ 1.1 St (uNOreUrRirSb_b['`:'`+@!jW Q~NSՋ7hT ‰[vQ[@m~ހf[0@muSf[I{chvq_T S$R[SՋ7hT[9eURir:'`+@v\O(u0 1.2 [Rir eP^ResN'Y USN'`+R k~'Y 8 12S0 1.3 NOre Me b RmRϑ g/kgss|m|529.5ˆnˆ}v*200.0|100.0ss|lemRBR 70.0~~ }50.0mTwirv(AIN-93G-MX)35.0mT~u }(AIN-93G-VX)10.0L-(lx /lSƀx3.0 2.5* NSO(uEDTAYtvjˆ}v AIN-93GmTwirvMe wir(mRϑ g or mg/kg mixCalcium carbonate anhydrous357.00Potassium phosphate monobasic196.00Potassium citrate, tripotassium monohydrate70.78Sodium chloride74.00Potassium sulfate46.60Magnesium oxide24.00Zinc carbonate1.65Sodium meta-silicater9H2O1.45Manganous carbonate0.63Cupric carbonate0.30Chromium potassium sulfater12H2O0.275Boric acid (17.5% B), mg81.50Sodium fluoride (45.24% F), mg63.50Nickel carbonate (45% Ni), mg31.80Lithium chloride (16.38% Li), mg17.40Sodium selenate anhydrous(41.79% Se), mg10.25 AIN-93GmT~u }Me ~u }mRϑ g/kg mixNicotinic acid3.000 Ca pantothenate1.600Pyridoxine-HCl0.700Thiamin-HCl0.600Riboflavin0.600Folic acid0.200Biotin0.020Vitamin B-12 (cyanocobalamin) (0.1% in mannitol)2.500Vitamin E (all-rac-a-tocopheryl acetate)2 (500 IU/g)15.000Vitamin A (all-trans-retinyl palmitate)2 (500,000 IU/g)0.800Vitamin D-3 (cholecalciferol) (400,000 IU/g)0.250Vitamin K-1 (phylloquinone)0.075Powdered sucrose974.655 1.4BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*NNO[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~kxxNbsNxN BRϑ:N2 ppmb2 mg/kg BW NFeCQ } 0SՋ7hT~Ne30)Y _eS^45)Y0 1.5 [ek 1.5.1 ^z:'`+@'Y !jW (ueP^esN'Y (W[sX N^3 5)YTrNNOreSSyP[4lbS4l Ǒ(u N<{SߘP Te Ǒ(ujR>\S@l>e@ 5)YN!k k!k0.3 0.5ml0[Ǐ z-NMQalg0,{3hT_YkhT SR'Y Ǒ>\@KmHb YYpeRirHbNON100g/Le Km[hQ'Y vSO͑SHb0 1.5.2 b` Y[ SHb<100g/Lv'Y \O:N[Rir 9hnc+@'Y Hb4ls^TSO͑\vQ:gR:NNO[gq~T N*N[~ T~GW~~rNNOre NO[gq~~Nv^nBR [~R+R~N N TBRϑvSՋ7hT SՋ7hT~Ne30)Y _eS^45)Y Km[SO͑STy@mf[ch0 1.6 ‰[ch SO͑0@~ˆ}v0~~ހky/~~ހQ8nyS_SIU0 1.6.1 @~ˆ}vKm[0lSؚl mIQ|pelThQf~lN vQNKm[@~ˆ}v0 1.6.1.1 8TIQ|pel 1.6.1.1.1 St @~ˆ}vhaemoglobin Hb 0lS'lSTubؚ@~ˆ}v QN0lyP[~Tb_b0lSؚ@~ˆ}v~r 0lSؚ@~ˆ}v~r g:N3z[ (W540nml N id\8TIQ|pe:N44000 ncdk (uRIQIQ^lKmvQIQ[^ Џ(u8TIQ|pe\O@~ˆ}vv[ϑKm[0 1.6.1.1.2 NhV RIQIQ^0 10_GS_ϑ8T{0 1.6.1.1.3 ՋBR ySxx"lNaHCO3 AR 140mg00lS200mg00lS50mg (u4lnv^zʑ0R1000mL0.X[NhrՋBRtQ (WfYbQ{4! OX[ \S3z[peg0R1t^0 1.6.1.1.4 [ek 1.6.1.1.4.1 SՋBR2.5mLN5mL&^vՋ{-N ReQ10L@m mST >en15R0 1.6.1.1.4.2 (u0.5Ss|IQ_krog N540nml N NՋBRp \@b_7hT{KNIQ[^XNN736 sS:N@~ˆ}vSm^g/L 0 {lQ_Y N Ct = Ct=_Kmv@~ˆ}vg/L Sm^0 = 0lSؚ@~ˆ}v(W540nml NKmQvIQ[^0 251 = Km[e@mvzʑ Ppe@10LReQՋBR2.5mL-N 44000 = 0lSؚ@~ˆ}vvid\8TIQ|pe 0.5 = krogvIQ_ 64458 = @~ˆ}vvRP[ϑ 1.6.1.1.5 laNy 1.6.1.1.5.1 ՋBR N>e(WZYNptQ NMQV0lyP[NvQS^ OՋBR\O(uMNO0 1.6.1.1.5.2 NhVVid\8TIQ|pel[hQO`NhVv8TIQ^eg{ EedklBl@b(uvNhV'`&{TBlYNhVvlQnxN&T NSupOe^S~'`I{ &TR\vcq_TKm[v~g0 1.6.1.1.5.3 NhV(WO(uMRg}Y^NWHOĉ[v0lSؚ@~ˆ}vSm!hckTQO(u0Smg}Y (uICSHVE@mf[hQSYXTO nx[v1uRIVwpQVzlQqQkSuxvzb 6R\Ov0lSؚ@~ˆ}vSmb Nwm;Sf[S@b6RYv0lSؚ@~ˆ}vhQm0 1.6.1.2 hQf~l 1.6.1.2.1 St @~ˆ}vhemoglobin Hb (W0lST0lSv\O(u Nubg:N3z[v0lSؚ@~ˆ}v~r vQrmEmN@~ˆ}vv+Tϑbckk0(uRIQIQ^(W540nml N Km[@~ˆ}vhQTTShQir(v8TIQ^ 6RbhQf~ Km__Km7hTv8TIQ^TghQf~sSS_HbvSm^0 1.6.1.2.2 NhV 10L@r }8T{b[ϑk~{ 5mLb10mL&^vՋ{ RIQIQ^ 1.6.1.2.3 ՋBR ySxx"lNaHCO3 AR 140mg00lS200mg00lS50mg (u4lnv^zʑ0R1000mL .X[NhrՋBRtQ OX[N4!Q{S3z[1t^0 1.6.1.2.4 [ek 8TS2.5mLՋBRN5mL&^vՋ{-N (u10L@r }8T{b[ϑk~{ S'Y >\@bY @10L>enN]>eeQՋBRvՋ{-NmS>en15min0 (u0.5cmIQ_krog N540nml N NՋBRNhVp Km[T7hT{v8TIQ^ TeKm[@~ˆ}vhQTShQir(v8TIQ^ ~6R@~ˆ}vvhQf~0ghQf~SBl__Km7hTTShQir(v@~ˆ}v+Tϑ(g/L) {Sir(vV6es0 1.6.1.2.5 laNy 1.6.1.2.5.1 N\ՋBR>e(WZYNptQ NMQV0lyP[NvQS^ OՋBR\O(uMNO0 1.6.1.2.5.2 N[vcO(umIQ|peel{@~ˆ}vv+Tϑ V:NNhVvlQnxN&T0NhVvupOe^T~'`I{V }GWvcq_TKm[~g0 1.6.1.2.5.3 k!kKm[e (W N TS YKm[@~ˆ}vhQmTShQir(NO0-N0ؚ3*NSm^ 0 1.6.1.3 pencYtS~g$R[ [pencS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` NSՋ7hT~MRTGSؚE^^s^GW0R10g/LN N $R[勞[~g3'`0 1.6.2 ~~ހQ8nyS_SIUKm[ 1.6.2.1 St @~ˆ}vvTbǏ z-N |^~~ހ-NvS_SIU(W@~ }Tbvv\O(u NN~T S_O^ Ne ~~ހQvS_SIUCNN8nyb__/}ywegǏck8^4ls^0Vdk hKm~~ހQ8nyS_SIUFree erythrocyte proloporphyrin FEP v+Tϑ/fhg:'`~~ހubv gHeel0 @m7hT~utv4lzʑT R+RNYNxYNoYNxmTm4:1 T0.5NvxcSRy@-N8nyS_SIU (WN[l NKm[vQS_SIUvgIQ:_^ [ϑ0 1.6.2.2 NhV 1.6.2.2.1 gIQRIQIQ^b930WgIQIQ^0 1.6.2.2.2 y_:g0 1.6.2.2.3 mehV0 1.6.2.3 ՋBR 1.6.2.3.1 }bQBR N/e12500USMOv }N0.9%utv4lzʑ25mL1mL=500USMO 0 1.6.2.3.2 5 %W/V ExWutv4l`Jmm yS5gExWR0.9%utv4l100mL0 1.6.2.3.3 4:1YNxYNoTYNxmTm0 1.6.2.3.4 0.5N HCl0 1.6.2.3.5 S_SIUhQm0 1.6.2.3.5.1 S_SIUhQ.Ym50mg/L yS5mgS_SIU R4mLe4lYNOKNn N1.5N HClzʑ100mL0 1.6.2.3.5.2 S_SIUhQ-Nm1.0mg/L S2mLS_SIU.Ym NYNxYNoNYNx4:1 mTmzʑ0R100mL0 1.6.2.3.5.3 S_SIUhQ^(um0.1mg/L S1mLS_SIU-Nm NYNxYNoNYNx4:1 mTmzʑ0R10mL0 1.6.2.4 [ek Ջ BR 7hT{ zz}v{ hQ{ }mL 0.10 0.10 0.10 hQ@mL 0.02 ( ( 4l mL ( 0.02 0.02 5%ExW`JmmmL 0.15 0.15 0.15 S_SIUhQ^(ummL ( ( 0.5 YNxYNoNYNx4:1 mTmmL 4 4 3.5 l c NhO!kReQTyՋBR (WReQYNxYNoNYNxmTmMR (umehVmT]ReQvmTm 6qTmTReQYNxYNoNYNxmTm0 y_15R \T{ NnmR+RPeQ10mLkr{-N k{R4mL 0.5Nvx /cGd5RYbkOKNRB\ \ NB\nBRbQ_S Km[vxmvgIQ:_^30RQkr 0 1.6.2.5 gIQKmϑ 1.6.2.5.1 O(uezMPF-4WgIQRIQIQ^Km[agN:NoSl:N403nm r10nmS\l:N605nm r:N5nm mi:N1cmSwi0 1.6.2.5.2 O(uVN930WgIQIQ^KmՋ agN:NoSnIQGr420 gIQnGr550 upOe^ 1500 n^_sQ_g'Y mi:N1cmSwi hQupOe^:N0.01g/4mL0(W N TϑS_SIU0g 0.01g 0.03g 0.05g 0.07g 0.1g HT~'`sQ|0 1.6.2.6 { 7hTgIQ:_^(zz}vgIQ:_^ 100 @-NS_SIU+Tϑg/LhQ@ = %%%%%%%%%%%%%%%hQ{S_SIU+Tϑg %%%%%%%%%10 hQ{gIQ:_^(zz}vgIQ:_^ 7hTS7hϑ(mL) 1.6.2.7 pencYtS~g$R[ [pencS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` sSS$R[勞[~g3'`0 1.6.2.8 laNy 1.6.2.8.1 gIQ:_^e^ np FO30RQW,g3z[0 1.6.2.8.2 RYNxYNo-YNxmTme N[mTReQ &TRq_TKm[~g0 1.6.2.9 n~lKm[ \n g20_GS@phQjR N>eeQՋ{-N TeS T7h'Y\zz}vn~>eeQhQ{Tzz}v{-N T{GWReQ5%ExW`Jmm0.2NGS /caT>enǏY N Nek Tvcl0 { FEP_KQ/100kGShQ@ =C/BA/D100 A=hQ{S_SIU+Tϑ0.02kKQ B=hQ{gIQ:_^-zz}v{gIQ:_^ C=@7hgIQ:_^-zz}v{gIQ:_^ D=S7hϑ 1.6.3 ~~ހSyKm[O(uhQꁨR@~ހRgNۏL0pencYtS~g$R[ T 1.6.2.7 0 1.7 pencYtT~g$R[ [pencS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` NvQMRTs^GWGSؚE^^0R10g/LN N Te SՋ7hT~~ހQ8nyS_SIUb~~ހSyNNO[gq~vk]_ g>fW'` S$R[SՋ7hT9eU:'`+@RRir[~g3'`0 1.8 laNy ,gy[sQ.(WN+@!jWv^z0NOre+Tϑg}Yc6R(W9mg/kgN N @b(uՋBR^:NRg~ Rirn(u4l^:NSyP[4lbS4l Ǒ(u N<{wQ @b(uhVv^(u10%]xxnmYt0[Ǐ z-N%N2YegvalgS|_dkNSalg0 2 NSOՋߘՋ 2.1 SՋ~eQhQ SՋ:N\~ހNOr }+@ N gfnxv:SVT4N^hsvbNT?Qz0 2.1.1 bN~eQhQ7u'` Hb 80g/L 130g/L sY'` Hb 80g/L 120g/L0 2.1.2 ?Qz~eQhQd"6\?Qz Hb 70g/L 110g/L7 18\R\t^80g/L 120g/L0 2.2 SՋcdhQ 2.2.1 Tv^ g_0@{000mSSI{%N͑uuS|^yu`0 2.2.2 ǏOeSO(b[SՋ7hTǏOe0 2.2.3 %N͑+@`0 2.2.4 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.2.5 *g chQ g(uSՋ7hT0De NhQq_TRHeb[hQ'`$Re0 2.3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋv@~ˆ}v4ls^:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Y'`+R0t^0~NmrQI{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq _NS g(uwQ g T7h\O(uv3'`ir0SՋ7hT~Ne30)Y _eS^120)Y0Ջg N9eSSegvnߘ`N` ck8^nߘ0 2.5 ‰[ch 2.5.1 [hQ'`ch 2.5.1.1 N,rQSb|^y0aw w0nߘ0'Y\O0@SI{ 2.5.1.2 @0?\0O8^ĉhg 2.5.1.3 0Rhg?QzSՋ NKm[dky 2.5.1.4 yB0Gr0_5uVhgTych(WՋMRhgN!k ?QzSՋ NKmdky 2.5.2 ߘg NՋ_YMR0~_gMRۏL N)Yvlߘg ‰[nߘV }[Ջ~gvq_T0 2.5.3 ur‰[ ߘ2k N/c0ONR0p04YUf0e\MQul  2.5.4.2.1 St N@n-Nvˆ}vSF NReQv125I hvSFzN'`0WNbˆ}vbSO~T0(u,{NbSORy~TR R+RKm[;`>e\'`Nlmir>e\'`pe0OnchQSFՋBR\OQhQf~ N S(Wf~ NgQv^7hT@nvSFSm^0 *SF+Ab !! *SF Ab+*SF + SF !! SF Ab + SF *SFhvˆ}v SF*ghvˆ}v Abbˆ}vbSO 2.5.4.2.2 NhV y_:g0symbol 103 \f "Symbol" \s 12!*g~b0R_(un0-\~peN0 2.5.4.2.3 ՋBR 125I @nˆ}v>e\MQuRgՋBRv.0 2.5.4.2.4 d\Oek 2.5.4.2.4.1 d\Oekˆ}vKm[d\O z^TՋBR(uϑmL  Nh 2.5.4.2.4.2~6RhQf~ NThQ{vB/ B0 %\O~PWh hQˆ}vSm^:N*jPWh[pe \OhQf~07hTb(c1uB/ B0 %fe @n]Q\ :N/feg:'`+@ʋeOncKNN0 2.5.4.3.2.1 )YRBvkrl )YRBv\O:N>frBRKm@n kǏSYǑ(uvT!TvUI{\O:N>frBR gؚvupOe^ vQKQRP[8TIQ|pe(W630nml N:N1.68105 Lmol-1cm-10S'Y'YQ\7hT@nϑ el{O Qnx0 2.5.4.3.2.1.1 St Fe3Fe2N)YRBCAB TASmQpW N2uWnSCTMA S^ b_b NCQVr~TirOՋBRrRm vQrRm z^N@n+Tϑbckk (WpH:N4.6 5.5 l:N630nme gg'Y8T6e\ )R(ugjx9:Nvc=BR 7hT:Nꁫzz}v Ndˆ}v sSSKmQ@nv+Tϑ0 2.5.4.3.2.1.2 ՋBR 2.5.4.3.2.1.2.1 Qnm pH4.75 S25ge4lx 110g/lS 8mLQx (u4l[[1000mL0(ux^KmpH^:N4.750 2.5.4.3.2.1.2.2 >frBR 2.5.4.3.2.1.2.2.1 0.1%)YRBvnmAm S0.1g)YRBv [[Nl00mL4l-N >e(Whrt-NS(W[)n NOX[1*Ng0 2.5.4.3.2.1.2.2.2 0.3%ASmQpW N2uWnSBm SASmQpW N2uWnS0.3g (u4l[[100mL0 2.5.4.3.2.1.2.2.3 >frBR^(umS90mL Bm 60mL Am \_mS (uQnm[[1000mL >e(WhrtQSOX[1*Ng0 2.5.4.3.2.1.2.3 c=BRy17.0ggjxC6H8O7H2O 35.0ggjxNa3C6H5O7H2O ~R50mL4lRpRn QtST[[l00mL0 2.5.4.3.2.1.2.4 hQm 2.5.4.3.2.1.2.4.1 .Ym3mmol/L S1.176gkxxN6RP[~vf4l \ϑ4l-N R50mLSm]xxmSS^10R (u4l[[1000mL0 2.5.4.3.2.1.2.4.2 ]\Om30mol/L S10mL.Ym (u4l[[1000mL0 2.5.4.3.2.1.3 el c NhReQTyՋBR0 7hT{hQ{zz}v1zz}v2zz}v3@nmL 0.10.1Feh30mol/L 0.14lmL 0.10.1>frBR^(ummL 3.03.03.03.03.0=BRmL 0.10.1mS >en20R (W721WRIQIQ^ N l630nm Nzz}v{pU_IQ[^0 l`$7hT{ThQ{Nzz}v10p a$zz}v{2Nzz}v30p0 2.5.4.3.2.1.4 { 7hT{IQ[^ zz}v2{IQ[^  @nSm^molL = 30 hQ{IQ[^ 7hT{IQ[^ zz}v2{IQ[^  b @nSm^g100mL = 167.55 hQ{IQ[^ 2.5.4.3.2.1.5 laNy 2.5.4.3.2.1.5.1 Bl@b(uhVv(u2NvxxmlǏY ՋBR~^:NRg~N N @b(u4l:NS4lbSyP[4l0 2.5.4.3.2.1.5.2 QmpH[~gq_T'Y Km[epH^O(W4.70 4.80KN0 2.5.4.3.2.1.5.3 %Ne(W4!Q{ 1mL+T1mg0 2.5.4.3.2.2.1.2.2 h]\OmS10mL.Ym (u0.1Nvx[[l00mL lmL=l00g0 2.5.4.3.2.2.2 d\O 2.5.4.3.2.2.2.1 7hT6eƖSYt SY @2mLNv gl0mgIxv5mLՋ{-NNkՋ{-NReQ0.2mL5%Ix np{-Npr^sSb y_3000l/R 15R0\RyQv@Fm8TeQSN&^v\Ջ{-N Y(u0 2.5.4.3.2.2.2.2 mS S1.0mL@Fm N100mLؚWpog-N ~R3mLmTxmSm Nvhv >enpe\ebǏY (Wltm5upg N__Rpnql (WQ}vrSmpop\O(uTnmHTerbmĞr0S^~N S Npogx(uϑ NY gTSQsnmSўsa dkeSQR2 mLmTxmSm~~mSvNr 0QtST(u10 20mLSyP[4lQmhvTogX dShv~~Rp v0RQ^Q}vrSmp _nmSOycяr^ kYuxϑ NǏl mL S NQtS (u4lzʑ3mL0 2.5.4.3.2.2.2.3 Km[ 8TS0.0mL 0.5mL 1.0mL 2.0mL 3.0mL 5.0mLhQ^(um (u0.1Nvx[[100mL mT T[ϑt-NkmLR+RvS_N0g 0.5g 1g 2g 3g 5g0 \YtTv7hm ՋBRzz}v h|RnmR+R[eQkp0qۏLKm[ Km[agNPekin-Elener403WSP[8T6eRIQIQ^ l248.3nmzz_4gop5uAm30mA r[0.2mm zzlAmϑ13.51/min YNpAmϑ5.21/R0N+Tϑ[^Sm^8TIQ^~6RhQf~ 9hnchQf~Bl_7hT+Tϑ0 2.5.4.3.2.2.2.4 { A1 A2 V  X 100 m _-NX% @Fm-Nv+Tϑg/100mL@n 0 A1%Km[(u7hTm-Nv+Tϑmg/L 0 A2%Km[zz}vm-Nv+Tϑmg/L 0 V%7hTYtm[[;`SOymL 0 m% @FmS7hϑmL 2.5.4.3.3;`~TϑKm[ 2.5.4.3.3.1ՋBR 2.5.4.3.3.1.1 hQm 2.5.4.3.3.1.1.1 )YRBvl 2.5.4.3.3.1.1.1.1.Ym3mmol/L S1.176gkxxN6RP[~vf4l n4l-N R50mLSm]xxmSS^10R (u4l[[1000mL0 2.5.4.3.3.1.1.1.2 ]\Om30mol/L S10mL.Ym (u4l[[1000mL0 2.5.4.3.3.1.1.2 SP[8T6eRIQIQ^l 2.5.4.3.3.1.1.2.1.YmS1.0000g~ё^\ (uvxb]xxnT (u0.1Nvxzʑ0R1000mL yeQZYNpQXetQ X[>e4oCQ{ 1mL+T1mg0 2.5.4.3.3.1.1.2.2 ]\OmS10mL.Ym (u0.1Nvx[[100mL 1mL=100g0 2.5.4.3.3.2 {(xxAAR bx_xxA vQ(ϑ^&{TBl0 2.5.4.3.3.3[ek 2.5.4.3.3.3.1 ^(u)YRBvelKm;`~Tϑ S0.1mL@n>eeQ\^y_{ R60mol/LhQm0.1mLEQRmT [)n>en15R0QR4 5mg{(xxA >en15R mT3 4!k06qTN3000l/Ry_5 8R S Nnm0.1mL c)YRBvkrlKm@nvekۏLd\O {0 2.5.4.3.3.3.2 SP[8T6eRIQIQ^lKm;`~Tϑ S1.0mL@n RhQm20g/mL 0.5mL EQRmT >en15R0R150mg{(xxA EQRmS1RN N >en30R mT3 4!k0y_10R S Nnm1mL cSP[8T6eRIQIQ^lKm@nvd\OekۏLmS Km[ {0 2.5.4.3.3.4 { 2.5.4.3.3.4.1 @n;`~TϑS(umg/100L h:y0 2.5.4.3.3.4.2 *gqTϑ=@n;`~Tϑ @n0 @n @nˆ}vЏˆ}vqT^% = %%%%%%%%%% 100 @n;`~Tϑ 2.5.4.3.4 pencYtS~g$R[ [pencS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` sSSR+R$R[ch~g3'`0 2.6 pencYtS~g$R[ Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(uthbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 ~g$R[ 9eU?Qz:'`+@ՋMRTꁫkTՋT~k @~ˆ}v0~~ހQ8nyS_SIUNych]_ g>fW'` Te Ջߘ~ꁫMRTk @~ˆ}vs^GWGSؚE^^e"10g/L S$R[SՋ7hTwQ g9eU:'`+@Rv\O(u0 9eUbN:'`+@ՋMRTꁫkTՋT~k @~ˆ}vch]_ g>fW'` Te Ջߘ~ꁫMRTk @~ˆ}vs^GWGSؚE^^e"10g/L @nˆ}v0~~ހQ8nyS_SIU/@nЏˆ}vqT^Nych-NNych3'` S$R[SՋ7hTwQ g9eU:'`+@R0 ASN0 gRN9eUuuRhel 1 SՋ~eQhQ b4N^uuI III^v?aSՋ` 7usYGWS0 2 SՋcdhQ 2.1 t^(W14\N Nb65\N N Y ZbTsNgYsY S[,gOePߘTǏOe0 2.2 Tv^ g_00@{00T @|~I{%N͑'`uuS|^yu`0 2.3 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.4 *g cĉ[ g(uSՋ7hTvSՋ De NhQq_TRHeb[hQ'`$Re0 3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋvuu`Q:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^0'`+R0u zI{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq0SՋ7hT~Ne30)Y _eSN^45)Y0SՋ(WՋg\PbkO(uvQ[S gSY(u gsQ{Q[yuuv(uT0Ջg N9eSSegvnߘ`N` ck8^nߘ0 5 ‰[ch 5.1 [hQ'`ch 5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{ 5.1.2 @0?\0O8^ĉhg 5.1.3 0Rhg 5.1.4 Gr0_5uV0yBhg(WՋ_YehgN!k 5.2 RHe'`ch 5.2.1 vlNvKm[ (ur^Qht84lnmKmvRNb:N;N dr^15RTKm[vlN Km[SgqhQ lN9-27:Nck8^0<9:NNOl0>27:Nؚl 5.2.2 uuvu ‰[SՋՋߘMRTte*NbMOvuuvu9eS`Q0 ՋߘMRTR+RU_b}v4Y|:R0ў4Y|:R0p'`Nu0S0V0~pevSv_cv z^0 6 pencYtS~g$R[ RHe$R[ gHeuupeϑQ\e"30% v_c z^Q{N^0 eHeuupevQ\<30% v_c z^eSS0 9hncv_c z^0uupeϑI{4N^`QۏLR~ [ՋߘMRTuupeϑ0v_c z^yRۏL~ Te{ gHes0 v_c z^R~TyR I ^ў4Y|:R ceSYS p'`NuceS0 1R II ^I ^ Em(W'`u p'`NupevXR @\P(Wb0 2R III ^II ^ m(W'`p'`Nu0~ Sub00̀ 3R c! ^III ^ V fb_buu SuN NJS 4R Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 gHesǑ(u(2hۏLh0VfQ\ N'YNI{N20% v_c z^yRf>fQ\ ]_GW g>fW'` vlN N>fWXR S$R[SՋ7hTwQ g gRN9eUuuRv\O(u0 AS N0 gRN9eUĞeRhel 1 SՋ~eQhQ ~SOh&{T NRagNv?aSՋ0 1.1 bmrmr LuPnZiveGr 8^[y'`R^ ep'`hsSޜQ\0 1.2 ef>fɉur0 1.3 ;NSu(WR%fgT sY'`YS0 1.4 gN[vc['` Y͑Q{0 1.5 ef>fQRluu v^cdvQ[uu_wvr }l@w0 2 SՋcdhQ 2.1 t^(W18\N Nb65\N N Y ZbTsNgYsY ǏOeSO(S[,gOePߘTǏOe0 2.2 Tv^ g_@{0@{00T @|~I{%N͑uuSQRluu |^yu`0 2.3 URb8Tp0 2.4 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.5 *g cĉ[ g(uSՋ7hT el$R[RHebDe NhQq_TRHeb[hQ'`$Re0 3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋvĞer0by`Q:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Y7bY;mR`Q0'`+R0t^I{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq0SՋ7hT~Ne30)Y _eSN^60)Y0SՋ(WՋg\PbkO(uvQ[S gSY(u gsQ{Q[yev(uT0Ջg N9eSSegvnߘ`N` ck8^nߘ0 5 ‰[ch 5.1[hQ'`ch 5.1.1 N,rQSb|^y0aw w0nߘ0'Y\O0@SI{ 5.1.2 @0?\0O8^ĉhg 5.1.3 0Rhg 5.1.4 _5uV0Gr0yBhg(WՋ_YMRhgN!k 5.2 RHe'`ch 5.2.1 bĞeby'Y\hKm(uh:\KmϑSՋMRTte*NbĞevbymm2 5.2.2 bĞermEmhKm cgq-NVyf[b0Wtxvz@bx6R Km~QHr>y1992t^QHrv 0[(uhQraS 0,{NHr -NvhrY M BKsSĞ T~ ўvSr raS:NĞemEmv$RehQI^1502005 II^30040010 III^40060015 6 pencYtT~g$R[ [ՋߘMRTĞeryRTbySSۏL~ Te{ gHes0raS`!^0a!^Tb!^R+R1R02RT3R0 RHe$R[hQ gHeĞer NMI^ byQ\'YN10% N NNueĞe0 eHeĞerSbyef>fSS Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nn0ck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 gHesǑ(u(2hۏLh0Vf NM ꁫMRTkSN[gq~k ]+RGW g>fW'` N NNuevĞe S$R[SՋ7hTwQ g gRN9eUĞeRv\O(u0 ASV0 gRN9eUv4lNrQRhel 1 SՋ~eQhQ 30-50\ Ǒ(ulQvNNv4lNKm[N bv4lNOPNO\O:N~eQhQ0 2 SՋcdhQ 2.1 Y ZbTsNgYsY ǏOeSO(S[,gOePߘTǏOe0 2.2 Tv^ g_@{000 @|~'`uuT|^yuS0 2.3 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.4 *g cՋBl g(uSՋ7hT el$R[RHebDe NhQq_TRHeb[hQ'`$Re0 3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋvv4lN`Q:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^I{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~ g(uI{ϑ[paBR0SՋ7hT~Ne30)Y _eSN^45)Y0SՋ(WՋg N_ g(uvQ[Ocv4lNvirTSq_T~g$R[vSYT0Ջg N9eSSegvnߘ`N` ck8^nߘ0 5 ‰[ch 5.1 [hQ'`ch 5.1.1 N,rQSb|^y0aw w0nߘ0'Y\O0@SI{ 5.1.2 @0?\0O8^ĉhg 5.1.3 0Rhg 5.1.4 Gr0_5uV0yBhg(WՋ_YehgN!k 5.2 RHe'`ch KmՋMR wvv4lN0 Km[sX(W[^e0ΘagNo}Y )n^0n^I{zzsX3z[vhg[ۏL0 (W[Yr` N(umQht84lnmKmMO dr^T15RۏL4lNvKm[ ՋߘMRTKm[]\O1u TNSNhV0 TNNd\O0 6 pencYtT~g$R[ [ՋߘMRTv4lNSSۏL~0 RHe$R[hQ gHe4lN_0R9eU v^~~f[h g>fW'`]_0 eHe4lNl g_0R>fW9eU0 Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(uthbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 ~g$R[ Ջߘ~v4lNf>f9eU ՋߘMRTꁫkSN[gq~k ]_GW g>fW'` S$R[SՋ7hTwQ g gRN9eUv4lRrQRv\O(u0 ASN0 gRNS̃Rhel 1 Rir[ 1.1[Rir cP(uяN|\ 18 22g USN'`+R k~10 15S0 1.2BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hT~Ne14)Y _eSN^30)Y0 1.3 [ek (W~NSՋ7hTKNMR ẽǑS\ 蕅Q|O0.1g 10 P|Rzʑ bTvzʑ^R+Rcy(WTW{QW N0W{QT Ñ=b_`0ipQlgr\h0uSS^I{t[pẽ= {QkKQnO-Nṽpe S[peTۏL~Yt0gTN!k~NSՋ7hTKNT24h N[MR T7he_Sv|O hKmS̃ el T N0 1.4 ‰[ch SO͑0SgkFg̃0sNFg̃0t̃0Fg̃0NlZh̃0 1.5 pencYtT~g$R[ DeS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` b[T[~N[gq~~k]_ g>fW'`0N[~[MRTꁫk]_ g>fW'` &{TN NNNy SN$R[SՋ7hTRir[~g3'`0 1.5.1 |O-NSgkFg̃T/bsNFg̃f>fXR NlZh̃Q\b NXR Fg̃0t̃ef>fSS0 1.5.2 |O-NSgkFg̃T/bsNFg̃f>fXR NlZh̃Q\b NXR Fg̃T/bt̃f>fXR FOXRvE^^NONSgkFg̃/sNFg̃XRvE^^0 2 NSOՋߘՋ 2.1 SՋ~eQhQ 2.1.1 N*NgQ*g`ǏÀuu0 2.1.2 N*NgQ*g g(uǏbu }0 2.2 SՋcdhQ 2.2.1 t^(W65\N N Y ZbTsNgYsY ǏOeSO(S[,gOePߘTǏOe0 2.2.2 Tv^ g_@{0@{00T @|~I{%N͑uuSQRluu |^yu`0 2.2.3 \P gSՋ7hTb-NR gvQ[oir el$ReRHebDe NhQ0 2.2.4 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋṽrQ:gR:NՋߘT[gq~ =\SQq_T~gv;NV }Yt^0'`+R0nߘV }I{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq0SՋ7hT~Ne14)Y _eSN^30)Y0Ջg N9eSSegvnߘ`N` ck8^nߘ0 2.5‰[ch 2.5.1 [hQ'`ch 2.5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{ 2.5.1.2 @0?\0O8^ĉhg 2.5.1.3 0RhgN(WՋ_YMRhgN!k 2.5.1.4 Gr0_5uV0yBhgN(WՋ_YMRhgN!k 2.5.2 RHe'`chSgkFg̃0sNFg̃0t̃0Fg̃0bFg̃0NlZh̃0 2.6 Ջek(W~NSՋ7hTKNMR ẽǑSSՋ|O1.0g 10 P|Rzʑ bTvzʑ^R+Rcy(WTW{QW N0W{QT Ñ=b_`0ipQlgr\h0uSS^I{t[pẽ= {QkKQnO-Nṽpe S[peTۏL~Yt0gTN!k~NSՋ7hTKNT24h Q!khKm el T N0 2.7pencYtT~g$R[ Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 &{TN NNNy NՋ~ՋߘMRTꁫkSՋߘTՋߘ~N[gq~k ]_GW g>fW'` SN$R[SՋ7hTwQ g gRNS̃Rv\O(u0 2.7.1 |O-NSgkFg̃T/bsNFg̃f>fXR NlZh̃Q\b NXR Fg̃0t̃0bFg̃ef>fSS0 2.7.2 |O-NSgkFg̃T/bsNFg̃f>fXR NlZh̃Q\b NXR Fg̃T/bt̃0bFg̃f>fXR FOXRvE^^NONSgkFg̃/sNFg̃XRvE^^0 DS̃h(uW{QWTW{QelRirTNSO(u yv W{QW W{QagN t[el Fg̃ O~݄frW0g NSPls^g0 t̃W{QWS.l ~vf+} NSPls^g0 2 mTb̃ }vM6R\aS } 100mg0e } 100mg0NS } 1 mg ňeQ\tQ ReQ1 mLẽ4l EQRnT Y(u0 NlZh̃ b'`W{QWTSCPls^g0 D-sN(lxnmM6Rn1g D-sN(lxN200mL4l Ǐnd̃T N4!QυOX[Y(u0 SgkFg̃ b'`W{QWBBLeeQ50mLv N҉pt-N ReQ0.05mol/Lvxnm15mLGdS >eeQe6R\Ovˆ}v{$N9h0^X}YtS (W37!R`)n{-Nu[24\e SQˆ}v{ (u:\Kmϑˆ}v{$NzfRv^mm NVzKNfW'`FfW'` Nߘir)R(usN4'`[gq~k Nf>fMNO S$R[勞[~g3'`0 1.6.2 \ЏR[ (W!jWbzvMRc N [~N!jW[gq~k XAlcۏsXR ~~Yt]_ g>fW'` S$R[勞[~g3'`0 1.6.3 mSvvKm[ [~N4'`[gq~k Àmϑ0Àˆ}vv;m'` Àˆ}vvcQϑ Nych-NNNchXR ~~Yt]_ g>fW'` S$R[勞[~g3'`0 ~g$R[ RirSO͑0SO͑X͑0Ddߘϑ0ߘir)R(us \ЏR[TmSvKm[ Neb-NNNeb[~g3'` S$R[SՋ7hTRir[~g3'`0 2. NSOՋߘՋ 9hnc N TSՋ7hT^Nv:S+R gRNmSRNSOՋߘՋ^z$NWYՋߘՋeHh sS[^N;N:N?Qzv?QzeHhT^N;N:NbNvbNeHh0 2.1 ?QzeHh 2.1.1 SՋ~eQhQSՋ b1uUS~nߘ NsO bvSO͑(W Ts^GWck8^SO͑50% vDe^(uyTh0 2.1.6.1 ߘ2k9eUߘ2kċNR:Nߘ2ksOۏe gߘ2k U"kTm 3R ߘ2kSۏeTmFOk T?Qz\ 2R ߘ2k]ۏe N?aTm k T?Qzf>fQ\ 1R N~0 ՋߘMRTՋߘ~ꁫk ߘ2kċRf>fXR ՋߘTՋߘ~N[gq~k ߘ2kċRbvQՋMRTv]fW'` S$R[ch3'`0 2.1.6.2 ۏߘϑ9eUՋߘMRTՋߘ~ꁫkۏߘϑf>fXR ՋߘTՋߘ~N[gq~k ۏߘϑbvQՋMRTv]fW'` S$R[ch3'`0 2.1.6.3 OPߘ9eUOPߘċNR:NeOPߘۏe Ncߘ 3R -NI{OPߘۏecߘFO(WR Nۏߘ 2R OPߘۏecߘ%N͑ (WR NN Nۏߘ 1R N~0 ՋߘMRTՋߘ~ꁫk OPߘċRf>fXR ՋߘTՋߘ~N[gq~k OPߘċRbvQՋMRTv]fW'` S$R[ch3'`0 2.1.6.4 SO͑KmϑT@~ˆ}v+TϑvKm[ ՋߘMRTՋߘ~ꁫk SO͑b@~ˆ}vf>fXR ՋߘTՋߘ~N[gq~k SO͑b@~ˆ}vf>fXR ~~Yt]_ g>fW'` S$R[SO͑b@~ˆ}vch3'`0 2.2 bNeHh 2.2.1 SՋ~eQhQ bR'`mS No 4O ggÀ N ;Nɋߘ2k N/c eq0lY Àn UTT NfSVba'`ylb'YOy~I{?aSՋ0 2.2.2 SՋcdhQ 2.2.2.1 %`'`yl0 2.2.2.2 %N͑hV('`uS_wvmS No0 2.2.2.3 SO(Z1_elcSՋ0 2.2.2.4 Tv^ g_@{00T @|~I{%N͑hQ'`uu`0 2.2.2.5 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.2.2.6 *g cBl g(uSՋ7hT el$ReՋߘ~g0 2.2.3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 cSՋvmSur{͑:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^0'`+R0u zI{ ۏLGWa'`h NO~vSk'`0k~SՋ gHeOpe N\N50O0 2.2.4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~(u[paBRbzz}v[gq _NS(uwQ g T7h\O(uv3'`ir0SՋ7hT~Ne30)Y _eS^45)Y0Ջg N9eSSegvnߘ`N` ck8^nߘ0 2.2.5 ‰[ch 2.2.5.1 [hQ'`ch 2.2.5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{ 2.2.5.1.2 @0?\O8^ĉhg 2.2.5.1.3 0Rhg 2.2.5.1.4 Gr0_5uV0yBhg(WՋ_YMRhgN!k 2.2.5.2 RHe'`ch 2.2.5.2.1 4N^ur‰[QnxU_SՋՋMRTv4N^ur c Nh~NϑSċR kՋMRTuryRvSS0 2.2.5.2.2 À/ЏRՋ@b gSՋ(WՋMR0Ջ~_geGWۏLÀ/ЏRhg cP(uagƉl(WۏߘvagN Nhg 0 2.2.6 pencYtT~g$R[ Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 h 4N^uryR ur{1R -N2R ͑3R yuc~ew N gouue ke4\e \_Suu͑ c~ goMbQ{Ul gS\O~8^S\O _S$N NA~S\O _S$NuulxvP gTxnߘ NsSTxA~Txyy(WweQuyu (WeQ Nteeyߘ2kߘ2k] mϑQ\1/2NQߘ2k] mϑQ\1/2^1/3eߘ2k mϑQ\2/3N NylbOyvP gylbOynߘ NsSylbOyA~ylbOy 2.2.6.1 4N^ur~g$R[ ՋߘMRTՋߘ~ꁫkSՋߘTՋߘ~N[gq~~k 4N^uryRf>fQ\ ~~Yt]_ g>fW'` S$R[ch3'`0 2.2.6.2 À/ЏRՋ~g ՋߘMRTՋߘ~ꁫkSՋߘTՋߘ~N[gq~~k À/ЏRՋchf>f9eU ~~Yt]_ g>fW'` S$R[ch3'`0 ~g$R[ [9eU?QzmSRv ߘ2k0ۏߘϑ0OPߘ9eU~g3'` SO͑T@~ˆ}vNych-NNych~g3'` S$R[SՋ7hTwQ g gRNmSRv\O(u0 [9eUbNmSRv 4N^urf>f9eU À/ЏR[~g3'` S$R[SՋ7hTwQ g gRNmSRv\O(u0 ASN0 gRNmORhel 1 Rir[ 1.1 \ЏR[ 1.1.1 St ~SLpÀ~N !joir Ye0WobmTN ^z\ \Rb6R!jW {N[eQ\vXAlcۏs eg$Re!jW\ ÀRR0 1.1.2 NhVTPge 1.1.2.1 NhVTՋBR Kb/gjR0fW'`FfWؚN!jW[gq~vXAlcۏse S$R[y[~g3'`0 1.2 cOe0|O|peT|O͑ϑvKm[ 1.2.1 St ~SLpÀ~N !joir Ye0WobmTN ^z\ Oy!jW Km[\ v|cўOcOe05b6\eQcO|peTcO͑ϑ egS f!jW\ vcO`Q0 1.2.2 NhVTPge 1.2.2.1 NhVTՋBR fW'`FfwN!jW[gq~ sSS$R[ych~g3'`0 5b6\eQcўO|pef>fؚN!jW[gq~ S$R[ych~g3'`0 5b6\eQcўO͑ϑf>fؚN!jW[gq~ S$R[ych~g3'`0 1.2.5 ~g$R[ 5b6\eQc|O͑ϑT|O|peNNy~g3'` Te\ЏR[TcOeNNy~g3'` S$R[y[~g3'`0 1.2.6 laNy 1.2.6.1 [-N^\ Ye0Wo`m Ne/ca NOcvQSm^GWN0mTNnm(W4!OX[ geOQs~vf >en[)nNkebRpTSn0 1.2.6.2 XAlM6Re_?b/ORpfTQReQx+g0 1.2.6.3 ^Sd\ cQ,{N|ўOMRv|O0 2 NSOՋߘՋ 2.1 ~eQSՋhQ 2.1.1cO!kpeQ\T|Olx^XR0 2.1.2 'YONhT\N3!k0 2.1.3 ehV('`Oy0 2.1.4 `N`'`Oy0 2.2 SՋcdhQ 2.2.1 N~Sۏߘb N cĉ[ g(uSՋ7hT0 2.2.2 ;Nɋ Nn0 2.2.3 SO(Z1_elۏLՋ0 2.2.4 30)YQۏLǏYyKb/g_wOyurSu0 2.2.5 V%N͑hV(uS_wvяgcOV~Lv %N͑vp0h; pu'`uI{ 2.2.6 OyVv^b guu0 2.2.7 30)YQSuǏ%`'`ÀSuu0 2.2.8 U[gS~gYsY0 2.2.9 Tv^ g_@{00T @|~I{%N͑hQuu`0 2.2.10 gvQ[4Ouuck(Wlu0 2.2.11 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.3 ՋSR~Bl Ǒ(uꁫT~[gq$NyՋ0 cSՋvOyurcO!kpe0|O'`r0urc~eI{ :gR:NՋߘ~T[gq~ =\SQ0Rq_T~gv;NV }Yt^0'`+R0e8^nߘ0OySVI{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.4 SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uel0 g(uϑ g(uSՋNT [gq~S g(u[paBRbǑ(uzz}v[gq _NS g(uwQ g T7h\O(uv3'`ir0 cvlۏLՋߘՋ0SՋ7hT~Ne7)Y _eSN^15)Y0Ջg N9eSSegvnߘ`N` ck8^nߘ0 2.5 ‰[ch 2.5.1 [hQ'`ch 2.5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{ 2.5.1.2 @0?\0O8^ĉhg 2.5.1.3 0Rhg 2.5.1.4 Gr0_5uV0yB(WՋ_YMRhgN!k 2.5.2 RHe'`ch ke[SՋۏLv^U_ TeU_SՋ g(uSՋ7hTMR6)YSՋev`Q0 2.5.2.1 kecO!kpe U_SՋՋߘMRTcO!kpevSS0 2.5.2.2 cOrQ 9hnccOV z^yubp|pa0 N`Wa0 Na g&TOFOcOV ϑ\I{ur R:NI IV~ ~yRf b gOFOcOV ϑ\ \Qsyubp|pa IV~3R ~8^Qsyubp|pa q_TcO 2.5.2.3 |O'`r 9hnc^̑eXbBristol |O'`rR{|l\|O'`rR:NI III~0 I~0R Pbdž s^n NoP FO(W[vhb gˆu ovVWW gf>fv[fcQ II~1R b_r FO gVWW~gcevWWr || PlFmr v|O III~2R RyvlxV Pg8h NfcQ 2.5.2.4 e8^nߘ`Q~~ }{|ߘirvkO0 2.5.2.5 U_ ge NoS^ v`_0l0yl0yuS|O_8^I{ 0 2.6 pencYtT~g$R[ Ջpenc:NϑDe S(uthۏLRg0Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThFOS_|pe*Y'YYCV>50% vDe^(uyTh0 ՋߘMRTՋߘ~ꁫkcO!kpef>fXR cOrQT|O'`rNych-NNychyRf>f NM ]_ g>fW'` ՋߘTՋߘ~N[gq~k cO!kpe0cOrQT|O'`rNNyf>f9eU ]_ g>fW'` S$R[SՋ7hTwQ g gRNmORv\O(u0 ASkQ0RObÀ|Rhel 1 Rir[ 1.1 St (WN[eQ~NN[ϑvSՋ7hT (u[À| g_c$O\O(uvir( b%`'`À|_c$O!jW ‰[TBRϑ~À|v_c$O z^b(u[À| g_c$O\O(uvir( bba'`Ànu!jW (WN[eQ~NN[ϑvSՋ7hT ‰[TBRϑ~ÀnuvbyTSOy S fSՋ7hT[À|vROb\O(u0 1.2 [Rir (uSDbWistar eP^'Y USN'`+R 180 220KQ k~8 12S0 1.3 [SBRϑR~ SՋir N*NBRϑ~ vQ-NN*N^:NNSOcPϑv5 PBRϑ~ v^ Tenck8^[gq~0 N Tv_c$O!jW ؏^nv^v!jW[gq~0ba'`nu!jW^HQ !j Kb/g!keQR~0SՋ7hT~NeN,:N14 30)Y _eSN^45)Y0 1.4 À|_c$O!jW 1.4.1 %`'`À|_c$Oe4lYN!jW 1.4.1.1 [Rir (uWistarbSDeP^'Y USN'`+R0 1.4.1.2 [ՋBRShVPge4lYN02u0VRhVh08nhaS:\0ut6RGr|~0>f_\I{0 1.4.1.3 [elRir:gRzz}v[gq~0!jW~TSՋ7hT N*NBRϑ~0TBRϑ~LpÀ7hT30)YT hQ萨Rir%Nf_\ Nb15mm Q@&^[^1-2mm>2mm-- ;`yR = Q@pRf_\I{0 1.4.2.3 [elRir:gRzz}v[gq~0!jW~TSՋ7hT N*NBRϑ~ LpÀ~NRirSՋir30)YT yߘ Ny4l24\e !jW~TBRϑ~~Nmpu40mg/kgN!k'`yTl\05\eTY{kRir VRy\ÀSQ ~Nb}^蕌T2 NASNcN}^~TYleQ10%2unm5 ml V[20RT lÀ'Y/_jR_ mQÀQ[ir U\_À| (u~8Tr^ ‰[À|_c$O z^0(u8nhaS:\KmϑÀQ@bnuvg'Y^S[^ NQ@bnuvg'Y[_\O:N_c$OchċR0mpu@bÀ|_c$OvnuN,\ 6mmQ@&^[^1-2mm>2mm--;`yR = Q@pRf_\ Npenu@b`SveenÀSO萘| N T{TReQQx0.2mL 1.5RT(uh~{8QQx TKb/gRS /gTck8^UߘT4l ,{N)Y\Kb/gTr`o}YvRir cSO͑:gR~0~o RirYnTKmϑI{d\O T N0 1.5 pencYtT~g$R[ pencS(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`0FfWMNO ba'`Ànu!jWvnubyT/bSOy>fWQ\ hfÀ|_c$Of>f9eU S$R[SՋ7hTRir[~g:N3'`0 1.6 laNy Riryߘ^[hQ ^%Nf 2R ͑u z_(uRsSQsuu uu N_S SugRp 3R :g bՋߘ~T[gq~T15OSՋۏLÀ\hg kՋߘՋMRTv9eS0 2.5 pencYtT~g$R[ ~urTSO_yR50% vDe^(uyTh0 ~g$R[ՋߘMRTՋߘ~ꁫkSՋߘTՋߘ~N[paBR[gq~~k 4N^ur0SO_yRf>fQ\ À\ Yg~g g9eUb NR͑ S$R[SՋ7hTwQ gRObÀ|ObR0 AS]N0 gRN~c@eP^4ls^ƀV/ul No Rhel 9hnc@_8^v{|W gRN~c@eP^4ls^ƀV/ul No R cgqSՋir\O(u:g6Rv N T zR{|vRirՋ0 RirՋRbNy`Q mTWؚ@uRir!jW ؚƀV@uRir!jW NSOՋߘՋ9hncՋv~g R Ny`QR+RۏL$R[ gRN~c@eP^4ls^R gRN~c@ƀVeP^4ls^R gRN~c@ul NoeP^4ls^R Rir[el 1.1 mTWؚ@uRir!jW 1.1.1 St (u+T gƀV0|0*sl0ƀxvreU{QRirSb_bN" }qNRir!jW Q~NRirSՋ7hT ShKmSՋ7hT[ؚ@uvq_T v^S$R[SՋ7hT[(v8T6e0ˆ}vvb_b0(vMbclNuvq_T0 1.1.2 NhVSՋBR VRhVh0RIQIQ^0ꁨRuSRgN0ƀV0ƀx0@n;`ƀVTC 0ul NoTG 0NO[^ˆ}vƀVLDL-C ؚ[^ˆ}vƀVHDL-C Km[ՋBRv0 1.1.3 Rir bSre 1.1.3.1 eP^bt^Ė'`'Y ^g~_ge SO͑20020g SD'Y k~8 12S0 1.1.3.2 !jWre (W~cre-NmR20.0%|015%*sl01.2%ƀV00.2%ƀx ϑvjˆ}v0xx"l0w|I{0dN|Y !jWrev4lR0|ˆ}v0|0|~~0|ppR00x0xGW0R~crevV[hQ0 1.1.4BRϑR~SSՋ7hT~Ne [ N*NBRϑ~0zz}v[gq~T!jW[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hT~Ne:N30)Y _eS^45)Y0 1.1.5 [ek 1.1.5.1^gNO\|~ N'Y Ur~cre‰[5 7)Y0 1.1.5.2 !jg cSO͑:gRb2~ 10S'Y ~N~cre\O:Nzz}v[gq~ 40S~N!jWre\O:N!jW~0khTyϑSO͑1!k0!jW~~N!jWre1 2hTT zz}v[gq~T!jW~'Y NyߘǑ@\ Ǒ@T=\_Ry@n Km[@nTC0TG0LDL-C0HDL-C4ls^09hncTC4ls^\!jW~:gRb4~sSN*N!jW[gq~0 N*NBRϑ~ R~T!jW~!jW[gq~T N*NBRϑ~ T~kTC0TG0LDL-C0HDL-C]_GWe>fW'`!jW~!jW[gq~T N*NBRϑ~ T~Nzz}v[gq~k TC0TG0LDL-CGSؚ]_GW g>fW'` $R[!jWbz0 1.1.5.3SՋ7hT~N R~T N*NBRϑ~k)Y~S~NSՋ7hT zz}v[gq~T!jW[gq~ Te~N TSOyvv^nBR zz}v[gq~~~~N~cre !jW[gq~S N*NBRϑ~~~~N!jWre v^[gyϑSO͑ N[~_ge NyߘǑ@ Ǒ@T=\_Ry@n Km[@nTC0TG0LDL-C0HDL-C4ls^0 1.1.6 ‰[chTC0TG0LDL-C0HDL-C0 1.1.7 pencYtT~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` $R[!jWbz01 TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO NNNBRϑ~@nul NoMNO ]_ g>fW'` TeTBRϑ~@nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@eP^4ls^RRir[~g3'`02 TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO ]_GW g>fW'` TeTBRϑ~@nul No N>fWؚN!jW[gq~ TBRϑ~@nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RRir[~g3'`03 TBRϑ~N!jW[gq~k NNBRϑ~@nul NoMNO ]_ g>fW'` TeTBRϑ~@n;`ƀVSNO[^ˆ}vƀV N>fWؚN!jW[gq~ @nؚ[^ˆ}vƀV N>fWNON!jW[gq~ S$R[SՋ7hT gRN~c@ul NoeP^4ls^RRir[~g3'`0 1.1.8 laNy 1.1.8.1 (W^zRir!jW-N SVRirT|0r{Q{t q_T!jWv^z0 1.1.8.2 O~crevTy%{QbR _eۏLhKm dN|Y !jWrev4lR0|ˆ}v0|~~0|ppR00x0xGW0R~crevV[hQ0 1.1.8.3 !jWreU{Qg !jW~@-NƀV4ls^k3z[ ul No4ls^Onb` Yck8^4ls^ Ee!jWre~Ne NǏ8hT0 1.2 ؚƀV@uRir!jW 1.2.1 St (u+T gƀV0*sl0ƀxvreU{QRirSb_bؚƀVN" }qNRir!jW Q~NRirSՋ7hT ShKmSՋ7hT[ؚƀV@uvq_T v^S$R[SՋ7hT[(v8T6e0ˆ}vvb_b0(vMbclNuvq_T0 1.2.2 NhVSՋBR VRhVh0RIQIQ^ ꁨRuSRgN ƀV0ƀx0@n;`ƀVTC 0ul NoTG 0NO[^ˆ}vƀVLDL-C ؚ[^ˆ}vƀVHDL-C Km[ՋBRv0 1.2.3 Rir bSre 1.2.3.1 'Y !jWeP^bt^Ė'`'Y ^g~_ge SO͑20020g SD'Y k~8 12S0 ёĞ0W !jWeP^bt^Ė'`ёĞ0W ^g~_ge SO͑10010g k~8 12S0 1.2.3.2 !jWre 'Y !jW(W~cre-NmR1.2%ƀV00.2%ƀx03-5%*sl ϑvjˆ}v0xx"l0w|I{0dN|Y !jWrevvQ[(ϑchGW0R~crevV[hQ0 ёĞ0W !jW(W~cre-NmR0.2%ƀV vQYO T'Y !jW0 1.2.4 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~0zz}v[gq~T!jW[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hT~Ne:N30)Y _eS^45)Y0 1.2.5 [ek 1.2.5.1^gNO\|~ NRirUr~cre‰[5 7)Y0 1.2.5.2 !jg cSO͑:gRb2~ 10SRir~N~cre\O:Nzz}v[gq~ 40S~N!jWre\O:N!jW[gq~0khTyϑSO͑1!k0 !jW~~N!jWre1 2hTT zz}v[gq~T!jW~'Y NyߘǑ@\ Ǒ@T=\_Ry@n Km[@nTC0TG0LDL-C0HDL-C4ls^09hncTC4ls^\!jW~:gRb4~sSN*N!jW[gq~0 N*NBRϑ~ R~T!jW~!jW[gq~T N*NBRϑ~ T~kTC0TG0LDL-C0HDL-C]_GWe>fW'`!jW~!jW[gq~T N*NBRϑ~ T~Nzz}v[gq~k TC0TG0LDL-CGSؚ]_GW g>fW'` $R[!jWbz0 1.2.5.3SՋ7hT~N R~T N*NBRϑ~k)Y~S~NSՋ7hT zz}v[gq~T!jW[gq~ Te~N TSOyvv^nBR zz}v[gq~~~~N~cre !jW[gq~S N*NBRϑ~~~~N!jWre v^[gyϑSO͑ N[~_ge NyߘǑ@ Ǒ@T=\_Ry@n Km[@nTC0TG0LDL-C0HDL-C4ls^0 1.2.6 ‰[chTC0TG0LDL-C0HDL-C0 1.2.7 pencYtT~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` @nul No]_e>fW'` $R[!jWbz0TBRϑ~N!jW[gq~k NNBRϑ~@n;`ƀVbNO[^ˆ}vƀVMNO ]_ g>fW'` v^NTBRϑ~@nؚ[^ˆ}vƀV N>fWNON!jW[gq~ @nul No N>fWؚN!jW[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RRir[~g3'`0 1.2.8 laNy 1.2.8.1 (W^zRir!jW-N SVRirT|0r{Q{t q_T!jWv^z0 1.2.8.2 O~crevTy%{QbR _eۏLhKm0 2 NSOՋߘՋel 2.1 SՋ~eQhQ 2.1.1 (Wck8^nߘ`Q N hKmyߘ12-14\eTv@4ls^ JSt^Q\ g$N!k@hKm~g @n;`ƀV(W5.18-6.21mmol/L v^N@nul No(W1.70-2.25mmol/L S\O:N gRN~c@eP^4ls^RՋY [a@nul No(W1.70-2.25mmol/L v^N@n;`ƀVd"6.21mmol/L S\O:N gRN~c@ul NoeP^4ls^RՋY [a@n;`ƀV(W5.18-6.21mmol/L v^N@nul Nod"2.25mmol/L S\O:N gRN~c@ƀVeP^4ls^RՋY [a (WSRir[~gW@x N bv^ch:NSՋ[a0 2.1.2 _w` TafN ?aSRՋ0 2.2cdSՋhQ 2.2.1 t^(W18\N Nb65\N N0 2.2.2 Y ZbTsNgYsY ǏOeSO(b[,gSՋ7hTǏOe0 2.2.3 Tv^ g_00T @|~I{%N͑uu |^yu`0 2.2.4 я$NhTf g(uMoirI{ q_T0R[~gv$Re0 2.2.5 ؚ@u`0 2.2.6*g cĉ[ߘ(uSՋ7hT bDe NhQ q_TRHeb[hQ'`$Re0 2.3SՋ7hTvBRϑTO(uel 9hncSՋ7hTcPϑTcPelnx[0 2.4ՋSR~Bl Ǒ(u~[gq09hnc:gvlvBlۏLR~0 cSՋ@4ls^:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }Yt^0'`+R0nߘI{ ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0Ջߘ~ g(uSՋ7hT [gq~S g(u[paBRbǑ(uzz}v[gq0ՋhTg45)Y NǏ6*Ng0 2.5 ‰[ch 2.5.1 [hQ'`ch 2.5.1.1 N,rQSb|^y0aw w0nߘ0'Y\O0@SI{ 2.5.1.2 @0?\0O8^ĉhg 2.5.1.3 0Rhg 2.5.1.4 Gr0_5uV0yBhgN(WՋ_YMRۏL 2.5.2 RHe'`ch 2.5.2.1 @n;`ƀVTC 4ls^SMNO~vRs0ul NoTG 4ls^SMNO~vRs0ؚ[^ˆ}vƀVHDL-C 4ls^S NGSE^^0NO[^ˆ}vƀVLDL-C 4ls^0 2.5.2.2 RHe$R[hQ gHeTC MNO>10%bMck8^<5.18mmol/L TG MNO>15%bMck8^<1.70mmol/L HDL-C NGS>0.104mmol/L0 eHe*g0R gHehQ0 ‰[@n;`ƀVTC gHes0ul NoTG gHes0ؚ[^ˆ}vƀVHDL-C gHesS;` gHes0 2.6 pencYtT~g$R[ Qꁫ[gqDeSNǑ(uM[th $N~GWpekǑ(ub~th TۏLe]P'`h [^ck`R^be] NPvpencۏLS_vSϑlbc _nck`e]PT (ulbcvpencۏLthlbcpencN Nnck`e]PBl 9e(ut hbyThe]PFOS_|pe*Y'YYCV>50% vDe^(uyTh0 gHesS;` gHesǑ(u(2hۏLh0VfW'` Te@nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~;` gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@eP^4ls^RNSOՋߘՋ~g3'`0 2.6.2 gRN~c@ƀVeP^4ls^R~g$R[ Ջߘ~ꁫkSՋߘ~N[gq~~k SՋ@n;`ƀV0NO[^ˆ}vƀVMNO ]_GW g>fW'` Te@nul No N>fWؚN[gq~ @nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~@n;`ƀV gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@ƀVeP^4ls^RNSOՋߘՋ~g3'`0 2.6.3 gRN~c@ul NoeP^4ls^R~g$R[ Ջߘ~ꁫkSՋߘ~N[gq~~k SՋ@nul NoMNO ]_ g>fW'` Te@n;`ƀVTNO[^ˆ}vƀV N>fWؚN[gq~ @nؚ[^ˆ}vƀV N>fWNON[gq~ Ջ~@nul No gHes>fWؚN[gq~ S$R[SՋ7hT gRN~c@ul NoeP^4ls^RNSOՋߘՋ~g3'`0 NAS0 gRN~c@|eP^4ls^Rhel 1 Rir[ 1.1 [Rir (ubt^Rir (u\ 262g b'Y 18020g USN'`+R 'Y k~8 12S0\ k~10 15S0 1.2 Pge 1.2.1 ՋBR V'l'VvUC4H2N2O4H2O,RP[ϑ160.08 b2PÕ }00W^Xs|~gxxl\m0a|b;S(um|0@|Km[Ջ~bՋBRv \ }0ul No0;`ƀVKm[ՋBRv 1.2.2 ؚpre *sl10%0|15%0ˆĞ|15%0jˆ}v5%0ƀV1.2%0ƀx0.2%0xx"l0.6%0w|0.4%0 ~ce52.6% 1.2.3 NhV @|N0hQꁨRuSN0SIQRIQIQ^0vhN0)Ys^0 1.3 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N!jW[gq~ NNSOcPϑv10 P\ b5 P'Y :NvQ-NvN*NBRϑ~ SN*NBRϑ~ ؚBRϑN, NǏ30 P _ezz}v[gq~0 Te~NSՋ7hTؚBRϑvck8^Rir~0SՋ7hT~Ne30)Y _eS^45)Y0 1.4 [el 1.4.1 ck8^RirM|[ eP^bt^Rir cyߘ3 5\ev@|4ls^R~ :g 1*N[gq~T1*NBRϑ~0[gq~~NnBR BRϑ~~NؚBRϑSm^SՋ7hT ޏ~30)Y Kmzzy@|\@ Km[zzysS~a|MR0\e @|

fW'` $R[!jW|N" }qNbz (WdkW@x N ‰[!jW[gq~NSՋ7hT~zzy@|0~a|T0.502\e @|S000.502\e@|f~ NbyvSS0 [MR@|

fGSؚ Nzz}v[gq~k ]_ g>fW'` $R[!jWN" }qNbz (WdkW@x N ‰[!jW[gq~NSՋ7hT~@SS0 1.4.2.2.1.3.3 \ } T~Riryߘ3 4\e hKm@n\ } !jW[gq~Nzz}v[gq~k\ }bbcpeef>f NM NRir|/N" }qNbz $R[\ }bb|\N" }qN!jWbR0‰[!jW[gq~NSՋ7hT~\ }bb`Q0 @|\ } \ }bbcpe = \ }/22.5e-3@| H"           22.5 1.4.2.2.2 V'l'VvU[\ }bb|/N" }qN!jW 1.4.2.2.2.1 St ؚpreUrW@x N N\BRϑV'l'VvUC4H2N2O4H2O,RP[ϑ160.08 b|/N" }qN \ }bb S['`|?\u0 1.4.2.2.2.2 !jel -eQeP^Ė'`'Y 15020g nf~ce^r{Q3 5)Y yߘ3 4\e S>\@ Km[~a|MRsS0\e @|

fW'` $R[!jW|N" }qNbz (WdkW@x N ‰[!jW[gq~NSՋ7hT~zzy@|0~a|T0.502\e @|S000.502\e@|f~ NbyvSS0 [MR@|

fGSؚ Nzz}v[gq~k ]_ g>fW'` $R[!jWN" }qNbz (WdkW@x N ‰[!jW[gq~NSՋ7hT~@SS0 1.4.2.2.2.3.3 \ } T~Riryߘ3 4\e hKm@n\ } !jW[gq~Nzz}v[gq~k\ }bbcpeef>f NM NRir|/N" }qNbz $R[\ }bb|\N" }qN!jWbR0‰[!jW[gq~NSՋ7hT~\ }bb`Q0 @|\ } \ }bbcpe = \ }/22.5e-3@| H"           22.5 1.5pencYtS~g$R[ N,Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfGSؚ [ck8^Rirzzy@|eq_T sSS$R[SՋ7hT gRN~c@|eP^4ls^RRir[~g3'`0 1.6 laNy 1.6.1 :NNO[Rir|N"Rr`=\ϑOcN _N:NNQnx0W cSO͑{SՋ7hTv(uϑ [MRRir^%NeQ'l O4-(lW[fkgNZ'lS)T ub~r{|STir S(Wl505nmkrKm[0 a|'lSv a| !a|x Ǐ'lS"l Ǐ'lSirv Ǐ'lS"l Z 4-(lW[fkg !~r{|STir 1.7.2 ՋBRM6R xxvQm0.2mol/L pH7.0 0.2mol/L Na2HPO461mL 0.2mol/L KH2PO439mLmTsSS0 vՋBRa|'lSv400u Ǐ'lSirv0.6mg 4-(lW[fkg10mg S.l100mg RxxvQm100mL PH70Q{X[>e\S3z[2*Ng0 ZՋBRZ100mgnN100mL4l-N0 vmTՋBRSI{ϑvՋBRTZՋBRmT0(WQ{-NSX[>e1*Ng0 a|hQmPX[me4lD-a|A.R. (Wp{-N80!p4\e QtST X[>eNr^qhV-NR`͑0|nxyS2gN0.25%2uxnmnv^yeQ100mL[ϑt-N Q(u2uxnmzʑ100mL0 ^(um(W100mL[ϑt-NQnxReQPX[m5mL Q(u0.25%2uxnmzʑ100mL sS1mg/mL^(um0 ˆ}vlmBRnxx"lN 10g0x10g0/lS9gN800mL4l-N ReQ1mol/Lvx125mL v^(u4lzʑ1000mL0 1.7.3 d\Oek Sˆ}vlmBR1mLReQ@Fm@n 50LmS0[)n>en7RT y_ S Nnmeˆ}v@nm Km[0a|hQ^(umNۏL T7hYt0 Km[{hQ{zz}v{eˆ}v@nmmL0.5--YtTva|hQmmL-0.5-ˆ}vlmmmL--0.5vmTՋBRmL444mST 37!4ltmO)n15R (uzz}v{p (Wl505nmYkr0 1.7.4 ~g{ Km[{OD @|+Tϑmmol/L =        100/18 hQ{OD 2 NSOՋߘՋ 2.1 Ջ ՋǑ(u:gR~ ~[gq0 2.2 SՋNT SՋNT_{/fwQ g[WSň0hf g(uelT g(uϑv[WNTaBRdRHebRY (WBRW0Sa0Y‰TSň NNSՋNTOcN0 2.3 SՋ b 2.3.1 ~eQhQ bzzy@|5.6 7mmol/L100 126mg/dL bT2\e@|7.8 11.1mmol/L140 200mg/dL v|S_cIGR N0 2.3.2 cdhQ 2.3.2.1 |?\uuN0 2.3.2.2 t^(W18\N Nb65\N N Y ZbTsNgYsY [SՋ7hTǏOe0 2.3.2.3 g_00I{;NhVv^Su bTv^ gvQ[%N͑uu |^yu` g(u|v(o }bvQ[q_T@|oir0 2.3.2.4 NMTnߘc6R q_T‰[~g0 2.3.2.5 я3*NgQ g|?\unu0x-NkNSag0 2.3.2.6 wgQ g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.3.2.7 Q N&{T~eQhQ *g cĉ[ g(uSՋ7hT bDe NhQq_T‰[~g0 2.4 SՋR~ Ǒ(u~[gq09hnc:gvlvBlۏLR~0 cSՋv|S@~ˆ}vb|S@nˆ}vS@|4ls^:gR:NՋߘ~T[gq~ =\SQq_T~gv;NV }ۏLGWa'`h NO~vSk'`0k~SՋ N\N50O0 2.5 Ջel ՋMR[kNMOSՋ c'`+R0t^0 N TRR:_^0t`SO͑SgqSegu;m`N`ĉ[v^vnߘ ՋߘgZWcnߘc6R lu|?\uvoiry{|TBRϑ NS0Ջߘ~(W govW@x N ccP g(uelT g(uϑke g(uSՋ7hT [gq~S g(u[paBRbǑ(uzz}v[gq0SՋ7hT~Ne2*Ng _eS^4*Ng0 2.6 ‰[ch 2.6.1 [hQ'`ch 2.6.1.1 N,rQSO_ Sb|^y0aw w0nߘ0'Y\O0@SI{ 2.6.1.2 @0?\0O8^ĉhg 2.6.1.3 0Rhg 2.6.1.4 Gr0_5uV0yBhgNՋMRhgN!k 2.6.2RHech 2.6.2.1ur‰[ ~uS N㉣`nߘ`Q (uo`Q ;mRϑ ‰[S4nYn0Yߘfe0&P `ONR0Y?\I{;N4N^ur cur{͑yR NՋߘMRT~yR

f n4lϑ 1 2 L/eS4n>fW n4lϑ>2L/eYߘfeeMR g{^eaMR gf>fea3 L/e&P `ONRe|^y N/c NRR |^yuON SZWc{SORRR|^yg^uON R:_ZWce8^;mR2.6.2.2zzy@| ‰[ՋߘMRTzzy@|50% vDe^(uyTh0 2.8.1 @| NME^^ ՋMRzzy@|  ՋTzzy@| zzy@| NM~vRs =                  100% ՋMRzzy@| ՋMRT2\e@|  ՋTT2\e@| T2\e@| NM~vRs =                      100% ՋMRT2\e@| 2.8.2 |S@~ˆ}vb|S@nˆ}v NME^^ ՋMR|S@~ˆ}v  ՋT|S@~ˆ}v |S@~ˆ}v NM~vRs =                      100% ՋMR|S@~ˆ}v ՋMR|S@nˆ}v  ՋT|S@nˆ}v |S@nˆ}v NM~vRs =                      100% ՋMR|S@nˆ}v 2.8.3RHe$R[hQ gHe = 1 \* GB2 t$ՋTzzy@|b` Yck8^d"5.6 mmol/L bzzy@| NME^^e"10%  = 2 \* GB2 u$ՋTT2\e@|b` Yck8^(d"7.8 mmol/L) bT2\e@| NME^^e"10% eHe*g0R gHehQ zzy@| gHeOpe zzy@| NM gHes =            100% zzy@|‰[Ope T2\e@| gHeOpe T2\e@| NM gHes =              100% T2\e@|‰[Ope 2.8.4ch$R[ 2.8.4.1 zzy@|  = 1 \* GB3 `$ՋMRTꁫk zzy@| NM]_ g>fW'` NՋTs^GW@|b` Yck8^b NME^^e"10% = 2 \* GB3 a$ՋTՋߘ~zzy@|fW'`  = 3 \* GB3 b$ՋTՋߘ~zzy@| NM gHesؚN[gq~ ]_ g>fW'`0n N3*NagN S$R[SՋ7hTzzy@|ch~g3'`0 2.8.4.2 T2\e@|  = 1 \* GB3 `$ՋMRTꁫk T2\e@| NM]_ g>fW'` NՋTs^GW@|b` Yck8^b NME^^e"10% = 2 \* GB3 a$ՋTՋߘ~T2\e@|fW'` = 3 \* GB3 b$ՋTՋߘ~T2\e@| NM gHesؚN[gq~ ]_ g>fW'`0n N3*NagN S$R[SՋ7hTT2\e@|ch~g3'`0 2.8.4.3 |S@~ˆ}vb|S@nˆ}v   = 1 \* GB3 `$ՋMRTꁫk |S@~ˆ}vb|S@nˆ}v NM]_ g>fW'` = 2 \* GB3 a$ՋTՋߘ~|S@~ˆ}vb|S@nˆ}v fW'`0n N2*NagN S$R[SՋ7hT|S@~ˆ}vb|S@nˆ}v ch~g3'`0 2.8.4.4 @nƀV  = 1 \* GB3 `$ՋMRTꁫk @nƀV NM]_ g>fW'` = 2 \* GB3 a$ՋTՋߘ~@nƀV NMN[gq~k ]_ g>fW'`0n N2*NagN S$R[SՋ7hT@nƀVch~g3'`0 2.8.4.5 @nul No  = 1 \* GB3 `$ՋMRTꁫk @nul No NM]_ g>fW'` = 2 \* GB3 a$ՋTՋߘ~@nul No NMN[gq~k ]_ g>fW'`0n N2*NagN S$R[SՋ7hT@nul Noch~g3'`0 2.8.5~g$R[ zzy@|0T2\e@|0|S@~ˆ}vb|S@nˆ}v 0@VychGWef>fGSؚ Nzzy@|0T2\e@|$Nych-NNych3'` [:gSOeP^e N)Rq_T S$R[SՋ7hTwQ g gRN~c@|eP^4ls^Rv\O(u0 NASN0 gRN~c@SeP^4ls^Rhel 1 Rir[ 1.1 [St NSՋ7hT~NSؚ@S'Y Rir!jWbǏ[el bvؚ@SRir!jW ‰[SՋ7hT[ؚ@SRir!jWv@S0_sI{chvq_T ċNSՋ7hTvM@S\O(u0 1.2 Km[el @S0_svKm[Ǒ(ucKmSl NhVvKmSStN,:N>\ dl0 1.3 [Q[ 1.3.1 Ջyv 1.3.1.1 N,`Q‰[SO͑ urQ 1.3.1.2 @S0_s 1.3.2[Rir cP(u'Y Sؚ@S'Y SHR SHR[ (u10-12hT SO͑180 220KQ ̖ĖSN|Q(u vQ!k:N@{Wؚ@S'Y 0k~8 12S0ck8^Rir bWistar0SD'Y I{0 1.3.3 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N4'`[gq~ NNSOcPϑv5 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ Te~NSՋ7hTؚBRϑvck8^Rir~0_e3'`[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 1.4 [el 1.4.1 @{Wؚ@S'Y !jW6RY @{Wؚ@S'Y Kb/g6RY 8^(u$NN9YW0/g-N (uQ_:N0.20-0.25mmv9Y >enN]R =\ϑ`я;NR Y030)YT (u@Se"21.3kPa160mmHg N3z[ _NS9hnc`Q (u@S/gMRGSؚ4KPa0 1.4.2 @S0_sKm[vwQSOel [MRNhT[SՋRirۏLY!k@SKmϑ OvQ^KmSsX0OncKmSNhVvBlۏLRirn0[Yr` Nv@S0_svKm[0[_YTkhTKmS1-2!k0\Pbk~NSՋ7hTKNT N,~~‰[v@Sb` Y[gq~4ls^b~~‰[7 14)Y0 1.4.3ck8^Rir eP^bt^Rir c1.4.2Km[@S0_s0 1.5 pencYtT~g$R[ @SKm[:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfNON[gq~ ]_wQ g>fW'` N[[~Rir_sTck8^Rirv@SS_seq_T S$R[ gRN~c@SeP^4ls^RRir[~g3'`0 1.6 laNy 1.6.1 Km[Rir@Se[)n^Oc(W25!0N>\R cKmSlKm['Y @Se ~'Y O)n ^lfR`)nv)n^SO)ne0T!k@SKm[Ǐ z-N)n^agNOcN0 1.6.2 d\O^{g Q\Rirv^oS^ 'Y >eeQV[<{-N_'Y [YTMbSۏLKmϑ 'Y Y(WKm[-NQsp CUTI{^oS^ ^͑eKmϑ0 1.6.3cPO(ueR'`\Rir@SKm[NhV0 >\WY^>enN >\v9h (u~g'}S_vWY0WYN~20 30mmHg/sv^EQlRS dlm1YKNT~20mmHgY0k!kKmϑN[e U__sSSd"10!k/R0@SSSd"6mmHgvޏ~ N!kpe SvQGWpe0 1.6.4 Rirvr{QsXOc[Y cdsXV }[@Svq_T0 2 NSOՋߘՋ 2.1 SՋ[a~eQhQ @SYNck8^VvOPؚ:Sck8^ؚ50% vDe^(uyTh0(WՋMR~k]_e>fW'`vMRc N SۏLՋT~k0 9eUs:NpeDe (u(2h0Vf NM ]_ g>fW'` N _S NMe"10mmHgbMck8^ b6e)S NMe"20mmHgbMck8^ ՋߘTՋߘ~N[gq~~k  _Sb6e)SKm[fW'` S$R[SՋ7hTwQ g gRN~c@SeP^4ls^Rv\O(u0 NASN0[Sf['`_c$O gRObRhel 1 eHhNV/lSx_c$O!jW 1.1 St V/lSxCCl4 S0R_|SOv;mSb:N N/l2up1uWCCl3" Nˆ}v(qQN~T[ˆ}vTbx0(RN" }qN _w~ހQul NoTG Ąy0CCl3" _NŏNO2~TlS:NǏ'lS N/l2up1uWCCl3O2" [(Ǐ'lS N _w~ހvS'`_c$O OvnoNSTy{|Wv~ހuS uOW{k0 1.2[Rir bt^'Y b\ USN'`+R 'Y 180 220KQ k~8-12S \ 18 22KQ k~10-15S0 1.3 [elTek 1.3.1 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*Nzz}v[gq~TN*N!jW[gq~ NNSOcPϑv10 P\ b5 P'Y :NvQ-NvN*NBRϑ~ S$N*NBRϑ~0(uCCl4Rg~ b_c$O!jW !je_SNLpÀbyTl\0\ CCl4LpÀSm^:N1% Nߘ(u iirlzʑ LpÀϑ5mL/kg BWbTCCl4vBRϑ:N80 mg/kgBW 'Y CCl4LpÀSm^:N2 3% LpÀϑ5mL/kg BWbTCCl4vBRϑ:N160 240 mg/kg BW 0_e3'`[gq~TnBR[gq~0SՋ7hT~Ne30)Y _eS^45)Y0 1.3.2 ~NSՋ7hTv_ ~SLpÀ~NSՋ7hT elLpÀe\SՋ7hTceQrebn4lNS v^U_kSRirvreDdeQϑbn4lϑ0 1.3.3 [ek SՋ~ke~SLpÀ~NSՋ7hT zz}v[gq~T!jW[gq~~N4l0\RirkhTy͑$N!k NteSՋ7hTBRϑ0N[,{30)Y\T~RirYyߘ16\e !jW~ST7hT~N!kLpÀ~NCCl4 zz}v[gq~~ߘ(u iirl SՋ~~~~NSՋ7hT[~_gNCCl4LpÀ4\eN N 0~NCCl4 T 9hnc[E`QN 24b48\eY{kRir S@Ry@n Km[ALT0AST v^SۏLut~~f[hKm0 1.3.4 hKmch @n7Nl(lvALT 7Il(lvAST ut~~f[hg 1.4 @n7Nl(lvALT 7Il(lvAST vKm[ 1.4.1 Km[elS (uhQꁨRuSRgNbVllՋBRv Km[0 1.4.2 pencYtT~g$R[ Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` SR+R$R[ALT0AST~g3'`0 1.5 ut~~f[SS0ʋehQT~g$R[ 1.5.1 [PgeS'Y ]S(u10%y\lgV[ N]S-NZP*jRbSPg 8^ĉut6RGrw!SW H.E.gr 0 1.5.2\hNvNzƉΑ_YU_~ހvutSS (u40 Pir\ޏ~‰[te*N~~RGr0S\S-N_'`~ހvL'`uST\pe~ހOW{k0;NuS{|W g~ހlt7hS0S'`0ހFmQZ0~ހ4l7hS'`T~ހOW{kI{0 1.5.3 ċRhQ R+RU_k*NƉΑ-NvTyuS@b`SƉΑvby v^/}@b‰[ƉΑvuS;`R0 ~ހlt7hS~ހ'Y ހFmkYu\0 'Yck8^ lt7hSv~ހ`Ste*NƉΑv1/4 lt7hSv~ހ`Ste*NƉΑv1/2 lt7hSv~ހ`Ste*NƉΑv3/4 lt7hSv~ހ`Ste*NƉΑ0R1R2R3R4R ~ހS'`~ހހFmQQsLuPnpfvnzzl0 'Yck8^ S'`v~ހ`Ste*NƉΑv1/4 S'`v~ހ`Ste*NƉΑv1/2 S'`v~ހ`Ste*NƉΑv3/4 S'`v~ހ`Ste*NƉΑ0R1R2R3R4R ހFmQZހFmU O~X:_ 'Yck8^ ހFmQZv~ހ`Ste*NƉΑv1/4 ހFmQZv~ހ`Ste*NƉΑv2/4 ހFmQZv~ހ`Ste*NƉΑv3/4 ހFmQZv~ހ%_+oX[(W`Ste*NƉΑ0R1R2R3R4R 4l7hS'` *g4l7hS'`v~ހ 4l7hS'`v~ހ`Ste*NƉΑv1/4 4l7hS'`v~ހ`Ste*NƉΑv2/4 4l7hS'`v~ހ`Ste*NƉΑv3/4 4l7hS'`v~ހ%_+o'`X[(W`Ste*NƉΑ0R1R2R3R4R~ހOW{kހFmU O~S QV'`OW{k *gOW{k~ހ ce(W*N+R~ހ`Ste*NƉΑv1/4 OW{k~ހ`Ste*NƉΑv2/4 OW{k~ހ`Ste*NƉΑv3/4 OW{k~ހ%_+o'`X[(W`Ste*NƉΑ0R1R2R3R4R1.5.4 pencYtTut~g$R[ Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` vQ[uS{|WN!jW[gq~kf>fQ{bef>f]_ S$ReRir[ut~g3'`0 1.5.4.2SՋ7hTNUON*NBRϑ~N!jW[gq~KN lt7hS0S'`0ހFmQZ04l7hS'`ُVy~ހuS{|WR͑TQ{ TeX[(W ]_ g>fW'` N~ހOW{k z^Q{ ]_ g>fW'` RS\vQTyutSSv_RvR ~ހOW{kċR2 PeQ N;`RۏL~Rg ]_ g>fW'` S$ReRir[ut~g3'`0 1.6 ~g$Re (W!jWbzvMRc N ALT0AST$Ny@muSch-NNUONyTut~g:N3'` S$R[SՋ7hT[Sf['`_c$O gROb\O(u0 2 eHhNR|_c$O!jW 2.1 St :gSO'YϑDdeQYNT (WYN1"lvvPS N'Yϑ1"l'lS O N_sxTx'lSQ1_ q_TN" O(W~ހQly0 TeYNo;m'lRP[ Nu'l1uW[􁝀~ހv(Ǐ'lSSSOQ؏SW7uvz0 2.2 [Rir bt^\ b'Y USN'`+R 'Y 180 220KQ k~8-12S \ 18 22KQ k~10-15S0 2.3 [elTek 2.3.1BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*Nzz}v[gq~TN*N!jW[gq~ NNSOcPϑv10 P\ b5 P'Y :NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0(ue4lYNRg~ b_c$O!jW e4lYNSm^:N50%N4lzʑ \ LpÀϑ12 14mL/kg BWbTYNvBRϑ:N6000 7000 mg/kg BW 0SՋ7hT~Ne30)Y _eS^45)Y0 2.3.2 ~NSՋ7hTv_ ~SLpÀ~NSՋ7hT elLpÀe\SՋ7hTceQrebn4lNS v^U_kSRirvreDdeQϑbn4lϑ0 2.3.3 [ek ke~SLpÀ~NSՋ7hT zz}v[gq~T!jW[gq~~N4l0RirkhTy͑$N!k cSO͑teSՋ7hTBRϑ0~NSՋ7hT~_ge\!jW[gq~ST7hT~N!kLpÀ~N50%YN12mL/kg BW zz}v[gq~~4l yߘ16\eY{kRir ۏLTychvhKmSut~~f[hg0 2.3.4 hKmch ~~-NNNMDA ؏SW7uGSH ul NoTG v+Tϑ0 2.4 SFm-NǏ'lS(M㉧NirNNMDA Km[el 2.4.1 St MDAmalondiadehycle /f~ހ(Ǐ'lSv~NirKNN hKmvQ+TϑSc0O(Ǐ'lSv z^0MDANkxN]kYx(Wx'`agN NqQp b_b|~r YTir 8T6e\(W535nm wQdkSKm_MDAv+Tϑ0 2.4.2 NhVNՋBR NhV 721RIQIQ^0_ϑR7hhV0R`)n4ltm0nfy_:g0mehV0wQ^Xy_{0~~SFmhV ՋBR 0.2MYNxvQm pH3.5 0.2MYNxnm 185mL 0.2MYNxnm 15mL 1mmol/LVYN'lWNp.Ym 4!OX[3*Ng 4N(uMR(u4lzʑb40nmol/mL 8.1%ASNpWkxxSDS 0.8%kxN]kYxTBA 0.2MxxvQm pH7.4 0.2Mxx"lN 1920mL 0.2M xxN"l 480mL 2.4.3 [ek 2.4.3.1 7hT6RY ~~SFm7hTSN[ϑv@bhV utv4lQm0br^0y͑0jRx nSFmhV-N ReQ0.2MxxvQm N20000r/minSFm10s Gk30s S YۏL3!k 6Rb5%~~SFmW/V 3000r/miny_5^10min S Nnm_Km0 2.4.3.2 7hTKm[ ՋBRzz}v{7hT{hQ{5%~~SFm0.1mL40nmol/mLVYN'lWNp0.1mL8.1%SDS0.2mL0.2mL0.2mL0.2MYNxvQm 1.5mL1.5mL1.5mL0.8%TBA1.5mL1.5mL1.5mLH2O0.8mL0.7mL0.7mLmS IQl4ltm60min Am4lQtS N532nmkr2.4.3.3 { Ǐ'lS(+Tϑnmol/mg~~  Ǐ'lS(+Tϑnmol/100mgˆ}v(   Azz}v{8TIQ^ B7hT{8TIQ^ FVYN'lWNp8TIQ^ CVYN'lWNpSm^40nmol/mL Kzʑ Ppe 2.4.3.4 pencYtS~g$R[ pencǑ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` $R[ch~g3'`0 2.5 SFm؏SW7uGSH Km[el 2.5.1 St GSHT5,5'-Nkx[]xW2uxDTNB S^(WGSH-PxPS NSubĞrv5-kxN2-]xW2ux4yP[ N423nml gg'Y8T6e\ Km[勻yP[Sm^ sSS{GSHv+Tϑ0 2.5.2 ՋBR 2.5.2.1 0.9%utv4l 2.5.2.2 4%xW4lhgxnm 2.5.2.3 1mol/L PBSnmpH=8.0  Na2HPO4 13.452g KH2PO4 0.722g R4l1000mL0 2.5.2.4 0.004%DTNBnmySDTNB 40mgnN1000mLv0.1mol/L PBSnmpH=8.0 -N0 2.5.2.5 S.l~Qm NaN316.25 mgEDTA-Na2  7.44 mgNa2HPO4 1.732 gNaH2PO4  1.076 gR4l1000mL (u\ϑHCl0NaOHpH7.0 4!OX[0 2.5.2.6 hQnmyS؏SWGSH 15.4mg RS.l~Qm50mL ~Sm^:N 1mmol/L 4N(uMRM6R0 2.5.3 el 2.5.3.1 7hTKm[S0.5gRutv4l5mLEQRxxb~Fm10%SFm mSTSFmm0.5mLR4%xW4lhgx0.5mLmS [)n N3000rpmy_10R S NnmsS:N7hT0 Km[{zz}v{7hT0.5mL 4%xW4lhgx 0.5mLDTNB4.5mL4.5mL mS [)n>en10RT 412nmYKm[8TIQ^0 2.5.3.2 hQf~ 1234561mmol/L GSHmL  00.050.100.150.200.25utv4lmL 0.500.450.400.350.300.25DTNBmL 4.504.504.504.504.50 4.50GSHϑ(mol/L 01002003004005002.5.3.3 { 7hTGSH+Tϑ(mol/g~~ = [^f~Sm^fW'`FfW'` $R[ch~g3'`0 2.6 SFm-Nul NoTG Km[el 2.6.1 Km[elǑ(uul NoKm[ՋBRvulxx'lSvǏ'lSirvl Km[10%SFm-Nvul No+Tϑ0N@nul NoKm[elv T NI{ϑ10%SFmfN@n cd\OffNۏLd\O Km[~gNmmol/g͑h:y0 2.6.2 pencYtT~g$R[ pencǑ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` $R[ch~g3'`0 2.7 ut~~f[SS0ʋehQT~g$R[ 2.7.1 [PgeN]S-NZP*jRbSPg QQRGr ς9Nb!grbl~Ogr0 2.7.2 \hNvNzƉΑ_YU_~ހvutSS (u40 Pir\ޏ~‰[te*N~~RGr0;N‰[n(WvR^0VTby0 2.7.3 ċRhQ ~ހQnce(W z\0 +Tnv~ހ NǏ1/4 +Tnv~ހ NǏ1/2 +Tnv~ހ NǏ3/4 ~~QNNnNf0R1R2R3R4R2.7.4 pencYtT~g$R[ Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`Ff_\01%vxI{0 1.3[el 1.3.1 [Rir\ 18 22g USN'`+R k~10 15S0 1.3.2 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N\!jW[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hTNgq\MR~N14 30)Y gq\TN6q~NSՋir _eS^45)Y0 1.3.3 [ek SՋ7hT~Ngq\MRT~Sޏ~~NSՋ7hT BRϑ~N\!jW[gq~GWN TNBRϑ\~hQgq\N!k gq\BRϑ[ b3Gy 5Gy0R+RNgq\MR0gq\T,{3)Y0gq\T,{14)Y N!kǑ+gh@20L ReQ0.38mL 1%vx-N mST ReQ@tpeg-N {pe`l-NV*N'YefW'`FfW'` QۏLgq\ST~[0 gq\T3)Y\!jW[gq~v}v~ހpeR+RNgq\MRۏLꁫk ]_ g>fW'` R$R[\_c$O!jWbzNNep0NNBRϑ~N\!jW[gq~k }v~ހ;`peXY ]_ g>fW'` RS$R[勞[3'`0 2Ӛ~ހDNA+TϑbӚ g8h~ހpe[ 2.1St Ӛ~ހDNA+TϑbӚ g8h~ހpeMNO/fN!k'`hQ\~gq\_w\_c$OvhsKNN (WN[VQ gq\BRϑNӚ~ހDNA+TϑbӚ g8h~ހpebSk b` YeNӚ~ހDNA+TϑbӚ g8h~ހpebckk Ӛ~ހDNA+TϑbӚ g8h~ހpeSNh @|~S_cvrQ0 2.2NhVTՋBR @tpeg0>f_\0l\hV0Kb/ghVh0+}YRIQIQ^0Hank smI{0 2.3[el 2.3.1 [Rir\ 18 22g USN'`+R k~10 15S0 2.3.2BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N\!jW[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hTNgq\MR~N14 30)Y gq\TN6q~NSՋir _eSS_^45)Y0 2.3.3 [ek SՋ7hT~Ngq\MRT~Sޏ~~NSՋ7hT BRϑ~N\!jW[gq~GWN TNBRϑ\~hQgq\N!k gq\BRϑ[ b3Gy 5Gy0Ngq\T,{3)Y i1Y{kRir eRyQ (u1mLl\hV6.5S4Y 8TSN[SOyvHank sm QQ-NvhQ萨Ӛ~ހgT ~ހ`mǏ4S4Yvl\hV O~ހ(W`m-NEQRRce0 \ Npe0{kmLӚ~ހ`m-Nv g8h~ހpe0 b(u+}YRIQIQ^260nmYKm[DNA+Tϑ0 2.4 pencYtS~g$R[ Ӛ g8h~ހpebӚ~ހDNA+Tϑ:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfW'` RS$R[勞[3'`0 3 \ Ӛ~ހ_8h[ 3.1 St Ӛ~ހ_8hpeXؚ/fN!k'`hQ\~gq\_w\_c$OvhsKNN (WN[VQ gq\BRϑNӚ~ހ_8hsbckk b` YeNӚ~ހ_8hsbSk Ӛ~ހ_8hpeSNh:gSOgrSOS_cvrQ0 3.2 NhVTՋBR VRhVh uir>f_\ }sGrI{0 \[r@n\[r@nñT>eeQ56!R`)n4ltmO)n1hۏLeSO;m'`mp;m0 20!OX[0NS(u'Y0\ @nNf0 GiemsagmS^(um 1/15mol/LxxvQmpH6.8 2uRg~ 3.3 [el 3.3.1 [Rir\ SO͑18 22g USN'`+R k~10 15S0 3.3.2BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N\!jW[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hTNgq\MR~N14 30)Y gq\TN6q~NSՋir _eSS_^45)Y0 3.3.3 [ek SՋ7hT~Ngq\MRT~Sޏ~~NSՋ7hT BRϑ~N\!jW[gq~GWN TNBRϑ\~hQgq\N!k gq\BRϑ[ b3Gy 5Gy0Ngq\T,{3)Y i1Y{kRir Sb (ubk@$cQӚmNsGrNzv\[r@nmS 8^ĉmGr0b(u\[r@nQmӚT6Rb~ހ`mmGr mGr6qr^qT >eeQ2u-NV[5 10min >eeQGiemsa^(um-N gr10 15min zsS(uxxvQmb4lQm ~fr^0\h kSRirpe1000*NUYg~~ހ-N_8h~ހpe _8hsNCSRsh:y0 b6Rs{ C D A% %%%%%%% 100% C E _-N A b6Rs C zSir[gq~_8hs D SՋ7hT~_8hs E 4'`[gq~_8hs 3.4 pencYtS~g$R[ Ǒ(uaSeh0l~gR^be]RgI{~elۏLpencYt0 NNBRϑ~_8hsNON\!jW[gq~_8hs ]_ g>fW'` S$R[勞[~g3'`0 4 @~~-N'lSirgkSvSOD ;m'`[ 4.1 St @~~-N'lSirgkSvSOD ;m'`MNO/fN!k'`hQ\~gq\_w\_c$OvhsKNN (WN[VQ gq\BRϑN@~~-N'lSirgkSvSOD ;m'`bSk b` YeN@~~-N'lSirgkSvSOD ;m'`bckk @~~-N'lSirgkSvSOD ;m'`SNh:gSO'lS؏SS^|~S_cvrQ0 O2 'lSWvg~Nir:NN]xxv T(W[(lWxxS2u\O(u NHTs+}~r (Wl530nmY gg'Y8T6e\ S(uRIQIQ^lۏLKm[ S_SODmdO2 Tb_bvN]xxvQ\0 4.2NhVNՋBR NhV 721RIQIQ^0y_:g0R`)n4ltm0SFmhV ՋBR 65mMxxvQmPBS pH7.80SODhQT0 N/l2up095%YNv/v 00.9%utv4l10mmol/Lvx vx6.95mg RPBS10mL 7.5mmol/LĞ VdT Ğ VdT11.41mg R0.1M NaOH 2.5mLn RPBS10mL 0.2mg/mLĞ VdT'lSv S10mg/mLĞ VdT'lSv0.2mLRQQPBS 9.8mL10mL 0.1%2u S0.2g -2unN40mLl4l Q[)nR50mLQx QR110mLQ4l200mL 0.33%[(lWxx S0.66g[(lWxxnN150mL)n4l R50mLQx200mL 4.3 [el 4.3.1 [Rir\ SO͑18 22g USN'`+R k~10 15S0 4.3.2 BRϑR~SSՋ7hT~Ne [ N*NBRϑ~TN*N\!jW[gq~ NNSOcPϑv10 P:NvQ-NvN*NBRϑ~ SN*NBRϑ~ _e3'`[gq~0SՋ7hTNgq\MR~N14 30)Y gq\TN6q~NSՋir _eSS_^45)Y0 4.3.3 [ek SՋ7hT~Ngq\MRT~Sޏ~~NSՋ7hT BRϑ~N\!jW[gq~GWN TNBRϑ\~hQgq\N!k gq\BRϑ[ b6Gy 8Gy0Ngq\T,{7)Y ۏL[0 4.3.3.1 ~~ހbcm6RY10LhQ@QeQ0.5mLutv4l 2000r/miny_3min _ Nn RQQvS4l0.2mLmS ReQ95%YN0.1mL /ca30s ReQ N/l2up0.1mL n_mThVbc1min 4000r/miny_3min RB\ NB\:NSODbcm -NB\:N@~ˆ}vlmir NB\:N N/l2up U_ NnmSOy_Km0 4.3.3.2 ~~SFmv6RYjRSN[ϑv@bhV utv4lQm0br^0y͑0jRx stSFmhV-NReQQutv4l20000r/minSFm10s Gk30s S YۏL N!k 6Rb1%~~SFm g}Y(uXlSuhVYt30s O~|SO/c4x N-N'`~ yl~Bgrf~|SO]/cx0N4000r/miny_5min S Nnm20L_Km0 4.3.3.3 SODhQb6Rf~ \SODhQT(uxxvQmM6Rb750U/mLvnm Qzʑ0R50 P sSSODϑ:N15U/mL1.5g/mL (u,glKm[ N TϑvSODhQmv~vRb6Rs N~vRb6Rs:N~PWh NSOD;mRUSMOU/mL:N*jPWh~6RhQf~0 [gq{OD Km[{OD SOD~vRb6Rs%%%%%%%%%%%%%%%%100% [gq{OD { kmLS^m-NSODb6Rs50%e@b[^vSODϑ:NN*NUSMO0 [gq{OD-Km[{OD 100% [gq{OD S^m;`ϑ6mL SOD;mRU/mL %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%7hTzʑ Ppe 50% Smϑ _NS(uvk;mlsSNk{7hTv~vRb6RsNSODhQf~gQv^vSOD U/mL XNNzʑ Ppe1mL/S7hϑ 0 7hT:N~~SFmm 9hncSFmSm^b~~ˆ}v(+Tϑ \USMObc{:NU/g~~bU/mgˆ}v07hT:N~~ހbcm 9hnc@~ˆ}v+Tϑ Sbc{:NU/g Hb0 4.3.3.47hTKm[ek ՋBRKm[{[gq{1/15mol/LxxvQm pH7.8mL 1.01.07hTA*10mmol/LvxmL 0.10.17.5mmol/LĞ VdTmL 0.20.20.2mg/mLĞ VdT'lSvmL 0.20.2S4lmL 0.490.49mS 25!R`)n4ltm20min 0.33%[(lWxxmL 2.02.00.1%2umL 2.02.0mS15minT PeQ1cmIQ_krog N4l 530nmYkrKm[ODfW'`FfW'` RS$R[勞[3'`0 5 @nn@ }[ 5.1St MQu|~/f:gSO\_c$OOeav~~KNN @nn@ }eeQ gstsvmp̃%b_t-N gN*NeTGdR N1~~ >eeQ4!Q{OX[Y(u SOX[2hT0 5.2.3.1.3.2 MQuRirS@nRy S@ (uutv4lmm3!k k!ky_2000r/min 10min0\SySRBC(uutv4lMb2%v/v v~ހ`m kS yTl\0.2mLۏLMQu04^5)YT Xdden~1h \QV@N{XeRy O@nEQRgQ 2000r/miny_10min 6eƖ@n0 5.2.3.1.3.3 QƖS^ (uutv4l\@n Pkzʑ \ N Tzʑ^v@nR+RnN_ϑ@Q[gQ kT[100L QReQ100L 0.5%v/v vSRBC`m mS ňeQnmvs^vQRv N37!)n{u[3h ‰[@tQƖ z^0 @nQƖ z^N,R:N5~0 IV U_ c N_{bSOype bSO4ls^S1+2S2+3S3& & nSn _-N10203& & nNh[ Pzʑvcpe SNhQƖ z^v~+R bSOype'Y h:y@nbSOؚ0 0~ ~~ހhQ Nl Ɩ-N(WT[^b_b[vWpr VhTmSOnpf0 I~ ~~ހ'YRlƖ(WT[^bVpr VhT g\ϑQƖv~~ހ0 II~ QƖv~~ހ(WT[^b_bB\ -N_SNf>f0RN*Nu~gv~p0 III~ QƖv~~ހGWS0Wce(WT[^bNB\ -N_~SN*N\~p0 IV~ QƖv~~ހGWS0Wce(WT[^bNB\ QWW gebwSbr0 5.2.3.1.4 pencYtS~g$R[ bSOype:NϑDe Ǒ(ue]Rg FO ce]Rgv z^HQۏLe]P'`h e]P {F

fW'`FfWؚN!jW[gq~vbSO4ls^ S$R[y[~g3'`0 5.2.3.1.5 laNy @nzʑeEQRmS0gTN*Nzʑ^^ NQsQƖsa0 5.2.3.2 JSpen@e@~ˆ}v ǏKm[@~ˆ}v+TϑS fRir@n-Nn@ }v+Tϑ0 5.2.3.2.2 NhVTPge 721RIQIQ^0y_:g0R`)n4ltm0SRBC0eSOZ @n 0SAQm0_ՋBRxx"l1.0g0ؚ0lS0.2g00lS0.05g R4l1000mL 0 5.2.3.2.3 [ek 5.2.3.2.3.1 SRBC ~Y S@ \@>eeQ gstsvmp̃%b_t-NgN*NeTGdR N1~~ >eeQ4!Q{OX[Y(u SOX[2hT0 5.2.3.2.3.2 6RYeSO ǑƖZ @ RyQ@n\5SZ vmT@n \1mLSySRBCReQ0R5mLZ @n-N >e4!Q{30min ~8^/ca y_S Nn Rň 70!OX[0(ueNSAm c16"8zʑ0 5.2.3.2.3.3 MQuRirS@nRy S@ (uutv4lmm3!k k!ky_2000r/min 10min0\SySRBC(uutv4lMb2%v/v v~ހ`m kS yTl\0.2mLۏLMQu04^5)YT Xdden~1h O@nEQRgQ 2000r/miny_10min b6000r/min 4min 6eƖ@n0 5.2.3.2.3.4 n@S^ S@n(uSAQmzʑN,:N200^500 P 0\zʑTv@n1mLnՋ{Q O!kReQ10%v/v SRBC 0.5mL eSO1mL(uSAm c1:8zʑ 0S NR@nv[gq{NSAmNf 0n37!R`)n4ltm-NO)n15^30minT Qtm~bkS^02000r/miny_10min0S Nnm1mL RlՋBR3mL TeS10%v/v SRBC 0.25mLRlՋBR4mL EQRmS >en10minT N540nmYN[gq{\Ozz}v R+RKm[T{IQ[^fW'`FfW'` RS$R[勞[3'`0 ~g$R[ (WYhT@-N}v~ހpe[0Ӛ~ހDNA+TϑbӚ g8h~ހpe[0\ Ӛ~ހ_8h[0@~~-N'lSirgkSv;m'`[0@nn@ }+Tϑ[-N NUO$Ny[~g3'` S$R[SՋ7hTwQ g[5uy\qS[ gRObRv\O(u0 NASV0 gRNcŔRhel 1 Rir[ 1.1 [St [Rir~S~N+TŔSTircPO(uxŔ S b~~-NŔ+TϑXؚ0 !jegN00~~-NXؚf>f KNT~~-NŔ+TϑnXؚ0k~N[RirSՋ7hTT !jWRir~~-NŔ+TϑvSS`Q Nnx[dkSՋ7hT/f&TwQ gOۏ:gSOcŔv\O(u0 1.2 [Rir cPO(ubt^'Y USN'`+R SO͑150 200KQ k~8 12S0\ R^O(uяN|Rir USN'`+R SO͑18 22KQ k~10 15S0 1.3BRϑR~SSՋ7hT~Ne [ N*NBRϑ~0N*Nzz}v[gq~TN*N!jW[gq~ N*NBRϑ~-N^SbN*NNSOcPϑv10 P\ b5 P'Y BRϑ~0SՋ7hT~Ne30)Y _eS^45)Y0 1.4 [ ,g[O(u2'`ؚŔRir!jW0 [g (W!jW[gq~0SՋ7hTTBRϑ~n(uxŔ4lnmcPSm^:N0.1% 0.2% bUr+TŔre !jv Te TBRϑ~LpÀ~NSՋ7hTbUr+T N TBRϑSՋ7hTvre0zz}v[gq~~NSyP[4lbW@xre0 1.5 ‰[ch N+g!k~NRirSՋ7hT24\eT yϑRirSO͑0S@v^Y{kRir Sϑ@007hT mSTO(uwXpSP[8T6eRIQIQ^bICP-MSI{el Km[Ŕ+Tϑ0 1.6 pencYtT~g$R[ N,Ǒ(ue]Rg FOHQۏLe]P'`h e]P R{FfW'`FfW'` ۏNekO(uY*N[~TN*N[gq~GWpev$N$NkelۏL~Rg0[^ck`R^be] NPvpencۏLS_vSϑlbc _nck`R^be]PvBlT (ulbcTvpencۏL~Rg~SϑlbcN N0Rck`R^be]Pvvv R9e(uyThۏL~Rg0 ~g$R[(WRir!jWbzvMRc N [~N!jW[gq~k NNBRϑ~Ŕ+Tϑ>fWMNO Te@ŔbŔ+Tϑ>fWMNO S$R[SՋ7hTRir[~g:N3'`0 2 NSOՋߘՋ 2.1 SՋ~eQhQ gŔf2cS0@Ŕ+Tϑؚv?aSՋ0cP b^\N@ŔwOPؚvN sS@Ŕ(W200(g/L 400(g/L1(mol/L 2(mol/L VQ b?\Ŕ(W70(g/L 120(g/L0.34(mol/L 0.58(mol/L VQ0 2.2 SՋcdhQ 2.2.1 @Ŕb?\ŔǏؚ gf>fŔ-Nkur0 2.2.2 ` g_@{00T @|~I{hQ'`uu0 2.2.3 Y ZTTsNgYsY0 2.2.4 Ջg g(uNSՋR gsQvirT q_T0R[~gv$Re0 2.2.5 \P gSՋ7hTb-NR gvQ[oir el$ReRHebDe NhQ0 2.3 ՋSR~Bl Ǒ(uꁫT~$Ny[gq0 c@Ŕ0?\Ŕ4ls^[SՋۏL:gR~ (WR~e=\SQq_T~gv;NV }YŔcS0t^0'`+RI{ ۏLGWa'`h NO~vSk'`0k~SՋ gHeOpe N\N50O0 2.4.SՋ7hTvBRϑTO(uel Ջߘ~ ccP g(uelT g(uϑke g(uSՋ7hT [gq~ g(uI{ϑ[paBR0Ջ~T[gq~O(u:g0vl[0SՋ7hT~Ne30)Y _eS^45)Y0ՋgSՋ N9eSu;m0]\OsX N9eSSegu;m0nߘ`N`0 2.5.‰[ch 2.5.1 [hQ'`ch 2.5.1.1 N,rQ Sb|^y0aw w0nߘ0'Y\O0@SI{0 2.5.1.2 @0?\0O8^ĉhg0 2.5.1.3 0Rhg0 2.5.1.4 Gr0_5uV0yBhgTychNՋMRhgN!k 0 2.5.1.5 ?\0?\ vKm[Km[e0!kpeTel T?\Ŕ0;`?\0;`?\ :NՋ_YT3!k?\b?\ Km[50% vDe ^O(uyTh0 ~g$R[ՋߘT Ջߘ~N[gq~~k \$N*N‰[ep?\ŔcQϑXRN>fWؚNՋMR b;`?\ŔcQϑf>fXR0 Te [;`?\0;`?\ vcQef>fq_T b;`?\0;`?\ cQXRvE^^\N;`?\ŔcQXRvE^^ S$R[SՋ7hTwQ g gRNcŔRv\O(u0     PAGE  PAGE \* MERGEFORMAT7 Xx\x2T "@|~jBd^`vTVZ\`bjJLNn(xz h=5h=6]o(h=OJQJ h=H* h=6] h=5\ h=aJh=KHaJo(h=KHaJUh=I Ln"@`vLN`n(LWD`Xfrtv8Dfp (*2HJVXpr:HNPTVxzh=H*KHaJh=KHOJQJaJ#jh=CJUmHnHsHtH h=CJh=@aJ h=aJo( h=aJh=KHaJo(h=KHaJh= h=o(?` vF  ">@"XZ*WD`(JZ\pP$IfWD`WD `$Ifqkd9$$If0 044 a$Ifqkd$$If0 044 a$Ifqkd?$$If0 044 aZ\j  WD`qkd$$If0 044 a&(PRln6:@BZ\jRTb6:NPTXbdhp&(46P\^bhpźh=5\o( h=aJo(h=5CJ aJo(h=5CJ aJh=KHaJh=5KH\aJh=KHaJ h=o( h=6]h= h=5\C68:Pd0|$If'WD`'WD`8DJPRThj~JNZ^(8@LPR` j h=H* j h=H* j h=H* j h=H* h=H*o( h=5\h=5\o( jmh=h= h=o(GWPkd$$IfTF0   44 laT$IfPkdE$$IfTx0   44 laTWPkd`$$IfT0   44 laT$IfPkd $$IfTP0   44 laTWPkd $$IfTP0   44 laT$IfPkd$$IfTP0   44 laT *2WPkd$$IfTg0   44 laT$IfPkd_$$IfT50   44 laT24BJLT^WPkd^$$IfTP0   44 laT$IfPkd $$IfT0   44 laT^`r(N  PnWD`Pkd$$IfTP0   44 laT`bprt~&(*.024@BFHNPR\^bdprvx&.028 j h= h=H* j h=h= h=o( j h=W8@BDFPXZ\^hprtv&(,2LNBX\^ $&FJTXjn pr. h=5\h=5\o( j h= h=H*h= h=o(Vr0:bHHf\^hWD`.048 8:(.JP\`48>BDLTV\f248:<>@HJhjnpxz| h=H* h=6]h=5\o( j ~h= h=o(h=W|~Z\vdfxz&,>@~$&*08P\^`jlr~2 jmh= h=H* h=H*o( h=5\h=5\o(h= h=o(Tvlvskd$$If0TH T044 la$If$a$WD` $Ifqkd$$If0TH T044 la$Ifqkd*$$If0TH T044 la$Ifqkd$$If0TH T044 la$Ifqkd$$If0TH T044 la$Ifqkd$$If0TH T044 la$Ifqkd$$If0TH T044 la"$Ifqkd$$If0TH T044 la"$2:$Ifskd$$If0TH T044 la:<.`JfWD`skd$$If{0TH T 044 la24HJf  , . 2 4 6 8 L V             8 < B F H P         fh$&,.xz~.0$@F j ~h=h=5\o( h=o(h=\   . V    L b   h&0XtWD`FRXt  "28<>np$&HJjlpz 026DFJLNPXbdp| h=5\ h=H* h=6]h=5\o(h= h=o(V "4>jl|tv(:WD`|~ ,8>DFHZ^dfrtvzJ`df&(08:TVZ\df  jmh=h=5\o( h=5\h= h=o(X.n<J : N!!"""8":"<"J"X""#2#D#L#WD`,.6Plz &(BTVX\fnp.08:PVrt:<DHJPZ\^jt $6: h=H* h=6]h=5\o( h=5\h= h=o(V  !!!!""8"<">"H"R"V"X""""##$#&#(#0#2#:#D#L#t$x$$$$$$$$$"%4%n%%%%%%&&6&ммŠ h=\o(h=5\o( h=5o(h=KHOJQJaJo(h=KHaJh=KHaJo(h=5KHaJo(h=5KHaJ h=aJo(h=5CJ aJo(h= h=H* h=o( h=6]9L#^#f#p#r#|##qkd:$$If0r6r 044 lal$If####$Ifqkd$$If0r6r 044 lal####$IfqkdB$$If0r6r 044 lal####$Ifqkd$$If0r6r 044 lal####$Ifqkd.$$If0r6r 044 lal##$$$Ifqkd$$If0r6r 044 lal$$@$J$$Ifqkd$$If0r6r 044 lalJ$L$X$b$j$r$$Ifqkd$$If0r6r 044 lalr$t$$$$$$$$Ifqkd$$If0r6r 044 lal$$$%2%$Iftkd|$$If0 y| 044 la2%4%p%~%$Iftkd $$If0 y| 044 la~%%%%$Iftkd$$If0 y| 044 la%%&&$Iftkd$$If0 y| 044 la&&8&D&$Iftkd$$If0 y| 044 laD&F&f&r&$Iftkd$$If0 y| 044 la6&F&d&t&&&&&&&''2'@'|'~''''' ((V(f((())):)J)R)T)Z)^)z)|)))))))))**(*8*L*\*h*j*t*x***P+b+++8,H,~,,,,,,,,,P-l-n-p-v- h=@ h=@o(h=5KHaJo(h=5KHaJ h=5o(h=mHo(sH h=H*h= h=o(Lr&t&&&$Iftkd$$If0 y| 044 la&&&&$Iftkd$$If0 y| 044 la&&''$Iftkd$$If0 y| 044 la''4'>'$Iftkd$$If0 y| 044 la>'@'''$Iftkd$$If0 y| 044 la''''$Iftkd $$If0 y| 044 la''(($Iftkd$$If0 y| 044 la((X(d($Iftkd $$If0 y| 044 lad(f((($Iftkd$$If0 y| 044 la(())$Iftkd $$If0 y| 044 la))):)B)J)\)$Iftkd$$If0 y| 044 la\)^)|)))))]Mkda$$If044 lal$IfOkd$$Ifv044 lal)))))**_Mkd$$If044 lal$IfMkd$$If044 lal****6*8*N*Z*_Mkd$$If044 lal$IfMkd9$$If044 lalZ*\*j*v*x***_Mkd$$If044 lal$IfMkdɨ$$If044 lal**R+`+b+++_Mkd$$If044 lal$IfMkdY$$If044 lal++:,F,H,,,_Mkd1$$If044 lal$IfMkd$$If044 lal,,,,,,,--._]]U]]WD`Mkd$$If044 lal$IfMkdy$$If044 lal v-x-z-|-----------.$.&.(.,..........//// /,/6/:/L/l/p/80:0B0J0L0|0~00000000011 1101~111111112(2,2.2:2@2N2d2h2j2v222 h=H* h=QJo(h=5KHaJo(h=5KHaJ h=o(h= h=@ h=@o(O. /6/:0L0~0000 12.2<2P2j2 3>33:4J4V4|444(5B5d552WD`2WD`22222222222222222233343<3X3^3d3f3h3j3l3n3p3333333333344,46484:4H4J4L4N4P4R4T4V4X4Z4\4l4r4z4|4~4444444444444444j7h=EHU h=EHjh=@EHU h=@o( h=@H* h=@ h=o(h=N4555"5&5.50525@5L5N5P5b5x5555556666667$7*77777777777`8j88888899"9$9,94969@9T9Z9\9h9t9v99999999999::: :$:.:4:h=OJQJ^Jo( h=H*h=KH\aJo(h=KH\aJh=KHOJQJ^J_HaJh= h=o(L55677788969B9\9: :;;<<=8=>>>? ?d$d7$8$9DN]> d7$8$9D>d&d7$8$9DP]>D D,D6D8D>DDDRDdDjDrDxD~DDDDDDDDDDDDDDDEEEE$E*E4E:E>EBEEEEEEEE FFFF,F.FJ@JJJLJNJXJZJ\JfJhJjJrJtJJJJJJJJJJKKK&Kh=CJRHP h=CJ j-h=CJRHPh=CJRHPo( h=@o( h=@ h=o(h=O&K(K*K0K4KLDLJL\L^LLLLLLLLLLLLLLLLLLLMMM:N@NFNLNTNVNZNƿƿ˿ƿƿ˿Ưƞƞ h=@o( h=@h=5@KHaJh=5KHaJo( h=H* h=6] h=o(h= j-h=CJRHP h=CJ h=CJo(h=CJRHPo(h=CJaJh=CJRHP;ZN`NjNNNNNNNNNNNOOOOOOpOtOOOOOOOOOOOOOO PP$P*P@PNPPP^PtPPPPPPPPQQ QQQQ,Q.QxQzQ~QQQQQQQQQQQQQQQQRRRh=KHaJo( h=H* h=6]h=5KHaJo(h=5KHaJ h=aJo(h= h=o(N,P`PPPQQ.QRRSStTTTTLUUUVHVdVVVWWWXXXWD`RS*S4SSSSSSSSS4T:TrTtTxTTTTTTTUU UUU"U*U.U0U:U[D[P[b[d[n[p[t[[[[[[[[[[[[["\&\X\\\b\t\\\\\\\̼ h=QJo(h=mHo(sHh=mHsH h=H*o( h=aJo(h=5KHaJo(h= h=o(h=5KHaJIXY>YvYYY6ZLZZZZ[D[t[[d\\\\]8]^]]]]]\^v^^WD`\\] ]]]0]2]]]]]]]]]]]]]]4^6^J^L^Z^\^h^j^p^r^~^^^^^^^^^^^^^^^__(_*_0_L_P_T_V_Z_________ `Ӽݼͼݼݼݼ h=aJo(h=@H*o( h=H*o( h=@o(h5@\o( h=@jh=@U h=o( h=QJo( h=@o( h=@h= h=@@^^__@_________ $$Ifa$$IfWD` ____```&`0`8`@`B`qkkkkkkkkkk$IfkdF$$IfT4F`H`0    44 laf4T `"````aaaaaaaaaabb*b,b.bXbZb^b`bjblbnbxbbbbbbb.c0cxczccccd$d0d2d8ddRddde ee.e0eeڿڳڿڿڧ頗h=KHaJh=KHaJo( h=KHo(jh=@EHUjUh=@EHUh=@H*o( h=@jh=@EHU h=@o(h=OJQJh= h=H*o( h=o( h=H*o(8B`D`L`N`V`^`82222$Ifkd$$IfT4ֈ  88 044 laf4T^```b`d`p`r`t`5kdα$$IfTֈ 88044 laT$Ift`v`~`````5kd$$IfTֈ 88044 laT$If```````5kdD$$IfTֈ 88044 laT$If```````5kd$$IfTֈ 88044 laT$If`````aa$Ifa a,a;2 $$Ifa$kd$$IfTֈ 88044 laT,a.a8a:aBaJaRaZa$Ifekdu$$IfTl044 laTZa\ata;2 $$Ifa$kd$$IfTֈ 88044 laTtavaaaa,*ekd6$$IfTl044 laT $$Ifa$ekd$$IfTl044 laTaaabb8bVbxbbb0czccc$d>dde,fXf(gJgjhh2iZiiWD`:WD,`:|WD`|eeeeee,f8f:f@fffffff(g4g6gg@gBgDgVgXg^g`gggjhvhxh~hhhhhhhhhhhhh2i>i@iFiHiJiZifihinipiriijj jjjjjjjjjjjk$k&k,k.k0kVkXkZk\k^k`kdkfkkkkk h=H*o( h=H*o(h= h=o( h=QJo(Yijkkkl mBmXmZmbmjmrmzmm$Ifkkkkkkkkkkkkkk l llllllllllll m,m.m4m6m8m@mBmVmXmZm`mbmhmjmpmrmxmzmmmmm o,o.o4o6o8oxo~oooooVp^pppppppqqqqqqqqqqqqrr`rlrjh=UmHnHsHtHh=5\o(h= h=H*o( h=o(UmmmmmmmA;;;;;$Ifkd$$If  ֈ m!H      0  44 lammmmmmm;kd2$$If  ֈ m!H      0  44 la$Ifmmmmmmm;kd$$If  ֈ m!H 0  44 la$Ifmmmnnn"n;kd$$If  ֈ m!H 0  44 la$If"n*n2n:nBnDnVn;kd,$$If  ֈ m!H 0  44 la$IfVnXnZn\ndnlnnn;kd$$If  ֈ m!H 0  44 la$Ifnnnn oFoopvpxppdqqqq`rr:sbsss}D}F}L}Z}`}d}h}l}x}}}}}}}}}}}}}}} ~~~~~~"~*~:~<~>~@~H~^~j~l~z~~~~~~~~~~~~~~~~ h=H*o(h= h=o(jh=UmHnHsHtHX~468:@FHNR`flntvx$&(*,6DFHJLNT^`tz|ЀԀހ   "(*,.<FNPxƁ؁ h=H* h=o(h=`؁,.<@JLNPX\jp‚ĂƂʂ؂ڂ܂ނ  "$&(*0:<JLVX^`|~ă 02|~ h=6] h=@o( h=@ h=@o( h=@ h=QJo( h=o(h=Q̂VX` 2څ†.bdxʊWD`WD`„ĄƄȄ҄΅ԅڅ$.†چ܆ "ćƇȇ̇ lv,.񿷿h=5\o( h=5\ h=5aJh=5aJo(h=OJQJh=5CJ aJo( h=5 h=5o(h=5KHaJo(h=5KHaJ h=6] h=o(h= h=H*<.:<>DbdhvxȊҊTXbfnrnpt|Ѝލ  .0NPXdfr ΏЏڏ܏  &8: h=aJo(h=5\o( h=5\h= h=o(XTlnnp~ҍPf*^Џ܏ :WD`&*,6:@ptvxz|̑Αܒ  ,0DH^`“046Z\^r ֗֘» h=5\ h=5aJh=5CJ aJo( h=5 h=H*o( h=H* jch=6]o( h=6] h=o(h=I.x024Z\^r&JHbWD` ԗ֗Ԙ֘4Trƙ 68Pț ,.| WD`ƙ8PFHpr26X\bd Ğ؞(x`~` h=5aJh=5aJo(h=5CJ aJh=5CJ aJo(h=5OJQJ jch=6] h=6] h=o(h=KHOJQJ^JaJo(h=KHaJ h=H* h=5\h= h=aJo(8ĞƞȞʞ̞ΞОҞԞ֞؞ڞܞޞ(vxƟDWD`^`~^`pĢBXr02Jlzʤ"WD` BX0J (*̥Υ"ܦ &(:>@FXZdhn*2:<fnpt(.dfnvxh=5\o( h=5aJh=5aJo(h=5CJ aJo(h=5CJ aJh=OJQJo(h=KHQJaJo( h=5 h=o( h=6] h=5\ h=aJo(h=>¦ĦƦȦʦ̦ΦЦҦԦ֦ئڦܦަަ (h*<fx̩<826H`ȭrWD`ʩ̩ (*HJNPXZ\^h:<6DTV06:FP^`lƭȭԭڭޭ&p~®ȯ̯Яүد°԰ܰ h=H*h=6]o(h= h=6] h=o( h=5\h=5\o(Sүİ*d.zrFHַ> d$dNd d&dPdWD`(:btx4<>B,.FHpr048VZ`xz "p~ĵƵDFHLP\bt|ƶҶ jnpr h=H*o( h=56 h=6]h=5\o( h=5\ h=aJo( h=o(h=Prҷ&.02<ȸҸָRZnz޹46@$26LNPRh|~̻ڻ޻ "$.fpȼҼԼּڼ h=H*o(h=56o( h=H*h= h=o(Y>|B~ܻ޻hּܼ$Ifd d&dP| d&dPWDx`| d&dPdڼܼ (,.2JR`fνԽ޽DFrtxzľξܾ (2@DJLV\~¿̿ҿԿ&0@HRXbhv| h=o(h=b cJkd$$If0< XX44 a$IfJkdt$$If0< XX44 a"$4>cJkdH$$If0< XX44 a$IfJkd$$If0< XX44 a>@T^`hvcJkd$$If0< XX44 a$IfJkd$$If0< XX44 avxFHtzcaYaaaWD`JkdP$$If0< XX44 a$IfJkd$$If0< XX44 a cJkd$$If0< XX44 aJkd$$If0< XX44 a$If¾ľоھcJkdt$$If0< XX44 a$IfJkd2$$If0< XX44 aھܾcJkd$$If0< XX44 a$IfJkd$$If0< XX44 a&(4>cJkd|$$If0< XX44 a$IfJkd:$$If0< XX44 a>@FTV^lcJkd$$If0< XX44 a$IfJkd$$If0< XX44 alnz|~Կֿ caYaaaWD`Jkd$$If0< XX44 a$IfJkdB$$If0< XX44 a $&2>cJkd.$$If0JJ 44 aJkd$$If0JJ 44 a$If>@JPRZ`cJkd$$If0JJ 44 a$IfJkdz$$If0JJ 44 a`bjtv~cJkd^$$If0JJ 44 a$IfJkd$$If0JJ 44 acJkd$$If0JJ 44 a$IfJkd$$If0JJ 44 acJkd$$If0JJ 44 a$IfJkdB$$If0JJ 44 acJkd&$$If0JJ 44 a$IfJkd$$If0JJ 44 a  &BHNlpz $6<Xdlx &0<HR\`lr8: "(: h=H* h=o(h=`  (,cJkd$$If0JJ 44 a$IfJkdr$$If0JJ 44 a,.<@BJ8caaaaaJkdV$$If0JJ 44 a$IfJkd $$If0JJ 44 a  (.cJkd$$If0< XX44 a$IfJkd$$If0< XX44 a.0@FHTZcJkd$$If0< XX44 a$IfJkdB$$If0< XX44 aZ\bjltcJkd$$If0< XX44 a$IfJkd$$If0< XX44 a:caYaaaWD`Jkd$$If0< XX44 a$IfJkdJ$$If0< XX44 a cJkd:$$If0 <  44 aJkd$$If0 <  44 a$If  "*4cJkd$$If0 <  44 a$IfJkd$$If0 <  44 a46DRTbrcJkdz$$If0 <  44 a$IfJkd*$$If0 <  44 a:BT`tx(.HRhr"@B\blpr|~$*4:FJZdnt~"&6<F h=5h= h=o(_rt~cJkd$$If0 <  44 a$IfJkd$$If0 <  44 acJkd$$If0 <  44 a$IfJkdj$$If0 <  44 avtllltttWD`7kdZ$$If$44 a$IfJkd $$If0 <  44 a "$,2cJkd$$If0< XX44 a$IfJkd$$If0< XX44 a24<DFPXcJkd~$$If0< XX44 a$IfJkd<$$If0< XX44 aXZflnv|cJkd$$If0< XX44 a$IfJkd$$If0< XX44 a|~cJkd$$If0< XX44 a$IfJkdD$$If0< XX44 acJkd $$If0< XX44 a$IfJkd$$If0< XX44 acJkd$$If0< XX44 a$IfJkdL$$If0< XX44 a^fH$6WD`Jkd$$If0< XX44 aFJLV\^dr|HN",46dfnvx6@ ,NP".0FJvLXth=5\o( h=5\h=5CJ aJh=5CJ aJo( h=o(h=Pfx P0tF`V`4XrWD`tv2<R^`X^bj|TVhp68<>@BDLNlnrt|~^`˾jh=Uh=6]o( h=H* h=6]h=5\o( h=5\ h=H* h=o(h=jh=UmHnHsHtHH24Vdpr,.6>@L0HZ<> rvƾƾh=5\o( h=5\ h=5o( h=5h= h=o(jh=Uj h=EHUjI h=UVKr.@ J,H.WD`*<F\,Bh$&@B ,>tvp(TVN` (*6DF *<Tf,>@&(h=5\o( h=5\ h=6]h= h=o(X.l.rP~*F,V @(XWD`&.2Vl|~  8:bd~"&*HLRjl "8:PTXZbdrt| h=6] h=aJo(h= h=o(\X~~ ln$If$a$WD`gaaaa$IfkdS$$If\  , 044 la":Rgaaaa$Ifkd$$If\  , 044 laRTZdt~gaaaa$Ifkd$$If\  , 044 la~gaaaa$Ifkd[$$If\  , 044 la$gaaaa$Ifkd $$If\  , 044 la"&02@BVXfjl|(*@B&0<>JNPZlt",.@Tth=5\o( h=5\h=5aJo( h=aJo(h=5CJ aJo( h=o(h=Q$&2BXhe____$Ifkd$$Ifb\  , 044 lahjl*Bgee]e]eeUvWD,`vWD`kd$$If\  , 044 la B(>P\vB0B0WD` &@B&.DNP~ "<Blnpt>  vjh=EHUjI h=UVjh=U h=H*#jh=CJUmHnHsHtH h=CJ h=CJo(h= h=o(G0P"L 6H^xp.JWD`vx|~ 46BFH\nv ,46:V`np$,>FJ`dflrv.Bh=5\o( h=5\ h=H*h= h=o( h=6]Wnh`rR8d]WD`B\fjLNft "^`dfp~&Pb &68>NP\h=5\o( h=5\ h=5 h=H* h=6]h= h=o(T8P \     6 |         4 v    8WD` \ d                 6 > z |    ~       ~             " 0 2 4 @ D H v        .68*,BJNP h=aJo(h=5\o( h=5\ h=o(h=Y,F|(LJfWD `WDR`WD`Px&(JPTV HJRdf~8:hlp :<@D\xſſŸ h=aJo( h=aJ h=5aJh=5aJo(h=5CJ aJo( h=6]h=5\o( h=5\h= h=o(H \xVn:FPV\bhp$If$a$WD`,2V  ,.8:^brv:<JR (04<  "BD(*8:j jh=aJh=OJQJaJo(h=CJKHOJQJaJh=5aJo( h=5aJ h=aJ h=aJo(Lprz;55555$IfkdL$$IfTTֈ Q[044 laT5kd$$IfTTֈ Q[044 laT$If5kd$$IfTTֈ Q[044 laT$If J5kd$$IfTTֈ Q[044 laT$IfJLNn $If$a$WD`dkd$$IfTTW044 laT jlnv  48@DJN`b,.@BRTV2468JLdfl $*TXhlN R    !!!!*!,!4! h=5aJ jh=aJh=OJQJaJo( h=aJ h=aJo(U$8L`;55555$Ifkd$$IfTTֈ i --044 laT`jlr|5kd$$IfTTֈ i --044 laT$If5kd$$IfTTֈ i --044 laT$If&(j5kd$$IfTTֈ i --044 laT$Ifjl0>!p!z!!!!!$If$a$dkd`$$IfTTi  044 laT 4!6!8!:!^!f!!!!!!!!!!!!!!!""""" """$"D"F"""D#F#N#P###########.$4$6$>$R$T$$$$$$$ %"%&%(%~%%%%%%%%%%%%%%&&&&R'T' jmh=aJ h=5aJ jh=aJh=OJQJaJo( h=aJ h=aJo(Q!!!!!!!RLLLLL$Ifkd$$IfTr48 044 la!!!!!!!RLLLLL$Ifkd$$IfTr48 044 la!!!""""RLLLLL$Ifkd`$$IfTr48 044 la""L"RL$Ifkd$$IfTr48 044 laL"N"l"###$V$r$&2'(((*++X+j+WD``kd$$IfT  044 laT'd'h'n''''''(()))) ))))4)6)8):)<)>)F)J)L)N)V)X)))))(*@*T**++X++-..///B0L000002141V1X1x1111\2d2j2l2t2x222223 3νh=OJQJaJ h=H*aJh=6]aJ h=5aJh=KHaJh=KHOJQJaJo( h=aJo( h=aJJj+++,,.-P---.@.l...///000$1H1j1111h22$a$WD`22222222"3F3_kdj$$If\  42  044 la$If 3"3$30343N3P3333333444"4(4.4t4x444*5.5b5f555555556@6B6j6l6666677*7.7<7>7P7T7Z7\777888@8~8888899ȹh=KHOJQJ^JaJh=KHOJQJ^JaJo( h=5o(h=5CJ aJh=5CJ aJo(h=6]aJ h=5aJ h=aJo( h=aJAF3H3N3X3p33e____$Ifkd $$If7\  42  044 la333333e____$Ifkd$$If7\  42  044 la33334@4e____$IfkdJ$$If7\  42  044 la@4B4H4f4~44e____$Ifkd$$If7\  42  044 la444 545l5556(6t7ec[[[[[c[[WD`kd$$If7\  42  044 la t7 8"8$8&8(8*8,8.80828486888:8<8>8@8r888889 $d7$8$H$a$$d7$8$H$WD`a$$da$WD`999&9(9<9>9t9v99999999999999:::::::::::; ;;;8;<;J;N;f;l;n;p;;;;;;;;;;;;; <"<&<2<:<<<T<V<`<b<n<p<~<ʹ㾹h=KHaJo( h=o(h=h=5\o( h=5\h=5KH\aJ h=5o(h=KHaJh=KHQJaJo(h=KHQJaJE9(9>9v999999::::;;"<<<d$d7$8$H$WD`a$dXD2$87$8$H$XDdYD2a$ & Fd$da$$ & Fd7$8$H$a$ $d7$8$H$a$$ & Fd7$8$H$a$~<<<<<<====6=8=p=r=============>*>,>.>0>4>:>>>D>J>L>Z>8?:???Z@\@^@b@l@x@z@@@@@@@@@2AZA^A`AdAfAļ覝˼˝˝˼h=QJ\aJh=QJ\aJo(h=OJQJaJo(h=QJaJ h=aJo(h=KHQJaJ h=5\h=5\o(h= h=aJh=KHaJh=KHaJo(><<=8===6>L>^@z@AAAPCdCGGjG HHH$87$8$H$XDdYD2a$ $d7$8$H$a$d7$8$H$WD`d$d7$8$H$WD`a$dXD2 dWD`fAlAnApArAxAzA|AAAAAAAAAAAAAAAA&B(B,B.B0B2B4BJ@JNJPJlJpJrJ|JJJJJJJJJJJKK$K&K(K,K0K2K6K8KBKJKLKfKlKnKvK|K~KKKKKKKKLLL4L6L^LLLLLLLMMMM Mh=QJaJh=OJQJaJo(h=KH\aJh=KHaJ h=5KH\aJh=KHQJaJo(h=KHQJaJh=KHaJF M(MPMRMTMVMZM\M`MbMjMrMtMMMMMMMMMMMMMMMMMOOOOOOOOO PP(P`PPPPPPPPPPPPPPPP򼠼h=KHaJh=QJaJo(h=KHQJaJh=5KH\aJ h=\aJh=QJ\aJh=KH\aJh=KHaJ h=PJaJo(h=OJQJaJo(h=PJaJh=QJaJ h=aJ8OPPQ~RR&TX@XBXXXZX^XfXnXpXrXtXvXzXXXXXXXXYYYYYYZ Z*Z,Z2Z4Z6Z[[ \\\2]N]^._d$87$8$H$XDdYD2a$ $d7$8$H$a$ $dXD2a$d7$8$H$WD`d`dXD2vZxZZZZZZZZZZZZZZZ[[$[&[>[B[N[\[`[~[[[[[[[[[[[[[[ \ \\\\"\H\J\P\T\Z\\\\\\\\\\\\\\]]]]0]2]N]h]پ캾h=KHQJh=h=5KH\aJ h=aJo(h=KH\aJh=KHaJh=KHQJaJo(h=KHQJaJh=KHaJo(Fh]j]]]]](^,^T^X^^^`^^^^^^^^^^^^__"_.__ `&`(`2`N`^`Da^abaxazaaaǼ{pg{h=KH\aJh=KH\aJo(h=5KH\aJo(h=KHaJh=KHQJaJo(h=KHQJaJh=5KHQJaJh=5KHQJaJo(h=5KH\aJh= h=H*KH jch=6KHQJ]h=KHQJo( h=KHh=KHQJh=6KH](._(`^`zaabbbbbbbbbbbbbbbbbbWD`d`$d7$8$H$WD`a$$87$8$H$XDdYD2a$ dWD`aabbbbbc(c*c.c2c:cDcLcNcfcjclcpczcccccccccccccccccccccccccccccccddddԹԭԭԭԭԭԭԉԉԉԉԉ h=H*o(h=OJQJo(j'h=EHUj*h=EHUh=h=5\o( h=5\h=5CJ aJh=5CJ aJo( h=o( h=aJo(h=KHQJaJo(h=KHQJaJh=5KH\aJ6bbbbbbbbc*c,c.ce@evexeeeeffffffffffffffgs@sBsssssssssssttttHuJuhujuxuuuuuuuuuuuuuuh=OJQJaJo(h=OJQJo(h=OJQJaJ h=o( h=QJh=h=QJaJ h=aJNuuuuuuvvvv\vvvwwww w"w2wFwTwnwwwwwwx x xx$x>xrxxxxx"y$y@yJyNyRyTyVypyyyyyyzzz&z(z,z.zVzXzZz˾ h=\ h=\o(h=H*OJQJaJo(h=CJH*OJQJo( h=CJH* h=aJh=OJQJo(h=OJQJaJh=OJQJaJo(h= h=o(>uv\vvwwwx$ypyyz.zzz}}}  ;dWD`; dWD` dWD`d dWD`dXD2d 'dWD`'Zz\z^z`zbzdzfzhzjzlznzzzzzzzzzzzzz {{{{{"{${&{({6{X{Z{{{{{{{{{{{{{{{{{{{|||||||||||||}}}@}B}ɼh=QJ\aJ h=\aJ h=aJh=QJaJjh=EHU h=\ h=\o(h=h=OJQJo( h=o( h=H*o(FB}D}F}`}b}d}f}}}}}}}}~~l~~~~~~~$(,0 *,<ZdfrzƀȀʀڀҁԁ0ʂ̂΂ƼƼh=OJQJaJh=OJQJaJo(h=OJQJ h=QJ h=o(h=h=QJaJ h=aJh=OJQJo(J ,ftvʀԁ4" dWD` dWD`d dWD`dXD2d dWD ` ;dWD`;  dWDF` d`4dWDnXD2`4gd'΂ނ4tz4.046>@BDN "46VXІ҆df‡ćVXڈ܈Ǻ볫뤟뫳뫳 h=H* h=6]h=5\o( h=5\h=H*OJQJaJo(h=CJH*OJQJo( h=CJH* h=aJh=OJQJaJh=h=OJQJaJo( h=o(>"6X҆fX܈~8:Ltv̌ތdXD2dXD2 dWD`d`d`d 8XDdYD2|~8:BJLVŠĊʊ̊26Z\rv~ʌ،܌ތ@Dzȍ>HVdhȎʎ&02DLXbdht| h=H*h=5\o( h=5\h=B*o(phh= h=o(UJ֎2ԏ<v $d$Ifa$ dYD2` dWD`d`d 8XDdYD2ddʏ̏ҏԏ܏24:<TX^jrvz|̐֐ ,28BR\`ltvʑ֑ڑ(.68<FTVlnz|̒h=5\o( h=5\ h=H* h=o(h=ZҒڒޒ $d$Ifa$rkd$$If\2 KT] N   44 a  $d$Ifa$rkd$$If\2 KT] N   44 a $(0 $d$Ifa$rkd$$If\2 KT] N   44 a "$&2<PX\fjړ,Xbdft~:<DNP\dfrxzЕҕؕڕ.<LTX`d h=QJ h=aJo( h=aJ h=\o( h=\ h=aJh=5\o( h=5\ h=o(h=M02BFJN $d$Ifa$rkdJ$$If\2 KT] N   44 aNP,dv}rii`W`d`dXD2Wd^W  dWD` 8XDdYD2drkd$$If\2 KT] N   44 a <Pf  ><x(&8Pښ.F dWD`ddXD2d`d:JNPv̗&(V&.68DN`lnȚ֚$,<DF "(,.026:>@BDHL h=RHZo( h=RHZ h=aJo( h=\h=5\o( h=5\ h=aJo( h=aJh= h=o(L "*6<HNZ`l$d$IfUDVD]^a$$da$ LPRTVZ^bdfhnvxz|œĜԜܜޜ"&*,046<>@DFHJLTXZ\`dfhjnrtvz~ȝʝBRV h=o(h=h=OJQJo( h=RHZo( h=RHZYlnx|T<<'d$IfUDVD]^$d$IfUDVD]^a$kd$$Ifr8 #!0044 laĜ$kd$$Ifr8 #!0044 la2d$IfUDVDWD]^2`d$IfUDVD]^$d$IfUDVD]^$d$IfUDVD]^a$$&,@\T<''d$IfUDVD]^$d$IfUDVD]^a$kdd$$Ifr8 #!0044 la\v?'$d$IfUDVD]^a$kd$$Ifr8 #!0044 lad$IfUDVD]^ʝd$IfUDVD]^$d$IfUDVD]^a$DdƞTKB=B=dd`dXD2kd$$Ifr8 #!0044 laV\`dt|ĞԞ.24bhnp|.26<FP^hnz|Ƞʠܠ"$&(¢̢ܢhjntvx֣أޣ:DFPZ^`dfhlh=KHaJo(h=KHQJaJh=KHaJh=5\o( h=5\ h=o(h=Q 4bp hƥ`dd`d`d` wed^w`e dWD`dXD2 d7$8$H$ 8XDdYD2d dWD`l,.\`dĥƥ0RT\^`.TX`bdHJfr ":<>þþþණh=OJQJ^Jo(jh=U h=\h=OJQJ\o(h=5OJQJ\o( h=aJh= h=6] h=o( h=5\h=5\o(CJV4t@Ԭ dWD`d 8XDdYD2 dWD`d`d` wed^w`edWDXD2`>@Īʪ֪ڪ24rtܫxƬҬԬ "$rtx|~tvh=OJQJ h=5\h=OJQJ\h=OJQJ\o( h=\h=OJQJo( h=o(h=OJQJ^Jo(h=jh=UFv&XWD`d` 8XDdYD2d dWD` 0246prίЯ&VXZrtvx԰ְذڰԱֱرڱ "$&(Բֲزڲ  $&(*³ij޴h=5CJ aJh=5CJ aJo( h=5\h=OJQJ^Jo(jh=Uh=OJQJ h=o(h=LHdxdd`dXD2d@&$da$$dpa$WD`&*FXbnvx¶ȶʶж$&*2@Z\&.0<VXҸָ08<Jbd:<>BHPZ\lv h=o(h=h=5\o( h=5\ h=aJo(h=5B*CJaJo(phRx4\0X>dH\&¼Լv LN`|rd@&dXD2d`d dWD` 248:BDFHR$&¼ʼҼԼt fjl|оԾ־ؾ JLNR^hz|"(,48p~@H\ $h=5\o( h=5 h=H*h= h=6] h=o( h=5\T@X| (^ d^`d^d`XD2 dWD`HdXD2 dXD2]d,48Vhz  &(4@jv68`b|~ $(FJP jch=6]o( h=6]h=5\o( h=5\ h=aJo( h=o(h=h=CJOJh=CJOJo(I *@BDFHJLNPRTVXZd$da$d`WD` dWD`d` |Z\^lnt<>~.00BDdhz|.n"$,LNP h=6]h=KHaJ h=H*h=5H*\ h=5\h=5aJo(h=5CJ aJh=5CJ aJo(h= h=o( h=H*Et0F.n@NXd`X `d^``$d9DH$`a$ dWD`dd`d`dXD2PRT\^`b@lhj|"$,.04`dfhjl赘h=CJ\o(jh=EHUjh=EHU h=CJh=OJQJ^Jo( h=o( h=5h=5EH\h=KHaJ h=5\h= h=H* h=6]h=OJQJ@F d$Iftkd $$If40Hh 044 laf4FHrt|||||| d$IfdtkdC $$If40Hh 044 laf4  d$Iftkd $$If40Hh`044 laf4   d$Iftkd $$If40Hh 044 laf4 d$Iftkd^$$If40Hh 044 laf4 & d$Iftkd $$If40Hh 044 laf4&(Ljlj||ss|s|dXD2d`dtkd$$If40Hh 044 laf4 (.8N^VtdWD^`d^d` dWD`d`ddXD2"8RHbdrz $d$Ifa$d dWD`dd` dWD`8dWD^8`  $d$Ifa$pkdO$$If\@ \ K44 a $d$Ifa$pkd$$If\@ \ K44 a $d$Ifa$pkd5$$If\@ \ K44 a,8DP $d$Ifa$pkd$$If\@ \ K44 aPRbnz $d$Ifa$pkd $$If\@ \ K44 a $d$Ifa$pkdy$$If\@ \ K44 a2JEE@dd7kdQ$$If44 a $d$Ifa$pkd$$If\@ \ K44 a24hzr| ,ldd`dXD2 $d9DH$a$ dWD`dhd`h`lHJNPTV^~r| (*prxzVX.0 jmh=h=OJQJ^Jo( h=EH h=o( h=5\h=KHaJh=OJQJ h=H* h=6]h= h=CJHdUMkd&$$If40` 44 la,f4Mkd$$If40` 44 la,f4 d$Ifd `ZQBbdWD|^b`d`Mkd$$If40` 44 la,f4 d$IfMkds$$If40` 44 la,f4dkd $$IfT4F X: : 4    44 af4T $d$Ifa$d  $d$Ifa$dkdu$$IfT4F X: : 4    44 af4T $ $d$Ifa$dkd$$IfT4F X: : 4    44 af4T$&(\^x~|pppppp $d$Ifa$$9d$If^9a$d`ddkd7$$IfT4F X: : 4    44 af4T RF=FFF d$If $d$Ifa$kd$$If4֞XP XX H88HH44 atf4&0Fkd-$$If4֞XP XX H88HH44 atf4 $d$Ifa$0:DFXblvFkd$$If4֞XP XX H88HH44 atf4 $d$Ifa$7kd;$$If4֞XP XX H88HH44 atf4id$IfWD2`i $d$Ifa$FAdkd$$If4֞XP XX H88HH44 atf4 $d$Ifa$JjJtNnBrJ`z $d$Ifa$ d$IfdXD2 $d9DH$a$d dWD`JtBrvx|~, BDFJjl(*0źޠޛ h=o(h=5\o(h=5aJo(h=5CJ aJh=5CJ aJo(h=OJQJo(h=OJQJ^Jo( h=H* h=5\h=KHaJh=OJQJ h=6]h==u $d$Ifa$ d$IftkdI$$If40XH` 044 laf4u $d$Ifa$ d$Iftkd$$If40XH  044 laf4u $d$Ifa$ d$Iftkd $$If40XH  044 laf4  u $d$Ifa$ d$Iftkd,!$$If40XH  044 laf44l zo^UdXD2$d9DH$WD`a$ $d9DH$a$ dWD`dtkd!$$If40XH  044 laf4 DF`l*<r6Pd7$8$;d`; dWD`dXD2d$da$d0:<@BdfprxBF468FHJNPTjlprtvx  h=H* h=6]h=CJOJo( h=H*o(jh=UmHnHsHtHh= h=o( h=5\h=5\o(J &p > n  $     t     dWD`dXD2d dWD`$&dfnprv~BFz~V Z ` f n p v            0 2 6 8 @ B D F P            r t v |          h=H* h=6]h= h=o( h=5\h=5\o(V  " . B P Z \ ^ l n p v ~            HLv~ $&*.2:H^l~FHv h=H*o( h=H*h=CJOJo( h=5 h=5\h=5\o(h= h=o(Q 0 ^ n     *<`FHxGd`d8`d` dWD`ddXD2d`x\n.`zBR"4nxd dWD`d`dXD2 4:>@BDZ\blnr| $,2>JNTVrx~$68JPRTblt"*246@h=5\o( h=5\ h=H*o( h=H* h=o(h=W@^`~pz,.@LPZdvz .4vx(*NTxz 04:@DPRbx~h= h=o(a(HJPRbn&(: @ F N            !!2!:!h!n!!!!!!!!!""B"H"d"h"r"z"""" h=CJ h=>*CJh=>*CJo( h=CJo( h=5\ h=o(h=ST(     d$Ifd$`*hd$WD]*`h)d$WDXD ])`gd'd` dWD`dd$ d$WD` dWDd`    !!!]kdn"$$IfFH!      44 a d$If!!!! !"!D!:]kd8#$$IfFH!      44 a d$If]kd"$$IfFH!      44 aD!L!T!V!x!!!]kd#$$IfFH!      44 a d$If!!!!!!!:]kdR$$$IfFH!      44 a d$If]kd#$$IfFH!      44 a!!!!"("0"8"d]kd$$$IfFH!      44 a d$If8":"R"Z"b"d":]kdl%$$IfF  E     44 a d$If]kd%$$IfF  E     44 a"""""""""""""### ###$#,#:#>#B#J#\#^###############$$$$$$>%@%B%X%\%b%0&2&4&6&@&B&D&F&H&N&d&f&h&j&&&&&&&&&z'|'~''''' h=H* h=6]h=5\o( h=5\ h=CJo( h=CJh= h=o(Qd"""""""# #NJkd &$$If09 UU44 aJkd%$$If09 UU44 a d$Ifd d&dP #.#@#B#^#$@%B%V%b%2&B&&&x''d`d dWD`dXD2JkdN&$$If09 UU44 a d$If''( (J(L(N(P(R(\(b(d(f(h(j(x(|(~(((((((((((((()4)6)8):)<)J)R)T)V)X)Z)z))))))))))***.*0*<*\*d*l*z*|*********** ++ +*+6+8+:+<+>+P+X+\+++++++++,,,,@, h=o(h=b'L(d(~(()6)T))8+,,,,>---.X..0L0j000d` ;dWD`;Bd`B dWD`dd`@,B,F,H,v,,,,,,,,,,,,,,,,,,,-<->-@-B-F-~----------....V.X.Z.\.^.l.~.......... ////// /"/,//0J0L0N0P0R0`0h0r000000000000 h=H* h=6]h=OJQJ^Jo( h=o(h=X000000111018111111111112 2&2.2:2B2J2T2`2l2p2r2t2v2x222222223333 3"3$3&3(3:3B3F3b3d3z333333333333333333344444*4.4D4F4R4r4z44444444444h= h=o(a0011r22"34\5X7777*8R890:2:<:;>;@;B; $d7$8$9Da$d$ 9d$WD`9d`d`d44445 5$5.525P5Z5\5^5`5b5p5r5t5|555555555555556 66666<6@6L6P6`6d6f6p66666666666666777$7.7p7t7x7777777778 88(8*8,8.808>8P8R888888 h=6] h=5\ h=H* h=o(h=Z8888888888888999.:0:;;;<;>;@;B;F;N;X;`;b;P<R<Z<d<<<<<<<<<<<<<<<<<<<<==d=h=t=v=====Ǿh=CJOJh=CJOJo(h=5\o( h=5\h=5aJo(h=5CJaJo(h=5CJ aJh=5CJ aJo( h=5 h=o( h=H* h=6]h=>B;P;b;R<d<<====>>j??:AAAAABC@CzC d,WD`dd` dWD`HWD`dXD2d@&========6>8>>>>>>>>"?(?h?j?r?????????????@@ @@@@@8A:AAAAAAAAARBVBXB^BbBfBhBnBrBtBzB~BBBBBBBBBBBBBB jmh=o( h=5 h=H* h=6] h=aJo(h=OJQJo(h=5\o( h=5\h= h=o(KBBBBBBBBBB CC(D0DDDE EE,EdEhEpEEEEEEEFFFFF(F:FBFFFlF~FFFFFFFFFGrGGGGGHDHHHlHpHHHHHII$I6I8IhIjIIIJJJJJJJJJ KKL h=6] h=aJo(h=5\o( h=5\ jmh=o(h= h=o(RzCCC(DDD E,EFF*FnFFFGtGGGI8IK LLd` dWD`dXD2dWDXD2]` dXD2]dLLLLLLLL L"L&L(L,L.L2L4LFLHLJLLLNLLLLLLC$a$ Chh]h`hC&`#$WD`LL"L$L(L*L.L0L4L6LBLDLFLNLPLzL|L~LLLLLLLLL h=o(hbchbcmHnHsHtHuh= h=0Jjh=Uh}Qjh}QULLLLLLWD`d C0P182P:p#y2 A!"#$l%S Dp=0P182P2 A!"#$l%S Dp$$If!vh#vo#vV#v,:V 6@0,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 6@0+,5o5V5,ae4ytF$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3M$$If!vh#vo#vV#v,:V 4 61+0+,5o5V5,ae4yt3MADd 28r  s 4A(8? VGr 13"2{lwI%_-׉W`!OlwI%_-׉`r xcdd``$D@9@, fbd02,(1dbfaJ`9.d3H1ibYh&nĒʂT 0b%E,a +L j'0 ZZ 1l.+,@VrA.Td9?@ h*sgY`4 jbիsAz%D _.p0$b#RpeqIj..F]L `u(HDd yur  s 4A(8? VGr 23"2 ds3ֈ`L1!\`! ds3ֈ`L1!@hx)fxcdd``a ĜL  312Ec21BUs30941E@ 7$# - :@@ l.#t&=&0Kb~35rN PsgY``0pY:q۩`]ߘE O=qSm'mèd]yl;LF^y9 aeɩ N! P0@p@ݣ! xA4Fi! ~ Ay 0ALb ` 'g.hrC0pXf``⪍I)$5N1iDd r  s 4A(8? VGr 33"2G#wtFla`!G#wtFla ex=KAggO&ƈbuAN@,MXa& j iJe/PIecV1hR6蹟Qcr7f &re`™'q:8SQA lD(Q96d9<^eI`J1^CқSz6Z "$X̮^M/Nn,iŽ8S=~J)'` ļ|/9iY-dǒfmn$4@Eo} Eq[?{Qrqk'_ʹ3YYt?F}݇xᣊ!,DkwfLUlpNZ\sDȝfݱ;7Dt_V &*_+/j~Dd r  s 4A(8? VGr 43"2'Z2E`!'Z2E L"3Zxcdd``a ĜL  312Ec21BUs301( Yjl R A@ ~ 7$# _L Qb% d bv#L ! ~ Ay Sq50mfg,f8dg*e%&*80@]?〚W%xӴ6i ϝy dA]Vm5ٛ=Nzd߽S'_[k=AA"0 S', \{=jcdbR ,.Iͅ 'f:Ihn*Dd r  s 4A(8? VGr 53"2dUY&6 @`!8UY&6 l{62xcdd``$@9@, fbd02,(1dbfab`Y2GA?H {zjx|K2B* Rj@naJ`u!019Y@V ?(L j'}ܙ@X'#H,s S;w}Nŕ" |owGPO5=:a @SUUr%\Sද5_yYg\K4j4DoY [MVn~Zv•tCKtSᬏxm9K7ֈd0ɳyz-C>Oޙ8&.ej qclsI5Unr![|x^q%6Dd bDr  s 4A(8? VGr 73"2HɮaOiIck `!HɮaOiIc  |&excdd``Nc ĜL  312Ec21BUs30)(H Yjl R A@ ~ p7$# - :@@ l.#t&>&0Kz-, dfjQ;f&br<f) @ڈi8H*>?L#Aw@:B8 YahhY>q Mc8}S +n&`XBj}Sg&3x5jT\Pl@-֌OϱM \0pf``121)WbV~Z1Dd x  :A(8mmm? VGr 83"2eơGtPo┽b}SA#`!9ơGtPo┽b}S@x]JAƿ.%#t Z ibIq #M@v>ŕ" |owGPO5=:a @SUUr%\Sද5_yYg\K4j4DoY [MVn~Zv•tCKtSᬏxm9K7ֈd0ɳyz-C>Oޙ8&.ej qclsI5Unr![|x^q%61Dd ,x   :A(8mmm? VGr 93"2eơGtPo┽b}SAK%`!9ơGtPo┽b}S@x]JAƿ.%#t Z ibIq #M@v>ŕ" |owGPO5=:a @SUUr%\Sද5_yYg\K4j4DoY [MVn~Zv•tCKtSᬏxm9K7ֈd0ɳyz-C>Oޙ8&.ej qclsI5Unr![|x^q%6x$$If!vh#v #v3#v#v[:V 5 5355[/ 4 aj$$If!vh#v #v3#v#v[:V 5 5355[4 aj$$If!vh#v #v3#v#v[:V 5 5355[4 aj$$If!vh#v #v3#v#v[:V 5 5355[4 aN$$If!vh#v?!:V 5?!/ 4 aj$$If!vh#v #v3#v#v[:V 5 5355[4 aN$$If!vh#v?!:V 5?!/ 4 ax$$If!vh#v\ #vK#v#v:V 5\ 5K55/ 4 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aN$$If!vh#v:V 5/ 4 ax$$If!vh#v\ #vK#v#v:V 5\ 5K55/ 4 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aN$$If!vh#v:V 5/ 4 a$$If!vh#v#v#v@#v#v#v:V 0555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT|$$If!vh#v#v:V 055aT|$$If!vh#v#v:V 055aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT|$$If!vh#v#v:V 055aT|$$If!vh#v#v:V 055aT$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!a$$If!vh#v #v #v :V 05 5 5 aj$$If!vh#vJ!:V 05J!aj$$If!vh#v#v #v :V 55 5 / 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #v :V 55 5 4 a\$$If!vh#v#v #vE :V 55 5E 4 a\$$If!vh#v#v #vE :V 55 5E 4 a@$$If!vh#vU:V 5U4 a@$$If!vh#vU:V 5U4 a@$$If!vh#vU:V 5U4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #v:V 5# 54 aDN$$If(!vh#v# #v:V 5# 54 aDx$$If!vh#v#v#v` #v(:V 555` 5(/ 4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aN$$If!vh#v:V 5/ 4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aN$$If!vh#v:V 5/ 4 ax$$If!vh#v#v#v` #v(:V 555` 5(/ 4 aN$$If!vh#v:V 5/ 4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 aj$$If!vh#v#v#v` #v(:V 555` 5(4 ax$$If!vh#v#v#v` #v(:V 555` 5(/ 4 aK$$If!vh#v #v:V 45 5a,f4K$$If!vh#v #v:V 45 5a,f4K$$If!vh#v #v:V 45 5a,f4K$$If!vh#v #v:V 45 5a,f4f$$If!vh#v: #v4:V 45: 54/ 4 af4Tf$$If!vh#v: #v4:V 45: 54/ 4 af4TX$$If!vh#v: #v4:V 45: 544 af4Tf$$If!vh#v: #v4:V 45: 54/ 4 af4Tf$$If!vh#v: #v4:V 45: 54/ 4 af4Tf$$If!vh#v: #v4:V 45: 54/ 4 af4TX$$If!vh#v: #v4:V 45: 544 af4Tf$$If!vh#v: #v4:V 45: 54/ 4 af4Tp$$IfX!vh#v#v#v:V 4555/ 4 atf4p$$IfX!vh#v#v#v:V 4555/ 4 atf4b$$IfX!vh#v#v#v:V 45554 atf4b$$IfX!vh#v#v#v:V 45554 atf4p$$IfX!vh#v#v#v:V 4555/ 4 atf4N$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDN$$If(!vh#v# #vC:V 5# 5C4 aDe$$If!vh#v| #v:V 5| 5/ 4 aTW$$If!vh#v| #v:V 5| 54 aTW$$If!vh#v| #v:V 5| 54 aTW$$If!vh#v| #v:V 5| 54 aTR$$If!vh#v:V 5/ 4 aTW$$If!vh#v| #v:V 5| 54 aTR$$If!vh#v:V 5/ 4 aTe$$If!vh#v| #v:V 5| 5/ 4 aTR$$If!vh#v:V 5/ 4 aTW$$If!vh#v| #v:V 5| 54 aTW$$If!vh#v| #v:V 5| 54 aTW$$If!vh#v| #v:V 5| 54 aTW$$If!vh#v| #v:V 5| 54 aTe$$If!vh#v| #v:V 5| 5/ 4 aT$$If!vh#v#v#v@#v#v#v:V 0555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT|$$If!vh#v#v:V 055aT|$$If!vh#v#v:V 055aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT$$If!vh#v#v#v@#v#v#v:V 40+555@555aT|$$If!vh#v#v:V 055aT|$$If!vh#v#v:V 055aTDd 7A igz   <A(8? [a 413" b*$);d(?*qjn$);d(?*qPNG  IHDR{sRGB/=-Ód8o̜9ٿ>'&'NYSꈾ<ε)#2AiӋs^"E6{N.IS)k2aIS{Wft6t9xܷРrm׾0UqV}Muk[Asx;5Nю9q2)~w3~˾CH^/أkƙM`IP<3+#SUn R }UvxrUΫ=OxiƳϰ`_lo>E1g{܌@;ȳNq>Sk3}{P}۴YL:g؏ 115JҬ&{zPpyI7:߿ h 2~I gZǗ^9˭ǰ=Q42f.=XܳTgSx?SLTDz9}:$>6uw$YZ| Ps9ODz}^{1nN?E݋:i}Ԝ9Mz>%T/iWMGD5SBUƫž}о"R+"mENPjjkUjO_-U/I}j΢ 8MYoWc*LdC>cvOhc|kt{ajG|,ew9mZD}1!5ֵꀂ=ToEQsz: {3ϰ7{: {3ϰ7{: {3}Z7XF@7Sj*dXwHf~=W?3TXn|=ք9-s# 1isjNs f}?V+w4! !aߚGsNr"qKu:= [yTY Ux|}:qU+үi~Gn|[#c{c:.MǗ{@dGbJDU-gsmWN%ru^`kX|_7E-ϚR]߫X{/Coy2?@_ΌNQ96WWR&TW9&g[ϵKUX߫ޡias԰wyZ{5z?G {Qޡias԰wyZ{5z?G {m7S{NN~maf4*ȶ¾hTGmm޽z0׶F#"3{o-~'dOɣ=}nwFa #|S E{4tax;<-=~=O {Ca9j;<-=~=O {Ca9j;<-=~:>-=/~;㎡=-=~=O {e=8Y̲Y$<יe)`ER{YY$<יe)`ER{YY$<יe)=wIENDB`$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 al$$If!vh#v#v8#v#v#v :V 0,558555 alCDdN    PA (8? *g}T TVGr 2*g}T T3" baSzFnZ m=yn5SzFnZ mPNG  IHDRosRGBPLTEIDATxu0 EcE b b NM#$@3 yW> ?p5jXKHnB]AI*$`gI9]$g|$N)gHsi}Wq 0z |Q9 =JC@߮ B@+IҡB~ˠBE*(ҠGn }Lp-$a (P8g&iU͊V T IPANҨ(WAA ^1UA!=GOXV)G "J*:Qs (H%U+bjߊH*}DE)W܃DR ĩHE9)n5emd/0b  `ZZo8찐&kxl}[/X?޼"\t]x=5#GGuXE;{} U4+.xCJr/\fcK :  9R6H>oNj?z2 w87p$ ^A|7$v7iu\m <)Ko;poHW*d~Dh1Nl31u&I9n/$o(<ĴCc 4%eB'/_N*X08b&T&tvmљM&9Tw)]'vN; 0L1mM3ANel:΂?u鉌g?WO}MwTE5җ*\B eQh^IENDB`$$If!vh#v\ #v(#v:V 05\ 5(5/ 4 a$$If!vh#v\ #v(#v:V 05\ 5(5/ / 4 a$$If!vh#v\ #v(#v:V 05\ 5(5/ 4 a$$If!vh#v\ #v(#v:V 05\ 5(5/ 4 a$$If!vh#v\ #v(#v:V 05\ 5(5/ / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/  / / / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/ / / / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/ / / / / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/ / / / / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/ / / / / 4 a$$If!vh#v #vd#v%#vS:V 05 5d5%5S/  / / / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#v#v#v#v` :V 05555` / / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#vt :V 05t / 4 a$$If!vh#v#v#v#v` :V 05555` / 4 a$$If!vh#v #v:V 05 54 a$$If!vh#v #v:V 05 54 a$$If!vh#v #v:V 05 54 a$$If!vh#v #v:V 05 54 aa$$If!vh#v #v :V x,5 5 / aTa$$If!vh#v #v :V F,5 5 / aTS$$If!vh#v #v :V P,5 5 aTS$$If!vh#v #v :V ,5 5 aTS$$If!vh#v #v :V P,5 5 aTS$$If!vh#v #v :V P,5 5 aTS$$If!vh#v #v :V 5,5 5 aTS$$If!vh#v #v :V g,5 5 aTS$$If!vh#v #v :V ,5 5 aTS$$If!vh#v #v :V P,5 5 aTa$$If!vh#v #v :V P,5 5 / aT$$IfT!vh#v #vT:V 05 5T/ a$$IfT!vh#v #vT:V 05 5T/ ax$$IfT!vh#v #vT:V 05 5Tax$$IfT!vh#v #vT:V 05 5Tax$$IfT!vh#v #vT:V 05 5Tax$$IfT!vh#v #vT:V 05 5Tax$$IfT!vh#v #vT:V 05 5Ta$$IfT!vh#v #vT:V 05 5T/ a$$IfT!vh#v #vT:V 05 5T/ a$$IfT!vh#v #vT:V {05 5T/ /  a$$If!vh#vr#v :V 05r5 / al$$If!vh#vr#v :V 05r5 / alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 alt$$If!vh#vr#v :V 05r5 al$$If!vh#vy#v| :V 05y5| / a$$If!vh#vy#v| :V 05y5| / a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| a}$$If!vh#vy#v| :V 05y5| aX$$If!vh#v#v:V v55/ alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alF$$If!vh#v#v:V 55alT$$If!vh#v#v:V 55/ al Dd /%z   s 6A (8 ? VGr 12C"` 2R}L6a/Cn.[`!&}L6a/Cn$ kxcdd``a 2 ĜL0##0KQ* W|@DRcgbR q=3PT obIFHeA*/&`b]F"L,a ˎL *'031d++&1 P1aԲP 3q90 `nlbfbbjvsS_ ׃XA|.(? R'Y@ejsB|<0CGS1j`19L&3AMdg\PvHkk*A7s@\Sdc +{wri/G8hfn.#Eqi-H#=H3LsyA&dBK0@qM1~a Jʧϝy4s&YP>X Zp pd%)lcdbR ,.IeaRp/VwDd +Un   c 0A (8  VGr 133" 2M Q5f=Y<>){`!! Q5f=Y<>x )xcdd`` @bD"L1JE `x0*0 Yjl R A@z ~T UXRYvo&`0L`A $37X/\!(?71a)%@y mhR5h~T 6 rf *Ru5g`$E#RpeqIj.C̥{30^7:$$If!vh#v#vH#v:V 40++55H5/  af4T$$If!vh#v#v8#v#v8#v:V 40++5585585/  / af4T$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#vl:V 05l/ aT$$If!vh#v#v8#v#v8#v:V 05585585/ aT$$If!vh#vl:V 05l/ aT$$If!vh#vl:V 05l/  aTDd %z  s 6A (8 ? VGr 14C"` 2Ruuvo콳c`!Ruuvo콳c BpxRJA;K B"b+F9Tt@.Fv"镴VnX޽}!N"1'\($I$˒Y'4ٺɄOB FByת&;=?ahrjZWdfOg0#I1@bytNKtaFDd @z  s 6A(8 ? VGr 16C"`2X /% A6`!X /% A  hCpxR=KA]ȡ$UH!IрHJ^Zx&Jm#i"bK-ٹCr{faB)ބ(0 R$< %Fk"!TM23=給{q3* |SԡVUB#hѣ]dC0^8w~0N6fI[97=-KCmx+9Q_TA L;|rG;=e,Fa SP2jmԸX:cP]=ۨx-淠x 3?Qg8nJy[^&ܠ&gB$8-N}ӯ!'/FFte2jS$z-Ja$$If!vh#vH #v#v#v:V 0  5H 555/  a$$If!vh#vH #v#v#v:V 0  5H 555/  / a$$If!vh#vH #v#v#v:V 0  5H 555/ a$$If!vh#vH #v#v#v:V 0  5H 555/ a$$If!vh#vH #v#v#v:V 0  5H 555/ a$$If!vh#vH #v#v#v:V 0  5H 555/ aN$$If!vh#vX:V 5X/ 4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 aN$$If!vh#vX:V 5X/ 4 aN$$If!vh#vX:V 5X/ 4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 aN$$If!vh#vX:V 5X/ 4 aX$$If!vh#vJ#v :V 5J5 / 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aJ$$If!vh#vJ#v :V 5J5 4 aX$$If!vh#vJ#v :V 5J5 / 4 aN$$If!vh#vX:V 5X/ 4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 aN$$If!vh#vX:V 5X/ 4 a\$$If!vh#v< #v :V 5< 5 / 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v< #v :V 5< 5 4 aN$$If!vh#v$:V 5$/ 4 aN$$If!vh#vX:V 5X/ 4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 a@$$If!vh#vX:V 5X4 aN$$If!vh#vX:V 5X/ 4 a3Dd z  <A?(8mmm [a 173"2eơGtPo┽b}S  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~     2*-./0Z13456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXY]^h`abcdefg\ijklmnopqrstuvwxyz{|}~Root Entry F/,@ Data &WordDocument^ ObjectPoolp//_1234567890 F

ŕ" |owGPO5=:a @SUUr%\Sද5_yYg\K4j4DoY [MVn~Zv•tCKtSᬏxm9K7ֈd0ɳyz-C>Oޙ8&.ej qclsI5Unr![|x^q%6$$If!vh#v #v, #v:V 05 5, 5/ a$$If!vh#v #v, #v:V 05 5, 5/ / /  / a$$If!vh#v #v, #v:V 05 5, 5/ / / a$$If!vh#v #v, #v:V 05 5, 5/ / / a$$If!vh#v #v, #v:V 05 5, 5/ / / a$$If!vh#v #v, #v:V b05 5, 5/ / /  / a$$If!vh#v #v, #v:V 05 5, 5/ a3Dd z  <A?(8mmm [a 183"2eơGtPo┽b}SA]`!9ơGtPo┽b}S@x]JAƿ.%#t Z ibIq #M@v>ŕ" |owGPO5=:a @SUUr%\Sද5_yYg\K4j4DoY [MVn~Zv•tCKtSᬏxm9K7ֈd0ɳyz-C>Oޙ8&.ej qclsI5Unr![|x^q%6$$If!vh#v#v[#v#v#v#v:V T0,55[5555/ aT$$If!vh#v#v[#v#v#v#v:V T0,55[5555/ aT$$If!vh#v#v[#v#v#v#v:V T0,55[5555/ aT$$If!vh#v#v[#v#v#v#v:V T0,55[5555/ / aT$$If!vh#vW:V T0,5W/ aT$$If!vh#v-#v#v#v-#v#v:V T0,5-555-55/ aT$$If!vh#v-#v#v#v-#v#v:V T0,5-555-55/ aT$$If!vh#v-#v#v#v-#v#v:V T0,5-555-55/ aT$$If!vh#v-#v#v#v-#v#v:V T0,5-555-55/ / aT$$If!vh#v :V T0,5 / aT$$If!vh#v#v#v#v#v:V T0,55555/ a$$If!vh#v#v#v#v#v:V T0,55555/ a$$If!vh#v#v#v#v#v:V T0,55555/ a$$If!vh#v#v#v#v#v:V T0,55555/ / a$$If!vh#v :V T0,5 / a$$If!vh#v#v4#v2 #v :V 0,55452 5 a$$If!vh#v#v4#v2 #v :V 70,55452 5 a$$If!vh#v#v4#v2 #v :V 70,55452 5 a$$If!vh#v#v4#v2 #v :V 70,55452 5 a$$If!vh#v#v4#v2 #v :V 70,55452 5 a$$If!vh#v#v4#v2 #v :V 70,55452 5 aDd z  <A(8? [a 353"2/&*Lɩ[ n`!&*Lɩ[ R`;!Rxcdd``^$@9@, fbd02,(1dbfaj`L`41p?0&dT20(m X+ss8@E!mcdbR ,.Ie(cd@UT:&P0q902ld 7D 'FXl A",Dd z  <A(8? [a 363"2/Z(~9'?R" k`!Z(~9'?R"R`;!Rxcdd``^$@9@, fbd02,(1dbfaj`L`41p?0&dT20(m X+ssAE!mcdbR ,.Ie(cd@U\:&P0q902ld 7D 'FXl Ax,`Dd ?z  <A(8? [a 373"2.CvI7B [q h`!CvI7B [qR`;!xuP; @}3O>h v zA@ 4鬬wHzug7f`;bm6Kdig"+ 2AL5&c:vBIz]BT[yX6?(6 5$:1ݙ+=DJ0O8AZuDz, 3Ex~+]jS혙~dbU,"Dd ?z  <A(8? [a 383"2.CvI7B [q d`!CvI7B [qR`;!xuP; @}3O>h v zA@ 4鬬wHzug7f`;bm6Kdig"+ 2AL5&c:vBIz]BT[yX6?(6 5$:1ݙ+=DJ0O8AZuDz, 3Ex~+]jS혙~dbU,"Dd z  <A(8? [a 393"2/Z(~9'?R" ``!Z(~9'?R"R`;!Rxcdd``^$@9@, fbd02,(1dbfaj`L`41p?0&dT20(m X+ssAE!mcdbR ,.Ie(cd@U\:&P0q902ld 7D 'FXl Ax,`Dd z  <A(8? [a 403"2/Z(~9'?R" ]`!Z(~9'?R"R`;!Rxcdd``^$@9@, fbd02,(1dbfaj`L`41p?0&dT20(m X+ssAE!mcdbR ,.Ie(cd@U\:&P0q902ld 7D 'FXl Ax,`n$$If!vh#vN #v#v :V 5N 55 / 4 a`$$If!vh#vN #v#v :V 5N 55 4 a`$$If!vh#vN #v#v :V 5N 55 4 a`$$If!vh#vN #v#v :V 5N 55 4 an$$If!vh#vN #v#v :V 5N 55 / 4 a$$If!vh#v#v#v#v0#v:V 0555505a$$If!vh#v#v#v#v0#v:V 0555505a$$If!vh#v#v#v#v0#v:V 0555505a$$If!vh#v#v#v#v0#v:V 0555505a$$If!vh#v#v#v#v0#v:V 0555505a$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / /  / af4$$IfH!vh#v#v:V 40+55/ / / / af4$$IfH!vh#v#v:V 40+55/ / / af4$$IfH!vh#v#v:V 40+55/ / af4$$IfH!vh#v#v:V 40+55/ / af4x$$If!vh#v\ #vK#v#v:V 5\ 5K55/ 4 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aj$$If!vh#v\ #vK#v#v:V 5\ 5K554 aN$$If!vh#v:V 5/ 4 aDd ckloz  <A(8?? [a 223"2!dkw6؀`!dkw6؀%E,&xcdd``$d@9`,&FF(`T ! KA?H1 @M3zjx|K2B* Rj8 :@u!f0109Y@$fL,&$7S?21d++&1&`1|I/i!v3BK$bh``&)&2\Ο&Ȉ$+B L;@M0n_w `晠cCSÄj^#|y)L̓L Ma()LX4 fo8!CķP0Cd$1!db Np{A|o8 4z.hpcM6F&&\ w0uX0t5!`$ԌIDd Iz  <A(8?? [a 233"2{^~y2< yG8?ׅ@|7{LP1桩aB5Uռ&TAc q&PW&0dpLh߷oAg/qpf݌$`%"tX)f; a 걄g] ϝyt0WD`4Z@4 ~e,g ?8$7$H$OJaJ424 Rh 2@VDWD88`8434 Rh 3AVDWD88`80@"0 cke)ۏ B`aJ< @2< (0uCa$$G$ 9r CJaJFR@BF ckee,g)ۏ 2Ddp9DH$`aJJC@RJ ckee,g)ۏEdp9DH$^\`\aJHQ@bH ckee,g 3Fda$$B*phCJaJ5hOrh Body Text 23%Gda$$9DH$`]CJOJaJKH^O^ Body Text 2Hda$$9DH$`CJOJaJKH`O` ckee,g)ۏ 31#Ida$$9D8$7$H$X`XCJOJaJKHTOT ckee,g 31Jda$$9D8$7$H$CJOJaJKHDoD 7h_K1$7$8$9DH$_HmH nHb\ 666666666tvpvvvvvv606>6666666666666666666666666666666646hH66666666666666466666666666666666666666666666666666666666666664668 0@P`p2(88 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XVxPJ_HmH nHsH tHJ`J cke $1$a$ CJKH_HaJmH nHsH tHJ@J $h 1da$$G$$@&H$CJPJ5\R@"R h 2$ & F @a$$$@& @ CJ4aJ5^@"^ h 3/ & F d$$@&  CJ aJ5j@"j %h 4/ & F `dx$$@&" `CJOJPJQJaJ5V@V  h 5a$$8$7$@&5$H$<CJOJQJaJKHj@"j "h 6/ & F d@$$@&@ CJOJPJQJaJ5^@"^ h 7/ & F d@$$@&@  CJaJ5f@"f #h 8/ & F d@$$@&@ CJOJPJQJaJb @"b )h 9/ & F 0d@$$@&@ 0OJPJQJaJ$A`$ ؞k=W[SONi@N 0nfho> D ckee,g)ۏ 2 Char CJKHaJ.o!. 3eg CharCJKHDo1D 7HTML *B*ph)@q uxFoF F ckee,g 3 Char5B*CJKHaJph:o: E ckee,g)ۏ Char CJKHaJ('`( ybl_(uCJaJ:o: 9 ckee,g 2 Char CJKHaJ^o^ h 3 Char Char*5CJ KHPJ\_HaJ mH nHsH tH6o6  h 2 Char 5CJ4KH8o8 20 yblFhe,g Char CJKHaJ6o6 - ckee,g Char CJKHaJ6o6  h 5 Char CJOJQJ<o< + ybl;N Char5CJKH\aJBo!B  h 6 Char5CJKHOJPJQJ>o1>  h 8 CharCJKHOJPJQJ@oA@  h 1 Char5CJKHPJ\aJBoQB  h 4 Char5CJKHOJPJQJ&/a& 0u w Char>oq> 6 ckee,g)ۏ 3 Char CJKHaJ2o2 C0u Char CJKHaJ>o> h 9 CharCJKHOJPJQJdOd Body Text Indent 21*d9DH$` CJaJKH*j@* !ybl;N+5\j Aj pTOC h!,da$$G$1$$@& H$!B* ph6_OJ PJQJ ^JaJKH(B( ckee,g-x4/4 Rh.^WD88`8rOr Body Text Indent 3#/da$$9D8$7$H$X`XCJOJaJKHF@F &u w0a$$8$7$1$ ! CJaJKHToT ??1$d81$7$8$9DH$a$CJ_HmH nHsH tH.@". 0yblFhe,g2CJaJ$L@$ eg3aJ0FB0 Rhc~ 3 4xVDX0ER0 Rhc~ 2 5xVD<S@sH tHbOb ckee,g)ۏ 21%Lda$$9DH$^p`pCJOJaJKH@O@ Plain TextMH$ OJQJ aJ@`@ 0ON CJKH_HaJmH nHsH tH`O` Body Text 25Oda$$9DH$`CJOJaJKH^O^ Body Text 31Pda$$9D8$7$H$CJOJaJKHVOV ckee,g 21Qda$$9DH$`CJOJaJKHfO"f Body Text 26#Rda$$9D8$7$H$]CJOJaJKHnO2n Body Text 24+Sda$$9D8$7$H$^`CJOJaJKH\OB\ Body Text 3Tda$$9D8$7$H$CJOJaJKHvORv Body Text Indent 31%Uda$$9DH$`]CJOJaJKHVObV ckee,g 22Vda$$9DH$`CJOJaJKH|Or| Body Text Indent 23+Wda$$9D8$7$H$^p`pCJOJaJKH4O4 ~e,g1XH$ OJQJ aJhh Qxjm)ʬuWLfdݮ+5_4csj-V?k3rm}gz gs嚋7xwsȈR W*)|jȫKXͫ dXIBF؇bnh ( *'vɗ3KZjz'c*_=}<9ݻw~]8^~_o?xYýg~^G}J0Emh=Ԅ Ξa>s$-, Oɠ=Hp Ua/ UO d*:(.fTU/!9$V[|hrvs-iUt. 6ڪ4Cebs)bMjBekp um,fd$͑{6GUVf~b#Vb@qTTW.ޛd)i@vdq9Y^X7{2%uHx+af6]>f#sm*qqDHehK)@?71oggo`:fղekp£2֌Nj8ǰD CB?81e>nEeU}H]dm1iQ6褣֧ 9 ^ E^  5558" \r",&6*6-03 :fB H\NTU0Z^bh@mzqfwy}:҉ 0ԳzHP&\   l^$).5d=DAEIN RxVZ_bfjmrw|$(.̶jJ4R| `~!&2/4H:&@nE`I~PTY.^agnjs~wx|6X`8.|2F|6&v-244:@ADG&KZNRW\ `eklr{~؁.rڼ:FtvBPj4!T' 39~<fACI MPBTrWvZh]adhlpuZzB}΂dLVl>Pl0 @"'@,048=BLLGKYdgikmoprtvy{} #)*68:;?GPRTVY^_kmp')029:<=HJLNO_rtuwxz|}~  !#%'(*+-.0248<>FHJLNPRTVzx ( B V v  P j  , T | %*-42l5"<AjF.K Q VZZ_dhNnsx}hDB8l <zV2`(fv8X& z $''' (:(n(((H)~))*X***+8+-3Z33334p444.5556>6666V<AH(I8IlIIIIPJzJKXKNN4OPQQW,XDX\XXXY>YZYYY\a:gg~hk8k\kkkklbnnno,oooou&{:|Prb*x2lzƏҘ2Xfƙ2nx2* D Z  \r>%<.,44=G:ITVW.WfWWXYYZ(Z\ZZ(]fmtttt&u'''(d(()\))*Z**+,.5pAG,PX^_B`^`t````a,aZataaimmmm"nVnnnx̂ަ>>vھ>l >`,.Z4r2X|r.XR~$hB08pJ`j!!!"L"j+2F333@44t79<<HOX._bezmu "0Nl$\xNTdnxNXblv8BLV`(2<F&P2d$0 x !D!!!8"d" #'0B;zCLLLHIJLMNOPQRSTUVWXZ[\]^_`abcefhjlnqsuwxz|~     !"$%&'(+,-./01234579<=>@ABCDEFHIJKLMNOQSUWXZ[\]`abcdefghijlnoqrstuvwxyz{|}~(*+,-./1345678;>?@ABCDEFGIKMPQRSTUVWXYZ[\]^`abcdefghijklmnopqsvy{    "$&),/135679:;=?@ABCDEGIKMOQSUWXYZ[\]^_`abcdefghijklmnopqrstuvwxy{|}~Ō%'<MO2223"3$3J4W4Y44444445!5#5S5`5b5555566%62646666666%72747M7Z7\7::"""""""""""""" /18!!Z 3 @H 0(  *)(  MB  S .()vcޏc&{ 13"?PK N@drs/PKN@*Vdrs/downrev.xmlMN0EH5HliPtddžvID)*0tFI  1֡naXw?:cg)wNdv, -tR=:zC5'ۢјۛyr*%ÏC)N{dTo ],h [|ʄB/PKN@DYdrs/e2oDoc.xmlSK1#q{ҝi3 A$ҖˤKp$vbɞp N&gYTW{gN%4|:i9S^io\=xflbyb!X#{>A1(8 Qy!9tLF& fֶ1$S %_V|ȯF9͖Mnm `i )OMP+%3" :ODpMU9iDU82/wČ̃'>MHcĎr/:Nש0?qa*,g&(8kk c\NJsk| ^`fzRֳO9uHZ +cm\vP %%4YǼzu\A|%ˇHxc^FpJrf} M&&(u,&C댧,V}BPK N@_rels/PKN@f< _rels/.relsj0 }qN/k؊c[F2e~"Kl`0;1 (6{PF783.#c(Y ̵W͘tT0Dlm#]ڀzgͿ0n .):&viUe6F,jY~}_G>~WoPKN@~ [Content_Types].xmlAN0EH%N@%邴K@`dOdlyLhoDX3'AL:*/@X*eRp208J妾)G,R}Q)=HiҺ0BL):T뢸WQDY;d]6O&8* VCLj"󃒝 yJ.;[wIC_ :{IOA !>Ø4 Swl9rj̛Mt֎k8풺toPKN@~  >[Content_Types].xmlPK N@ _rels/PKN@f<  D_rels/.relsPK N@drs/PKN@*V "drs/downrev.xmlPKN@DY $drs/e2oDoc.xmlPKYfLB  S .()vcޏc&{ 33"?PK N@drs/PKN@ drs/downrev.xmlM;O0{$H4'># qph%׹_;3\ v4>܀"nuT]J|Peu|TbiʭN:r SQ4#xoq Z'Ky5RY>t8mGj6笙6=ܣs' s*!_СuܲOjp`할g1lŏtU /PKN@Ydrs/e2oDoc.xmlSK1#q{ҝV:0lDP'm?L:@b+ 1(; B\zUuj,۩&O'-gʋ GO8 ^ ^_->XS0+Ubcχc4('!*O:$i#;q3$c B!Rtuˊ֨2=rMr6A80jdrFA Z*b3mcj*Y&n=̃Ot˷w@'vQD#v{t¸N^'Wąj-/˜0?S_8C瘩ޥl|6'82. Zyc-kԧP"_Jp̫Wȧ^|$=e$gV`dRkiQmxe~>_hPK N@_rels/PKN@f< _rels/.relsj0 }qN/k؊c[F2e~"Kl`0;1 (6{PF783.#c(Y ̵W͘tT0Dlm#]ڀzgͿ0n .):&viUe6F,jY~}_G>~WoPKN@~ [Content_Types].xmlAN0EH%N@%邴K@`dOdlyLhoDX3'AL:*/@X*eRp208J妾)G,R}Q)=HiҺ0BL):T뢸WQDY;d]6O&8* VCLj"󃒝 yJ.;[wIC_ :{IOA !>Ø4 Swl9rj̛Mt֎k8풺toPKN@~  =[Content_Types].xmlPK N@_rels/PKN@f<  C_rels/.relsPK N@drs/PKN@  "drs/downrev.xmlPKN@Y "drs/e2oDoc.xmlPKYeOB  S .()vcޏc&{ 43"?PK N@drs/PKN@* drs/downrev.xmlMN0HH\N qzrBqKg8hr}:Esk幞@ńpL>)º:?+pOtؤVI -t)ֱc\X0yLrNv:7f=,:鮣cbJkU(?>/P 6E5XolIbנ$Lj+TPKN@`drs/e2oDoc.xmlS͎0#4i@t[ JLm'?yLӾ/ N6<c9Lo2Y\a[Q{L9vC߾~3L$T Z"#:>ڪB1* 8A9}JFݚjQBpɗHUb4[*6ɶZ."QSXЎV(E4VP׿y=BP $?XrLˎq'>e-^u<0cfovEIXKLP_c_U!bze.s/0Q3JKa9Lo k@7ZFkmL8lLd[KPLpIMV!\cT 9><Ek=66I r_-qer\PK N@_rels/PKN@f< _rels/.relsj0 }qN/k؊c[F2e~"Kl`0;1 (6{PF783.#c(Y ̵W͘tT0Dlm#]ڀzgͿ0n .):&viUe6F,jY~}_G>~WoPKN@~ [Content_Types].xmlAN0EH%N@%邴K@`dOdlyLhoDX3'AL:*/@X*eRp208J妾)G,R}Q)=HiҺ0BL):T뢸WQDY;d]6O&8* VCLj"󃒝 yJ.;[wIC_ :{IOA !>Ø4 Swl9rj̛Mt֎k8풺toPKN@~  @[Content_Types].xmlPK N@"_rels/PKN@f<  F_rels/.relsPK N@drs/PKN@*  "drs/downrev.xmlPKN@` $drs/e2oDoc.xmlPKYhNB  S .()vcޏc&{ 23"?PK N@drs/PKN@ drs/downrev.xmlMN0HH\*j7JƅRu/IDNcE3oHS[X (&[ ۗf*&dC`IE '~&JJ8hKi,MG<⽇csj$~Й1KgH5W_ff6PxzDkTs C%Lp``!7Kْ0( +vJA PKN@!h,0drs/e2oDoc.xmlSK1#q{ҙJg H*t[O.N.%{np N&gYTW;gV%4l6LyC߼3%U ;Ն1X#{>A1*8 Qy!9tLC#Ll)$S %_V|/F9͖Mnm q48'd`og"&hm76Fr!q0d+^l׉3o>~O-"M;ʽt~WoPKN@~ [Content_Types].xmlAN0EH%N@%邴K@`dOdlyLhoDX3'AL:*/@X*eRp208J妾)G,R}Q)=HiҺ0BL):T뢸WQDY;d]6O&8* VCLj"󃒝 yJ.;[wIC_ :{IOA !>Ø4 Swl9rj̛Mt֎k8풺toPKN@~  ?[Content_Types].xmlPK N@!_rels/PKN@f<  E_rels/.relsPK N@drs/PKN@  "drs/downrev.xmlPKN@!h,0 $drs/e2oDoc.xmlPKYgB  c 0()1? v~ 96C"?2  s 6((1? -iW 97C"?   z((.e,gFh 228`T`T`T`T#" ? jB  C &()v~ 257#" ? jB  C &()v~ 258#" ? jB  C &()v~ 259#" ?jB  C &()v~ 260#" ? jB  C &()v~ 261#" ? jB  C &()v~ 262#" ? B  c 4()?vcޏc&{ 13" ?PK!8[Content_Types].xmlAN0EH%N@%邴K@`dOdlyLhoDX3'AL:*/@X*eRp208J妾)G,R}Q)=HiҺ0BL):T뢸WQDY;d]6O&8* VCLj"󃒝 yJ.;[wIC_ :{IOA !>Ø4 p;fɑ3׶Vc.ӵn(&poPK!8! _rels/.relsj0 }qN/k؊c[F232zQLZ%R6zPT]( LJ[ۑ̱j,Z˫fLV:*f"N.]m@= 7LuP[i?T;GI4Ew=}3b9`5YCƵkρؖ9#ۄo~e?zrPK!Xfdrs/e2oDoc.xmlTˎ0#V$m&ͤ)FA]i,;ݦ$vbɞa 6C BJ's/vuLi.EEg rN7wK!mޞiby$l KYQM4IhR30T56T*z]0TQ0awzs_EAU7Fƕ9N 7%'?XԘ hA՜(eaΈY0d-q\.PeOK^mo5HtϏ_~ (Ej@l&nMms-;J,̑7n'WB7URR#]v-$0^3txQڼ`FvzZ8km4C춐K^UNJ6f]в0֫RhgVN”Ji~̫nxٰcۇEY>ͧƹb&pe%I)er=5/JpL/pd202/h>j$ t@ oPot oot9`I`t ddtP `t`t` tp _Toc18596090 _Toc18597324 _Toc18596091 _Toc18597325 _Toc18596092 _Toc18597326 _Toc18596093 _Toc18597327 _Toc18596094 _Toc18597328 _Toc18596095 _Toc18597329 _Toc18596096 _Toc18597330 _Toc18596097 _Toc18597331 _Toc18596098 _Toc18597332 _Toc18596099 _Toc18597333 _Toc18596100 _Toc18597334 _Toc18596101 _Toc18597335 _Toc18596102 _Toc18597336 _Toc18596103 _Toc18597337 _Toc18596104 _Toc18597338 _Toc18596105 _Toc18597339 _Toc18596106 _Toc18597340 _Toc18596107 _Toc18597341 _Toc18596108 _Toc18597342 _Hlk51681166 OLE_LINK10 OLE_LINK11 _Toc18596109 _Toc18597343 _Toc18596110 _Toc18597344 OLE_LINK3 OLE_LINK4 _Hlk51686020 _Hlk51686699 _Toc18596111 _Toc18597345 _Hlk51687348 _Hlk51687253 _Hlk51688686 _Hlk51689114 _Hlk51689035 _Hlk51689919 _Toc18596112 _Toc18597346 _Hlk51690806 _Hlk51690843 _Hlk51773669 _Toc18596113 _Toc18597347 _Toc18596114 _Toc18597348 OLE_LINK7 OLE_LINK8 _Toc18596115 _Toc18597349 _Hlk51694827 _Toc18596116 _Toc18597350 _Toc18596117 _Toc18597351 _Hlk51749272 _Hlk51696056 _Hlk51696069 _Toc18596118 _Toc18597352 _Hlk51774115 OLE_LINK6 OLE_LINK9 _Hlk51774221 _Hlk51774265 _Hlk51774234 _Toc18596119 _Toc18597353 _Toc18596120 _Toc18597354 OLE_LINK19 OLE_LINK20 _Toc18596121 _Toc18597355 _Toc18596122 _Toc18597356 _Toc18596123 _Toc18597357 _Toc18596124 _Toc18597358 _Toc18596125 _Toc18597359 _Hlk51749746 _Toc18596126 _Toc18597360 _Toc18596127 _Toc18597361 OLE_LINK5 _Hlk51740667 OLE_LINK16 OLE_LINK1 OLE_LINK29 9 U U z z   ~~ r!r!z$z$&&((P,(2(2<<<<<<2ZcSvSv||ƭyy*UU  /:/::~@@AAI4J4JOJOJiJRQRQnn֑֑¢¢;;88BBOrkS/  !"#$%&'()*+,/0-.123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnoR R a a  !!$$&&(([,*2*2<<<<4ZcHvHvavav||ͭrcc??  :::::@@AA4JOJOJiJJJbQbQnnҢҢOOJJPPwt4Y/%/139;?GW]djqw~',19@HOWZcfgktw$0Mtv$CJly9Ibp"5E_h 3C]k./XY(+,=SVWk~  . [ \ p     / 2 9 R W a f j q s z | }    " - 4 I N R r y {  G H S U m o x |   $ * 3 @ B K b i r { ;@DK!*/8=DJSW`dms|07HOnsw~#*jkov{"BIX[\dej|*1PUY`$+07?FQW[bmt  #+/6=BFM\cy $)->B#(,3IPkr4;Lm ,gnuf  "(,4T\go \ %/3=BLUV_eiq(06@z  (4<Ya    ( 0 L T s y } !!7!=!A!u!!!!!!!!!!!!!!!!!!!!!" """"'"*"4"7"A"G"M"Q"Y"o"w""""""""""(#-#.#J#a#f#g##########&$+$,$L$M$x$}$$$$$$$$$$$$$$$$$$ % %%%(%*%6%<%F%J%V%\%h%i%j%o%v%z%%%%%%%%%%%I&O&Y&&&&&&&&&&''''' '*'.'8'<'F'J'T'X'`'f'p't'~''''''''''''(((;(A(E(M(((((((((())))")%)4):)D)H)R)T)^)b)h)l)t)x)))))* **A*I*q*************+ +@+E+f+l++++++++++++++++,,,,),3,>,D,H,P,f,n,,,,,,,,,,,-----`----X..../ ///%/q/w/|////////////////00%0&0-020000000000j1o11122#2'2/232:2O2P2Z2d2r2~2222222222222222223333 3&30343>3@3A3E3O3V3\3c3m3q3{3333333333 4 4(464>4]4c4g4o4t4445+5,5V5W55555555555555555566 6666#696A6^6f6y66666667;7@7N7T7X7c7}7777777777777778888*8/8<8D8J8N8V8a8i8888888888888888999 9#9$9&9Y9]9k9q9u9}99999999999999999:?:C:U:j::::::::::::::; ;;;;&;(;2;4;>;@;F;J;R;h;p;~;;;;;;;;;<<<<<<<<<<<<<<<< =&=1=:=<=N=S=W=\=`=a=o==============> >>> >">&>'>/>2>3>9>;>>>B>M>P>S>W>Y>^>`>z>}>>>>>>>>>>>>>>>>>>???? ? ? ???? ?!?'?(?,?-?/?0?7???@?D?E?V?e?h?m?v?w????????????????????????? @#@&@.@/@8@>@@@A@G@W@`@c@z@}@@@@@@@@@@@@@@@@@@@@@@@@@@@AA AAAA!A)A1ABAHAJAUAXArAtA~AAAAAAAAAAAAAAAAAAABBBBBBBB!B"BBBBBBBBBBBCC'C.C4C=C?CACKCNCOCSCTCaCdCeChCwCyCCCCCCCCCCCCCCCCCCCD DDDDD#D+D,D0D1D5D:DDIDMDRDTDYD]D_DDDDDDDDDDDDDDDD EEE,E/E6E>EIEJEKENEOERESE^EfErExE~EEEEEEEEEEEEEEEEEEEEEEEEEEEF*F-F.F/F8FAFfFhFiFjFpFqFFFFFFFFFGGGGGG G&G(G1G3GBGGGOGTG]GdGmGqGvGGGGGGGGGGGGGGGGH HH!H%H0H4H9H;HAHKHSHcHfHrHtHuHwHHHHHHHHHHHHHHHHHHHHIII2I5IK?KBKCKHKIKWK]KcKzKKKKKKKKKKKKKKKKKKKKK LLLLLLLLLLLLLMM M MMMMM#M(M.M5M7MEMTMXMnMrMMMMMMMMMMMMMMMMN/N0N;NNGNKNYN[N\NgNjNlNpNsNvN|N}NNNNNNNNNNNNNNNNNNNNNNN OOO$O5O;OT@TETGTQTZTcTTTTTTTTTTTTTTT'U)U*U+U.U^UoUqUtUvUxUyUzU{U|U}UUUUUUUUUUUUVV6V7V^VbVVVVVVVVVVVVVW WW W$W.W0W=WAWGWKWOWTWZWjWnWWWWWWWWWWWWWWWWWWWWWWXXXXXXXX"X-X6XDXJXZX^XbXiXjXlXpX}XXXXXXXXXXXXXXXXXXXXXXXXYYYYYYY0Y3Y7Y8Y:Y_B_c_x_________n`t`{`````!a+aPaZa]aoaua{a~aaaaaaaaaaaaaaaaaaaaaaab b"b7b8b9b>bFbGbWbXbZbdbgblbxb~bbbbbbbbbbbbbbbbbbbbbbbbb ccc!c"c.c/c7cDcJcWc[c\ccchcocsc{cccccccccccccccccd dddd#d>dCdVdXd[d]d^d`dddddddddddddd ee4eLene}eeeeeeef ffff&f.fVfWfXf]fffgfmfyffffffffffffffffggggg#g=g@gIgPgVgXg]gcgngggggggggghh(h,h?hCh]hihlhuh~hhhhhhhhhhhhhhhiiii i iiiiiiiiii!r%r(r8rRrUr\rbrdrerkr{rrrrrrrrrrrrrrrrrrrrr sss/s5s6s;s@sAsCsJsLsnsvs{ssssssssssssssssstttttttt t"t(tPtRtStTtZt[tktmtrtstttutytztttt uuu>uEuGupuuvvv!v(v;vDvfvjvovsvxvvvvvvvvvvvvvvvvvvvwwww(w*w,w1w5wx?xIx\xexhxixoxpxuxxxzx}xxxxxxxxxyyy&y(y]yayby{|~:<TUWY]_hqstxy&'-DIhjuy(HSTt{*+/PRSUW`m-1 !(9AL\iklzX^fhjk (/029t(3 (=CEOQ (M "$(089bcfhj~!(Z]_`c@G\cgj|~89=>^_klt} !'(Ybf~ ((57EFMW(V(Hbk(Ucgnuwy{ %-MRw{}')-16<DEXYgiqw~ !S^_cgz #'*.:DJKQU\_bdhjnpuwz|,12FY]kor{|"$%0<=HKOTpx4S   %-48"$&-038JZaens&)YZ_entw"sx  " < D L P                        " 2 6 7 < E I N ] ^ b { }                        " 4 7 8 9 ? P Q S Y Z [ \ a  9 = F I      " U ` e l s w        "'(*.0135;Hlr  $-KNOPVghjpqrsx DHQV|~  -4;Wa}-6$)26S\elvx 28@ACDGalst"/05AOZ\fhst0?DHXY[_abdfkx5Adoq{}!#*18<=ASiw/16789=>OQX]mq*/4=DM[fhrt #'(:>Adn"#$=B       J O P W [ \ ` a f o t x          AAAB\_78;8BBi\k\փ "2KYt&ALj{7CEK`r$/G\r.EZm,?Vf(?Sacm~ * N U r   /   < ? d g !mo78uxRU(+9<DE !G!I!!!"""""")#*#@#C#b#c#y#|#####$$'$($>$A$c$d$j%m%&&))6*9*1+4+o+r+++--....s1v1118292f2g2333333{4|4444477a7b777n8q8y8z88888&9)9;;;;<<9<<<B<F<Q<U<V<Y<b<f<g<j<q<v<<<*=-=f=g=== @ @m@n@@@@@@@zAASBVB[B^BBB!D"D8D9DDDE EEEEEF FFFFF!G&G(G+GGGHHIIIIJJJJyJzJjKkKKKMLPLULXLLLLLLLLL*M+MJMKMMMMM N NNNNNNO*O0OOOPPPPQQ4Q7QQQQQRR R!R$R'R1R6R7R;RRSSSTTTTA9;KR69)*PQcg()56?@NO׎؎!,_`{|ǑʑՑ֑OcEHLMϓГ%VW•ST%9Ƙǘژݘ;? 12=>EF(+؟ޟ./LO^a^_Ңբ\_z~ǩʩ`cORګ۫gn &CDDIKPɷ̷ad}LOwx #&*.SVJMZ\~-/ -0hk-2#%WXcfop!%*nsKOz25adilhq18:?#;AY\jn'+WZ #=>NR(, ),@Ahk(+ovDGTYim*+@Aru$'TWijmq 45LO*.OP/2u x         CF<?SWsv#x| %(hlorwzAB _csuTW\_    " """C"G"k#p#########}$~$$$$$$$e&j&&&7'8'I'L'''''(((!(.(<(G(M(N(T(V(\(](c(r(((((())h)m)[*^*c*f*****-- .$.&.'.////000000a2g2 44C4F444445555!7$7%7&7)7.78888'9(9d9j999::,;/;j;n;W<Z<_<b<<<<<==Z=a=>>>>>>????@@@@@@AABBC CCCCCDD)D.DPDUDDDDDDD E EEEEEEE,F1FkFpFFFFFGGGGGGXH[HiJlJJJJJAKDK5N6NNNOOOOPPz`#՜.+,D՜.+, X`lt| H d ?GKSOProductBuildVer2052-10.8.2.7129  FMicrosoft Word 97-2003 ĵ Q}QQQQQRRRRRRUU1V7VVVVVVVVVxWyWWWWWXX'X(XXXZZ[[[[ \\\\\\^_H_K_N_O_ ``QaRatawaaa:b=bbbbbbbbbbb8c;c(d-dddee"e#egg ggNgSgfgkgugzgggggghhh,i2iYi\i_i`ijjjjkkXl]lmmmmn$n/n2npnunnnnnIoLo5t8tttttuu1u4upusuuuuutvuvwwxx@yCy({+{{{||||$})}E}K}~~΀1Dix{gj$x{|}݋ߋҍՍۍߍ̎Ўnr)-HK<?“œMPkn$&,04jnEGTUʙ˙ҙәDGRU RU!kobejmƠ(+7:cd$%W[gk69bcEGlnvx57ѮӮ}įƯ !#ްDZʱY\-058rsٳܳ!"47ST@CTUgj¸)*MVYZJM"%CD˽̽սֽ6:CDBCKN.3%&03|=@ps/2Z[RSir "(VX`buw25?B#)orv'.>DNRW]gjtwGLW[di  RXY^-./1stQT!%78/3=B@CLQ@C36^_VYad^a8=>EFmՃփssssssssssssssssssssssssssssssssssssssssssssssssssssssss333333s3333s3s333s3s333sssssss3s3s3ss3s3s333333333333ss3s3ssssss3ss33333333333333sssss3s3333sssss333333333333sss33s3ssss3ssss33s3sss333s333ss333s33333s33333333333333s3333s333ssssssssss33333333sssssssssssss333333333ss333333333333ss33s333s3s33ssss3ss33ss33sssss3ss3sss3sss33sss3sss3ssss33ssssss3s3s33s33333333333s3s33333s33333333333ss33333333s33s333ss3333333s333333s3ss3sss33333333s33333333s33333333333333s33s33s333sssss3333333333s33ss333333s333s333s333333s333333333333333s33333333333s3ssss3s333s3333333ssssssss33s3ss33s3333s33s3333333s3s333333333s3s333s3333333333333333333333333333333333333333333333ss3s33s333s333333s3s3s333333333s3s3333333333s3s33333333333s33333333333333333333s3333333333sss33333s33333ss333333333s33333333333333333333sss333333333s3333333333ss3s3333s3sss3s3sssssss3s333s33s3s3s3s3s33ss3s3ssss3s33ss3sss3sss333333s333333s3s333333ss333333s3333s33333sss3333s33333333s3s3333sss3333s333333333ss33s333s33333s333333333333s3333333333ss 1?JWqt>~~~~7k},>8o|;Hq}ߕGTϖܖ Id^rѠ >i*ԣVbrѧRj vα)8Hóгp=wA=[`/Fb''''''(D)46M6X6666OO"OOOTTu]]ao*p>p#rLrs5s#z3;D+=aLBRX.o?rx p_09GWgf'5A:/@2QUGo$- 1x@zw4 jD TH _ l!&!J!R^!"""&"%7"](#0#M#[#"m# $2$^]$#%%g#%c%'l%{% &%&*&)4&H&R&\&\&c&t '/'z1'F'R'( (U(p((M=(@(dF(R()!)H)`){)*n*)@*y*+K +AH+\p+(,<,8,4H,\,h},Y'-*-F8-9-DE-el-4.=.K.N.y.//8/o=/N/P/o/Xt/u/Z(0;0C!1)1aF1iv12 2@V2g2s2w2a3z34k44\l4m4m]5h5y536C6O6}679H9H9f9?:U:&;;*;6]<^_<d<==;=`=a=&m='>+>?1?8?9?0@pAhABB)B(B5B8BYBoBUCV4Cw^CuwC'D_(D>DLD-]DKEWEE2FF#F G G!G&G)GfM`N6N@NqJNXN!OP PPPU,Pa-Pe6P> QRR'R&RVRS\RuR~SSSoTT?!T~(ThJTcTuTzTU[4U!pUW|U"CVA}V W3W W|6W9W:WX Y+YRYWYQhYwZIZOUZUZFVZbZ|pZ~ZT[O[t[\J"\6\0D\W\dc\5n\mn\|\=]]]P]6]I^X^=f^o^_(_$`>`~P`iaD0a DalaYb}~}F ~62~J~_~q{~x~~X%\)M5m?cWilV!l)|DJBTy#^^eE&-G [h]Fj1psF]y_%q[|udv?;-cPru}wO %'Y1M8sVX[er&EKCM%m^.n96NaSk# ,O@EJasdil8=NV0YoZeep^%r1t;VQ[am'917zHb|n!v!#{V#3?0F\@2a=7:1FFmYz'42:I"a4?IVL[r[FL|C fye=$t *< -3'=2Xz6;  #)Y[ rC/!){.58= 4_N&]$ei>'%hy  ALV| $B.f`]"=UvWF_bcf,L),l<[g -$LOxWr!(^=ewCPqu 1BXZ>cGk"D Q~E/JV`!op[r &9PUWR_:!v'#yxT,yx!C-Jd gQ0|K3>N`bf{ PN!9K:0MHN Tgz+/A KD^#0J~Sar)4/Uy#aIVMT0c#z? Vz!/*]o0+8 )ha~-/_8 5yR'']Z$@:[\cp}!gH)Bp:Lt`%NjC40Trw}r!*?L00K9Y iy=t m+Fq`rt!29AG1|<%[>sjU<RbDmoK B}".C?AR`Vw (=IWOUr7d,Q(n{+ A=p{fkaU3,j0AqYc\p\rOdjpepqtvփ؃@0  (0678?BEHKNPW\beikopr|}!#%&')-0138<B&02BFHXhtvx  $(*:>DLPXZbhl|~,DJNRTVZbhjnxUnknownG*Ax Times New Roman5Symbol3. *Cx Arial;= |8ўSOSimHei7E eck\h[{SO;([SOSimSun;5 N[_GB23121NSeN[7.@Calibri;Wingdings?= *Cx Courier New5. .[`)Tahoma7@CambriaA$BCambria Math  QhËGËGËG `#H`#HZ&!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[KQP) $PV4C2! xx LOVEOPEY A.Mr. Wave    MSWordDocWord.Document.89q